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Journal Arh Hig Rada Toksikol

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Epigenetic toxicity and cytotoxicity of perfluorooctanoic acid and its effects on gene expression in embryonic mouse hypothalamus cells.

Hun Kim, Min-Wook Hong, Yun-Ho Bae, Sung-Jin Lee,

Even though the endocrine-disrupting potential of perfluorooctanoic acid (PFOA) is well known, the mechanisms underlying its cellular and epigenetic toxicity at the critical stage of hypothalamic development are poorly understood. This is why we studied its effects on the embryonic mouse hypothalamic cell line N46 (mHypoE-N46) with a hope to ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(3):182-190]

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Nuclear medicine staff exposure to ionising radiation in 18F-FDG PET/CT practice: a preliminary retrospective study.

Bojan Pavičar, Jasna Davidović, Biljana Petrović, Goran Vuleta, Saša Trivić, Vlatko Šajinović, Nataša Egeljić-Mihailović, Nataša Todorović, Branko Predojević,

This retrospective study provides an insight into the levels of radiation exposure of six nuclear medicine (NM) staff (four technologists and two nurses) performing routine diagnostic <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG) positron emission tomography-computed tomography (PET/CT) at the University Clinical Centre of the Republic of Srpska, Department of Nuclear Medicine and Thyroid Disorders, ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(3):216-224]

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Covid-19 as occupational disease in healthcare workers: a brief review of cases in the Clinical Hospital Centre Rijeka, Croatia.

Hrvoje Lalić,

The coronavirus disease 19 (COVID-19) pandemic has had a tremendous impact on every facet of private life and work organisation in virtually all social and economic sectors worldwide. People who stand on the first line of defence are healthcare workers (HCWs) risking exposure to infected patients. However, even though they ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(3):240-243]

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Associations of NLRP3 and CARD8 gene polymorphisms with alcohol dependence and commonly related psychiatric disorders: a preliminary study.

Anja Plemenitaš Ilješ, Blanka Kores Plesničar, Vita Dolžan,

We investigated two functional polymorphisms in NLRP3 inflammasome genes (<i>NLRP3</i> rs35829419 and <i>CARD8</i> rs2043211) and their association with alcohol dependence and related anxiety, depression, obsession-compulsion, or aggression in 88 hospitalised alcohol-dependent patients, 99 abstinent alcohol-dependent participants, and 94 controls, all male Caucasian. Alcohol dependence-related psychiatric disorders were assessed with the ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(3):191-197]

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The role of pumpkin pulp extract carotenoids against mycotoxin damage in the blood brain barrier in vitro.

Manuel Alonso-Garrido, Noelia Pallarés, Guillermina Font, Paola Tedeschi, Lara Manyes, Manuel Lozano,

Some mycotoxins such as beauvericin (BEA), ochratoxin A (OTA), and zearalenone (ZEA) can cross the blood brain barrier, which is why we tested the anti-inflammatory action of a pumpkin carotenoid extract (from the pulp) against these mycotoxins and their combinations (OTA+ZEA and OTA+ZEA+BEA) on a blood brain barrier model with ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(3):173-181]

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Radium interference during radon measurements in water: comparison of one- and two-phase liquid scintillation counting.

Ivana Stojković, Nataša Todorović, Jovana Nikolov,

Assessment of radiation exposure to drinking, surface, and groundwater and of the associated health risks calls for accurate and precise <sup>226</sup>Ra and <sup>222</sup>Rn measurements. One method that fits the bill is liquid scintillation counting (LSC), which allows measurements in one-phase (homogenous) or two-phase samples. The aim of our study was ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(3):205-215]

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New psychoactive and classic substances in pooled urine samples collected at the Ultra Europe festival in Split, Croatia.

Davorka Sutlović, Sendi Kuret, Marija Definis,

We believe that analysing pooled urine samples for recreational drugs used at mass events can provide useful information about trends in drug use. An opportunity arose with the Ultra Europe music festival, which is attended by more than 150,000 people from over 150 countries every year. We analysed 30 pooled ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(3):198-204]

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Job demands, job control, and social support as predictors of job satisfaction and burnout in Croatian palliative care nurses.

Ivana Tucak Junaković, Ivana Macuka,

The Job Demands-Control-Support (JDCS) model has seldom been tested in palliative care settings, and occupational well-being of palliative care professionals has never before been investigated in Croatia. Our aim was therefore to fill that gap by testing the JDCS model among Croatian nurses providing palliative care. More specifically, we wanted ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(3):225-231]

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Work from home and musculoskeletal pain in telecommunications workers during COVID-19 pandemic: a pilot study.

Azra Huršidić Radulović, Roko Žaja, Milan Milošević, Bojana Radulović, Ivica Luketić, Tajana Božić,

One of the side-effects of the COVID-19 pandemic is a global change in work ergonomic patterns as millions of people replaced their usual work environment with home to limit the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection. The aim of our cross-sectional pilot study was to ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(3):232-239]

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Pro-oxidant potency of clothianidin in rainbow trout.

Tarek Fakhereddin, Demet Doğan,

Clothianidin is a systemic neonicotinoid insecticide interfering with the central nervous system by acting as a nicotinic acetylcholine receptor agonist. Although previous studies on fish report low toxicity, its proven toxic potential for aquatic invertebrates and lack of data on its effect on juvenile fish have prompted us to investigate ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(3):164-172]

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Prevalence of five pharmacologically most important CYP2C9 and CYP2C19 allelic variants in the population from the Republic of Srpska in Bosnia and Herzegovina.

Stojko Vidović, Ranko Škrbić, Miloš P Stojiljković, Vanja Vidović, Jelena Bećarević, Svjetlana Stoisavljević-Šatara, Nela Maksimović,

The enzymes of the cytochrome P450 superfamily play a critical role in phase I drug metabolism. Among them, CYP2C9 and CYP2C19 are clinically important, as they can mediate severe toxicity, therapy failure, and increased susceptibility to cancer and other diseases caused by chemicals. The aim of this study was to ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(3):129-134]

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Environmental and occupational exposures associated with male infertility.

Tihana Marić, Aleksandra Fučić, Anna Aghayanian,

The upsurge in male infertility over the last two decades, possibly due to environmental exposure, has raised significant interest, particularly boosted by reports from fertility clinics, which showed that chronic diseases and hereditary or other medical conditions might only partially explain current incidence of male infertility. Both environmental and occupational ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(3):101-113]

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Drug-drug-gene interactions as mediators of adverse drug reactions to diclofenac and statins: a case report and literature review.

Nada Božina, Lana Ganoci, Livija Simičević, Katarina Gvozdanović, Iva Klarica Domjanović, Margareta Fistrek Prlić, Tena Križ, Ana Borić Bilušić, Mario Laganović, Tamara Božina,

Concomitant treatment with drugs that inhibit drug metabolising enzymes and/or transporters, such as commonly prescribed statins and nonsteroidal anti-inflammatory drugs (NSAIDs), has been associated with prolonged drug exposure and increased risk of adverse drug reactions (ADRs) due to drug-drug interactions. The risk is further increased in patients with chronic diseases/comorbidities ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(3):114-128]

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Differences in fungal contamination of broiler litter between summer and winter fattening periods.

Mario Ostović, Ivica Ravić, Matija Kovačić, Anamaria Ekert Kabalin, Kristina Matković, Ivana Sabolek, Željko Pavičić, Sven Menčik, Danijela Horvatek Tomić,

This study aimed to compare fungal contamination of poultry litter between warm and cold seasons. It was carried out in commercial production conditions over two five-week fattening periods: one in the summer (July-August) and one in the winter (December-January). Broilers were reared on a litter composed of chopped straw and ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(3):140-147]

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Radioactivity of soil in Croatia II: 137Cs, 40K, and absorbed dose rate.

Marko Šoštarić, Branko Petrinec, Mak Avdić, Ljerka Petroci, Milica Kovačić, Željka Zgorelec, Božena Skoko, Tomislav Bituh, Jasminka Senčar, Gina Branica, Zdenko Franić, Iva Franulović, Davor Rašeta, Ivan Bešlić, Dinko Babić,

We took samples of uncultivated soil from the surface layer (0-10 cm) at 138 sites from all over Croatia and measured their radionuclide activity concentrations with high-resolution gamma-ray spectrometry. This second part of our report brings the results on <sup>40</sup>K and <sup>137</sup>Cs to complement those on the <sup>232</sup>Th and <sup>238</sup>U ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(1):15-22]

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Presence of nitrosamine impurities in medicinal products.

Ilijana Sedlo, Teo Kolonić, Siniša Tomić,

In 2018, some sartan medicinal products were reported to be contaminated with nitrosamine compounds, which are potent mutagenic carcinogens. Two nitrosamines received particular attention: <i>N</i>-nitrosodimethylamine (NDMA) and <i>N</i>-nitrosodiethylamine (NDEA). These have since been confirmed in different types of medicinal products, including ranitidine and metformin. Consequently, the European Medicines Agency (EMA) ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(1):1-5]

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Epidemiology of occupational injuries among insured workers in Saudi Arabia between 2004 and 2016.

Mohsin Abbas, Rashid Saeed, Zaki-Ul-Zaman Asam,

This is a retrospective analysis of annual reports on occupational injuries issued by the national social insurance agency of the Kingdom of Saudi Arabia (KSA) for the years 2004 through 2016. For each criterion we calculated an index based on the equation <i>N<sub>Y</sub>/N<sub>ref</sub></i> x100, where <i>N<sub>Y</sub></i> is the number of ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(1):42-52]

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Chemical and biological characteristics of propolis from Apis mellifera caucasica from the Ardahan and Erzurum provinces of Turkey: a comparative study.

Mehmet Arslan, Yusuf Sevgiler, Celal Güven, Zehra Tuğba Murathan, Nurcan Erbil, Deniz Yıldırım, Mehmet Büyükleyla, Şakire Karadaş, Rima Çelik, Eyyüp Rencüzoğulları,

The aim of this study was to compare the biological activities of ethanolic propolis extracts of <i>Apis mellifera caucasica</i> obtained from Ardahan and Erzurum provinces of Turkey. Samples were tested for antioxidant, anticytotoxic, anticarcinogenic, antibacterial, and antifungal potentials using different techniques. Propolis samples from the two provinces had different mineral ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(1):53-69]

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Application of a new in situ calibration technique for gamma spectrometry and comparison of in situ and laboratory measurements.

Davor Rašeta, Branko Petrinec, Dinko Babić, Marko Šoštarić,

<i>In situ</i> gamma ray spectrometry was developed to quickly measure large areas of land following nuclear accidents. However, a proper calibration of detectors for <i>in situ</i> measurements is a long and complicated process. One tool designed to make this calibration quick is the InSiCal software. We compared 5,000 s <i>in ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(1):29-35]

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Unusual aetiology of a type 2 myocardial infarction: a case-based review.

David Toma, Tania-Emima Toma, Cristina Bologa, Cătălina Lionte,

Organophosphate pesticide (OP) poisoning is quite common and can cause cardiovascular complications and even direct myocardial injury. However, no guideline has included an acute poisoning as a potential cause for a type 2 myocardial infarction (MI) so far. Here we present a case of a 61-year-old woman brought by ambulance ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(1):80-87]

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Characterisation of twelve newly synthesised N-(substituted phenyl)-2-chloroacetamides with QSAR analysis and antimicrobial activity tests.

Aleksandra Bogdanović, Anita Lazić, Slavica Grujić, Ivica Dimkić, Slaviša Stanković, Slobodan Petrović,

In this study we screened twelve newly synthesised <i>N</i>-(substituted phenyl)-2-chloroacetamides for antimicrobial potential relying on quantitative structure-activity relationship (QSAR) analysis based on the available cheminformatics prediction models (Molinspiration, SwissADME, PreADMET, and PkcSM) and verified it through standard antimicrobial testing against <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, methicillin-resistant <i>S. aureus</i> (MRSA), and <i>Candida ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(1):70-79]

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Characteristics of work-related COVID-19 in Croatian healthcare workers: a preliminary report.

Roko Žaja, Ivana Kerner, Jelena Macan, Milan Milošević,

Healthcare workers (HCWs) are considered to run a higher occupational risk of becoming infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and develop coronavirus disease (COVID-19) than the rest of the population. The aim of this study was to describe and analyse the characteristics of work-related COVID-19 in Croatian ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2021, 72(1):36-41]

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The influence of specific aspects of occupational stress on security guards' health and work ability: detailed extension of a previous study.

Jovica Jovanović, Ivana Šarac, Jasmina Debeljak Martačić, Gordana Petrović Oggiano, Marta Despotović, Biljana Pokimica, Blerim Cupi,

In our earlier study of security guards, we showed that higher occupational stress was associated with health impairments (metabolic syndrome, diabetes, hypertension, cardiovascular diseases) and work disability. The aim of this study was to further explore the association of specific occupational stressors with health impairments and work disability parameters in ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2020, 71(4):359-374]

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Biomonitoring findings for occupational lead exposure in battery and ceramic tile workers using biochemical markers, alkaline comet assay, and micronucleus test coupled with fluorescence in situ hybridisation.

Vilena Kašuba, Mirta Milić, Davor Želježić, Marin Mladinić, Alica Pizent, Zorana Kljaković-Gašpić, Melita Balija, Irena Jukić,

Manufacture of lead-containing products has long been associated with various health risks. To get an insight into the related genotoxic risks, we conducted a biomonitoring study in 50 exposed workers and 48 matched controls using a battery of endpoints that sensitively detect the extent of genome instability in peripheral blood ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2020, 71(4):339-352]

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Experiences with the accreditation of the Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Zdenko Franić, Tomislav Bituh, Ranka Godec, Mirjana Čačković, Tomislav Meštrović, Jerko Šiško,

Accreditation in accordance with the international General Requirements for the Competence of Testing and Calibration Laboratories (HRN EN ISO/IEC 17025 standard) has become a widely accepted method of quality management and objective evidence of technical competence, knowledge, and skills of testing and calibration laboratories. In 2010, the Institute for Medical ... Read more >>

Arh Hig Rada Toksikol (Arhiv za higijenu rada i toksikologiju)
[2020, 71(4):312-319]

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