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Journal Arch Dis Child

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Towards evidence-based medicine for paediatricians.

Bob Phillips,

Arch Dis Child (Archives of disease in childhood)
[2021, 106(2):195]

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What happens to children after an episode of concussion?

Arch Dis Child (Archives of disease in childhood)
[2021, 106(2):124]

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Let's add in some clindamycin.

Arch Dis Child (Archives of disease in childhood)
[2021, 106(2):107]

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Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis.

Carolin Fleischmann, Felix Reichert, Alessandro Cassini, Rosa Horner, Thomas Harder, Robby Markwart, Marc Tröndle, Yoanna Savova, Niranjan Kissoon, Peter Schlattmann, Konrad Reinhart, Benedetta Allegranzi, Tim Eckmanns,

<h4>Background</h4>Neonates are at major risk of sepsis, but data on neonatal sepsis incidence are scarce. We aimed to assess the incidence and mortality of neonatal sepsis worldwide.<h4>Methods</h4>We performed a systematic review and meta-analysis. 13 databases were searched for the period January 1979-May 2019, updating the search of a previous systematic ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Gestational age at birth and child special educational needs: a UK representative birth cohort study.

Neora Alterman, Samantha Johnson, Claire Carson, Stavros Petrou, Oliver Rivero-Arias, Jennifer J Kurinczuk, Alison Macfarlane, Elaine Boyle, Maria A Quigley,

<h4>Objective</h4>To examine the association between gestational age at birth across the entire gestational age spectrum and special educational needs (SENs) in UK children at 11 years of age.<h4>Methods</h4>The Millennium Cohort Study is a nationally representative longitudinal sample of children born in the UK during 2000-2002. Information about the child's birth, ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Morphine or hydromorphone: which should be preferred? A systematic review.

Sarah Spénard, Charles Gélinas, Evelyne D Trottier, Fannie Tremblay-Racine, Niina Kleiber,

<h4>Objective</h4>To systematically review available paediatric literature on comparisons between morphine (Mo) and hydromorphone (Hm), to guide clinicians to rationally use these medications.<h4>Design</h4>Systematic review within four databases for all studies published from 1963 to July 2019.<h4>Setting</h4>All paediatric settings.<h4>Eligibility</h4>All studies comparing Mo to Hm in individuals younger than 21 years.<h4>Main outcome measures</h4>The ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Resilience in research: TORPEDO-CF.

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Opioid use in young adults.

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Can fosfomycin be used for the treatment of Gram-negative urinary tract infections in children?

Rachael Purcell, Nelson Wang, Amanda Gwee,

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Indirect effects of the COVID-19 pandemic on paediatric healthcare use and severe disease: a retrospective national cohort study.

Thomas C Williams, Clare MacRae, Olivia V Swann, Haris Haseeb, Steve Cunningham, Philip Davies, Neil Gibson, Christopher Lamb, Richard Levin, Catherine M McDougall, Jillian McFadzean, Ian Piper, Alastair Turner, Stephen W Turner, Margrethe Van Dijke, Donald S Urquhart, Bruce Guthrie, Ross J Langley,

<h4>Objectives</h4>To determine the indirect consequences of the COVID-19 pandemic on paediatric healthcare utilisation and severe disease at a national level following lockdown on 23 March 2020.<h4>Design</h4>National retrospective cohort study.<h4>Setting</h4>Emergency childhood primary and secondary care providers across Scotland; two national paediatric intensive care units (PICUs); statutory death records.<h4>Participants</h4>273 455 unscheduled primary care ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Continuously advancing quality care.

Aoife Molloy, Terence Stephenson, Martin Marshall,

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Intestinal parasites among children with diarrhoea from Santiago (Cape Verde).

Denise Andrade Colito, Roberto Dorta-Guerra, Hailton Spencer Da Costa Lima, Carine Pina, Deisy Gonsalvez, Basilio Valladares, Pilar Foronda,

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Is nasal balloon autoinflation an effective treatment for children with glue ear?

Kiran Joshi,

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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CONservative TReatment of Appendicitis in Children: a randomised controlled feasibility Trial (CONTRACT).

Nigel J Hall, Simon Eaton, Frances C Sherratt, Isabel Reading, Erin Walker, Maria Chorozoglou, Lucy Beasant, Wendy Wood, Michael Stanton, Harriet Corbett, Dean Rex, Natalie Hutchings, Elizabeth Dixon, Simon Grist, Esther M Crawley, Bridget Young, Jane M Blazeby,

<h4>Objective</h4>To establish the feasibility of a multicentre randomised controlled trial to assess the effectiveness and cost-effectiveness of a non-operative treatment pathway compared with appendicectomy in children with uncomplicated acute appendicitis.<h4>Design</h4>Feasibility randomised controlled trial with embedded qualitative study to inform recruiter training to optimise recruitment and the design of a future ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Work of a paediatric bioethics centre during the COVID-19 pandemic first phase.

Joe Brierley, Sarah Aylett, Anne MacNiven, Mariana Dittborn,

<h4>Objectives</h4>Decisions with an ethical component have been controversial during the COVID-19 pandemic, whether leaked intensive care unit (ICU)-rationing documents, transfer of people to care-homes to 'protect the National Health Service' or the duty to treat patients despite inadequate personal protective equipment. To counter criticism of ethics per se, and to ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Fetal alcohol spectrum disorders: an overview of current evidence and activities in the UK.

Lisa Schölin, Raja A S Mukherjee, Neil Aiton, Carolyn Blackburn, Sarah Brown, Kate M Flemming, Paul R Gard, Helen Howlett, Moira Plant, Alan D Price, Jennifer Shields, Lesley A Smith, Michael Suttie, David C Zammitt, Penny A Cook, ,

Estimates for the UK suggest that alcohol consumption during pregnancy and prevalence of fetal alcohol spectrum disorder (FASD)-the most common neurodevelopmental condition-are high. Considering the significant health and social impacts of FASD, there is a public health imperative to prioritise prevention, interventions and support. In this article, we outline the ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Childhood acute respiratory illnesses: will normal inadequate services be resumed?

Prasad Nagakumar, Andrew Bush, Atul Gupta,

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Lethality of racism for Black children in the USA: a primer.

Max Jordan Nguemeni Tiako, Eugenia C South, Heather H Burris,

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Case for change: a standardised inpatient paediatric early warning system in England.

Damian Roland, Philippa Anna Stilwell, Peter-Marc Fortune, John Alexander, Simon J Clark, Simon Kenny,

Most children in hospital who are clinically deteriorating are monitored regularly, and their treatment is escalated effectively. However a small, but significant, number of deteriorating children experience suboptimal outcomes because of a failure to recognise and respond to acute deterioration early enough leading to unintended harm. Tragically this occasionally can ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Population-based surveillance of severe microcephaly and congenital Zika syndrome in Canada.

Shaun K Morris, Daniel S Farrar, Steven P Miller, Marianna Ofner, Ari Bitnun, Chantal R M Nelson, Michael Shevell, Aideen M Moore, Joanne Tataryn, Jane A Evans, Amy R Zipursky, Charlotte Moore Hepburn,

<h4>Purpose</h4>To estimate the minimum incidence of congenital Zika syndrome (CZS) and severe microcephaly in Canada and describe key clinical, epidemiological, aetiological and outcome features of these conditions.<h4>Methods</h4>Two separate national surveillance studies were conducted on CZS and severe microcephaly using the well-established Canadian Paediatric Surveillance Program from 2016 to 2019. Over ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Wormian bones: thinking beyond osteogenesis imperfecta.

Rebecca Kylie Halligan, Leanne Royle, Claire Lloyd, Roshni Vara, Moira Shang-Mei Cheung,

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Safeguarding in the COVID-19 pandemic: a UK tertiary children's hospital experience.

Kavitha Masilamani, William B Lo, Ashish Basnet, Jane Powell, Desiderio Rodrigues, William Tremlett, Deepthi Jyothish, Geoff Debelle,

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Why are certain age bands used for children in paediatric studies of medicines?

Kalle Hoppu, Helena Fonseca,

Rational prescribing of medicines requires evidence from clinical trials on efficacy, safety and the dose to be prescribed, based on clinical trials. Regulatory authorities assess these data and information is included in the approved summary of product characteristics. Regulatory guidelines on clinical investigation of medicinal products in the paediatric population ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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Does Beckwith-Wiedemann syndrome require intensive Wilms tumour surveillance?

Colin P McGrath, Michael A Boyle,

Arch Dis Child (Archives of disease in childhood)
[2021, :]

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What is the risk of missing orbital cellulitis in children?

Laila F Ibrahim, Franz E Babl, Sandy M Hopper, Penelope A Bryant,

<h4>Background</h4>Preseptal cellulitis can be difficult to distinguish from orbital cellulitis in children. The majority of patients with periorbital infections are admitted for intravenous antibiotics. This study aimed to investigate the risk of missing orbital cellulitis and the outcomes of missed patients.<h4>Methods</h4>A prospective cohort study of children aged 3 months to ... Read more >>

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[2021, :]

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