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Journal Anticancer Res.

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Clinical Outcome of Surgically Treated Leiomyosarcoma of the Extremities: A Retrospective Overview.

Annelies VAN Beeck, Michiel VAN DE Sande, Veroniek VAN Praag, Dietmar Dammerer, Jozef Michielsen, Thomas Schubert, Bilal Kapanci, Felix Shumelinsky, Johan Somville, Sander Dijkstra,

AIM:This study was interested in extremity leiomyosarcoma with focus on clinical outcome after surgery with or without adjuvant therapy. PATIENTS AND METHODS:A retrospective case series of all patients with leiomyosarcoma, surgically treated between 2000 and 2015 and a minimum follow-up of 2 years, was drawn from institutional databases in Belgium ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):5319-5325]

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Randomized Study of Postoperative Single Intravesical Instillation With Pirarubicin and Mitomycin C for Low-risk Bladder Cancer.

Shinya Yamamoto, Yukio Kageyama, Yasuhisa Fujii, Taku Aizawa, Shinji Urakami, Iwao Fukui,

BACKGROUND:To assess the prophylactic efficacy of postoperative single intravesical instillation with pirarubicin (THP) and mitomycin C (MMC) for low-risk non-muscle-invasive bladder cancer (NMBC). PATIENTS AND METHODS:A total of 103 clinically low-risk NMBC patients were preoperatively randomized into either THP (n=49) or MMC (n=54) groups. The primary endpoint was recurrence-free survival. ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):5295-5299]

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Successful Management of Platinum-resistant Ovarian Cancer by Weekly Nedaplatin Followed by Olaparib: Three Case Reports.

Shu Soeda, Takafumi Watanabe, Norihito Kamo, Tetsu Sato, Chikako Okabe, Makiko Ueda, Yuta Endo, Kojima Manabu, Shinji Nomura, Shigenori Furukawa, Hidekazu Nishigori, Toshifumi Takahashi, Keiya Fujimori,

BACKGROUND:Treatment for platinum-resistant ovarian cancer is difficult and challenging because available chemotherapeutic agents only offer short survival improvements. The efficacy of re-treatment with platinum-based agents including nedaplatin for platinum-resistant patients has not been fully investigated. CASE REPORT:We describe herein three cases of heavily treated platinum-resistant ovarian cancer that were successfully ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):5263-5270]

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Gamma/Delta T-Cells Enhance Carboplatin-induced Cytotoxicity Towards Advanced Bladder Cancer Cells.

Yueh Pan, Ya-Hsu Chiu, Shao-Chih Chiu, DER-Yang Cho, Liang-Ming Lee, Yu-Ching Wen, Jacqueline Whang-Peng, Chi-Hao Hsiao, Ping-Hsiao Shih,

BACKGROUND/AIM:Bladder cancer (BLCA, urothelial bladder cancer) is one of the most common malignancies with increasing incidence and mortality worldwide. Poor diagnosis and the limitation of treatment is still an unmet need in clinical practice. γδ T-Cells have been paid increasing attention because of their potent cytotoxicity against tumors. Herein, we ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):5221-5227]

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Inhibitory Effects of Beraprost Sodium in Murine Hepatic Sinusoidal Obstruction Syndrome.

Makoto Nakura, Tomoharu Miyashita, Yasuhiko Yamamoto, Satoshi Takada, Shunsuke Kanou, Hidehiro Tajima, Hiroyuki Takamura, Tetsuo Ohta,

BACKGROUND/AIM:In this study, the liver sinusoidal endothelial cells (LSECs)-protective effects of beraprost sodium (BPS) were investigated using mice with monocrotaline (MCT)-induced sinusoidal obstruction syndrome (SOS). MATERIALS AND METHODS:The mice were divided into BPS, placebo and control groups. They were killed 48 h after MCT administration, and blood samples and liver ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):5171-5180]

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Antitumor Effect of Shikonin, a PKM2 Inhibitor, in Cholangiocarcinoma Cell Lines.

Unchalee Thonsri, Wunchana Seubwai, Sakda Waraasawapati, Sopit Wongkham, Thidarat Boonmars, Ubon Cha'on, Chaisiri Wongkham,

BACKGROUND/AIM:Pyruvate kinase M2 (PKM2) is an enzyme that is predominantly overexpressed in various types of cancer. The role of PKM2 in liver fluke-associated cholangiocarcinoma (CCA) remains unclear. This study aimed to investigate the antitumor activity of shikonin, a PKM2 inhibitor, in CCA cells. MATERIALS AND METHODS:Immunohistochemistry and immunoblotting were used ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):5115-5124]

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Setanaxib as a Potent Hypoxia-specific Therapeutic Agent Against Liver Cancer.

Satoshi Owada, Hitoshi Endo, Chisa Okada, Kazuhiro Yoshida, Yukari Shida, Masayuki Tatemichi,

BACKGROUND/AIM:Liver cancer has extremely poor prognosis. The cancerous tissues contain hypoxic regions, and the available drugs are poorly effective in hypoxic environments. NADPH oxidase 4 (NOX4), producing reactive oxygen species (ROS), may contribute to cancer malignancy under hypoxic conditions. However, its role in liver cancer has not been examined in ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):5071-5079]

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A New Ciprofloxacin-derivative Inhibits Proliferation and Suppresses the Migration Ability of HeLa Cells.

Moustafa Fathy, Sijia Sun, Qing-Li Zhao, Mohamed Abdel-Aziz, Gamal El-Din A Abuo-Rahma, Suresh Awale, Toshio Nikaido,

BACKGROUND/AIM:This study aimed to investigate the effect of a new 7-(4-(N-substituted carbamoylmethyl) piperazin-1-yl) ciprofloxacin-derivative on the proliferation and migration abilities of HeLa cells. MATERIALS AND METHODS:Cell viability and morphological alterations were examined. Changes in migration were detected using wound healing and colony formation assays. Flow cytometry and western blotting were ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):5025-5033]

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Brucea javanica Increases Survival and Enhances Gemcitabine Efficacy in a Patient-derived Orthotopic Xenograft (PDOX) Mouse Model of Pancreatic Cancer.

Haitao Yang, Zhong Tong, Lei Shen, Y U Sun, Robert M Hoffman, Jun Huang,

BACKGROUND/AIM:Traditional Chinese medicine (TCM) Brucea javanica (BJO) has shown anti-proliferation efficacy on human carcinoma cells in vitro. The aim of the present study was to evaluate for the first time the efficacy of BJO combined with the first-line chemotherapeutic drug gemcitabine (GEM) on tumor growth-inhibition and survival in a pancreatic ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):4969-4978]

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Phenothiazines and Selenocompounds: A Potential Novel Combination Therapy of Multidrug Resistant Cancer.

MÁriÓ GajdÁcs, MÁrta NovÉ, Ákos Csonka, Borisz Varga, Carmen SanmartÍn, Enrique DomÍnguez-Álvarez, Gabriella Spengler,

BACKGROUND/AIM:Phenothiazines constitute a versatile family of compounds in terms of biological activity, which have also gained a considerable attention in cancer research. MATERIALS AND METHODS:Three phenothiazines (promethazine, chlorpromazine and thioridazine) have been tested in combination with 11 active selenocompounds against MDR (ABCB1-overexpressing) mouse T-lymphoma cells to investigate their activity as ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):4921-4928]

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A Potential Mechanism of Anticancer Immune Response Coincident With Immune-related Adverse Events in Patients With Renal Cell Carcinoma.

Taigo Kato, Eisuke Tomiyama, Yoko Koh, Makoto Matsushita, Yujiro Hayashi, Kosuke Nakano, Y U Ishizuya, Cong Wang, Koji Hatano, Atsunari Kawashima, Takeshi Ujike, Keisuke Kawasaki, Eiichi Morii, Kunihito Gotoh, Hidetoshi Eguchi, Kazuma Kiyotani, Kazutoshi Fujita, Norio Nonomura, Motohide Uemura,

BACKGROUND/AIM:Some reports showed encouraging efficacy of immune checkpoint inhibitors among patients who experienced immune-related adverse events (irAEs). Thus, characterization of T-cell repertoire and immune signatures in peripheral blood mononuclear cells (PBMCs) and tumors before and after immune checkpoint inhibitors treatment should contribute to better understanding of irAE-provoked anticancer immune responses. ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):4875-4883]

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Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer: Review of the Literature and Perspectives of Clinical Research.

Angiolo Gadducci, Stefania Cosio,

Concurrent cisplatin-based chemotherapy and radiotherapy (CCRT) plus brachytherapy is standard treatment for locally advanced cervical cancer. Platinum-based neoadjuvant chemotherapy (NACT) followed by radical hysterectomy has been proposed as an alternative approach, especially for patients with stage Ib2-IIb disease. This review analyzes the most commonly used combination regimens in this clinical ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):4819-4828]

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Recovery of the Sensitivity to Anti-PD-1 Antibody by Celecoxib in Lung Cancer.

Kunihiko Kobayashi, Kyoichi Kaira, Hiroshi Kagamu,

BACKGROUND/AIM:Experimental studies have shown that celecoxib is related to the downregulation of Tregs and an increase in the therapeutic efficacy of PD-1 inhibitors; however, such effect has not been shown in human cancers. Our report confirmed the synergistic effect of celecoxib with a PD-1 inhibitor. CASE REPORT:A 57-year-old male with ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):5309-5311]

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Salvage Chemotherapy After Nivolumab for Recurrent or Metastatic Head and Neck Carcinoma.

Chihiro Fushimi, Isaku Okamoto, Takashi Matsuki, Tatsuo Masubuchi, Takuro Okada, Hiroki Sato, Kiyoaki Tsukahara, Takahito Kondo, Taku Yamashita, Kenji Hanyu, G O Omura, Hideaki Takahashi, Yuichiro Tada, Kouki Miura,

BACKGROUND/AIM:The treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) has remained challenging. The effect of salvage chemotherapy (SCT) after nivolumab has been identified recently in other cancer types. The aim of this study was to examine the efficacy of SCT after nivolumab treatment ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):5277-5283]

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Mogamulizumab Plus EPOCH Therapy for Patients With Newly Diagnosed Aggressive Adult T-cell Leukemia/lymphoma.

Tatsuro Jo, Kaori Matsuzaka, Haruna Shioya, Hiroo Tominaga, Takahiro Sakai, Yohei Kaneko, Shizuka Hayashi, Masatoshi Matsuo, Jun Taguchi, Kuniko Abe, Kazuto Shigematsu, Ritsuko Kubota-Koketsu,

BACKGROUND/AIM:Adult T-cell leukemia/lymphoma (ATLL) is a relatively refractory CD4-positive peripheral T-cell lymphoma. VCAP-AMP-VECP (mLSG15) is one of the standard chemotherapeutic regimens for patients with aggressive ATLL. Mogamulizumab (moga), a monoclonal antibody for C-C chemokine receptor 4 antigen expressed on the cell surface, has recently been poised for use as monotherapy ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):5237-5243]

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Methylsulfonylmethane Induces Cell Cycle Arrest and Apoptosis, and Suppresses the Stemness Potential of HT-29 Cells.

Doh Hoon Kim, Dong Young Kang, Nipin Sp, Eun Seong Jo, Alexis Rugamba, Kyoung-Jin Jang, Young Mok Yang,

BACKGROUND/AIM:Colorectal cancer is one of the most common malignancies worldwide. Small molecule-based chemotherapy is an attractive approach for the chemoprevention and treatment of colorectal cancer. Methylsulfonylmethane (MSM) is a natural organosulfur compound with anticancer properties, as revealed by studies on in vitro models of gingival, prostate, lung, hepatic, and breast ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):5191-5200]

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Temozolomide and AZD7762 Induce Synergistic Cytotoxicity Effects on Human Glioma Cells.

Yun Chen, Bor-Jiun Tseng, Ya-Hui Tsai, Sheng-Hong Tseng,

BACKGROUND/AIM:This study investigated the effects of temozolomide (TMZ) and/or checkpoint kinase inhibitor AZD7762 in human glioma cells. MATERIALS AND METHODS:Glioma cells were treated with TMZ and/or AZD7762 for 24 or 48 h, then the cellular survival was studied and the expression of various proteins was investigated. RESULTS:Both TMZ and AZD7762 ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):5141-5149]

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YM155 Reverses Cabazitaxel Resistance in Castration-resistant Prostate Cancer by Reducing Survivin Expression.

Takeshi Miyao, Hidekazu Koike, Yoshitaka Sekine, Akira Ohtsu, Daisuke Oka, Kazuhiro Suzuki,

BACKGROUND/AIM:The purpose of the present study was to clarify whether treatment with YM155, a novel small-molecule inhibitor of survivin, reversed cabazitaxel resistance in castration-resistant prostate cancer (CRPC). MATERIALS AND METHODS:Cabazitaxel resistance was induced in the castration-resistant prostate cancer cell line, 22Rv1-CR. In vitro and in vivo models were used to ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):5091-5095]

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Inhibitory Effect of Eicosapentaenoic Acid on the Migration of the Esophageal Squamous Cell Carcinoma Cell Line TE-1.

Hisako Kubota, Toshihiro Hirai, Akira Yamauchi, Ayako Ogo, Hideo Matsumoto, Tomio Ueno,

BACKGROUND/AIM:Eicosapentaenoic acid (EPA) inhibits NF-ĸB activation and IL-6 production in TE-1 esophageal cancer cells. NF-ĸB is related to cancer cell migration. The aim of this study is to evaluate whether EPA has a metastasis suppressing effect. Herein, we investigated EPA-treated TE-1 cell migration using TAXIScan. MATERIALS AND METHODS:EZ-TAXIScan® was used ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):5043-5048]

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Ephemeranthol A Suppresses Epithelial to Mesenchymal Transition and FAK-Akt Signaling in Lung Cancer Cells.

Nongyao Nonpanya, Ornjira Prakhongcheep, Korrakod Petsri, Cholasit Jitjaicham, Sucharat Tungsukruthai, Boonchoo Sritularak, Pithi Chanvorachote,

BACKGROUND/AIM:Epithelial to mesenchymal transition (EMT) is a cellular process that facilitates cancer metastasis. Therefore, therapeutic approaches that target EMT have garnered increasing attention. The present study aimed to examine the in vitro effects of ephemeranthol A on cell death, migration, and EMT of lung cancer cells. MATERIALS AND METHODS:Ephemeranthol A ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):4989-4999]

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ALK Inhibitors Do Not Increase Sensitivity to Radiation in EML4-ALK Non-small Cell Lung Cancer.

Kathrin Fleschutz, Lisa Walter, Rumo Leistner, Lucie Heinzerling,

BACKGROUND/AIM:ALK inhibitors like Crizotinib, Ceritinib and Alectinib are targeted therapies used in patients with anaplastic lymphoma kinase (ALK)-positive, advanced non-small cell lung cancer (NSCLC). Since in this tumor entity radiotherapy is employed sequentially or concomitantly, potential synergistic effects were investigated, which may support the hypothesis of induced radiosensitization by using ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):4937-4946]

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Effect of Phosphoribosyltransferase Down-regulation on Malignant Glioma Cell Characteristics.

Minori Kamada, Keiichi Ikeda, Yoshinobu Manome,

BACKGROUND/AIM:Nicotinamide phosphoribosyl-transferase (NAMPT) is a rate-limiting enzyme in the pathway synthesizing nicotinamide adenine dinucleotide (NAD (+)) from nicotinamide (NAM). Glioma tissues exhibit up-regulated NAMPT expression associated with a poor prognosis of patients. To determine if NAMPT can be a molecular therapeutic target, we investigated the effects of short hairpin RNA ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):4895-4905]

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Inhibitors of Fatty Acid Synthesis and Oxidation as Potential Anticancer Agents in Colorectal Cancer Treatment.

Paulina Mozolewska, Katarzyna Duzowska, Alicja Pakiet, Adriana Mika, Tomasz ŚledziŃski,

Aberrant fatty acid (FA) metabolism has long been recognized in colorectal cancer (CRC) cells. Since de novo lipogenesis is required for CRC tumour growth and survival, the inhibition of FA metabolism is a promising potential therapeutic target. Inhibition of the opposite process, β-oxidation of FAs, has also showed promising results ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):4843-4856]

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Erratum.

Anticancer Res. (Anticancer research)
[2020, 40(9):5327]

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Severe Gastrointestinal Mucositis Following Concurrent Palbociclib and Palliative Radiation Therapy.

Umair M Nasir, Alexander M Mozeika, Mutlay Sayan, Imraan Jan, Noel Kowal, Bruce Haffty, Sushil Ahlawat, Neil Kothari,

BACKGROUND/AIM:Palbociclib is an FDA-approved cyclin-dependent kinase inhibitor for the treatment of advanced breast cancer. Limited information is available regarding the toxicity of palbociclib and concurrent radiation therapy. CASE REPORT:Herein, we report a case of esophageal toxicity in a patient treated with palbociclib and radiation therapy. A 63-year-old woman was treated ... Read more >>

Anticancer Res. (Anticancer research)
[2020, 40(9):5291-5294]

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