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Journal Ann Pharmacother

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Cenobamate: A New Adjunctive Agent for Drug-Resistant Focal Onset Epilepsy.

Christopher T Buckley, Olivia R Waters, George DeMaagd,

Objective: To review the pharmacology, efficacy, and safety of oral cenobamate in the treatment of uncontrolled focal epilepsy. Data Sources: The PubMed database and ClinicalTrials.gov were searched using the following terms: cenobamate, Xcopri, and YKP3089. Study Selection and Data Extraction: Articles published in English between January 2000 and April 2020 ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020941113]

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Ertapenem Neurotoxicity in Hemodialysis Patients-Safe and Effective Dosing Is Still Needed: A Retrospective Study and Literature Review.

Wasim S El Nekidy, Hazem Elrefaei, Terrence J Lee St John, Nizar M Attallah, Farah Kablaoui, Ahmad Nusair, Bartlomiej Piechowski-Jozwiak, Janise Phillips, Islam M Ghazi,

Background: The approved dosing of ertapenem in patients with chronic kidney disease stage 5 utilizing dialysis (CKD-5D) is 0.5 g intravenous daily. Several reports associated this dosing strategy with neurotoxicity. Objective: The purpose of this study is to identify the incidence of neurotoxicity in this population and the risk factors ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020938059]

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Safety of Continuous Neostigmine for the Treatment of Impaired Gastrointestinal Motility in Pediatric Patients.

Jesse Cramer, Inez Pabian,

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020940622]

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Amzeeq (Minocycline Topical Foam): A New Drug for the Treatment of Acne.

Erin St Onge, W Cary Mobley,

Objective: To review the safety and efficacy of minocycline 4% topical foam for the treatment of moderate to severe acne vulgaris in adults and pediatric patients aged 9 years and older. Data Sources: A literature search through PubMed and EMBASE was conducted using the following keywords: FMX101, minocycline, foam, and ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020939926]

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Longitudinal Medication Adherence in Older Adults With Multimorbidity and Association With Health Care Utilization: Results From the Irish Longitudinal Study on Ageing.

Caroline A Walsh, Caitriona Cahir, Kathleen E Bennett,

Background: The association between objectively measured nonadherence and health care utilization in multimorbid older people is unclear. Objective: To measure medication adherence across multiple chronic conditions, identify adherence patterns, and estimate the association between adherence and self-reported health care utilization. Methods: This is a retrospective cohort study of multimorbid participants ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020937996]

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Lumateperone: A Novel Antipsychotic for Schizophrenia.

Jessica Greenwood, Rucha B Acharya, Valerie Marcellus, Jose A Rey,

Objective: To provide a concise review of the new Food and Drug Administration (FDA)-approved antipsychotic, lumateperone, for use in schizophrenia. Data Sources: A literature search of PubMed was performed (January 2000 to May 2020) using the following key terms: lumateperone, Caplyta, and ITI-007. Abstracts from conferences, review articles, clinical trials, ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020936597]

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Clinical Pharmacist-Led Impact on Inappropriate Albumin Utilization and Associated Costs in General Ward Patients.

Mitchell S Buckley, Sumit K Agarwal, Jake M Lansburg, Brian J Kopp, Brian L Erstad,

Background: Inappropriate albumin use in clinical practice remains problematic. Health-systems face continued challenges in promoting cost-appropriate use. Objective: To evaluate the clinical and economic impact of a clinical pharmacist-led intervention strategy targeting inappropriate albumin use in general ward patients. Methods: A retrospective cohort study evaluated all adult (≥18 years) general ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020935575]

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The Impact of Multiple Renal Estimates on Pharmacist Dosing Recommendations: A Randomized Trial.

Sean M McConachie, Claudia M Hanni, Joshua N Raub, Rima A Mohammad, Sheila M Wilhelm,

Background: Numerous equations are used for estimation of renal function, and many electronic medical records report multiple clearance estimates to assist with drug dosing. It is unknown whether the presence of multiple clearance estimates affects clinical decision-making. Objective: To determine whether the presence of multiple renal clearance estimates affects pharmacist ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020935447]

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Syndrome of Inappropriate Antidiuretic Hormone Secretion in a Patient Treated With Melatonin.

Giuseppe Famularo,

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020936997]

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High-Dose Inactivated Influenza Vaccine Quadrivalent for Older Adults.

Elias B Chahine,

Objective: To review the efficacy and safety of the high-dose inactivated influenza vaccine quadrivalent (HD-IIV4) in the prevention of influenza in older adults. Data Sources: A literature search was performed using PubMed and Google Scholar with the search terms high-dose, influenza vaccine, and quadrivalent. Other resources included the Centers for ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020935645]

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Description of Bivalirudin Use for Anticoagulation in Pediatric Patients on Mechanical Circulatory Support.

Christopher T Campbell, Lucas Diaz, Brian Kelly,

Background: Although heparin has previously been the anticoagulant of choice during mechanical circulatory support (MCS), there is a lack of consistency in dose-response in pediatric patients. Bivalirudin offers more consistent dose-response in adults; however, there are limited data for pediatrics use. Objective: The purpose was to characterize the usage, dosage, ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020937819]

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Impact of Early Reinitiation of Neuropsychiatric Medications on Agitation and Delirium in the Intensive Care Unit: A Retrospective Study.

Michaelia D Cucci, Brittany S Cunningham, Jaimini S Patel, Alan T Shimer, Dania I Mofleh, Chanda L Mullen,

Background: Approximately 17% of intensive care unit (ICU) patients are prescribed at least 1 home neuropsychiatric medication (NPM). When abruptly discontinued, withdrawal symptoms may occur manifesting as agitation or delirium in the ICU setting. Objective: To evaluate the impact of early reinitiation of NPMs. Methods: This was a retrospective, observational ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020935589]

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Recurrent Renal Dysfunction Secondary to Probable Piperacillin-Tazobactam-Induced Acute Interstitial Nephritis.

Katie A Parsels, Robert W Seabury, William Darko, Luke A Probst, Jeffrey M Steele,

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020936778]

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A Systematic Review of Newer Antidiabetic Agents in the Treatment of Nonalcoholic Fatty Liver Disease.

John A Dougherty, Erenie Guirguis, Krisy-Ann Thornby,

Objective: To evaluate glucagon-like peptide 1 receptor agonists (GLP-1 RAs), dipeptidyl-peptidase IV (DPP-4) inhibitors, and sodium-glucose cotransporter 2 (SGLT) inhibitors to treat nondiabetic and type 2 diabetes mellitus (T2DM) nonalcoholic fatty liver disease (NAFLD) as it relates to improvement in hepatosteatosis (HS) or steatohepatitis (SH). Data Sources: MEDLINE and CINAHL ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020935105]

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Doravirine Use in Treatment-Experienced HIV-Positive Patients.

Patricia Pecora Fulco, Leah B Herity,

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020935763]

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Assessment of Kidney Function in Patients With Extreme Obesity: A Narrative Review.

Brian L Erstad, David E Nix,

Objectives: To discuss the evidence and caveats associated with estimated and measured creatinine clearance (eClCr and mClCr) and glomerular filtration rate (eGFR and mGFR) assessments of kidney function in patients with more extreme forms of obesity. Data Sources: PubMed (1976 to mid-May 2020) was used, with bibliographies of retrieved articles ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020935580]

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A New Intravenous Immune Globulin: Novel or Not?

Brittany N Bates, Mark E Olah,

Objective: To assess the clinical use and determine the place in therapy for immune globulin intravenous (IV), human-slra, a recently approved IV immune globulin for the treatment of primary immune deficiency diseases (PIDD). Data Sources: A PubMed and MEDLINE search (2010 to April 2020) was conducted for relevant articles. Data ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020934722]

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Trifarotene for the Treatment of Facial and Truncal Acne.

Katheryn A Bell, Caitlin M Brumfiel, Wasim Haidari, Laura Boger,

Objective: This article reviews clinical trials to assess the efficacy, safety, and clinical application of trifarotene 0.005% cream (Aklief). Data Sources: A systematic review of the literature was performed using the terms trifarotene OR Aklief OR CD5789 in MEDLINE (PubMed) and EMBASE databases. Articles prior to May 2020 were considered ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020934892]

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Risk Factor Evaluation for Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa in Community-Acquired Pneumonia.

Paul O Lewis,

Background: The 2019 community-acquired pneumonia guidelines recommend using recent respiratory cultures and locally validated epidemiology plus risk factor assessment to determine empirical coverage of methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Objective: To develop a methodology for evaluating local epidemiology and validating local risk factors for P aeruginosa and MRSA. ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020935106]

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Focused Updates: SGLT2 Inhibitors in Patients With Heart Failure and/or Chronic Kidney Disease.

Judy W M Cheng, Vincent Colucci, James S Kalus, Sarah A Spinler,

Sodium-glucose cotransporter (SGLT2) inhibitors have demonstrated cardiovascular (CV) benefits in large-scale clinical trials of people who have type 2 diabetes and either established CV disease or multiple CV risk factors. These studies also indicated early signals in benefiting heart failure (HF) patients and those with chronic kidney diseases. This article ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020934001]

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Walk the Line-The Importance of Well-Informed Interpretation of QT Prolongation.

Zachary R Noel, Vincent Y See, Alexander H Flannery,

Acute care pharmacists play an integral role in identifying drug-drug interactions that may predispose patients to QT prolongation. Although most pharmacists are equipped with a baseline understanding of drug interactions and the risks of QTc prolongation, few understand the limitations of QTc calculation and interpretation. In this commentary, we put ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020934718]

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Cefiderocol: A Siderophore Cephalosporin.

Rania M El-Lababidi, John George Rizk,

Objective: This article reviews the available data on the chemistry, spectrum of activity, pharmacokinetic and pharmacodynamic properties, clinical efficacy, and potential place in therapy of cefiderocol. Data Sources: A literature search through PubMed, Google Scholar, and ClinicalTrials.gov was conducted (2009 to March 2020) using the search terms cefiderocol and S-649266. ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020929988]

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Geosocial Factors Associated With Adherence to Statin Medications.

Steven R Erickson, Mercedes Bravo, Joshua Tootoo,

Background: Individual patient characteristics, social determinants, and geographic access may be associated with patients engaging in appropriate health behaviors. Objective: To assess the relationship between statin adherence, geographic accessibility to pharmacies, and neighborhood sociodemographic characteristics in Michigan. Methods: The proportion of days covered (PDC) was calculated from pharmacy claims of ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020934879]

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Treatment Considerations for CNS Infections Caused by Vancomycin-Resistant Enterococcus faecium: A Focused Review of Linezolid and Daptomycin.

Benjamin J Lee, Betty N Vu, Amanda N Seddon, Hayley A Hodgson, Sheila K Wang,

Objective: To review the current literature describing pharmacology, pharmacokinetics/pharmacodynamics (PK/PD), efficacy, and safety of linezolid and daptomycin for the treatment of central nervous system (CNS) infections caused by vancomycin-resistant Enterococcus (VRE) faecium. Data Sources: A literature search of PubMed/MEDLINE databases was conducted (from 1950 to April 2020) utilizing the following ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020932513]

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Validation of Bleeding Risk Prediction Scores for Patients With Major Bleeding on Direct Oral Anticoagulants.

Stephanie Tchen, Nicole Ryba, Vishal Patel, Joseph Cavanaugh, Jesse B Sullivan,

Background: Direct oral anticoagulants (DOACs) offer many benefits over vitamin K antagonists (VKAs) but still carry a significant risk of major bleeding. Bleeding risk prediction scores such as the Hypertension, Abnormal Renal/Liver Function, Stroke, Bleeding History or Predisposition, Labile International Normalized Ratio, Elderly, and Drugs/Alcohol (HAS-BLED), Hepatic or Renal Disease, ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2020, :1060028020933186]

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