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Dermatology for the internist: optimal diagnosis and management of atopic dermatitis.

Shanthi Narla, Jonathan I Silverberg,

Internists are front-line health care providers that commonly provide the first encounter to patients for dermatological conditions, especially atopic dermatitis (AD). Internists need to be comfortable with managing mild-moderate AD in their practices. Criteria and guidelines established in dermatology literature are available to help the general practitioner diagnose and treat ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):2165-2177]

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Epidemiological trends in mortality, event rates and case fatality of acute myocardial infarction from 2004 to 2015: results from the KORA MI registry.

Christina Krämer, Christa Meisinger, Inge Kirchberger, Margit Heier, Bernhard Kuch, Christian Thilo, Jakob Linseisen, Ute Amann,

<h4>Aim</h4>This study examines epidemiological trends of acute myocardial infarction (AMI) in Germany from 2004-2015 across different age groups, using data of the population-based KORA myocardial infarction registry.<h4>Methods</h4>Annual age-standardised, age-group- and sex-specific mortality and event rates (incident and recurrent) per 100,000 population as well as 28-day case fatality were calculated from ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):2142-2152]

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Predicting mortality in non-cystic fibrosis bronchiectasis patients using distance-saturation product.

Chun-Yu Lin, Meng-Heng Hsieh, Yueh-Fu Fang, Chien-Wei Peng, Jia-Shiuan Ju, Yu-Lun Lo, Shu-Min Lin, Horng-Chyuan Lin,

<h4>Background</h4>The bronchiectasis severity index (BSI) and FACED score are currently used in predicting outcomes of non-cystic fibrosis bronchiectasis (NCFB). Distance-saturation product (DSP), the product of distance walked, and lowest oxygen saturation during the 6-min walk test showed strong predictive power of mortality in non-CF bronchiectasis patients. This study aimed to ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):2034-2040]

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Reference values for the Modified Timed Up and Go Test in Saudi children aged 4-12 years old in Riyadh city: cross-sectional study.

Nora Saleh Al-Toaimi, Afaf A M Shaheen, Maha Fahad Algabbani, Rehab F M Gawad,

<h4>Purpose</h4>The study aimed to report within-session reliability, estimate the reference values for the Modified Timed Up and Go (mTUG) test in typically developing (TD) Saudi children aged 4-12 years old, develop a reference equation for the estimated mTUG, and compare the measured mTUG in the present study with the predicted mTUG ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1905-1913]

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Harm reduction for the treatment of patients with severe injection-related infections: description of the Jackson SIRI Team.

David P Serota, Hansel E Tookes, Belén Hervera, Babley M Gayle, Cara R Roeck, Edward Suarez, David W Forrest, Michael A Kolber, Tyler S Bartholomew, Allan E Rodriguez, Susanne Doblecki-Lewis,

<h4>Introduction</h4>Hospitalizations for severe injection-related infections (SIRI), such as endocarditis, osteomyelitis, and skin and soft tissue infections (SSTI) are increasingly common. People who inject drugs (PWID) experiencing SIRIs often receive inadequate substance use disorder (SUD) treatment and lack of access to harm reduction services. This translates into lengthy hospitalizations with high ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1960-1968]

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What are the recommendations for returning athletes who have experienced long term COVID-19 symptoms?

Rosie K Lindsay, Jason J Wilson, Mike Trott, Olawale Olanrewaju, Mark A Tully, Guillermo F López-Sánchez, Jae Il Shin, Damiano Pizzol, Peter Allen, Laurie T Butler, Yvonne Barnett, Lee Smith,

Currently, there is limited research reporting the symptoms of long COVID among athletes, and the recommendations for athletes returning to competition/training who have experienced long COVID symptoms. Therefore, the aim of this systematic review is to synthesise the recommendations for returning athletes who have experienced long COVID symptoms. The protocol ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1935-1944]

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Transcriptomic analysis of human endometrial stromal cells during early embryo invasion.

Shuo Han, Minghui Liu, Shan Liu, Yuan Li,

<h4>Purpose</h4>During early embryo invasion (48 h after embryo attachment), what functional changes accompany dynamic gene expression alterations in human endometrial stromal cells?<h4>Method</h4>In the present study, primary human endometrial stromal cells (phESCs) were cultured. After <i>in vitro</i> decidualization, primary human endometrial stromal cells (phESCs) were cultured with blastocysts for 48 h. During this ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1758-1771]

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Enterococcal bloodstream infections in critically ill patients with COVID-19: a case series.

Daniele Roberto Giacobbe, Laura Labate, Stefania Tutino, Federico Baldi, Chiara Russo, Chiara Robba, Lorenzo Ball, Silvia Dettori, Anna Marchese, Chiara Dentone, Laura Magnasco, Francesca Crea, Edward Willison, Federica Briano, Denise Battaglini, Nicolò Patroniti, Iole Brunetti, Paolo Pelosi, Matteo Bassetti,

<h4>Background</h4>An unexpected high prevalence of enterococcal bloodstream infection (BSI) has been observed in critically ill patients with COVID-19 in the intensive care unit (ICU).<h4>Materials and methods</h4>The primary objective was to describe the characteristics of ICU-acquired enterococcal BSI in critically ill patients with COVID-19. A secondary objective was to exploratorily assess ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1779-1786]

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Influence of changes in body fat on clinical outcomes in a general population: a 12-year follow-up report on the Ansan-Ansung cohort in the Korean Genome Environment Study.

Byung Sik Kim, Yonggu Lee, Hyun-Jin Kim, Jeong-Hun Shin, Jin-Kyu Park, Hwan-Cheol Park, Young-Hyo Lim, Jinho Shin,

<h4>Background</h4>The impact of the changes in the obesity status on mortality has not been established; thus, we investigated the long-term influence of body fat (BF) changes on all-cause deaths and cardiovascular outcomes in a general population.<h4>Methods</h4>A total of 8374 participants were observed for 12 years. BF was measured at least two ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1646-1658]

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Pre-class online video learning and class style expectation: patterns, association, and precision medical education.

Cheng-Maw Ho, Chi-Chuan Yeh, Jann-Yuan Wang, Rey-Heng Hu, Po-Huang Lee,

<h4>Background</h4>Online video learning has been gaining substantial attention in medical education. The purpose of the study was to evaluate medical students' online video-viewing patterns as well as to identify features associated with their class style preferences in precision medicine courses.<h4>Methods</h4>A mixed methods research design was used. Part of the cognitive ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1390-1401]

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Positive-word stimuli via a smartphone application have no immediate-term effects on multi-directional reach ability in standing position: a randomized controlled trial.

Kenta Azukizawa, Kodai Hirose, Yuta Morigami, Naoki Higashi, Hiroyuki Uchida, Kazuki Hirao,

<h4>Objectives</h4>The purpose of the study was to examine the immediate-term effect of positive-word stimuli via a smartphone application on the multi-directional reach ability in standing position in young adults.<h4>Methods</h4>This study was an immediate-term, assessor-blinded, two-arm, parallel-group, randomized controlled trial among young adults recruited from one university in Japan. Participants were ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1402-1409]

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Obesity, dyslipidaemia and candidate gene polymorphisms: a cross-sectional study among the Liangmai and Mizo tribes of Manipur, India.

Somorjit Singh Ningombam, Masan Kambo Newmei, Varhlun Chhungi, Prakash Ranjan Mondal, Naorem Kiranmala Devi, Kallur Nava Saraswathy,

<h4>Background</h4>The prevalence of obesity and dyslipidaemia was observed to be increased among the tribal populations, due to globalization.<h4>Materials and methods</h4>In the present study, data on demographic, somatometric and blood samples were collected from 613 participants of both sex, age 18-60 years, further lipid profiling and genotyping was executed. Multifactor dimensionality ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1438-1446]

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Screening differentially expressed genes between endometriosis and ovarian cancer to find new biomarkers for endometriosis.

Zhenzhen Lu, Ying Gao,

<h4>Aim</h4>Endometriosis is one of the most common reproductive system diseases, but the mechanisms of disease progression are still unclear. Due to its high recurrence rate, searching for potential therapeutic biomarkers involved in the pathogenesis of endometriosis is an urgent issue.<h4>Methods</h4>Due to the similarities between endometriosis and ovarian cancer, four endometriosis ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1377-1389]

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Evaluating red blood cell distribution width from community blood tests as a predictor of hospitalization and mortality in adults with SARS-CoV-2: a cohort study.

Tamar Banon, Joshua Wortsman, Shay Ben Moshe, Sivan Gazit, Asaf Peretz, Amir Ben Tov, Gabriel Chodick, Galit Perez, Tal Patalon,

<h4>Background</h4>Red blood cell distribution width (RDW) has been assessed during COVID-19 patient hospitalization, however, further research should be done to evaluate RDW from routine community blood tests, before infection, as a risk factor for COVID-19 related hospitalization and mortality.<h4>Patients and methods</h4>RDW was measured as a predictor along with age, sex, ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1410-1418]

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The digestive system involvement of antiphospholipid syndrome: pathophysiology, clinical characteristics, and treatment strategies.

Jin Zhang, Cheng Li, Xiaorong Han, Zhongbo Chen, Binay Kumar Adhikari, Yinghui Wang, Yonggang Wang, Jian Sun,

Antiphospholipid syndrome (APS) is an autoimmune disease mainly characterised by vascular thrombosis and pregnancy morbidity. APS has broad spectrum of clinical manifestations. The digestive system involvement of antiphospholipid syndrome is a critical but under-recognised condition. Digestive system involvement may be the result of direct (autoimmune-mediated) or indirect (thrombotic) mechanisms. Liver ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1328-1339]

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Impact of the COVID-19 pandemic on ophthalmologic outpatient care: experience from an Italian Tertiary Medical Center.

Alfonso Savastano, Matteo Ripa, Maria Cristina Savastano, Raphael Kilian, Giorgio Marchini, Stanislao Rizzo,

<h4>Purpose</h4>To evaluate the impact the COVID-19-related national lockdown has had on Ophthalmologic Outpatient Care in an Italian Tertiary Medical Centre.<h4>Methods</h4>We reviewed all the performances that were carried out as outpatient services at our department between 1 January 2020 and 30 November 2020. We compared data among four different periods: from ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1349-1357]

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Uterine dehiscence in pregnant with previous caesarean delivery.

Zhengfeng Zhu, HeZhou Li, JunQing Zhang,

<h4>Background</h4>The main risk factor for uterine scar dehiscence is a previous caesarean section. Better characterisation of the ultrasonographic features of uterine scar dehiscence may improve preoperative diagnostic accuracy in pregnant women with a caesarean scar. This study aimed to evaluate the ultrasonographic features of uterine scar dehiscence in pregnant women ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1265-1269]

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Cost-minimization analysis of sequential genetic testing versus targeted next-generation sequencing gene panels in patients with pheochromocytoma and paraganglioma.

Weenita Pipitprapat, Oraluck Pattanaprateep, Nareenart Iemwimangsa, Insee Sensorn, Bhakbhoom Panthan, Poramate Jiaranai, Wasun Chantratita, Kinnaree Sorapipatcharoen, Preamrudee Poomthavorn, Pat Mahachoklertwattana, Thanyachai Sura, Atchara Tunteeratum, Kanoknan Srichan, Chutintorn Sriphrapradang,

<h4>Introduction</h4>Pheochromocytomas and paragangliomas (PPGLs) are highly heritable tumours, with up to 40% of cases carrying germline variants. Current guidelines recommend genetic testing for all patients with PPGLs. Next-generation sequencing (NGS) enables accurate, fast, and inexpensive genetic testing. This study aimed to compare the costs related to PPGL genetic testing between ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1243-1255]

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Statin therapy in chronic viral hepatitis: a systematic review and meta-analysis of nine studies with 195,602 participants.

Amir Vahedian-Azimi, Sajad Shojaie, Maciej Banach, Farshad Heidari, Arrigo F G Cicero, Masoum Khoshfetrat, Tannaz Jamialahmadi, Amirhossein Sahebkar,

<h4>Background</h4>Conflicting data suggest that statins could cause chronic liver disease in certain group of patients, while improving prognosis in those with chronic viral hepatitis (CVH).<h4>Purpose</h4>To quantify the potential protective role of statins on some main liver-related health outcomes in clinical studies on CVH patients.<b>Data Sources:</b> The search strategy was explored ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1227-1242]

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A multi-stage SEIR(D) model of the COVID-19 epidemic in Korea.

Hee-Young Shin,

<h4>Background</h4>This paper uses a SEIR(D) model to analyse the time-varying transmission dynamics of the COVID-19 epidemic in Korea throughout its multiple stages of development. This multi-stage estimation of the model parameters offers a better model fit compared to the whole period analysis and shows how the COVID-19's infection patterns change ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1159-1169]

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Effectiveness of multimodal nutrition interventions during pregnancy to achieve 2009 Institute of Medicine gestational weight gain guidelines: a systematic review and meta-analysis.

Andrew R Beauchesne, Kelly Copeland Cara, Jiawen Chen, Qisi Yao, Laura Paige Penkert, Wenfang Yang, Mei Chung,

<h4>Background</h4>In 2009, the Institute of Medicine (IOM) published a revision to its 1990 recommendations on gestational weight gain (GWG). The objective of this review is to update a previous systematic review and meta-analysis to evaluate the effectiveness of nutrition interventions in achieving recommended GWG.<h4>Methods</h4>We conducted updated literature searches in MEDLINE<sup>®</sup> ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1179-1197]

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Circulating white blood cells and lung function impairment: the observational studies and Mendelian randomization analysis.

Xiulong Wu, Chenming Wang, Hang Li, Hua Meng, Jiali Jie, Ming Fu, Yansen Bai, Guyanan Li, Wei Wei, Yue Feng, Mengying Li, Xin Guan, Meian He, Xiaomin Zhang, Huan Guo,

<h4>Background</h4>Circulating white blood cell (WBC) counts have been related to lung function impairment, but causal relationship was not established. We aimed to evaluate independent effects and causal relationships of WBC subtypes with lung function.<h4>Methods</h4>The 19,159 participants from NHANES 2011-2012 (<i>n</i> = 3570), coke-oven workers (COW, <i>n</i> = 1762) and Dongfeng-Tongji (DFTJ, <i>n</i> = 13,827) cohorts were ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1118-1128]

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Pioglitazone improves skeletal muscle functions in reserpine-induced fibromyalgia rat model.

Fatma E Hassan, Hader I Sakr, Passant M Mohie, Howayda Saeed Suliman, Ayman Saber Mohamed, Mohamed H Attia, Dalia M Eid,

<h4>Background</h4>Fibromyalgia (FM) is characterized by musculoskeletal pain, fatigue, sleep and memory disturbance. There is no definitive cure yet for FM-related health problems. Peroxisome proliferator-activated receptor's (PPAR's) activation is associated with insulin sensitisation and improved glucose metabolism. PPAR-γ was reported to alleviate FM allodynia. Limited data are discussing its effect on ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1032-1040]

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Supplementation of EPA and DHA in pregnant women with type 1 diabetes mellitus.

Marina Ivanisevic, Marina Horvaticek, Karlo Delmis, Josip Delmis,

<h4>Background/objective</h4>Lower proportions of n-3 PUFAs have been observed in neonates born to diabetic mothers. We aimed to investigate the association between DHA and EPA supplementation during pregnancy complicated with type 1 diabetes on concentration and proportion of fatty acids in maternal and foetal blood.<h4>Subjects and methods</h4>We conducted a prospective randomized, ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):848-859]

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Risk factors and predictive model for abdominal wound dehiscence in neonates: a retrospective cohort study.

Shouxing Duan, Xuan Zhang, Xuewu Jiang, Wenhui Ou, Maxian Fu, Kaihong Chen, Xinquan Xie, Wenfeng Xiao, Lian Zheng, Shuhua Ma, Jianhong Li,

<h4>Background</h4>Abdominal wound dehiscence (AWD) is a major complication of abdominal surgery, and neonates are a group with a high risk of AWD, which has serious consequences or can even result in death. The purpose of this study is to explore the risk factors for neonatal AWD and construct a predictive ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):900-907]

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