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Journal Ann Lab Med

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Active Surveillance for Carbapenem-resistant Enterobacteriaceae at a Single Center for Four Years.

Inho Choi, Yangsoon Lee,

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(3):367-369]

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Substantial Improvement in Nontuberculous Mycobacterial Identification Using ASTA MicroIDSys Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry with an Upgraded Database.

Junhyup Song, Shinyoung Yoon, Yongha In, Daewon Kim, Hyukmin Lee, Dongeun Yong, Kyoungwon Lee,

Identifying <i>Mycobacterium</i> using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is challenging. We evaluated the performance of MALDI-TOF MS in identifying nontuberculous mycobacteria (NTM) using the ASTA MicroIDSys system (ASTA Inc., Suwon, Korea) with the MycoDB v1.95s and upgraded MycoDB v2.0-beta databases. We tested 124 NTM isolates collected from ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(3):358-362]

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Prevalence of a Single-Nucleotide Variant of SARS-CoV-2 in Korea and Its Impact on the Diagnostic Sensitivity of the Xpert Xpress SARS-CoV-2 Assay.

Ki Ho Hong, Ji Won In, Jaehyeon Lee, So Yeon Kim, Kyoung Ah Lee, Seunghyun Kim, Yeoungim An, Donggeun Lee, Heungsup Sung, Jae-Seok Kim, Hyukmin Lee,

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(3):389]

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Myelodysplastic Syndromes with Bone Marrow Fibrosis: An Update.

Akriti G Jain, Ling Zhang, John M Bennett, Rami Komrokji,

Myelodysplastic syndrome (MDS) is a diverse hematological malignancy with a wide spectrum of presentations and implications. Treatment strategies for patients with MDS heavily rely on prognostic scoring systems, such as the revised international prognostic scoring system (IPSS-R). Bone marrow fibrosis (BMF) has been identified as an independent risk factor for ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(3):299-305]

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Genetic Counseling and Long-Term Surveillance Using a Multidisciplinary Approach in von Hippel-Lindau Disease.

Sun Joo Yoon, Won Kyung Kwon, Geehay Hong, Ja-Hyun Jang, Byong Chang Jeong, Jae Hyeon Kim, Jong-Won Kim,

<h4>Background</h4>von Hippel-Lindau (VHL) disease is an autosomal dominant disorder caused by variants of the VHL tumor suppressor gene (<i>VHL</i>). Early detection and treatment are essential to prevent morbidity and mortality. We evaluated the effectiveness of surveillance strategies and the utility of a VHL clinic with a multidisciplinary team for the ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(3):352-357]

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Current State of Blood Management Services in Korea.

Hyun Ok Kim,

Blood is lifesaving; however, it can neither be limitlessly acquired nor artificially produced. The supply and use of blood, as an invaluable biological commodity, necessitate systematic and rational management under governmental guidance to ensure safe and reliable transfusions. Despite Korea's blood donation rate of 5.04%, which is higher than the ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(3):306-313]

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Incidence Evaluation of SARS-CoV-2 Variants in the Ulsan Area, Korea, Using PowerChek SARS-CoV-2 S-gene Mutation Detection Kit: A Pilot Study.

Sang Hyuk Park, Hyun-Ki Kim, Hang Kang, Jung Heon Kim, Jaeseung Lee, Ji-Hun Lim, Seon-Ho Lee, Joseph Jeong,

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(3):363-366]

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The First Korean Case of Griscelli Syndrome Type 2 With Hemophagocytic Lymphohistiocytosis and Partial Albinism.

Youngeun Lee, Hyun Jin Park, Hyoung Jin Kang, Jung Min Ko, Boram Kim, Yoon Hwan Chang, Hyun Kyung Kim, Jee-Soo Lee, Man Jin Kim, Sung Sup Park, Moon-Woo Seong,

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(3):384-388]

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Promotion to Top-Tier Journal and Development Strategy of the Annals of Laboratory Medicine for Strengthening its Leadership in the Medical Laboratory Technology Category: A Bibliometric Study.

Sun Huh,

<h4>Background</h4>A bibliometric analysis of the <i>Annals of Laboratory Medicine</i> (ALM) was performed to understand its position in the medical laboratory technology category and to suggest a developmental strategy.<h4>Methods</h4>Journal metrics, including the number of articles by publication type, country of authors, total citations, 2-year impact factor, country of cited authors, journals ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(3):321-330]

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RNA Sequencing for Elucidating an Intronic Variant of Uncertain Significance (SDHD c.314+3A>T) in Splicing Site Consensus Sequences.

Hyunjung Gu, Jinyoung Hong, Woochang Lee, Sung-Bae Kim, Sail Chun, Won-Ki Min,

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(3):376-379]

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Current Issues, Challenges, and Future Perspectives of Genetic Counseling in Korea.

Namhee Kim, Sun-Young Kong, Jongha Yoo, Do-Hoon Kim, Soo Hyun Seo, Jieun Kim,

Genetic testing has become increasingly integrated into all areas of healthcare, and complex genetic testing usage continues to grow; thus, the demand for genetic counseling (GC) is likely to increase. However, it is unclear whether the current clinical GC capacity is sufficient for meeting the existing demand. This review describes ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(3):314-320]

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Effect of Outlier Elimination on the 99th Percentile Upper Reference Limits of High-Sensitivity Cardiac Troponin I Assays Based on a Strictly Selected Healthy Reference Population.

Sunyoung Ahn, Hyun-Ki Kim, Woochang Lee, Sail Chun, Won-Ki Min,

<h4>Background</h4>We established high-sensitivity cardiac troponin I (hsTnI) 99th percentile upper reference limits (URLs) for the Centaur XPT High-Sensitivity Troponin I assay (Centaur hsTnI; Siemens, Erlangen, Germany) and Atellica IM High-Sensitivity Troponin I assay (Atellica hsTnI; Siemens) and assessed the effect of outlier elimination.<h4>Methods</h4>The reference population comprised 380 men and 387 ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(3):331-341]

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Skewed X-Chromosome Inactivation in a Korean Girl with Severe Mucopolysaccharidosis Type II.

Hwa Young Kim, Man Jin Kim, Moon-Woo Seong, Jung Min Ko,

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(3):373-375]

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Invasive Hormographiella aspergillata Infection Identified Using DNA Sequencing.

Eunbin Chong, Hui-Jin Yu, Tae Yeul Kim, Keon Hee Yoo, Yae-Jean Kim, Hee Jae Huh, Nam Yong Lee,

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(3):370-372]

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RNA Sequencing Provides Evidence for Pathogenicity of a Novel CHEK2 Splice Variant (C.1009-7T>G).

Rae Na, Jinyoung Hong, Hyunjung Gu, Woochang Lee, Jae-Lyun Lee, Sail Chun, Won-Ki Min,

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(3):380-383]

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Questionnaire Survey on Current Red Blood Cell Transport and Storage in Korea for Reducing Wastage.

Mikyoung Park, Mina Hur, Hahah Kim, Kyungmi Oh, Hyunmi Kim, Young Hye Song, Dae-Hyun Ko, Yousun Chung,

<h4>Background</h4>To ensure safe red blood cell (RBC) transfusion practice, it is important to comply with storage and transport requirements of RBC units. We conducted a comprehensive survey on the practice of RBC transport and storage to explore the awareness of and compliance with the 30-minute rule, the current status of ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(3):342-351]

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Concomitant Diagnosis of Primary Bone Marrow B-Cell Non-Hodgkin Lymphoma and Essential Thrombocythemia: A Case Report.

Hongkyung Kim, Hye Min Kim, Jin Ju Kim, Saeam Shin, Doh Yu Hwang, Seung-Tae Lee, Jong Rak Choi,

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(2):282-285]

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Comparison of Non-Invasive Clinical Algorithms for Liver Fibrosis in Patients With Chronic Hepatitis B to Reduce the Need for Liver Biopsy: Application of Enhanced Liver Fibrosis and Mac-2 Binding Protein Glycosylation Isomer.

Mina Hur, Mikyoung Park, Hee-Won Moon, Won Hyeok Choe, Chae Hoon Lee,

<h4>Background</h4>Non-invasive clinical algorithms for the detection of liver fibrosis (LF) can reduce the need for liver biopsy (LB). We explored the implementation of two serum biomarkers, enhanced liver fibrosis (ELF) and Mac-2 binding protein glycosylation isomer (M2BPGi), in clinical algorithms for LF in chronic hepatitis B (CHB) patients.<h4>Methods</h4>Two clinical algorithms ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(2):249-257]

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Biomarker Rule-in or Rule-out in Patients With Acute Diseases for Validation of Acute Kidney Injury in the Emergency Department (BRAVA): A Multicenter Study Evaluating Urinary TIMP-2/IGFBP7.

Hyun Suk Yang, Mina Hur, Kyeong Ryong Lee, Hanah Kim, Hahn Young Kim, Jong Won Kim, Mui Teng Chua, Win Sen Kuan, Horng Ruey Chua, Chagriya Kitiyakara, Phatthranit Phattharapornjaroen, Anchalee Chittamma, Thiyapha Werayachankul, Urmila Anandh, Sanjeeva Herath, Zoltan Endre, Andrea Rita Horvath, Paola Antonini, Salvatore Di Somma, ,

<h4>Background</h4>Urine tissue inhibitor of metalloproteinases-2/insulin-like growth factor-binding protein 7 (TIMP-2/IGFBP7) (NephroCheck, Ortho Clinical Diagnostics, Raritan, NJ, USA) is a US Food and Drug Administration-approved biomarker for risk assessment of acute kidney injury (AKI) in critically ill adult patients in intensive care units; however, its clinical impact in the emergency department ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(2):178-187]

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Review of the Use of Liquid Chromatography-Tandem Mass Spectrometry in Clinical Laboratories: Part I-Development.

Brian A Rappold,

The process of method development for a diagnostic assay based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) involves several disparate technologies and specialties. Additionally, method development details are typically not disclosed in journal publications. Method developers may need to search widely for pertinent information on their assay(s). This review summarizes the ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(2):121-140]

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First Case of Bacteremia and Epididymo-orchitis Caused by Oceanobacillus oncorhynchi subspecies incaldanensis in an Immunocompetent Patient.

Mutbyul Kim, Jae Hwi Choi, Hyoshim Shin, Woo Kon Lee, Jung-Hyun Byun,

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(2):290-292]

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Serotype Distribution and Antimicrobial Resistance of Salmonella Isolates in Korea between 2016 and 2017.

Si Hyun Kim, Gyung-Hye Sung, Eun Hee Park, In Yeong Hwang, Gyu Ri Kim, Sae Am Song, Hae Kyung Lee, Young Uh, Young Ah Kim, Seok Hoon Jeong, Jong Hee Shin, Kyeong Seob Shin, Jaehyeon Lee, Joseph Jeong, Young Ree Kim, Dongeun Yong, Miae Lee, Yu Kyung Kim, Nam Hee Ryoo, Seungok Lee, Jayoung Kim, Sunjoo Kim, Hyun Soo Kim, Jeong Hwan Shin,

<i>Salmonella</i> is one of the major causes of food-borne infections. We investigated the serotype distribution and antimicrobial resistance of <i>Salmonella</i> isolates collected in Korea between January 2016 and December 2017. In total, 669 <i>Salmonella</i> isolates were collected from clinical specimens at 19 university hospitals. Serotyping was performed according to the ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(2):268-273]

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Diagnosis of Balamuthia mandrillaris Encephalitis by Thymine-Adenine Cloning Using Universal Eukaryotic Primers.

Ju Yeong Kim, Myung-Hee Yi, Myungjun Kim, Joon-Sup Yeom, Hyun Dong Yoo, Seong Min Kim, Tai-Soon Yong,

<h4>Background</h4>Identifying the causal pathogen of encephalitis remains a clinical challenge. A 50-year-old man without a history of neurological disease was referred to our department for the evaluation of an intracranial lesion observed on brain magnetic resonance imaging (MRI) scans, and the pathology results suggested protozoal infection. We identified the species ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(2):196-202]

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Periodic Comparability Verification and Within-Laboratory Harmonization of Clinical Chemistry Laboratory Results at a Large Healthcare Center With Multiple Instruments.

Youngwon Nam, Joon Hee Lee, Sung Min Kim, Sun-Hee Jun, Sang Hoon Song, Kyunghoon Lee, Junghan Song,

<h4>Background</h4>Results from laboratories using multiple instruments should be standardized or harmonized and comparability-verified for consistent quality control. We developed a simple frequent comparability verification methodology applicable to large healthcare centers using multiple clinical chemistry instruments from different manufacturers.<h4>Methods</h4>Comparability of five clinical chemistry instruments (Beckman Coulter AU5800, Abbott Architect Ci16000, two ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(2):150-159]

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A Case of Next-generation Sequencing Gene Testing: Points to be Considered in Testing and Reporting.

Na-Kyoung Kim, Jong-Won Kim,

Ann Lab Med (Annals of laboratory medicine)
[2022, 42(2):296-297]

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