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Epstein-Barr Virus-negative Marginal Zone Lymphoma as an Uncommon Form of Monomorphic Posttransplant Lymphoproliferative Disorder.

Pallavi Galera, Richard Flavin, Natasha M Savage, Annapurna Saksena, Shunyou Gong, Huan-You Wang, Niall Swan, Liqiang Xi, Mark Raffeld, Stefania Pittaluga, Elaine S Jaffe,

Monomorphic posttransplant lymphoproliferative disorders have been defined as lymphoid or plasmacytic proliferations that fulfill criteria for one of the B-cell or T/NK-cell neoplasms recognized in immunocompetent hosts in the current WHO Classification. Low-grade B-cell neoplasms have historically been excluded from this category, although rare reports of marginal zone lymphoma (MZL) ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, 44(10):1340-1352]

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PHOX2B Immunostaining: A Simple and Helpful Tool for the Recognition of Ganglionic Cells and Diagnosis of Hirschsprung Disease.

Philippe Drabent, Arnaud Bonnard, Fabien Guimiot, Michel Peuchmaur, Dominique Berrebi,

Hirschsprung disease (HD) is a congenital disorder of the enteric nervous system that occurs in ∼1 in 5000 live births. It is characterized by the absence of ganglionic cells (GCs) in the distal intestine. The diagnosis relies on the thorough analysis of a rectal suction biopsy (RSB), which must show ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, 44(10):1389-1397]

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Diagnostic Utility of LEF1 Immunohistochemistry in Differentiating Deep Penetrating Nevi From Histologic Mimics.

Shyam S Raghavan, Atif Saleem, Jennifer Y Wang, Kerri E Rieger, Ryanne A Brown, Roberto A Novoa,

Deep penetrating nevi (DPNs) are intermediate grade lesions which have the capacity to recur, metastasize, or progress to melanoma. Differentiating DPN from other melanocytic lesions including blue and cellular blue nevi can be diagnostically challenging, and markers to distinguish these entities can be useful. Mutations of the β-catenin and mitogen-activated ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, 44(10):1413-1418]

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Chronic Intervillositis of Unknown Etiology: Development of a Grading and Scoring System That Is Strongly Associated With Poor Perinatal Outcomes.

Fanny Sauvestre, Aurélien Mattuizzi, Loïc Sentilhes, Marion Poingt, Patrick Blanco, Clémence Houssin, Dominique Carles, Fanny Pelluard, Gwenaëlle Andre, Estibaliz Lazaro,

Chronic intervillositis of unknown etiology (CIUE) is a rare placental disease characterized by intervillous infiltration of maternal macrophages and associated with poor pregnancy outcomes and a high risk of recurrence in subsequent pregnancies. Its pathophysiology remains unclear and prognostic factors have not yet been established. In addition, clear relationships between ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, 44(10):1367-1373]

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Expanding the Molecular Spectrum of Secretory Carcinoma of Salivary Glands With a Novel VIM-RET Fusion.

Alena Skálová, Martina Banečkova, Lester D R Thompson, Nikola Ptáková, Todd M Stevens, Luka Brcic, Martin Hyrcza, Michael Michal, Roderick H W Simpson, Thalita Santana, Michal Michal, Tomas Vaněček, Ilmo Leivo,

BACKGROUND:Secretory carcinoma (SC), originally described as mammary analogue SC, is a predominantly low-grade salivary gland neoplasm characterized by a recurrent t(12;15)(p13;q25) translocation, resulting in ETV6-NTRK3 gene fusion. Recently, alternative ETV6-RET, ETV6-MAML3, and ETV6-MET fusions have been found in a subset of SCs lacking the classic ETV6-NTRK3 fusion transcript, but still ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, 44(10):1295-1307]

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PD-1 and PD-L1 Immunohistochemistry as a Diagnostic Tool for Classic Hodgkin Lymphoma in Small-volume Biopsies.

Ashley Volaric, Carlos E Bacchi, Alejandro A Gru,

It is becoming increasingly important to obtain detailed diagnostic information on small-volume tissue biopsies, such as core needle biopsies. This is particularly crucial in the workup and diagnosis of classic Hodgkin lymphoma (CHL) and other morphologically similar lymphomas such as T-cell/histiocyte-rich large B-cell lymphoma (THRLBL), where small-volume lymph node biopsies ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, 44(10):1353-1366]

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Recurrent Loss of SMARCA4 in Sinonasal Teratocarcinosarcoma.

Lisa M Rooper, Nasir Uddin, Jeffrey Gagan, Lodewijk A A Brosens, Kelly R Magliocca, Mark A Edgar, Lester D R Thompson, Abbas Agaimy, Justin A Bishop,

Molecular analysis has reshaped the landscape of high grade sinonasal tumors by defining novel entities and identifying recurrent mutations in established tumor types. However, sinonasal teratocarcinosarcoma (TCS), a rare and aggressive tumor with intermixed teratomatous, carcinomatous, and sarcomatous elements, remains poorly understood. The multiphenotypic differentiation of TCS has engendered persistent ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, 44(10):1331-1339]

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A Proposed Grading Scheme for Medullary Thyroid Carcinoma Based on Proliferative Activity (Ki-67 and Mitotic Count) and Coagulative Necrosis.

Talia L Fuchs, Anthony J Nassour, Anthony Glover, Mark S Sywak, Stan B Sidhu, Leigh W Delbridge, Roderick J Clifton-Bligh, Matti L Gild, Venessa Tsang, Bruce G Robinson, Adele Clarkson, Amy Sheen, Loretta Sioson, Angela Chou, Anthony J Gill,

We investigated the prognostic value of a range of histologic parameters in medullary thyroid carcinoma (MTC) to design a grading system to predict overall survival. We assessed 76 patients with MTCs undergoing primary tumor resection for age, sex, tumor size, vascular space invasion, lymph node metastasis, multiple endocrine neoplasia type ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, 44(10):1419-1428]

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Clear Cell Change in Reactive Angiogenesis: A Potential Diagnostic Pitfall.

Iva Brčić, Smiljana Spasić, Jonathan S England, Yiqin Zuo, Jaylou Velez-Torres, Julio A Diaz-Perez, Gregor Gorkiewicz, Andrew E Rosenberg,

Reactive angiogenesis is commonplace, occurs in many circumstances, and is important in the repair of injured tissue. Histologically, it is characterized by newly formed capillaries arranged in a lobular architecture and lined by plump endothelial cells. We have encountered a form of reactive angiogenesis not well described; composed of large ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, :]

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Nonkeratinizing Squamous Cell Carcinoma of the Sinonasal Tract With DEK-AFF2: Further Solidifying an Emerging Entity.

Justin A Bishop, Jeffrey Gagan, Claire Paterson, Douglas McLellan, Ann Sandison,

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, :]

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Molecular Profiling of Salivary Oncocytic Mucoepidermoid Carcinomas Helps to Resolve Differential Diagnostic Dilemma With Low-grade Oncocytic Lesions.

Alena Skálová, Abbas Agaimy, Olga Stanowska, Martina Baneckova, Nikola Ptáková, Laura Ardighieri, Piero Nicolai, Davide Lombardi, Monika Durzynska, Luigi Corcione, Jan Laco, Olena Koshyk, Radim Žalud, Michal Michal, Tomáš Vanecek, Ilmo Leivo,

Oncocytic mucoepidermoid carcinoma (OMEC) is a rare but diagnostically challenging variant of mucoepidermoid carcinoma (MEC). OMEC is notable for differential diagnostic considerations that are raised as a result of overlap with other benign and low-grade oncocytic salivary gland tumors. Diffuse and strong immunoreactivity of p63 protein may be useful in ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, :]

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Amyloid-like Fibronectin Deposits in the Liver: A Novel Morphologic Finding.

Saba Yasir, Karen L Rech, Zongming Eric Chen, Michael S Torbenson,

Amyloid deposits in the liver are recognized by their hematoxylin and eosin (H&E) findings, consisting of acellular eosinophilic deposits in various compartments of the liver parenchyma, including the stroma, vessels, and rarely the hepatocytes. H&E findings that suggest amyloid are then confirmed by Congo red stains and subtyped when clinically ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, :]

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NF2 Tumor Suppressor Gene Inactivation in Advanced Papillary Renal Cell Carcinoma.

Evgeny Yakirevich, Dean C Pavlick, Carmen M Perrino, Melissa Stanton, Shaolei Lu, Benedito Carneiro, Gennady Bratslavsky, Jeffrey S Ross,

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, :]

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Pseudocarcinomatous Squamous Hyperplasia Involving Bone: A Diagnostic Pitfall Mimicking Squamous Cell Carcinoma.

Smiljana Spasić, Oleksandr N Kryvenko, Darcy A Kerr, Gunnlaugur P Nielsen, Carmen Gomez-Fernandez, Andrew E Rosenberg,

BACKGROUND:Pseudocarcinomatous squamous hyperplasia (PSH) within the bone is uncommon and closely mimics well-differentiated squamous cell carcinoma (SCC). It arises from cutaneous or mucosal surfaces and grows directly into the bone. This study analyzes a large series of PSH and discusses the clinicopathologic features that facilitate its distinction from SCC. DESIGN:Cases ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, :]

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Langerhans Cell Histiocytosis Associated With Renal Cell Carcinoma Is a Neoplastic Process: Clinicopathologic and Molecular Study of 7 Cases.

Abbas Agaimy, Michael Bonert, Asghar Naqvi, Chunjie Wang, Kiril Trpkov, Peer Dettmar, Hanns-Olof Wintzer, Robert Stoehr, Ondřej Hes, Sean R Williamson, Ian W Gibson, Arndt Hartmann,

Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder composed of Langerhans cells admixed with reactive mononuclear and granulocytic cells, associated with prominent eosinophils. LCH is considered a neoplasm, driven in most cases by oncogenic RAS/RAF/MEK/ERK pathway mutations. The disease predominantly affects children. Urinary system involvement has rarely been reported ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, :]

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Claudin-18 as a Marker for Identifying the Stomach and Pancreatobiliary Tract as the Primary Sites of Metastatic Adenocarcinoma.

Wan-Ting Li, Yung-Ming Jeng, Ching-Yao Yang,

Identification of the primary site of cancer is essential for the treatment of patients with cancer. Numerous immunohistochemical markers have been developed to determine the differentiation of tumor cells and suggest possible primary sites, but markers of gastric and pancreatic adenocarcinomas are still lacking. Claudin-18 is a tight-junction protein uniquely ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, :]

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BRG1, INI1, and ARID1B Deficiency in Endometrial Carcinoma: A Clinicopathologic and Immunohistochemical Analysis of a Large Series From a Single Institution.

Atsushi Kihara, Yusuke Amano, Daisuke Matsubara, Noriyoshi Fukushima, Hiroyuki Fujiwara, Toshiro Niki,

Switch/sucrose nonfermenting complex subunits, such as BRG1, INI1, and ARID1B, are inactivated in a subset of endometrial undifferentiated carcinoma and dedifferentiated carcinoma (DC). Limited information is currently available on their prevalence in other subtypes or the nosological status of endometrial carcinoma with their deficiencies. This study immunohistochemically examined the expression ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, :]

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Secondary Involvement of the Uterine Cervix by Nongynecologic Neoplasms: A Detailed Clinicopathologic Analysis.

Gulisa Turashvili, Wesley R Samore, Esther Oliva, Olga Ioffe, Robert Riddell, Kay J Park, Lars-Christian Horn,

Secondary involvement of the uterine cervix by nongynecologic neoplasms is rare accounting for <2% of metastases to the gynecologic tract. This study aimed to analyze the clinicopathologic features of cervical involvement by nongynecologic malignancies. A total of 47 cases were identified including 39 (83%) carcinomas, 6 lymphomas (12.8%), and 2 ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, :]

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Rare DICER1 and Absent FOXL2 Mutations Characterize Ovarian Juvenile Granulosa Cell Tumors.

Pauline Baillard, Catherine Genestie, Sabrina Croce, Françoise Descotes, Etienne Rouleau, Isabelle Treilleux, Sebastien Gouy, Philippe Morice, Isabelle Ray-Coquard, W Glenn McCluggage, Mojgan Devouassoux-Shisheboran,

FOXL2 somatic mutation occurs in a high percentage of ovarian adult granulosa cell tumors and DICER1 mutations in a high proportion of Sertoli-Leydig cell tumors. These mutations have only been studied in a limited number of juvenile granulosa cell tumors (JGCTs), and their occurrence and frequency in these neoplasms is ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, :]

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Genomic Profiling Aids Classification of Diagnostically Challenging Uterine Mesenchymal Tumors With Myomelanocytic Differentiation.

Pier Selenica, Niamh Conlon, Carlene Gonzalez, Denise Frosina, Achim A Jungbluth, Regina G H Beets-Tan, Mamta K Rao, Yanming Zhang, Ryma Benayed, Marc Ladanyi, David B Solit, Sarah Chiang, David M Hyman, Martee L Hensley, Robert A Soslow, Britta Weigelt, Rajmohan Murali,

Although diagnosis of high-grade uterine mesenchymal tumors (UMTs) exhibiting classic morphologic features is straightforward, diagnosis is more challenging in tumors in which prototypical features are poorly developed, focal, and/or coexist with features seen in other neoplasms. Here, we sought to define the repertoire of somatic genetic alterations in diagnostically challenging ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, :]

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IgG4-related Lymphadenopathy: A Comparative Study of 41 Cases Reveals Distinctive Histopathologic Features.

Jacob R Bledsoe, Judith A Ferry, Azfar Neyaz, Leonardo Boiocchi, Cara Strock, Karen Dresser, Lawrence Zukerberg, Vikram Deshpande,

Lymphadenopathy is common in patients with immunoglobulin G4-related disease (IgG4-RD). However, the described histopathologic features of IgG4-related lymphadenopathy have been shown to be largely nonspecific. In an attempt to identify features specific for nodal IgG4-RD we examined the histopathologic features of lymph nodes from 41 patients with established IgG4-RD, with ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, :]

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Clinicopathologic Significance of EGFR Mutation and HPV Infection in Sinonasal Squamous Cell Carcinoma.

Takahiro Hongo, Hidetaka Yamamoto, Rina Jiromaru, Yui Nozaki, Ryuji Yasumatsu, Kazuki Hashimoto, Reiko Yoneda, Azusa Sugii, Kenichi Taguchi, Muneyuki Masuda, Takashi Nakagawa, Yoshinao Oda,

Sinonasal squamous cell carcinoma (SNSCC) is sometimes associated with high-risk human papillomavirus (HR-HPV) infection and inverted sinonasal papilloma or oncocytic sinonasal papilloma. Frequent mutations of EGFR and KRAS are reported in inverted sinonasal papilloma-related sinonasal squamous cell carcinoma (ISP-SCC) and oncocytic sinonasal papilloma-related SNSCC, respectively. Here, we attempted to determine ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, :]

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Optimal Criteria for G3 (Poorly Differentiated) Stage II Colon Cancer: Prospective Validation in a Randomized Controlled Study (SACURA Trial).

Hideki Ueno, Megumi Ishiguro, Eiji Nakatani, Toshiaki Ishikawa, Hiroyuki Uetake, Shigeyuki Matsui, Satoshi Teramukai, Kenta Murotani, Yoichi Ajioka, Hideyuki Shimazaki, Atsuyuki Maeda, Kunio Takuma, Takefumi Yoshida, Takeshi Kambara, Keiji Matsuda, Akinori Takagane, Naohiro Tomita, Kenichi Sugihara, ,

Grade 3 (G3, poorly differentiated) is an important treatment-decision factor in stage II colon cancer, but no unified diagnostic criteria are established. According to previous studies, an intratumoural poorly differentiated area with no glandular formation (POR) that fills the microscopic field of a ×40 objective lens was an essential factor ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, :]

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Primary Female Urethral Carcinoma: Proposed Staging Modifications Based on Assessment of Female Urethral Histology and Analysis of a Large Series of Female Urethral Carcinomas.

Manju Aron, Sanghui Park, Brett M Lowenthal, Sounak Gupta, Debashis Sahoo, John C Cheville, Donna E Hansel,

Primary female urethral carcinoma is rare. Limited clinicopathologic information has hindered development of staging criteria in this disease. We analyzed 29 primary female urethral carcinoma resections from 3 academic medical centers to characterize histopathologic features, clinical outcomes, and applicability of current and a novel modified staging criteria. We complemented this ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, :]

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AKT1 Mutations in Peripheral Bronchiolar Papilloma: Glandular Papilloma and Mixed Squamous Cell and Glandular Papilloma Is Distinct From Bronchiolar Adenoma.

Eiichi Sasaki, Katsuhiro Masago, Shiro Fujita, Akari Iwakoshi, Hiroaki Kuroda, Waki Hosoda,

Glandular papilloma (GP) and mixed squamous cell and glandular papilloma (MP) are rare benign pulmonary tumors occurring in the bronchi. Bronchiolar adenoma (BA) was recently characterized as a pulmonary tumor exhibiting alveolar spread. Both GP/MP and BA are composed of a mixture of glandular, ciliated, squamous, and basal cells. We ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, :]

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