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Systems analysis of benign bladder disorders: insights from omics analysis.

Ali Hashemi Gheinani, Alexander Bigger-Allen, Amanda Wacker, Rosalyn M Adam,

The signaling pathways and effectors that drive the response of the bladder to nonmalignant insults or injury are incompletely defined. Interrogation of biological systems has been revolutionized by the ability to generate high-content data sets that capture information on a variety of biomolecules in cells and tissues, from DNA to ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2020, 318(4):F901-F910]

Cited: 0 times

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Reply to An et al.

Juin-Hong Cherng, Yu-Juei Hsu, Chuan-Chieh Liu, Shou-Hung Tang, Dewi Sartika, Shu-Jen Chang, Gang-Yi Fan, Sheng-Tang Wu, En Meng,

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2020, 318(2):F507-F508]

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miR-214 represses mitofusin-2 to promote renal tubular apoptosis in ischemic acute kidney injury.

Yu Yan, Zhengwei Ma, Jiefu Zhu, Mengru Zeng, Hong Liu, Zheng Dong,

Disruption of mitochondrial dynamics is an important pathogenic event in both acute and chronic kidney diseases, but the underlying mechanism remains poorly understood. Here, we report the regulation of mitofusin-2 (Mfn2; a key mitochondrial fusion protein) by microRNA-214 (miR-214) in renal ischemia-reperfusion that contributes to mitochondrial fragmentation, renal tubular cell ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2020, 318(4):F878-F887]

Cited: 1 time

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CORRIGENDUM.

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2020, 318(1):F283]

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Medullary and cortical thick ascending limb: similarities and differences.

Lise Bankir, Lucile Figueres, Caroline Prot-Bertoye, Nadine Bouby, Gilles Crambert, J Howard Pratt, Pascal Houillier,

The thick ascending limb of the loop of Henle (TAL) is the first segment of the distal nephron, extending through the whole outer medulla and cortex, two regions with different composition of the peritubular environment. The TAL plays a critical role in the control of NaCl, water, acid, and divalent ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2020, 318(2):F422-F442]

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NBCe1-A is required for the renal ammonia and K+ response to hypokalemia.

Hyun-Wook Lee, Autumn N Harris, Michael F Romero, Paul A Welling, Charles S Wingo, Jill W Verlander, I David Weiner,

Hypokalemia increases ammonia excretion and decreases K+ excretion. The present study examined the role of the proximal tubule protein NBCe1-A in these responses. We studied mice with Na+-bicarbonate cotransporter electrogenic, isoform 1, splice variant A (NBCe1-A) deletion [knockout (KO) mice] and their wild-type (WT) littermates were provided either K+ control ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2020, 318(2):F402-F421]

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Regulation of NKCC2B by TNF-α in response to salt restriction.

Shoujin Hao, Joseph Salzo, Mary Hao, Nicholas R Ferreri,

We have previously shown that TNF-α produced by renal epithelial cells inhibits Na+-K+-2Cl- cotransporter (NKCC2) activity as part of a mechanism that attenuates increases in blood pressure in response to high NaCl intake. As the role of TNF-α in the kidney is still being defined, the effects of low salt ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2020, 318(1):F273-F282]

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A model of mitochondrial O2 consumption and ATP generation in rat proximal tubule cells.

Aurélie Edwards, Fredrik Palm, Anita T Layton,

Oxygen tension in the kidney is mostly determined by O2 consumption (Qo2), which is, in turn, closely linked to tubular Na+ reabsorption. The objective of the present study was to develop a model of mitochondrial function in the proximal tubule (PT) cells of the rat renal cortex to gain more ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2020, 318(1):F248-F259]

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CORRIGENDUM.

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2019, 317(6):F1707]

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Peritoneal dialysis induces alterations in the transcriptome of peritoneal cells before detectible peritoneal functional changes.

Alena Parikova, Petra Hruba, Zdenek Krejcik, Viktor Stranecky, Janka Franekova, Raymond T Krediet, Ondrej Viklicky,

Long-term peritoneal dialysis (PD) is associated with functional and structural alterations of the peritoneal membrane. Inflammation may be the key moment, and, consequently, fibrosis may be the end result of chronic inflammatory reaction. The objective of the present study was to identify genes involved in peritoneal alterations during PD by ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2020, 318(1):F229-F237]

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NHE8 attenuates Ca2+ influx into NRK cells and the proximal tubule epithelium.

Shane A Wiebe, Allein Plain, Wanling Pan, Debbie O'Neill, Branko Braam, R Todd Alexander,

To garner insights into the renal regulation of Ca2+ homeostasis, we performed an mRNA microarray on kidneys from mice treated with the Ca2+-sensing receptor (CaSR) agonist cinacalcet. This revealed decreased gene expression of Na+/H+ exchanger isoform 8 (NHE8) in response to CaSR activation. These results were confirmed by quantitative real-time ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2019, 317(2):F240-F253]

Cited: 1 time

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Sustained, delayed, and small increments in glomerular permeability to macromolecules during systemic ET-1 infusion mediated via the ETA receptor.

Julia Dolinina, Anna Rippe, Carl M Öberg,

Emerging evidence indicates that endogenous production of endothelin (ET)-1, a 21-amino acid peptide vasoconstrictor, plays an important role in proteinuric kidney disease. Previous studies in rats have shown that chronic administration of ET-1 leads to increased glomerular albumin leakage. The underlying mechanisms are, however, currently not known. Here, we used ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2019, 316(6):F1173-F1179]

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Tracking renal injury using multiparametric MRI.

Shuangtao Ma, Chunqi Qian, Donna H Wang,

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2018, 315(6):F1656-F1657]

Cited: 0 times

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Corrigendum.

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2018, 315(3):F746]

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Absence of renal hypoxia in the subacute phase of severe renal ischemia-reperfusion injury.

Connie P C Ow, Jennifer P Ngo, Md Mahbub Ullah, Giannie Barsha, Ruth C Meex, Matthew J Watt, Lucinda M Hilliard, Maarten P Koeners, Roger G Evans,

Tissue hypoxia has been proposed as an important event in renal ischemia-reperfusion injury (IRI), particularly during the period of ischemia and in the immediate hours following reperfusion. However, little is known about renal oxygenation during the subacute phase of IRI. We employed four different methods to assess the temporal and ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2018, 315(5):F1358-F1369]

Cited: 1 time

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Morphologic and morphometric study on microvasculature of developing mouse kidneys.

Jie Zhang, Jing Cong, Jie Yang, Jesper Skovhus Thomsen, Arne Andreasen, Shi-Jie Chang, Kai-Yue Wang, Ling Gu, Xiao-Yue Zhai,

A proper morphogenesis of the renal microvasculature is crucial not only for fulfilling the renal function but also to slow down the progression of chronic kidney disease in adulthood. However, the current description of the developing microvasculature is incomplete. The present study investigated the morphogenesis and volume densities of the ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2018, 315(4):F852-F860]

Cited: 0 times

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Mechanisms of altered renal sodium handling in age-related hypertension.

Alissa A Frame, Richard D Wainford,

The prevalence of hypertension rises with age to approximately two out of three adults over the age of 60 in the United States. Although the mechanisms underlying age-related hypertension are incompletely understood, sodium homeostasis is critical to the long-term regulation of blood pressure and there is strong evidence that aging ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2018, 315(1):F1-F6]

Cited: 3 times

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Novel differences in renal gene expression in a diet-induced obesity model.

Victoria L Halperin Kuhns, Jennifer L Pluznick,

Obesity is a significant risk factor for both chronic kidney disease and end-stage renal disease. To better understand disease development, we sought to identify novel genes differentially expressed early in disease progression. We first confirmed that mice fed a high-fat (HF) diet exhibit early signs of renal injury including hyperfiltration. ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2018, 314(4):F517-F530]

Cited: 4 times

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Free circulating active elastase contributes to chronic inflammation in patients on hemodialysis.

Eman Khatib-Massalha, Regina Michelis, Beny Trabelcy, Yoram Gerchman, Batya Kristal, Amiram Ariel, Shifra Sela,

Atherosclerosis and cardiovascular complications are prevalent among patients undergoing chronic hemodialysis (HD). In this population, peripheral polymorphonuclear leukocytes (PMNLs) are primed, releasing proinflammatory mediators such as elastase. Elastase is normally inhibited by a specific inhibitor, avoiding undesirable degradation of cellular and extracellular components. This study tested the hypothesis that in ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2018, 314(2):F203-F209]

Cited: 0 times

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Deletion of β1-integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis.

Fahmy A Mamuya, Dongping Xie, Lei Lei, Ming Huang, Kenji Tsuji, Diane E Capen, BaoXue Yang, Ralph Weissleder, Teodor G Păunescu, Hua A Jenny Lu,

The renal collecting duct (CD) contains two major cell types, intercalated (ICs) and principal cells (PCs). A previous report showed that deletion of β1-integrin in the entire renal CD causes defective CD morphogenesis resulting in kidney dysfunction. However, subsequent deletion of β1-integrin specifically in ICs and PCs, respectively, did not ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2017, 313(4):F1026-F1037]

Cited: 4 times

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Corrigendum.

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2017, 312(5):F848]

Cited: 0 times

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Caspase-11 promotes cisplatin-induced renal tubular apoptosis through a caspase-3-dependent pathway.

Naijun Miao, Bao Wang, Dan Xu, Yanzhe Wang, Xinxin Gan, Li Zhou, Hong Xue, Wei Zhang, Xiaoxia Wang, Limin Lu,

Renal tubular injury is the hallmark of cisplatin-induced nephrotoxicity. Caspase-11, a member of the caspase family, plays an important role in inflammation and cell death. However, its role in cisplatin-induced renal tubular injury remains unclear. In cisplatin-treated mice, caspase-11 expression was significantly elevated and the expression of caspase-11 was mainly ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2018, 314(2):F269-F279]

Cited: 4 times

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Adaptive changes in GFR, tubular morphology, and transport in subtotal nephrectomized kidneys: modeling and analysis.

Anita T Layton, Aurélie Edwards, Volker Vallon,

Removal of renal mass stimulates anatomical and functional adaptations in the surviving nephrons, including elevations in single-nephron glomerular filtration rate (SNGFR) and tubular hypertrophy. A goal of this study is to assess the extent to which the concomitant increases in filtered load and tubular transport capacity preserve homeostasis of water ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2017, 313(2):F199-F209]

Cited: 10 times

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Letter to the editor: "Urothelial barrier dysfunction: cause or outcome of ketamine-induced voiding dysfunction".

Zhao Wang, Long Wang, Long-Fei Liu, Yu-Meng Huang, Zheng-Yan Tang,

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2016, 311(5):F907]

Cited: 2 times

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Nitric oxide synthase inhibition causes acute increases in glomerular permeability in vivo, dependent upon reactive oxygen species.

Julia Dolinina, Kristinn Sverrisson, Anna Rippe, Carl M Öberg, Bengt Rippe,

There is increasing evidence that the permeability of the glomerular filtration barrier (GFB) is partly regulated by a balance between the bioavailability of nitric oxide (NO) and that of reactive oxygen species (ROS). It has been postulated that normal or moderately elevated NO levels protect the GFB from permeability increases, ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2016, 311(5):F984-F990]

Cited: 3 times

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