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Journal Am J Clin Exp Urol

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BETting on next-generation bromodomain inhibitors.

Matthew K Collins, Cindy H Chau, Douglas K Price, William D Figg,

Within the last decade, bromodomain and extraterminal (BET) domain inhibitors were introduced as the first in a wave of new agents known as bromodomain inhibitors. These original examples exhibited anti-inflammatory and anticancer properties, and some have progressed to human clinical trials. BET proteins and their conserved N-terminal bromodomains, BD1 and ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2020, 8(4):129-132]

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Enterocystoplasty and appendicovesicostomy in adults: a description of demographics and 30-day outcomes of bladder augmentation.

Joseph G Brungardt, Caleb S Miller, Kurt P Schropp,

Within the adult population, studies of the granular clinical outcomes of appendicovesicostomy (AV) and augmentation enterocystoplasty (AE) have been limited to case series. Using the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) data, this study sought to describe the population undergoing these procedures. An analysis of ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2020, 8(4):133-139]

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Intra-arterial injection to create bone metastasis of prostate cancer in mice.

Lin Zhong, Haiyan D Miller, Yongfeng Zhang, Ben Jin, Dongxia Ge, Zongbing You,

Human prostate cancer often metastasizes to the bone, but the mechanisms are not quite clear. The difficulties in studying the biology of bone metastasis are due to lack of animal models with high frequency of bone metastases. In the present study, we tested two intra-arterial injection methods, i.e., intra-caudal artery ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2020, 8(4):93-100]

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Distinct cell-types in the prostate share an aging signature suggestive of metabolic reprogramming.

Preston D Crowell, Jenna M Giafaglione, Takao Hashimoto, Andrew S Goldstein,

Age is a significant risk factor for disease of the prostate. However, the mechanisms by which age increases disease risk have not been well described. We previously reported age-related changes within the inflammatory and luminal compartments of the mouse prostate. Old mouse prostates exhibit an expansion of the population of ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2020, 8(4):140-151]

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Scarless laparoscopic varicocelectomy using percutaneous intruments.

Nicola Zampieri,

BACKGROUND:Varicocele is one of the most frequent andrological diseases in adolescents; laparoscopic varicocelectomy is a good option. The aim of this study is to investigate, report and evaluate surgical outcomes of laparoscopic technique in pediatric age using percutaneous instruments. MATERIALS AND METHODS:We report our experience with a new technique for ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2020, 8(4):101-105]

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Triple Aberrant Prostate Cancer (TAPC) - Aggregate role of aberrations in TP53, PTEN and RB1 on ETS gene fusions and prognosis in metastatic castrate resistant prostate cancer.

Allison P Watson, Ashraf Shabaneh, Jinhua Wang, Scott M Dehm, Arpit Rao, Charles J Ryan,

BACKGROUND:Aberrations in TP53, PTEN and RB1 are key drivers of therapy resistance in prostate cancer. Up to 50% of prostate cancers harbor ETS gene rearrangements, a potentially compounding aggressive biological event. Little is known about the impact of aggregate aberrations and gene fusion events in prostate cancer. METHODS:Using cBioportal for ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2020, 8(4):106-115]

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Genome and transcriptome profiling of FBXW family in human prostate cancer.

Ruoxin Lan, Ben Jin, Yao-Zhong Liu, Kun Zhang, Tianhua Niu, Zongbing You,

F-box and WD repeat domain containing (FBXW) family of E3 ligases has 10 members that ubiquitinate substrate proteins for proteasome-mediated degradation. Publicly archived datasets from The Cancer Genome Atlas (TCGA), Prostate Cancer Transcriptome Atlas (PCTA), and cBioPortal were analyzed for mRNA expression and genetic alterations of 10 FBXW genes. We ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2020, 8(4):116-128]

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Micturition defects and altered bladder function in the klotho mutant mouse model of aging.

Sarah N Bartolone, Elijah P Ward, Zunyi Wang, Bernadette Mm Zwaans, Michael B Chancellor, Dale E Bjorling, Laura E Lamb,

INTRODUCTION AND OBJECTIVES:Symptoms associated with detrusor underactivity (DU) or underactive bladder (UAB) can severely impact a person's quality of life, and growing old is the main etiological factor of DU and UAB. The gene Klotho has been associated with suppression of several aging phenotypes, and there is moderate klotho expression ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2020, 8(3):81-92]

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Natural compound Alternol as a novel therapeutic for prostate cancer treatment.

Haixia Xu, Zeqiang Zhou, Benyi Li,

Alternol is a monomeric compound purified from the fermentation of a microbial strain obtained from the bark of the yew tree. Recent studies have confirmed that it has specific anti-prostate cancer efficacy in vitro and in vivo. In in vitro cell culture experiments Alternol inhibits prostate cancer cell proliferation by ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2020, 8(3):76-80]

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Novel discoveries in urology: big data to microbiome - highlights of the society for basic urologic research 2019 annual meeting.

Ben Jin, Gail S Prins, Rosalyn Adam, Jindan Yu, Karen S Sfanos, Benyi Li, Chang-Deng Hu, Yan Dong, Zongbing You,

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2020, 8(2):73-75]

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EAF2 loss induces prostatic intraepithelial neoplasia from luminal epithelial cells in mice.

Laura E Pascal, Lora H Rigatti, Junkui Ai, Aiyuan Zhang, Jianhua Zhou, Joel B Nelson, Zhou Wang,

Defining the cell of origin for prostatic carcinogenesis is fundamentally important for understanding the mechanisms leading to prostate cancer. Lineage tracing studies have demonstrated that luminal epithelial cells are capable of self-replication in multiple organs, including the adult murine prostate, and cell of prostate cancer origin studies have shown that ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2020, 8(1):18-27]

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Frequencies of accessory renal arteries in 129 Iranian patients.

Hadi Maleki, Reza Shahriar, Reza Kazemi, Farinaz Khodadadi,

INTRODUCTION:Anatomical variation of accessory renal artery has a great clinical importance especially in surgical operations. This issue might bring different complications during surgeries. The prevalence of these variations have been reported differently among populations. Here in this paper, we aimed to have a study on frequencies of anatomical variation of ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2020, 8(1):38-42]

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Serum levels of total and urine level of PCA3 in patients with benign prostatic hyperplasia and prostate cancer.

Mozhde Askari, Amid Yazdani, Mohammad Yazdani, Mohammad Hossein Izadpanahi,

BACKGROUND:Urine test with the PSA result will provide a good prognosis of the prostate cancer. Therefore, considering the importance of PCA3 in this study, we aimed to compare the serum total and urinary PCA3 levels in patients with benign hyperplasia and prostate cancer. METHODS:This cross-sectional study was performed on 90 ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2020, 8(1):43-47]

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Protein tyrosine kinase 6 signaling in prostate cancer.

Wanian M Alwanian, Angela L Tyner,

More than 25 years have passed since the discovery of protein tyrosine kinase 6 (PTK6), a non-receptor tyrosine kinase distantly related to SRC family kinases. Since then, a variety of data suggest that PTK6 promotes oncogenic signaling and tumorigenesis, generally dependent on its kinase activity. Increased PTK6 expression, activation at ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2020, 8(1):1-8]

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Transcriptional profiling of tumor associated macrophages in human renal cell carcinoma reveals significant heterogeneity and opportunity for immunomodulation.

Thomas R Nirschl, Margueritta El Asmar, Wesley W Ludwig, Sudipto Ganguly, Michael A Gorin, Michael H Johnson, Phillip M Pierorazio, Charles G Drake, Mohamad E Allaf, Jelani C Zarif,

Among the more notable immunotherapies are checkpoint inhibitors, which prevent suppressive signaling on T cells, thereby (re)activating them to kill tumor cells. Despite remarkable treatment responses to immune checkpoint blockade, with a subset of patients achieving complete responses, a large population have little-to-no response, dictating the necessity of further research ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2020, 8(1):48-58]

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Transforming growth factor beta 1 impairs benign prostatic luminal epithelial cell monolayer barrier function.

Feng Li, Laura E Pascal, Ke Wang, Yibin Zhou, Goundappa K Balasubramani, Katherine J O'Malley, Rajiv Dhir, Kai He, Donna Stolz, Donald B DeFranco, Naoki Yoshimura, Joel B Nelson, Tie Chong, Peng Guo, Dalin He, Zhou Wang,

Our recent studies identifying the presence of luminal secretory protein PSA in the stroma, decreased E-cadherin expression, and reduced number of tight junction kiss points in benign prostatic hyperplasia (BPH) tissues suggest that epithelial barrier permeability is increased in BPH. However, the cause of increased epithelial permeability in BPH is ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2020, 8(1):9-17]

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Trends in epidural anesthesia use at the time of radical cystectomy and its association with perioperative and survival outcomes: a population-based analysis.

Brady L Miller, E Jason Abel, Glenn Allen, Jessica R Schumacher, David Jarrard, Tracy Downs, Kyle A Richards,

Epidural anesthesia is used to improve pain control after major surgeries. Few data describe the impact of epidural use for bladder cancer patients treated with radical cystectomy (RC). Here, we evaluate epidural use on perioperative and long-term outcomes for patients treated with radical cystectomy for bladder cancer. Patients who received ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2020, 8(1):28-37]

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Comparison of the effect of antibiotic-lock and ethanol-lock methods on infection rate in children with hemodialysis catheter.

Alireza Merikhi, Alaleh Gheysari, Yahya Madihi, Mehryar Mehrkash, Enayatollah Poorebrahim, Leila Ghambarinia,

BACKGROUND:Hemodialysis catheter-related infection has a high incidence and complications. Antibiotic-lock or ethanol-lock can be used to prevent such infections. The aim of this study was to compare the effectiveness of antibiotic-lock and ethanol-lock methods in children undergoing hemodialysis and to evaluate the optimality of these methods. METHODS:In this cohort clinical ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2019, 7(6):384-390]

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Genetic alterations of interleukin-17 and related genes in human prostate cancer.

Ruoxin Lan, Kun Zhang, Tianhua Niu, Zongbing You,

Interleukin-17 (IL-17) has been shown to promote development of hormone-naïve prostate cancer (HNPC) and castration-resistant prostate cancer (CRPC) as well as lymph node metastasis in mouse models. Gene alterations of IL-17 family of cytokines and their downstream genes in human prostate cancer have not been investigated. We studied 7 datasets ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2019, 7(6):352-377]

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Feasibility, complication and long-term follow-up of the newly nelaton based urethral dilation method, retrospective study.

Jalil Hosseini, Morteza Fallah-Karkan, Amirhossein Rahavian, Farzin Soleimanzadeh, Hojjat Salimi, Keyvan Ghadimi, Maryam Fahim,

Introduction: Current methods for Urethral dilatation include filiforms and followers, metal sounds, balloon dilators, catheters of increasing size, introduction of a Council catheter over a guidewire, and coaxial dilators of increasing size. These methods however are effective but expensive and use of them is limited in many third world countries. ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2019, 7(6):378-383]

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Evaluation of several botulinum toxins-A delivering systems into the bladder in interstitial cystitis/painful bladder syndrome (IC/PBS).

Farbod Torkamand, Seyed Javad Mirjavadi, Fatemeh Khatami, Fateme Guitynavard, Seyed Mohammad Kazem Aghamir,

Botulinum toxins were primary suggested for the neurogenic lower urinary tract dysfunction (LUTD) treatment about thirty years ago. The application of BTX-A in LUTD have just developed and the approval of BTX-A injection confirmed in for patients with both overactive bladders (OAB) and neurogenic detrusor overactivity (NDO). Actually the BTX-A ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2019, 7(5):346-351]

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Renal cell carcinoma with leiomyomatous stroma: a review of an emerging entity distinct from clear cell conventional renal cell carcinoma.

Yunshin A Yeh, Michael Constantinescu, Catherine Chaudoir, Anthony Tanner, Faye Serkin, Xiuping Yu, Tajammul Fazili, Aubrey A Lurie,

Clear cell renal cell carcinomas accounts for 65 to 75% of all malignant renal tumors. The International Society of Urological Pathology 2012 Vancouver Classification of renal neoplasia and the World Health Organization 2016 Classification of renal tumors have included renal cell carcinoma with leiomyomatous stroma in a category of emerging/provisional ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2019, 7(5):321-326]

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Bioinformatics analyses of publicly available NEPCa datasets.

Siyuan Cheng, Xiuping Yu,

Gene expression profiles are valuable resources for the identification of key players that driver disease progression. However, neuroendocrine prostate cancer (NEPCa) specimens are rare, limiting research on this aggressive disease. In this study, we generated a 12-gene signature of NEPCa and used this signature to differentiate NEPCa from prostate adenocarcinoma ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2019, 7(5):327-340]

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Prostatic adenocarcinoma with novel NTRK3 gene fusion: a case report.

Yunshin A Yeh, Shu Yang, Michael Constantinescu, Catherine Chaudoir, Anthony Tanner, Mishala Henry, Sheila Anderson, Juan-Sebastian Saldivar, Faye Serkin, Tajammul Fazili, Aubrey A Lurie, Xiuping Yu,

TMPRSS2-ERG gene fusion occurs in approximately 50% of prostatic adenocarcinoma and their expression is associated with aggressive phenotype, higher tumor stage, and tumor metastasis. A case of prostatic adenocarcinoma with IRF2BP2-NTRK1 translocation was previously reported. We report a prostatic adenocarcinoma with novel NTRK3 gene fusion that occurs in a 71-year-old ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2019, 7(5):341-345]

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Humanized mice for immune checkpoint blockade in human solid tumors.

Henry Yip, Carl Haupt, Grace Maresh, Xin Zhang, Li Li,

Immunotherapy, specifically research involving immune checkpoint blockers (ICBs), has become a popular trend in anticancer research over the last three years. Due to the difficulties and often poor translation of results from in-vitro models, in-vivo models have become more relevant than ever. With the discovery of NOD, Prkdcscid , and ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2019, 7(5):313-320]

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