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Journal Am J Alzheimers Dis Other Demen

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Stress-Induced Neurodegeneration: The Potential for Coping as Neuroprotective Therapy.

Shelby A Kline, Michael S Mega,

Stress responses are essential for survival, but become detrimental to health and cognition with chronic activation. Chronic hypothalamic-pituitary-adrenal axis release of glucocorticoids induces hypothalamic-pituitary-adrenal axis dysfunction and neuronal loss, decreases learning and memory, and modifies glucocorticoid receptor/mineralocorticoid receptor expression. Elderly who report increased stress are nearly 3 times more likely ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520960873]

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An Agenda for Addressing Multimorbidity and Racial and Ethnic Disparities in Alzheimer's Disease and Related Dementia.

Ana R Quiñones, Jeffrey Kaye, Heather G Allore, Anda Botoseneanu, Stephen M Thielke,

Advancements in Alzheimer's disease and related dementias (ADRD) research on the U.S. population acknowledge the importance of the high burden of ADRD on segments of the population and yet-to-be characterized risks attributable to the burden of multiple chronic diseases (multimorbidity). These realizations suggest successful strategies in caring for people with ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520960874]

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The Effect of Hormone Replacement Therapy on Cognitive Function in Female Patients With Alzheimer's Disease: A Meta-Analysis.

ChengCheng Zhou, Qingguang Wu, Zongwei Wang, Qi Wang, Youya Liang, Sijun Liu,

Previous studies have indicated that estrogen may delay disease progression and minimize the cognitive decline in patients with Alzheimer's disease (AD). However, the evidence for an estrogen deficiency in women with dementia and cognitive dysfunction is inconsistent. In the present review, a fixed effect meta-analysis revealed that the hormone replacement ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520938585]

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Longitudinal Sensitivity of Alzheimer's Disease Severity Staging.

Julia S Benoit, Wenyaw Chan, Linda Piller, Rachelle Doody,

Understanding Alzheimer's disease (AD) dynamics is essential in diagnosis and measuring progression for clinical decision-making; however, clinical instruments are imperfect at classifying true disease stages. This research evaluates sensitivity and determinants of AD stage changes longitudinally using current classifications of "mild," "moderate," and "severe" AD, using Mini-Mental State Examination (MMSE), ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520918719]

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Neuroprotective Properties and Therapeutic Potential of Bone Marrow-Derived Microglia in Alzheimer's Disease.

Chang Li, Yu-Hua Chen, Ke Zhang,

Alzheimer's disease (AD) is the most common form of dementia, which is characterized by a progressive cognitive decline and senile plaques formed by amyloid β (Aβ). Microglia are the immune cells of the central nervous system (CNS). Studies have proposed 2 types of microglia, namely, the resident microglia and bone ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520927169]

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A Metabolic Imaging Study of Lexical and Phonological Naming Errors in Alzheimer Disease.

Valeria Isella, Cristina Rosazza, Maria Gazzotti, Jessica Sala, Sabrina Morzenti, Cinzia Crivellaro, Ildebrando Marco Appollonio, Carlo Ferrarese, Claudio Luzzatti,

Patients with Alzheimer disease (AD) produce a variety of errors on confrontation naming that indicate multiple loci of impairment along the naming process in this disease. We correlated brain hypometabolism, measured with 18fluoro-deoxy-glucose positron emission tomography, with semantic and formal errors, as well as nonwords deriving from phonological errors produced ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520922390]

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Insulin Resistance Is Independently Associated With Enlarged Perivascular Space in the Basal Ganglia in Nondiabetic Healthy Elderly Population.

Danhong Wu, Xiaoli Yang, Ping Zhong, Xiaofei Ye, Chen Li, Xueyuan Liu,

OBJECTIVES:To investigate the association between insulin resistance (IR) and enlarged perivascular space (EPVS) in the basal gangliain nondiabetic healthy elderly population. METHODS:A total of 235 nondiabetic healthy elderly population were recruited. A 3-level scale was used to evaluate the burden of EPVSs. The homeostasis model assessment-estimated insulin resistance index (HOMA-IR) ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520912126]

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Effects of Cystatin C on Cognitive Impairment in Older Chinese Adults.

Zhizhen Cui, Guizhen Cao, Youyi Wang, Qinghua Ma, Congju Wang, Yong Xu, Hongpeng Sun, Yana Ma,

OBJECTIVE:To find a suitable dividing value to classify cystatin C and evaluate the association between cognition and levels of cystatin C. METHODS:Using data from the China Health and Retirement Longitudinal Study, We conducted a longitudinal analysis of a prospective cohort of 6,869 middle-aged and older Chinese without cognitive impairment at ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520965101]

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Caregivers' Dementia Knowledge and Care Approach in Residential Aged Care Facilities in China.

Yunyun Dai, Jia Zhao, Shenmei Li, Chaochao Zhao, Yan Gao, Claire Elizabeth Johnson,

OBJECTIVE:To investigate the dementia knowledge and care approach used by caregivers in residential aged care facilities (RACFs) in China. METHOD:A cross-sectional survey of 785 caregivers from a random sample of 34 RACFs in China. Caregivers' knowledge and care approach were assessed using the Chinese version of the Dementia Knowledge Assessment ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520937096]

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Low Hippocampal Dentate Gyrus Volume Associated With Hypertension-Related Cognitive Impairment.

Huagang Li, Dong Sun, Dongwei Lu, Junjian Zhang, Junjie Zeng,

Hypertension increases the risk of cognitive impairment independent of detectable stroke or cerebral lesions. However, the principal pathophysiological basis of this increase has not been fully elucidated. The present study investigates the relationships among blood pressure, hippocampal subfields volume, and cognitive function in a relatively young non-stroke population. A total ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520949782]

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Observed Physical Function Is Associated With Better Cognition Among Elderly Adults: The Adventist Health Study-2.

Nicole M Gatto, Jennifer Garcia-Cano, Crissy Irani, Tiantian Liu, Cameron Arakaki, Gary Fraser, Charles Wang, Grace J Lee,

Lifestyle factors may individually protect against the development of mild cognitive impairment. We investigate the relationships between both self-reported physical activity and measured physical function with cognition in a population of elderly adults, more than half of whom follow vegetarian dietary patterns. Otherwise healthy adults (n = 127, mean age ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520960868]

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The Dual GLP-1/GIP Receptor Agonist DA4-JC Shows Superior Protective Properties Compared to the GLP-1 Analogue Liraglutide in the APP/PS1 Mouse Model of Alzheimer's Disease.

Mark Maskery, Elizabeth Mary Goulding, Simon Gengler, Josefine Ulrikke Melchiorsen, Mette Marie Rosenkilde, Christian Hölscher,

Alzheimer's disease (AD) is a neurodegenerative disorder for which there is no cure. Here, we test a dual GLP-1/GIP receptor agonist (DA4-JC) that has a cell penetrating sequence added to enhance blood-brain barrier penetration. We show in a receptor activity study that DA4-JC has balanced activity on both GLP-1 and ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520953041]

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New-Onset Alzheimer's Disease and Normal Subjects 100% Separated Statistically by P300 and ICA.

Barrie William Jervis, Cristin Bigan, Mircea Besleaga,

Previously, we described how patients with new-onset Alzheimer's disease were differentiated from healthy, normal subjects to 100% accuracy, based on the amplitudes of the nonrhythmic back-projected independent components of the P300 peak at the electroencephalogram electrodes and their latency in the response to an oddball, auditory evoked potential paradigm. A ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520935675]

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"What" and "How": A New Perspective for Understanding Unawareness in Alzheimer's Disease Through a Combination of Two Perspectives.

Amandine Mayelle, Mohamad El Haj, Pascal Antoine,

OBJECTIVES:Assessments of unawareness in Alzheimer's disease mainly focus on the objects (the "what") of unawareness. A recent person-centered approach proposes to also assess the processes (the "how"). The present study combines 2 approaches to understand this heterogeneity in assessments of unawareness. METHOD:We recruited 46 participants from 8 nursing homes. They ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520925333]

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Loneliness and Burden Perceived by Family Caregivers of Patients With Alzheimer Disease.

Verena Bramboeck, Korbinian Moeller, Josef Marksteiner, Liane Kaufmann,

BACKGROUND:The present study aimed at investigating loneliness and burden experienced by family members caring for relatives diagnosed with Alzheimer disease. METHODS:Participants were 40 caregivers of inpatients with Alzheimer disease. Correlation and multiple regression analyses were conducted to investigate whether caregivers' loneliness (uni- and multidimensional) and burden are associated with and ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520917788]

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BESI: Behavioral and Environmental Sensing and Intervention for Dementia Caregiver Empowerment-Phases 1 and 2.

Azziza Bankole, Martha S Anderson, Nutta Homdee, Ridwan Alam, Ashley Lofton, Nykesha Fyffe, Hilda Goins, Temple Newbold, Tonya Smith-Jackson, John Lach,

BACKGROUND AND OBJECTIVES:Caregiver burden associated with dementia-related agitation is one of the commonest reasons a community-dwelling person with dementia (PWD) transitions to a care facility. Behavioral and Environmental Sensing and Intervention for Dementia Caregiver Empowerment (BESI) is a system of body-worn and in-home sensors developed to provide continuous, noninvasive agitation ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520906686]

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Reduction of Amyloid in the Brain and Retina After Treatment With IVIG for Mild Cognitive Impairment.

Shawn Kile, William Au, Carol Parise, Jaideep Sohi, Tracy Yarbrough, Alan Czeszynski, Ken Johnson, Dan Redline, Tammy Donnel, Andrea Hankins, Kimberley Rose,

OBJECTIVE:To assess whether intravenous immunoglobulin (IVIG) in subjects with mild cognitive impairment (MCI) results in a reduction in amyloid in the central nervous system (CNS). METHODS:Five subjects with MCI underwent baseline Florbetapir positron emission tomography and retinal autofluorescent imaging. All were administered IVIG (Octagam 10%) at 0.4 g/kg every 14 ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317519899800]

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Aphasia in Alzheimer's Disease and Other Dementias (ADOD): Evidence From Chinese.

Brendan Stuart Hackett Weekes,

Speech and language impairments (aphasia) are typical of patients with Alzheimer's Disease and other dementias (ADOD) and in some pathologies are diagnostic e.g. Primary Progressive Aphasia (PPA). One question concerns the reliability and validity of symptomatology across typologically different languages. A review of aphasia in ADOD across languages suggests a ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520949708]

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The Pupil Diameter as a Possible Indicator of Neurodegenerative Diseases and Response to Acetylcholinesterase Inhibitors Therapy: In-Depth Measurements Following Topical Administration of Tropicamide and Pilocarpine.

Raffaele Nuzzi, Alessandro Bojino, Maria Sole Polito, Chiara Luppi, Federico Tridico, Massimiliano Massaia,

BACKGROUND:The aim of this study is to assess whether pupillary modifications following ocular anticholinergic and cholinergic drugs can identify subjects with neurodegenerative diseases from early stages. METHODS:51 subjects were divided into 3 groups, according to different neurodegenerative diseases, and compared with a control group of 10 patients. Pupil diameter has ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520951693]

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Unwinding Complexities of Diabetic Alzheimer by Potent Novel Molecules.

Sumeet Gupta, Anroop Nair, Vikas Jhawat, Nazia Mustaq, Abhishek Sharma, Meenakshi Dhanawat, Shah Alam Khan,

Diabetes mellitus is one of the aggressive disorders in global society. No pharmacotherapy is available for permanent diabetes cure, although management is possible with drugs and physical activities. One of the recent complications noticed in type 2 diabetes mellitus includes diabetes-induced Alzheimer. It has been proposed that the possible diabetes-induced ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520937542]

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Dementia and COVID-19: The Ones Not to Be Forgotten.

Duarte Barros, Flávia Borges-Machado, Óscar Ribeiro, Joana Carvalho,

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520947505]

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An Automated Approach to Examining Pausing in the Speech of People With Dementia.

Rachel A Sluis, Daniel Angus, Janet Wiles, Andrew Back, Tingting Amy Gibson, Jacki Liddle, Peter Worthy, David Copland, Anthony J Angwin,

Dementia is a common neurodegenerative condition involving the deterioration of cognitive and communication skills. Pausing in the speech of people with dementia is a dysfluency that may be used to signal conversational trouble in social interaction. This study aimed to examine the speech-pausing profile within picture description samples from people ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520939773]

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Machine-Learning Algorithms Based on Screening Tests for Mild Cognitive Impairment.

Jin-Hyuck Park,

BACKGROUND:The mobile screening test system for mild cognitive impairment (mSTS-MCI) was developed and validated to address the low sensitivity and specificity of the Montreal Cognitive Assessment (MoCA) widely used clinically. OBJECTIVE:This study was to evaluate the efficacy machine learning algorithms based on the mSTS-MCI and Korean version of MoCA. METHOD:In ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520927163]

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Caregiver Psychological Distress: Longitudinal Relationships With Physical Activity and Diet.

Shane A Snyder, Peter P Vitaliano,

Given limited longitudinal research with caregivers (CGs, n = 122) of spouses with Alzheimer disease, and demographically matched noncaregivers (NCGs, n = 117), we compared these groups on psychological distress (anxiety, depression), burden, and health behaviors over 2 years. Analyses examined group differences in relationships of micronutrient recommended daily allowances ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317520904554]

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Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study.

Hong Wang, Xiangrong Shi, Hannah Schenck, James R Hall, Sarah E Ross, Geoffrey P Kline, Shande Chen, Robert T Mallet, Peijie Chen,

Although intermittent hypoxia training (IHT) has proven effective against various clinical disorders, its impact on mild cognitive impairment (MCI) is unknown. This pilot study examined IHT's safety and therapeutic efficacy in elderly patients with amnestic MCI (aMCI). Seven patients with aMCI (age 69 ± 3 years) alternately breathed 10% O2 ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2020, 35:1533317519896725]

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