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Journal Allergy

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Reply to: "Arginase inhibitors: An alternative in treatment of obese asthma?"

Herman Meurs, Johan Zaagsma, Harm Maarsingh, Marcel van Duin,

Allergy (Allergy)
[2020, 75(6):1527-1528]

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In This Issue: Graphical Abstracts.

Allergy (Allergy)
[2020, 75(6):1287-1290]

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Correspondence to "Bronchiolitis needs a revisit: Distinguishing between virus entities and their treatments".

Tuomas Jartti, Hermelijn H Smits, Klaus Bønnelykke, Ozlem Cavkaytar, Varpu Elenius, Jon R Konradsen, Heidi Makrinioti, Jakob Stokholm, Gunilla Hedlin, Nikolaos Papadopoulos, Marek Ruszczynski, Klaudia Ryczaj, Bianca Schaub, Jürgen Schwarze, Wojciech Feleszko, ,

Allergy (Allergy)
[2020, 75(6):1529-1530]

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Reply to correspondence: "Bronchiolitis needs a revisit: Distinguishing between virus entities and their treatments".

Sara Manti, Amelia Licari, Salvatore Leonardi, Gian Luigi Marseglia, Eugenio Baraldi,

Allergy (Allergy)
[2020, 75(6):1531-1532]

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Arginase inhibitors: An alternative in treatment of obese asthma?

Mara Morelo Rocha Felix, Fábio Chigres Kuschnir,

Allergy (Allergy)
[2020, 75(6):1525-1526]

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Integrin β6 microparticles in nasal lavage fluids; potential new biomarkers for basal cell activation in chronic rhinosinusitis.

Toru Takahashi, Atsushi Kato, Lydia A Suh, Roderick G Carter, Whitney W Stevens, Caroline P E Price, James E Norton, Ava R Weibman, Kathleen E Harris, Anju T Peters, Leslie C Grammer, Kevin Welch, Stephanie Shintani-Smith, David B Conley, Sergejs Berdnikovs, Bruce K Tan, Robert C Kern, Robert P Schleimer,

Allergy (Allergy)
[2020, :]

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Lanadelumab demonstrates rapid and sustained prevention of hereditary angioedema attacks.

Marc A Riedl, Marcus Maurer, Jonathan A Bernstein, Aleena Banerji, Hilary J Longhurst, H Henry Li, Peng Lu, James Hao, Salomé Juethner, William R Lumry, ,

BACKGROUND:Lanadelumab demonstrated efficacy in preventing HAE attacks in the phase 3 HELP Study. OBJECTIVE:To assess time to onset of effect and long-term efficacy of lanadelumab, based on exploratory findings from the HELP Study. METHODS:Eligible patients with HAE type I/II received lanadelumab 150 mg every 4 weeks (q4wks), 300 mg q4wks, ... Read more >>

Allergy (Allergy)
[2020, :]

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Acute systemic reactions to sublingual immunotherapy for house dust mite.

N S Janssens, L van Ouwerkerk, R Gerth van Wijk, A F Karim,

Allergy (Allergy)
[2020, :]

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Validation of the MASK-air App for assessment of allergic rhinitis.

Joaquín Sastre, Alfonso Del Cuvillo, Carlos Colás, Ana M Navarro, Jean Bousquet, Antonio Valero, Joaquim Mullol,

Allergy (Allergy)
[2020, :]

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Epithelial cell dysfunction, a major driver of asthma development.

Irene H Heijink, Virinchi Kuchibhotla, Mirjam P Roffel, Tania Maes, Darryl A Knight, Ian Sayers, Martijn C Nawijn,

Airway epithelial barrier dysfunction is frequently observed in asthma and may have important implications. The physical barrier function of the airway epithelium is tightly interwoven with its immunomodulatory actions, while abnormal epithelial repair responses may contribute to remodelling of the airway wall. We propose that abnormalities in the airway epithelial ... Read more >>

Allergy (Allergy)
[2020, :]

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Validation of the ARIA items to assess allergic rhinitis control (ARIA-C).

Antonio Valero, Alfonso Del Cuvillo, Ana M Navarro, Carlos Colás, Joaquín Sastre, Joaquim Mullol,

Allergy (Allergy)
[2020, :]

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Low prevalence of bronchial asthma and chronic obstructive lung disease among intensive care unit patients with COVID-19.

Sergey Avdeev, Sergey Moiseev, Michail Brovko, Andrey Yavorovskiy, Karina Umbetova, Larisa Akulkina, Natalya Tsareva, Zamira Merzhoeva, Viliya Gainitdinova, Victor Fomin,

Allergy (Allergy)
[2020, :]

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IgMand IgA in addition to IgG autoantibodiesagainst FcεRIα are frequent and associated with disease markers of chronic spontaneous urticarial.

Sabine Altrichter, Vasiliki Zampeli, André Ellrich, Ke Zhang, Martin K Church, Marcus Maurer,

BACKGROUND:IgG-autoantibodiesagainst the high affinity IgE-receptor,FcεRIα, contribute the pathogenesis of autoimmune chronic spontaneous urticaria (CSU). However, it is not known if such patients also exhibit IgM or IgA autoantibodies against FcεRIα. OBJECTIVES:To develop an ELISAto assess serum levels of IgG, IgM andIgA autoantibodies against FcεRIα, and to investigateif their presence is ... Read more >>

Allergy (Allergy)
[2020, :]

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ADHD in school-age children is related to infant exposure to systemic H1-antihistamines.

Saskia Fuhrmann, Falko Tesch, Marcel Romanos, Susanne Abraham, Jochen Schmitt,

Allergy (Allergy)
[2020, :]

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APPEAL-1: A pan-European survey of patient/caregiver perceptions of peanut allergy management.

Katharina Blumchen, Audrey DunnGalvin, Frans Timmermans, Lynne Regent, Sabine Schnadt, Marcia Podestà, Angel Sánchez, Pascale Couratier, Mary Feeney, Betina Hjorth, Ram Patel, Tessa Lush, Robert Ryan, Andrea Vereda, Helen R Fisher, Montserrat Fernández-Rivas,

BACKGROUND:Peanut allergy (PA) is associated with marked quality-of-life (QoL) impairment. However, data are lacking on the experience and impact of living with PA from the perspectives of persons with PA (PwPA) and their caregivers. Allergy to Peanuts imPacting Emotions And Life study 1 (APPEAL-1) was a pan-European survey investigating these ... Read more >>

Allergy (Allergy)
[2020, :]

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Effect of structural stability on endolysosomal degradation and T-cell reactivity of major shrimp allergen tropomyosin.

Sandip D Kamath, Sandra Scheiblhofer, Christopher M Johnson, Yoan Machado, Thomas McLean, Aya C Taki, Paul A Ramsland, Swati Iyer, Isabella Joubert, Heidi Hofer, Michael Wallner, Josef Thalhamer, Jennifer Rolland, Robyn O'Hehir, Peter Briza, Fatima Ferreira, Richard Weiss, Andreas L Lopata,

BACKGROUND:Tropomyosins are highly conserved proteins, an attribute that forms the molecular basis for their IgE antibody cross-reactivity. Despite sequence similarities, their allergenicity varies greatly between ingested and inhaled invertebrate sources. In this study, we investigated the relationship between the structural stability of different tropomyosins, their endolysosomal degradation patterns and T-cell ... Read more >>

Allergy (Allergy)
[2020, :]

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Mast cells and complement system: Ancient interactions between components of innate immunity.

Daniel Elieh Ali Komi, Farzaneh Shafaghat, Petri T Kovanen, Seppo Meri,

The emergence and evolution of the complement system and mast cells (MCs) can be traced back to sea urchins and the ascidian Styela plicata, respectively. Acting as a cascade of enzymatic reactions, complement is activated through the classical (CP), the alternative (AP) and the lectin pathway (LP) based on the ... Read more >>

Allergy (Allergy)
[2020, :]

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COVID-19Clinical trials: quality matters more than quantity.

Sergio Bonini, Giuseppe Maltese,

Despite the ferment aroused in the scientific community by the COVID-19 outbreak and the over 11,000 papers listed in PubMed, published evidence on safe and effective drugs has not progressed yet at the same speed of the pandemic. However, clinical research is rapidly progressing, as shown by the hundreds of ... Read more >>

Allergy (Allergy)
[2020, :]

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iTRAQ-based proteomic analysis reveals potential serum biomarkers of allergic and non-allergic asthma.

Juan José Nieto-Fontarigo, Francisco Javier González-Barcala, Luis Juan Andrade-Bulos, María Esther San-José, María Jesús Cruz, Luis Valdés-Cuadrado, Rosa María Crujeiras, Pilar Arias, Francisco Javier Salgado,

BACKGROUND:Asthma is heterogeneous disease with different phenotypes, endotypes, and severities. Definition of these subgroups requires the identification of biomarkers in biological samples, and serum proteomics is a useful and minimally invasive method for this purpose. Therefore, the aim of this study was to detect serum proteins whose abundance is distinctively ... Read more >>

Allergy (Allergy)
[2020, :]

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Real-life assessment of chronic rhinosinusitis patients using mobile technology: the mySinusitisCoach project by EUFOREA.

Sven F Seys, Shana De Bont, Wytske J Fokkens, Claus Bachert, Isam Alobid, Manuel Bernal-Sprekelsen, Leif Bjermer, Ina Callebaut, Lars-Olaf Cardell, Sean Carrie, Paolo Castelnuovo, Russell Cathcart, Jannis Constantinidis, Leen Cools, Marjolein Cornet, Gregory Clement, Tony Cox, Lieve Delsupehe, Jaime Correia-de-Sousa, Lauren Deneyer, Geert De Vos, Zuzana Diamant, Maria Doulaptsi, Simon Gane, Philippe Gevaert, Claire Hopkins, Valérie Hox, Thomas Hummel, Werner Hosemann, Raf Jacobs, Mark Jorissen, Anette Kjeldsen, Basile N Landis, Winde Lemmens, Andreas Leunig, Valerie Lund, Gert Mariën, Joaquim Mullol, Metin Onerci, Susanna Palkonen, Isabel Proano, Emmanuel Prokopakis, Dermot Ryan, Herbert Riechelmann, Pernilla Sahlstrand-Johnson, Sanna Salmi-Toppila, Christine Segboer, Kato Speleman, Andreas Steinsvik, Pavol Surda, Peter-Valentin Tomazic, Olivier Vanderveken, Laura Van Gerven, Thibaut Van Zele, Jan Verfaillie, Benedicte Verhaeghe, Kathie Vierstraete, Stephan Vlaminck, Martin Wagenmann, Benoit Pugin, Peter W Hellings,

BACKGROUND:Chronic rhinosinusitis (CRS) is a chronic inflammatory disease associated with a substantial personal and socio-economic burden. Monitoring of patient-reported outcomes by mobile technology offers the possibility to better understand real-life burden of CRS. METHODS:This study reports on the cross-sectional evaluation of data of 626 users of mySinusitisCoach (mSC), a mobile ... Read more >>

Allergy (Allergy)
[2020, :]

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Allergy and asthma in children and adolescents during the COVID outbreak: what we know and how we could prevent allergy and asthma flares?

Amelia Licari, Martina Votto, Ilaria Brambilla, Riccardo Castagnoli, Emanuela Piccotti, Roberta Olcese, Maria Angela Tosca, Giorgio Ciprandi, Gian Luigi Marseglia,

Coronavirus disease 2019 (COVID-19) pandemic is affecting people at any age with a more severe course in patients with chronic diseases or comorbidities, males and elderly patients. The Center for Disease Control and Prevention (CDC) initially proposed that patients with chronic lung diseases, including moderate-severe asthma, and allergy may have ... Read more >>

Allergy (Allergy)
[2020, :]

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Metabolic shift favoring C18:0 ceramide accumulation in obese asthma.

Youngwoo Choi, Minji Kim, Su Jung Kim, Hyun-Ju Yoo, Seung-Hyun Kim, Hae-Sim Park,

BACKGROUND:Obesity associated with various complications has increased worldwide. Body weight gain alters lipid metabolites (especially sphingolipids) contributing to obesity-induced inflammation. However, the significance of the metabolites in the development of obese asthma is not yet clear. METHODS:The serum levels of sphingolipids were measured using liquid chromatography-tandem mass spectrometry in obese ... Read more >>

Allergy (Allergy)
[2020, :]

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Medical Algorithm: Diagnosis and Treatment of Hypereosinophilic Syndrome.

Barbara Schuster, Alexander Zink, Kilian Eyerich,

Hypereosinophilic syndrome (HES) is a group of rare disorders characterized by persistently elevated eosinophil count and eosinophil-mediated organ damage. The most frequent symptoms are cutaneous (e.g. urticaria, angioedema) and respiratory (e.g. asthma, sinusitis)1 . HES can further cause gastrointestinal, cardiovascular, neurologic, and hematologic involvement, with cardiac manifestations having the most ... Read more >>

Allergy (Allergy)
[2020, :]

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A highly sensitive bioluminescent method for measuring allergen-specific IgE in microliter samples.

Sophie Goyard, Bianca Balbino, Rebecca S Chinthrajah, Shu-Chen Lyu, Yves L Janin, Pierre Bruhns, Pascal Poncet, Stephen J Galli, Kari C Nadeau, Laurent L Reber, Thierry Rose,

Allergy (Allergy)
[2020, :]

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Managing ocular allergy in the time of COVID-19.

Andrea Leonardi, Jean L Fauquert, Serge Doan, Luis Delgado, Nicolas Andant, Ludger Klimek, Banu Bozkurt,

Allergy (Allergy)
[2020, :]

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