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Journal Aliment Pharmacol Ther

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Letter: neuromodulators in functional dyspepsia-the right indication in the right dose.

Chhagan Lal Birda, Anuraag Jena, Antriksh Kumar,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1217-1218]

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Corrigendum.

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1223]

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Letter: neuromodulators in functional dyspepsia-the right indication in the right dose. Authors' reply.

Isariyaphong Kotikula, Nithi Thinrungroj, Kanokwan Pinyopornpanish,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1219]

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Corrigendum.

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1224-1227]

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Corrigendum.

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1221-1222]

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Editorial: understanding IBS pathophysiology through "converging channels" of research.

Jill E Elwing, Gregory S Sayuk,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1213-1214]

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Corrigendum.

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1220]

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Editorial: understanding IBS pathophysiology through "converging channels" of research-authors' reply.

Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A Houghton,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1215-1216]

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Use of contraceptives and risk of inflammatory bowel disease: A nested case-control study.

Thomas Joshua Pasvol, Stuart Bloom, Anthony Walter Segal, Greta Rait, Laura Horsfall,

How contraceptive formulation, dose, duration of therapy and mode of delivery affects the risk of inflammatory bowel disease (IBD) is poorly described. To examine associations between types of hormonal contraception and development of IBD. This was a nested case-control study using IQVIA Medical Research Data. Women aged 15-49 years with a ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Review article: drug-induced small bowel injury.

Shadi Hamdeh, Dejan Micic, Stephen Hanauer,

Drug-induced gastrointestinal injury has been increasingly reported, but its exact incidence is not known. The small and large intestines represent the most affected sites of injury, accounting for 20%-40% of all gastrointestinal side effects. To provide an updated literature review detailing medications linked to the development of small bowel injury. ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Trends in statin utilisation in US adults with non-alcoholic fatty liver disease.

Jacqueline B Henson, Yuval A Patel, Andrew J Muir,

<h4>Background</h4>Non-alcoholic fatty liver disease (NAFLD) has high morbidity and mortality related to cardiovascular disease (CVD), but statins have been historically underutilised in these patients due to concern for hepatotoxicity.<h4>Aims</h4>To characterise trends in statin use among individuals with NAFLD and to determine predictors of statin utilisation in this population.<h4>Methods</h4>Individuals with NAFLD ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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The impact of IBD medications on risk of pneumonia and pneumonia-related hospitalisation: a nationwide cohort study of 56 410 IBD patients.

Nabeel Khan, Dhruvan Patel, Chinmay Trivedi, Tyler Pernes, Himanshu Kavani, Dawei Xie, Yu-Xiao Yang,

There are limited data on the incidence of pneumonia and pneumonia-related hospitalisation in the IBD population, and on any association of IBD medications with such outcomes. To evaluate the impact of IBD medications on the risk of pneumonia, pneumonia-related hospitalisations and death. We conducted a retrospective cohort study of IBD ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Limited evidence of moderation of the association between gastrointestinal symptoms and prospective healthcare utilisation by quality of life.

David T McNaughton, Anna Andreasson, Brjánn Ljótsson, Alissa P Beath, Julia M Hush, Gunnar Ljunggren, Peter T Schmidt, Nicholas J Talley, Lars Agréus, Michael P Jones,

An individual's drive to seek medical help remains a complex behavioural process, incorporating psychological, social and symptom-specific factors. Within irritable bowel syndrome (IBS), gastrointestinal symptoms only predict a small portion of the high healthcare-seeking experienced. To examine the moderating role of quality of life (QoL) domains on this relationship to ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Dose-response relationships of accelerometer-measured sedentary behaviour and physical activity with non-alcoholic fatty liver disease.

Kenji Tsunoda, Naruki Kitano, Yuko Kai, Takashi Jindo, Ken Uchida, Takashi Arao,

<h4>Background</h4>Although a few studies have confirmed the association of accelerometer-measured sedentary behaviour (SB) and physical activity (PA) with non-alcoholic fatty liver disease (NAFLD), PA intensity and co-dependent daily time-use of movement behaviours are yet to be studied.<h4>Aims</h4>To cross-sectionally examine the dose-response relationship between accelerometer-measured SB or PA and NAFLD using ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Clinicopathological characteristics of early onset colorectal cancer.

Fanny E R Vuik, Stella A V Nieuwenburg, Iris D Nagtegaal, Ernst J Kuipers, Manon C W Spaander,

<h4>Background</h4>The rising incidence of early onset colorectal cancer (EOCRC) might reflect a novel tumour entity.<h4>Aims</h4>To evaluate clinicopathological characteristics of sporadic EOCRC (in patients < 50 years old) and investigate changes over time METHODS: All patients with sporadic EOCRC between 1989 and 2016 were included and divided by age: 20-29 years (group I), ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Autoimmune diseases in microscopic colitis: A Danish nationwide case-control study.

Signe Wildt, Lars Kristian Munck, Matilde Winther-Jensen, Tine Jess, Nynne Nyboe Andersen,

<h4>Background</h4>The association between autoimmune diseases and microscopic colitis remains uncertain.<h4>Aims</h4>To describe the association between autoimmune diseases and microscopic colitis by using a matched case-control design based on nationwide registry data.<h4>Methods</h4>All adult Danish patients with a diagnosis of microscopic colitis from 2001 to 2018 were identified from nationwide registries. Odds of ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Prevalence, symptoms and risk factor profile of rumination syndrome and functional dyspepsia: a population-based study.

Mudar Zand Irani, Michael P Jones, Magnus Halland, Linda Herrick, Rok Seon Choung, Yuri A Saito Loftus, Marjorie M Walker, Joseph A Murray, Nicholas J Talley,

<h4>Background</h4>Rumination syndrome is a functional gastroduodenal disorder characterised by effortless regurgitation of recently ingested food. Emerging evidence reports duodenal eosinophilic inflammation in a subset, suggesting a shared pathophysiology with functional dyspepsia (FD).<h4>Aim</h4>To assess the clinical features of rumination syndrome and FD in a community-based study.<h4>Methods</h4>We mailed a survey assessing gastrointestinal ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Worldwide post-marketing safety surveillance experience with tofacitinib in ulcerative colitis.

David T Rubin, Irene Modesto, Séverine Vermeire, Silvio Danese, Siew C Ng, Kenneth K Kwok, Nana Koram, Thomas V Jones,

<h4>Background</h4>Tofacitinib is an oral Janus kinase inhibitor for the treatment of ulcerative colitis (UC). Post-marketing surveillance (PMS) is an important part of monitoring adverse events (AEs).<h4>Aims</h4>To report an analysis of PMS case safety reports for tofacitinib in patients with UC METHODS: Worldwide tofacitinib PMS reports received in the Pfizer safety ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Prediction model for hepatocellular carcinoma occurrence in patients with hepatitis C in the era of direct-acting anti-virals.

Yuki Tahata, Ryotaro Sakamori, Ryoko Yamada, Takahiro Kodama, Hayato Hikita, Hideki Hagiwara, Yasuharu Imai, Naoki Hiramatsu, Shinji Tamura, Keiji Yamamoto, Masahide Oshita, Kazuyoshi Ohkawa, Taizo Hijioka, Hiroyuki Fukui, Toshifumi Ito, Yoshinori Doi, Yukinori Yamada, Takayuki Yakushijin, Yuichi Yoshida, Tomohide Tatsumi, Tetsuo Takehara, ,

<h4>Background</h4>Several factors associated with hepatocellular carcinoma (HCC) occurrence after sustained virological response (SVR) in patients with hepatitis C have been reported. However, few validation studies have been performed in the era of direct-acting anti-virals (DAAs).<h4>Aims</h4>To develop a prediction model for HCC occurrence after DAA-mediated SVR and validate its usefulness.<h4>Methods</h4>We analysed ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Agreement between local and central reading of endoscopic disease activity in ulcerative colitis: results from the tofacitinib OCTAVE trials.

Brian G Feagan, Reena Khanna, William J Sandborn, Séverine Vermeire, Walter Reinisch, Chinyu Su, Leonardo Salese, Haiyun Fan, Jerome Paulissen, Deborah A Woodworth, Wojciech Niezychowski, Bruce E Sands,

<h4>Background</h4>Endoscopy is routine in trials of ulcerative colitis therapies.<h4>Aim</h4>To investigate agreement between central and local Mayo endoscopic subscore (MES) reads in the OCTAVE programme METHODS: Flexible sigmoidoscopy was performed in tofacitinib induction (OCTAVE Induction 1&2, NCT01465763 and NCT01458951), maintenance (OCTAVE Sustain, NCT01458574) and open-label, long-term extension (OCTAVE Open, NCT01470612) studies. ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Editorial: the risk of chronic diseases and congenital malformations during childhood and adolescence after in utero drug exposure to thiopurines.

Robert N Lopez, Andrew S Day,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(8):1088-1089]

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Letter: hepatocellular carcinoma risk in patients with non-selective beta blockers-authors' reply.

Karn Wijarnpreecha, Fang Li, Yifang Dang, C Burcin Taner, Liu Yang, Cui Tao,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(8):1095-1096]

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Letter: universal screening for hepatitis C in pregnant women, children and adolescents.

Isabel Garrido, Guilherme Macedo,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(7):977-978]

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Letter: universal screening for hepatitis C in pregnancy, children and adolescents-authors' reply.

Giuseppe Indolfi, Ersilia Lucenteforte,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(7):979-980]

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Editorial: coeliac disease-it's a family affair. Authors' reply.

Saana Paavola, Katri Kaukinen, Kalle Kurppa,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(7):969]

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