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Journal Ageing Res Rev

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Hippuric acid: Could became a barometer for frailty and geriatric syndromes?

Giulia De Simone, Claudia Balducci, Gianluigi Forloni, Roberta Pastorelli, Laura Brunelli,

Aging is a natural biological event that has some downsides such as increased frailty, decline in cognitive and physical functions leading to chronical diseases, and lower quality of life. There is therefore a pressing need of reliable biomarkers to identify populations at risk of developing age-associated syndromes in order to ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, :101466]

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Widowhood and cognitive decline in adults aged 50 and over: A systematic review and meta-analysis.

Timothy Singham, Georgia Bell, Rob Saunders, Joshua Stott,

While widowhood is known to be associated with poorer physical and mental health outcomes, studies examining the association of widowhood with cognition have yielded mixed results. This review aimed to elucidate the link between widowhood and cognitive decline. A systematic search of Medline, Embase, PsycInfo, CINAHL and Scopus (until December ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101461]

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Autophagy and the Hallmarks of Aging.

Susmita Kaushik, Inmaculada Tasset, Esperanza Arias, Olatz Pampliega, Esther Wong, Marta Martinez-Vicente, Ana Maria Cuervo,

Autophagy, an essential cellular process that mediates degradation of proteins and organelles in lysosomes, has been tightly linked to cellular quality control for its role as part of the proteostasis network. The current interest in identifying the cellular and molecular determinants of aging, has highlighted the important contribution of malfunctioning ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, :101468]

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Dietary intakes of monounsaturated fatty acids and risk of mortality from all causes, cardiovascular disease and cancer: A systematic review and dose-response meta-analysis of prospective cohort studies.

Keyhan Lotfi, Asma Salari-Moghaddam, Mahsa Yousefinia, Bagher Larijani, Ahmad Esmaillzadeh,

<h4>Background</h4>Findings on the link between dietary intakes of monounsaturated fatty acids (MUFA) and risk of mortality are conflicting. This study aimed to summarize existing literature regarding the association between MUFA intake and risk of mortality from all causes, cardiovascular diseases (CVDs), and cancer.<h4>Methods</h4>PubMed, Scopus, and ISI Web of Science was ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, :101467]

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Principles of brain aging: Status and challenges of modeling human molecular changes in mice.

Verena Kluever, Eugenio F Fornasiero,

Due to the extension of human life expectancy, the prevalence of cognitive impairment is rising in the older portion of society. Developing new strategies to delay or attenuate cognitive decline is vital. For this purpose, it is imperative to understand the cellular and molecular events at the basis of brain ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, :101465]

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Female specific risk factors for the development of Alzheimer's disease neuropathology and cognitive impairment: Call for a precision medicine approach.

Chinedu Udeh-Momoh, Tam Watermeyer, ,

Alzheimer's disease (AD) includes a long asymptomatic stage, which precedes the formal diagnosis of dementia. AD biomarker models provide a framework for precision medicine approaches during this stage. However, such approaches have ignored the possible influence of sex on cognition and brain health, despite female sex noted as a major ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101459]

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Shared and distinct mechanisms of skeletal muscle atrophy: A narrative review.

Dylan Wilburn, Ahmed Ismaeel, Steven Machek, Emma Fletcher, Panagiotis Koutakis,

Maintenance of skeletal muscle mass and function is an incredibly nuanced balance of anabolism and catabolism that can become distorted within different pathological conditions. In this paper we intend to discuss the distinct intracellular signaling events that regulate muscle protein atrophy for a given clinical occurrence. Aside from the common ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101463]

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Autophagy in Alzheimer's Disease Pathogenesis: Therapeutic Potential and Future Perspectives.

Zhigang Zhang, Xifei Yang, You-Qiang Song, Jie Tu,

Alzheimer's disease (AD) is a complex neurodegenerative disease in the elderly and the most common cause of human dementia. AD is characterized by accumulation of abnormal protein aggregates including amyloid plaques (composed of beta-amyloid (Aβ) peptides) and neurofibrillary tangles (formed by hyper-phosphorylated tau protein). Synaptic plasticity, neuroinflammation, calcium signaling etc. ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, :101464]

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Bridging geriatric medicine, clinical pharmacology and ageing biology to understand and improve outcomes of medicines in old age and frailty.

Sarah N Hilmer,

Ageing Res Rev (Ageing research reviews)
[2021, 71:101457]

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Metabolic determinants of Alzheimer's disease: a focus on thermoregulation.

Marine Tournissac, Manon Leclerc, Josue Valentin-Escalera, Milène Vandal, Cristina R Bosoi, Emmanuel Planel, Frédéric Calon,

Alzheimer's disease (AD) is a complex age-related neurodegenerative disease, associated with central and peripheral metabolic anomalies, such as impaired glucose utilization and insulin resistance. These observations led to a considerable interest not only in lifestyle-related interventions, but also in repurposing insulin and other anti-diabetic drugs to prevent or treat dementia. ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, :101462]

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Fruit and vegetable intake and risk of frailty: A systematic review and dose response meta-analysis.

Seyed Mojtaba Ghoreishy, Farzaneh Asoudeh, Ahmad Jayedi, Hamed Mohammadi,

<h4>Purpose</h4>This systematic review and dose-response meta-analysis of observational studies was conducted to summarize available findings on the association between fruits and vegetables (FVs) consumption and risk of frailty.<h4>Methods</h4>Online databases including Medline, Scopus, and Embase were searched to detect related publications up to February 2021. Study selection and data extraction were ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101460]

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Underrepresentation of older adults in clinical trials on COVID-19 vaccines: A systematic review.

Nicola Veronese, Mirko Petrovic, Athanase Benetos, Michael Denkinger, Adalsteinn Gudmundsson, Wilma Knol, Christine Marking, George Soulis, Stefania Maggi, Antonio Cherubini, ,

During the COVID-19 pandemic older subjects have been disproportionately affected by the disease. Vaccination is a fundamental intervention to prevent the negative consequences of COVID-19, but it is not known if the needs and vulnerabilities of older people are adequately addressed by their inclusion in randomized clinical trials (RCTs) evaluating ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101455]

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A common signature of cellular senescence; does it exist?

Ewa Sikora, Anna Bielak-Zmijewska, Grazyna Mosieniak,

Cellular senescence is a stress response, which can be evoked in all type of somatic cells by different stimuli. Senescent cells accumulate in the body and participate in aging and aging-related diseases mainly by their secretory activity, commonly known as senescence-associated secretory phenotype-SASP. Senescence is typically described as cell cycle ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101458]

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How good is the evidence that cellular senescence causes skin ageing?

Evon Low, Ghazaleh Alimohammadiha, Lucy A Smith, Lydia F Costello, Stefan A Przyborski, Thomas von Zglinicki, Satomi Miwa,

Skin is the largest organ of the body with important protective functions, which become compromised with time due to both intrinsic and extrinsic ageing processes. Cellular senescence is the primary ageing process at cell level, associated with loss of proliferative capacity, mitochondrial dysfunction and significantly altered patterns of expression and ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101456]

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Abnormal amyloid beta metabolism in systemic abnormalities and Alzheimer's pathology: Insights and therapeutic approaches from periphery.

Rahat Ullah, Tae Ju Park, Xu Huang, Myeong Ok Kim,

Alzheimer's disease (AD) is an age-associated, multifactorial neurodegenerative disorder that is incurable. Despite recent success in treatments that partially improve symptomatic relief, they have failed in most clinical trials. Re-holding AD for accurate diagnosis and treatment is widely known as a challenging task. Lack of knowledge of basic molecular pathogenesis ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101451]

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Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

Aurelia Santoro, Elisa Bientinesi, Daniela Monti,

During aging the immune system (IS) undergoes remarkable changes that collectively are known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects both natural and acquired immunity and plays a critical role in most chronic diseases in older people. For a long time, immunosenescence has been considered detrimental ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101422]

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Diagnostic accuracy of blood biomarkers for Alzheimer's disease and amnestic mild cognitive impairment: A meta-analysis.

Ying-Ren Chen, Chih-Sung Liang, Hsin Chu, Joachim Voss, Xiao Linda Kang, Grant O'Connell, Hsiu-Ju Jen, Doresses Liu, Shu-Tai Shen Hsiao, Kuei-Ru Chou,

<h4>Objective</h4>To examine the diagnostic accuracy of blood-based biomarkers for detecting Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI).<h4>Methods</h4>Seven electronic databases were comprehensively searched for studies evaluating the diagnostic accuracy of blood-based biomarkers for detecting AD or aMCI up to July 31, 2020. The pooled sensitivity, specificity, and the diagnostic ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101446]

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Adverse health outcomes in vitamin D supplementation trials for depression: A systematic review.

Karen S van den Berg, Radboud M Marijnissen, Rob H S van den Brink, Richard C Oude Voshaar, Johanna M Hegeman,

<h4>Background</h4>Vitamin D deficiency is a universal risk factor for adverse health outcomes. Since depression is consistently associated with low vitamin D levels as well as several adverse health outcomes, vitamin D supplementation may be especially relevant for depressed persons. This review examines the potential benefits of vitamin D for (somatic) ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101442]

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Affective symptoms and risk of progression to mild cognitive impairment or dementia in subjective cognitive decline: A systematic review and meta-analysis.

Roopal Desai, Tim Whitfield, Glorianne Said, Amber John, Rob Saunders, Natalie L Marchant, Joshua Stott, Georgina Charlesworth,

<h4>Aims</h4>To systematically review the literature on outcomes for individuals with subjective cognitive decline (SCD) with concurrent affective symptoms. To conduct a meta-analysis to establish whether either higher depressive symptoms or higher levels of anxiety increased the risk of progression SCD to mild cognitive impairment (MCI) or dementia.<h4>Methods</h4>Five databases were searched ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101419]

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Risk factors for falls in older people with cognitive impairment living in the community: Systematic review and meta-analysis.

Thanwarat Chantanachai, Daina L Sturnieks, Stephen R Lord, Narelle Payne, Lyndell Webster, Morag E Taylor,

<h4>Purpose</h4>This systematic review aimed to identify risk factors for prospectively ascertained falls, focusing on those that are potentially modifiable (physical and neuropsychological factors), in older people with cognitive impairment living in the community.<h4>Results</h4>A comprehensive search of five databases identified 16 high quality (Newcastle-Ottawa Scale ≥8/9) relevant articles. Meta-analyses were undertaken ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101452]

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Cerebral blood flow in mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis.

Heng Zhang, Yan Wang, Diyang Lyu, Yan Li, Wenwen Li, Qi Wang, Yan Li, Qi Qin, Xuechu Wang, Min Gong, Haishan Jiao, Wenying Liu, Jianping Jia,

<h4>Background</h4>Reduced cerebral blood flow (CBF) contributes to the pathophysiology of Alzheimer's disease (AD). However, it is unclear whether there is a spatial-temporal-specific pattern of changed CBF in AD progression.<h4>Methods</h4>We systematically screened literature databases for cross-sectional and longitudinal studies reporting resting CBF or CBF velocity (CBFv) among patients with AD, mild ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101450]

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Effectiveness of caregiver non-pharmacological interventions for behavioural and psychological symptoms of dementia: An updated meta-analysis.

Xiangfei Meng, Jianping Su, Huanhuan Li, Dongfei Ma, Yingnan Zhao, Yijing Li, Xu Zhang, Zehui Li, Jiao Sun,

<h4>Background</h4>The behavioural and psychological symptoms of dementia (BPSD) have significant negative effects on the health of both patients with dementia and their caregivers. However, the reported effectiveness of non-pharmacological interventions targeting caregivers of patients with dementia for BPSD is inconsistent.<h4>Methods</h4>We systematically searched the databases PubMed, PsycINFO, CINAHL, Embase, Cochrane Library ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101448]

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The microglial lysosomal system in Alzheimer's disease: Guardian against proteinopathy.

Zoë P Van Acker, Anika Perdok, Marine Bretou, Wim Annaert,

Microglia, the brain-resident immune cells, play an essential role in the upkeep of brain homeostasis. They actively adapt into specific activation states based on cues from the microenvironment. One of these encompasses the activated response microglia (ARMs) phenotype. It arises along a healthy aging process and in a range of ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101444]

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CircadiOmic medicine and aging.

Siamak Tabibzadeh,

The earth displays daily, seasonal and annual environmental cycles that have led to evolutionarily adapted ultradian, circadian and infradian rhythmicities in the entire biosphere. All biological organisms must adapt to these cycles that synchronize the function of their circadiome. The objective of this review is to discuss the latest knowledge ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101424]

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Targeting impaired adult hippocampal neurogenesis in ageing by leveraging intrinsic mechanisms regulating Neural Stem Cell activity.

Sébastien Gillotin, Vishal Sahni, Tjaša Lepko, Maya A Hanspal, Jina E Swartz, Zoi Alexopoulou, Fiona H Marshall,

Deficits in adult neurogenesis may contribute to the aetiology of many neurodevelopmental, psychiatric and neurodegenerative diseases. Genetic ablation of neurogenesis provides proof of concept that adult neurogenesis is required to sustain complex and dynamic cognitive functions, such as learning and memory, mostly by providing a high degree of plasticity to ... Read more >>

Ageing Res Rev (Ageing research reviews)
[2021, 71:101447]

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