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Journal Adv. Biochem. Eng. Biotechnol.

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Organ-on-a-Chip.

Ilka Maschmeyer, Sofia Kakava,

Limitations of the current tools used in the drug development process, cell cultures, and animal models have highlighted the need for a new powerful tool that can emulate the human physiology in vitro. Advances in the field of microfluidics have made the realization of this tool closer than ever. Organ-on-a-chip ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, :]

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Impact of Protein Glycosylation on the Design of Viral Vaccines.

Kathleen Schön, Bernd Lepenies, Guillaume Goyette-Desjardins,

Glycans play crucial roles in various biological processes such as cell proliferation, cell-cell interactions, and immune responses. Since viruses co-opt cellular biosynthetic pathways, viral glycosylation mainly depends on the host cell glycosylation machinery. Consequently, several viruses exploit the cellular glycosylation pathway to their advantage. It was shown that viral glycosylation ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, :]

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Droplet Microfluidics for Microbial Biotechnology.

Sundar Hengoju, Miguel Tovar, DeDe Kwun Wai Man, Stefanie Buchheim, Miriam A Rosenbaum,

Droplet microfluidics has recently evolved as a prominent platform for high-throughput experimentation for various research fields including microbiology. Key features of droplet microfluidics, like compartmentalization, miniaturization, and parallelization, have enabled many possibilities for microbiology including cultivation of microorganisms at a single-cell level, study of microbial interactions in a community, detection ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, :]

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Digitalization and Bioprocessing: Promises and Challenges.

Thomas Scheper, Sascha Beutel, Nina McGuinness, Stefanie Heiden, Marco Oldiges, Frank Lammers, Kenneth F Reardon,

The production of pharmaceuticals, industrial chemicals, and food ingredients from biotechnological processes is a vast and rapidly growing industry. While advances in synthetic biology and metabolic engineering have made it possible to produce thousands of new molecules from cells, few of these molecules have reached the market. The traditional methods ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, :]

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Emerging Technologies and Materials for High-Resolution 3D Printing of Microfluidic Chips.

Frederik Kotz, Dorothea Helmer, Bastian E Rapp,

In recent years, 3D printing has had a huge impact on the field of biotechnology: from 3D-printed pharmaceuticals to tissue engineering and microfluidic chips. Microfluidic chips are of particular interest and importance for the field of biotechnology, since they allow for the analysis and screening of a wide range of ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, :]

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When Is an In Silico Representation a Digital Twin? A Biopharmaceutical Industry Approach to the Digital Twin Concept.

Rui M C Portela, Christos Varsakelis, Anne Richelle, Nikolaos Giannelos, Julia Pence, Sandrine Dessoy, Moritz von Stosch,

Digital twins (DTs) are expected to render process development and life-cycle management much more cost-effective and time-efficient. A DT definition, a brief retrospect on their history and expectations for their deployment in today's business environment, and a detailed financial assessment of their attractive economic benefits are provided in this chapter. ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, :]

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Digital Twins and Their Role in Model-Assisted Design of Experiments.

Kim B Kuchemüller, Ralf Pörtner, Johannes Möller,

Rising demands for biopharmaceuticals and the need to reduce manufacturing costs increase the pressure to develop productive and efficient bioprocesses. Among others, a major hurdle during process development and optimization studies is the huge experimental effort in conventional design of experiments (DoE) methods. As being an explorative approach, DoE requires ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, :]

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Digital Seed Train Twins and Statistical Methods.

Tanja Hernández Rodríguez, Björn Frahm,

Model-based concepts and simulation techniques in combination with digital tools emerge as a key to explore the full potential of biopharmaceutical production processes, which contain several challenging development and process steps. One of these steps is the time- and cost-intensive cell proliferation process (also called seed train) to increase cell ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, :]

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Analytics in Microfluidic Systems.

Martina Viefhues,

Microfluidic analysis proved to be very sufficient in supporting biotechnological studies. This is due to the wide range of new analysis methods that provide further insight into biotechnological questions but also to intrinsic advantages of the systems themselves. To name two of them, only very small sample amounts are needed, ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, :]

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Microfluidic Single-Cell Analytics.

Christian Dusny,

What is the impact of cellular heterogeneity on process performance? How do individual cells contribute to averaged process productivity? Single-cell analysis is a key technology for answering such key questions of biotechnology, beyond bulky measurements with populations. The analysis of cellular individuality, its origins, and the dependency of process performance ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, :]

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Emerging Biosensor Trends in Organ-on-a-Chip.

Mario Rothbauer, Peter Ertl,

Organ-on-a-chip technology is ideally suited to cultivate and analyze 2D/3D cell cultures, organoids, and other tissue analogues in vitro, because these microphysiological systems have been shown to generate architectures, structural organization, and functions that closely resemble their respective human tissues and organs. Although great efforts have been undertaken to demonstrate ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, :]

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Microbioreactors for Process Development and Cell-Based Screening Studies.

Lasse Jannis Frey, Rainer Krull,

Microbioreactors (MBRs) have emerged as potent cultivation devices enabling automated small-scale experiments in parallel while enhancing their cost efficiency. The widespread use of MBRs has contributed to recent advances in industrial and pharmaceutical biotechnology, and they have proved to be indispensable tools in the development of many modern bioprocesses. Being ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, :]

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Lab-on-a-Chip Devices for Point-of-Care Medical Diagnostics.

Sofia Arshavsky-Graham, Ester Segal,

The recent coronavirus (COVID-19) pandemic has underscored the need to move from traditional lab-centralized diagnostics to point-of-care (PoC) settings. Lab-on-a-chip (LoC) platforms facilitate the translation to PoC settings via the miniaturization, portability, integration, and automation of multiple assay functions onto a single chip. For this purpose, paper-based assays and microfluidic ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, :]

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Microfluidics for Environmental Applications.

Ting Wang, Cecilia Yu, Xing Xie,

Microfluidic and lab-on-a-chip systems have become increasingly important tools across many research fields in recent years. As a result of their small size and precise flow control, as well as their ability to enable in situ process visualization, microfluidic systems are increasingly finding applications in environmental science and engineering. Broadly ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, :]

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Correction to: Animal Cell Expression Systems.

M Butler, U Reichl,

On page 3, as per the author's request the current list of abbreviations is replaced with complete list of abbreviations. ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, :]

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The Sustainability and Life Cycle Assessments of Industrial Biotechnology: An Introduction.

Magnus Fröhling, Michael Hiete,

Industrial biotechnology (IB) uses biological and biochemical processes in industrial production and is often regarded as an emerging key technology revolutionizing the production of many products while protecting resources and the environment and fostering economic development. This contribution describes the background and sketches the content of the volume 'Sustainability and ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, 173:3-9]

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Sustainability and Life Cycle Assessment in Industrial Biotechnology: A Review of Current Approaches and Future Needs.

Magnus Fröhling, Michael Hiete,

The development and implementation of industrial biotechnology (IB) is associated with high expectations for reductions of environmental impacts and risks, particularly in terms of climate change and fossil resource depletion, positive socioeconomic effects, hopes for new competitive products and processes, and development in rural areas. However, not all products and ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, 173:143-203]

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Aptamer-Modified Nanoparticles in Medical Applications.

Alina Eilers, Sandra Witt, Johanna Walter,

Since aptamers have been selected against a broad range of target structures of medical interest and nanoparticles are available with diverse properties, aptamer-modified nanoparticles can be used in various diagnostic and therapeutic applications. While the aptamer is responsible for specificity and affinity of the conjugate, the nanoparticles' function varies from ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, 174:161-193]

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Industrial Challenges of Recombinant Proteins.

Scott R Rudge, Michael R Ladisch,

The use of recombinant DNA methods to produce large quantities of protein for therapeutic uses has revolutionized medicine. Industrial challenges for manufacture of biotherapeutic proteins are related to the characteristics of these proteins and the increasing quantities required to address needs of patients, worldwide. A brief overview of therapies in ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, 171:1-22]

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Insights on the Formulation of Recombinant Proteins.

Rita Ribeiro, Teresa Raquel Abreu, Ana Catarina Silva, João Gonçalves, João Nuno Moreira,

Recombinant proteins are large and complex molecules, whose therapeutic activity highly depends on their structure. Formulation of biopharmaceuticals aims at stabilizing protein conformation, promoting its efficacy, and preventing safety concerns, such as immunogenicity. Currently, the rational design of formulations is possible due to the availability of several techniques for molecule ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, 171:23-54]

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Addressing the Manufacturing Challenges of Cell-Based Therapies.

Miguel de Almeida Fuzeta, André Dargen de Matos Branco, Ana Fernandes-Platzgummer, Cláudia Lobato da Silva, Joaquim M S Cabral,

Exciting developments in the cell therapy field over the last decades have led to an increasing number of clinical trials and the first cell products receiving marketing authorization. In spite of substantial progress in the field, manufacturing of cell-based therapies presents multiple challenges that need to be addressed in order ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, 171:225-278]

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Aptamer-Based Affinity Chromatography for Protein Extraction and Purification.

G Perret, E Boschetti,

Aptamers are oligonucleotide molecules able to recognize very specifically proteins. Among the possible applications, aptamers have been used for affinity chromatography with effective results and advantages over most advanced protein separation technologies. This chapter first discusses the context of the affinity chromatography with aptamer ligands. With the adaptation of SELEX, ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, 174:93-139]

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Starch-Modifying Enzymes.

Suhaila Omar Hashim,

Starch is a carbohydrate polymer found abundantly on earth. It is synthesized in plants as a short-term storage compound for respiration in the leaves and for long-term storage in the tubers, seeds and roots of plants. A wide variety of enzymes modify or convert starch into various products. The classes ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, 172:221-244]

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Challenges and Perspectives in Nucleic Acid Enzyme Engineering.

Darko Balke, Robert Hieronymus, Sabine Müller,

Engineering of nucleic acids has been a goal in research for many years. Since the discovery of catalytic nucleic acids (ribozymes and DNAzymes), this field has attracted even more attention. One reason for the increased interest is that a large number of ribozymes have been engineered that catalyze a broad ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, 170:21-35]

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Strategies for Characterization of Enzymatic Nucleic Acids.

Fatemeh Javadi-Zarnaghi, Claudia Höbartner,

Practical application of enzymatic nucleic acids has received more attention in recent years. Understanding the mechanism of catalysis and availability of information on potentials and limitations of these enzymes expands their application scope. A general approach for characterization of functional macromolecules including enzymatic nucleic acids is to perturb a specific ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2020, 170:37-58]

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