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Constitutive AKT Activity Predisposes Lung Fibrosis by Regulating Macrophage, Myofibroblast and Fibrocyte Recruitment and Changes in Autophagy.

Duaa Dakhlallah, Yijie Wang, Tierra A Bobo, Emily Ellis, Xiaokui Mo, Melissa G Piper, Timothy D Eubank, Clay B Marsh,

The etiology and pathogenesis of pulmonary fibrosis is poorly understood. We and others reported that M-CSF/CSF-1, M-CSF-R and downstream AKT activation plays an important role in lung fibrosis in mice models and in IPF patients. To understand potential molecular pathways used by M-CSF-R activation to direct lung fibrosis, we used ... Read more >>

Adv Biosci Biotechnol (Advances in bioscience and biotechnology (Print))
[2019, 10(10):346-373]

Cited: 3 times

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TALEN-Mediated FLAG-Tagging of Endogenous Histone Methyltransferase DOT1L.

Cheng An, Guangjing Zhu, Suzanne N Martos, Xue Feng, Haimou Zhang, Yankai Jia, Zhibin Wang,

Histone modification including H3 lysine 79 methylation (H3K79me) plays a key role during gene transcription and DNA damage repair. DOT1L, the sole methyltransferase for three states of H3K79me, is implicated in leukemia, co-lorectal cancer, and dilated cardiomyopathy. However, understanding of DOT1L and H3K79me in these pathways and disease pathogenesis has ... Read more >>

Adv Biosci Biotechnol (Advances in bioscience and biotechnology (Print))
[2017, 8(9):311-323]

Cited: 0 times

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The Role of DNA Mismatch Repair and Recombination in the Processing of DNA Alkylating Damage in Living Yeast Cells.

Hernan Flores-Rozas, Lahcen Jaafar, Ling Xia,

It is proposed that mismatch repair (MMR) mediates the cytotoxic effects of DNA damaging agents by exerting a futile repair pathway which leads to double strand breaks (DSBs). Previous reports indicate that the sensitivity of cells defective in homologous recombination (HR) to DNA alkylation is reduced by defects in MMR ... Read more >>

Adv Biosci Biotechnol (Advances in bioscience and biotechnology (Print))
[2015, 6(6):408-418]

Cited: 2 times

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Single Nucleotide Polymorphisms: A Window into the Informatics of the Living Genome.

Georgia M Dunston, Tshela E Mason, William Hercules, James Lindesay,

Nested in the environment of the nucleus of the cell, the 23 sets of chromosomes that comprise the human genome function as one integrated whole system, orchestrating the expression of thousands of genes underlying the biological characteristics of the cell, individual and the species. The extraction of meaningful information from ... Read more >>

Adv Biosci Biotechnol (Advances in bioscience and biotechnology (Print))
[2014, 5(7):623-626]

Cited: 1 time

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Evaluation of HemogloBind™ treatment for preparation of samples for cholinesterase analysis.

Kevin G McGarry, Ryan A Bartlett, Nicholas J Machesky, Thomas H Snider, Robert A Moyer, David T Yeung, Matthew K Brittain,

Acetylcholine is an essential neurotransmitter found throughout the nervous system. Its action on postsynaptic receptors is regulated through hydrolysis by various carboxylesterases, especially cholinesterases (ChEs). The acute toxicity of organophosphate (OP) compounds is directly linked to their action as inhibitors of ChE. One widely used assay for evaluating ChE activity ... Read more >>

Adv Biosci Biotechnol (Advances in bioscience and biotechnology (Print))
[2013, 4(12):1020-1023]

Cited: 5 times

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Aging promotes pro-fibrotic matrix production and increases fibrocyte recruitment during acute lung injury.

Viranuj Sueblinvong, Wendy A Neveu, David C Neujahr, Stephen T Mills, Mauricio Rojas, Jesse Roman, David M Guidot,

Fibrotic lung diseases increase with age. Previously we determined that senescence increases tissue expression of fibronectin EDA (Fn-EDA) and decreases fibroblast expression of Thy-1, and that fibrocytes contribute to fibrosis following bleomycin-induced lung injury in mice. In this study we hypothesized that fibroblasts lacking Thy-1 expression produce an extracellular matrix ... Read more >>

Adv Biosci Biotechnol (Advances in bioscience and biotechnology (Print))
[2014, 5(1):19-30]

Cited: 22 times

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Role of TGF-β in breast cancer bone metastases.

Antonella Chiechi, David L Waning, Keith R Stayrook, Jeroen T Buijs, Theresa A Guise, Khalid S Mohammad,

Breast cancer is the most prevalent cancer among females worldwide leading to approximately 350,000 deaths each year. It has long been known that cancers preferentially metastasize to particular organs, and bone metastases occur in ~70% of patients with advanced breast cancer. Breast cancer bone metastases are predominantly osteolytic and accompanied ... Read more >>

Adv Biosci Biotechnol (Advances in bioscience and biotechnology (Print))
[2013, 4(10C):15-30]

Cited: 37 times

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Synergistic interaction between C5a and NOD2 signaling in the regulation of chemokine expression in RAW 264.7 macrophages.

Hui Tang, Umme Amara, Dora Tang, Mark A Barnes, Christine McDonald, Laura E Nagy,

The innate immune response is a complex process involving multiple pathogen-recognition receptors, including toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors. Complement is also a critical component of innate immunity. While complement is known to interact with TLR-mediated signals, the interactions between NOD-like receptors and complement are not well ... Read more >>

Adv Biosci Biotechnol (Advances in bioscience and biotechnology (Print))
[2013, 4(8C):30-37]

Cited: 9 times

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Cyclophosphamide Induces an Early Wave of Acrolein-Independent Apoptosis in the Urothelium.

Francis M Hughes, Alexa G Corn, Andrew R Nimmich, Jeffery D Pratt-Thomas, J Todd Purves,

<h4>Purpose</h4>Hemorrhagic cystitis (HC or bladder inflammation) affects a significant number of patients undergoing cyclophosphamide (CP) chemotherapy despite treatment with 2-mercapto<i>e</i>thane <i>s</i>ulfonate (Mesna) to inactivate the metabolite acrolein. While the mechanism is unknown, there is clearly acrolein-independent damage to the urothelium. In this study we have explored the induction of apoptosis ... Read more >>

Adv Biosci Biotechnol (Advances in bioscience and biotechnology (Print))
[2013, 4(88):]

Cited: 5 times

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LL-37 induced cystitis and the receptor for advanced glycation end-products (RAGE) pathway.

Lindsi McCoard Roundy, Wanjian Jia, Jianxing Zhang, Xiangyang Ye, Glenn D Prestwich, Siam Oottamasathien,

To elucidate pathways in bladder inflammation, we employed our physiologically relevant LL-37 induced cystitis model. Based on inflammatory studies involving other organ systems implicating the receptor for advanced glycation end-products (RAGE), we first hypothesized that RAGE is critically involved in LL-37 induced cystitis. We further hypothesized a common RAGE ligand ... Read more >>

Adv Biosci Biotechnol (Advances in bioscience and biotechnology (Print))
[2013, 4(8B):1-8]

Cited: 9 times

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Physiological effects of nickel chloride on the freshwater cyanobacterium Synechococcus sp. IU 625.

Brian Nohomovich, Bao T Nguyen, Michael Quintanilla, Lee H Lee, Sean R Murray, Tin-Chun Chu,

Harmful algal blooms (HABs) are a serious environmental problem globally. The ability of cyanobacteria, one of the major causative agents of HABs, to grow in heavy metal polluted areas is proving a challenge to environmental restoration initiatives. Some cyanobacteria secrete toxins, such as microcystin, that are potentially dangerous to animals ... Read more >>

Adv Biosci Biotechnol (Advances in bioscience and biotechnology (Print))
[2013, 4(7B):10-14]

Cited: 3 times

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Increased resistance to apoptosis during differentiation and syncytialization of BeWo choriocarcinoma cells.

Bih-Rong Wei, Chuan Xu, Neal S Rote,

Transition from mononuclear villous cytotrophoblast into multinuclear syncytiotrophoblast in the human placenta is accompanied by changes in apoptosis-related proteins and an apparent increased resistance to induced apoptosis. We investigated the specific nature and timing of changes in Bcl-2, Bax, p53, and caspases 3 and 8 in forskolin-treated BeWo choriocarcinoma cells, ... Read more >>

Adv Biosci Biotechnol (Advances in bioscience and biotechnology (Print))
[2012, 3(6A):805-813]

Cited: 2 times

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Increased survivin expression contributes to apoptosis-resistance in IPF fibroblasts.

Thomas H Sisson, Toby M Maher, Iyabode O Ajayi, Jessie E King, Peter D R Higgins, Adam J Booth, Rommel L Sagana, Steven K Huang, Eric S White, Bethany B Moore, Jeffrey C Horowitz,

Fibroblasts perform critical functions during the normal host response to tissue injury, but the inappropriate accumulation and persistent activation of these cells results in the development of tissue fibrosis. The mechanisms accounting for the aberrant accumulation of fibroblasts during fibrotic repair are poorly understood, although evidence supports a role for ... Read more >>

Adv Biosci Biotechnol (Advances in bioscience and biotechnology (Print))
[2012, 3(6A):657-664]

Cited: 39 times

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Vitamin C activation of the biosynthesis of epoxyeicosatrienoic acids.

Houli Jiang, Fiona E Harrison, Kavita Jain, Samantha Benjamin, James M May, Joan P Graves, Darryl C Zeldin, John R Falck, Bruce D Hammock, John C McGiff,

The cardiovascular effects of vitamin C (VitC) could be mediated by epoxyeicosatrienoic acids (EETs). We aimed to study the mechanism of VitC-dependent microsomal formation of <i>cis</i>- and <i>trans</i>-EETs and the regulation of EET levels in rat isolated perfused kidneys and <i>in vivo</i>. VitC biphasically stimulated rat kidney microsomal <i>cis</i>- and ... Read more >>

Adv Biosci Biotechnol (Advances in bioscience and biotechnology (Print))
[2012, 3(3):204-218]

Cited: 1 time

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Degradation of naturally occurring and engineered antimicrobial peptides by proteases.

Bernard J Moncla, Kara Pryke, Lisa Cencia Rohan, Phillip W Graebing,

We hypothesized that current antimicrobial peptides should be susceptible to proteolytic digestion. The antimicrobial peptides: Griffithinsin, RC-101, LL-37, LSA-5, PSC-RANTES and DJ007 were degraded by commercially available proteases. Two different species of anaerobic vaginal flora, Prevotella bivia and Porphyromonas asaccharolytica also degraded the materials. Griffithsin was resistant to digestion by ... Read more >>

Adv Biosci Biotechnol (Advances in bioscience and biotechnology (Print))
[2011, 2(6):404-408]

Cited: 31 times

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pHluorin2: an enhanced, ratiometric, pH-sensitive green florescent protein.

Matthew J Mahon,

Green florescent protein (GFP) variants that are sensitive to changes in pH are invaluable reagents for the analysis of protein dynamics associated with both endo- and exocytotic vesicular trafficking. Ratiometric pHluorin is a GFP variant that displays a bimodal excitation spectrum with peaks at 395 and 475 nm and an ... Read more >>

Adv Biosci Biotechnol (Advances in bioscience and biotechnology (Print))
[2011, 2(3):132-137]

Cited: 73 times

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