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Journal Adv Anat Pathol

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Carcinomas of the Uterine Cervix: Comprehensive Review With An Update on Pathogenesis, Nomenclature of Precursor and Invasive Lesions, and Differential Diagnostic Considerations.

Maria Arafah, Sameera Rashid, Asma Tulbah, Mohammed Akhtar,

Most cervical carcinomas and their related lesions are attributed to an infection by human papillomavirus (HPV). The infection usually starts in the basal cells at the squamocolumnar junction. It causes cell proliferation and maturation abnormalities along with nuclear abnormalities resulting in low-grade squamous intraepithelial lesions. An overwhelming majority of these ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):150-170]

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Emerging Entities and New Diagnostic Markers for Head and Neck Soft Tissue and Bone Tumors.

Alessandro Franchi, Lester D R Thompson, Juan C Hernandez-Prera, Abbas Agaimy, Michelle D Williams, Lauge H Mikkelsen, Justin A Bishop, Stefan M Willems, Henrik Hellquist, Alfio Ferlito,

Bone and soft tissue tumors of the head and neck are relatively uncommon tumors that often represent a diagnostic challenge because of the wide range of entities that must be considered in the differential diagnosis. Over the past few years, classification of bone and soft tissue tumors has evolved primarily ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):139-149]

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High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance.

Alena Skalova, Ilmo Leivo, Henrik Hellquist, Abbas Agaimy, Roderick H W Simpson, Göran Stenman, Vincent Vander Poorten, Justin A Bishop, Alessandro Franchi, Juan C Hernandez-Prera, David Slouka, Stefan M Willems, Kerry D Olsen, Alfio Ferlito,

High-grade transformation (HGT) or dedifferentiation has been described in a variety of salivary gland carcinomas, including acinic cell carcinoma, secretory carcinoma, adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, polymorphous adenocarcinoma, low-grade mucoepidermoid carcinoma, and hyalinizing clear cell carcinoma. High-grade (HG) transformed tumors are composed of a conventional low-grade component characterized by specific ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):107-118]

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Historical Advancements and Evolution in Understanding Human Anatomy and Pathology: The Contribution of the Middle Ages.

Alon L Roguin, Ariel Roguin, Nathan Roguin,

Dissections and autopsies are critical for understanding human anatomy, pathology, and uncovering mechanisms of disease. This review presents an historical journey from ancient times until the late Middle Ages. The major steps and developments are summarized with key figures and events presented. ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):171-177]

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The 2020 WHO Classification of Tumors of Bone: An Updated Review.

Joon Hyuk Choi, Jae Y Ro,

Bone tumors are a rare and heterogeneous group of neoplasms that occur in the bone. The diversity and considerable morphologic overlap of bone tumors with other mesenchymal and nonmesenchymal bone lesions can complicate diagnosis. Accurate histologic diagnosis is crucial for appropriate management and prognostication. Since the publication of the fourth ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):119-138]

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A Simple and Practical Guide for Triaging Lymphocyte-rich Effusions for Ancillary Studies.

Chih-Yi Liu, Shih-Sung Chuang,

Lymphocyte-rich effusions of the body cavities may represent a reactive/benign condition, primary effusion lymphoma, or systemic lymphoma with secondary malignant effusion, either as initial presentation or as a late complication. Cytomorphologic examination is essential and fundamental for diagnosis and may provide important clues to the nature of diseases. However, based ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(2):94-104]

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Differential Diagnoses in Surgical Pathology: Soft Tissue and Bone.

Raza S Hoda, Syed A Hoda,

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(2):105]

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The Differential Diagnosis of Intrahepatic Ductular Reaction in Medical Liver Biopsy.

Richa Jain, Ian Clark,

Intrahepatic ductular reaction is a pathologic proliferation of phenotypical biliary channels. Ductular reactions aim to restore compromised physiological function after liver injury and are one of the archetypal responses of the liver to a wide variety of etiologies, among them are parenchymal loss, biliary tract disease, neoplasms, after liver transplantation, ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(2):72-80]

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Major Pathologic Response in Patients Treated for Non-small Cell Carcinoma of the Lung: Is There a Magic Number in the Histologic Sections to Be Evaluated?

Diana M Oramas, Cesar A Moran,

Over the last years, great advancements have taken place in the medical approach to lung non-small cell carcinomas. Currently, with the use of biomarkers and diagnostic molecular pathology, tumors that in the past were treated with conventional chemotherapy, radiation therapy, or both, now similar patients afflicted by non-small cell carcinoma ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(2):67-71]

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Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.

M Hasan Toper, Sulen Sarioglu,

Salivary gland neoplasms are an uncommon and widely heterogeneous group of tumors. In recent years, there has been considerable progress in efforts to reveal the molecular landscape of these tumors, although it is still limited and appears to be only the tip of the iceberg. Genomic aberrations, especially specific chromosomal ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(2):81-93]

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Similarities and Differences in the 2019 ISUP and GUPS Recommendations on Prostate Cancer Grading: A Guide for Practicing Pathologists.

Steven C Smith, Jatin S Gandhi, Holger Moch, Manju Aron, Eva Compérat, Gladell P Paner, Jesse K McKenney, Mahul B Amin,

Contemporary subspecialization of practice in prostate pathology has seen a transition to complex, nuanced reporting, where a growing number of histopathologic parameters may signal differences in patient management. In this context, the International Society of Urological Pathology (ISUP) and the Genitourinary Pathology Society (GUPS) both published proceedings papers on the ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(1):1-7]

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Extranodal Follicular Dendritic Cell Sarcoma-A Review: "What the Mind Does Not Know the Eye Does Not See".

Ramandeep Kaur, Jay Mehta, Anita Borges,

Follicular dendritic cell sarcoma (FDCS) is an intermediate-grade malignancy of follicular dendritic cells, which are derived from mesenchymal stem cells. Nodal FDCS is well-recognized. However, when it occurs at an extranodal site, it may not be recognized and is often misdiagnosed. These tumors exhibit a variable spindle to epithelioid cell ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(1):21-29]

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Comprehensive Review of Numerical Chromosomal Aberrations in Chromophobe Renal Cell Carcinoma Including Its Variant Morphologies.

Reza Alaghehbandan, Kiril Trpkov, Maria Tretiakova, Ana S Luis, Joanna D Rogala, Ondrej Hes,

Chromophobe renal cell carcinoma (ChRCC) accounts for 5% to 7% of all renal cell carcinomas. It was thought for many years that ChRCC exhibits a hypodiploid genome. Recent studies using advanced molecular genetics techniques have shown more complex and heterogenous pattern with frequent chromosomal gains. Historically, multiple losses of chromosomes ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(1):8-20]

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The 2020 WHO Classification of Tumors of Soft Tissue: Selected Changes and New Entities.

Joon Hyuk Choi, Jae Y Ro,

Soft tissue tumors are a relatively rare and diagnostically challenging group of neoplasms that can have varying lines of differentiation. Accurate diagnosis is important for appropriate treatment and prognostication. In the 8 years since the publication of the 4th Edition of World Health Organization (WHO) classification of soft tissue tumors, ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(1):44-58]

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Endometriosis: A Comprehensive Review.

Maria Arafah, Sameera Rashid, Mohammed Akhtar,

Endometriosis is a relatively common condition in which endometrial tissue is established in locations outside the uterus where, like the eutopic endometrium, it responds to hormonal stimuli and develops internal bleeding, inflammation, and fibrosis. These changes are associated with chronic and often debilitating cyclic pain and infertility. The pathogenesis of ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(1):30-43]

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Anti-glomerular Basement Membrane Disease: What Have We Learned?

Mohammed Akhtar, Noheir M Taha, Muhammad Asim,

Since the first clinicopathologic description by Ernest Goodpasture of a patient whom he considered to have died of influenza in 1919, substantial progress has been made in our knowledge of anti-glomerular basement membrane disease. This has led to a significant decrease in the morbidity and mortality associated with this disease. ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(1):59-65]

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Giant Rhinophyma.

Yan Wang, Philip W Allen,

A 42-year-old woman presented with a clinically obvious giant rhinophyma. The protocol of the unit handling the case mandated that all lesions amenable to biopsy should have a core biopsy before any definitive surgery, but the unnecessary biopsy was not representative and suggested an incorrect diagnosis of perifollicular fibroma. The ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2020, 27(6):422-424]

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Mucous Gland Adenoma: The Spectrum of Growth Patterns and the Diagnostic Challenges.

Michael P Zaleski, Neda Kalhor, Cesar A Moran,

Mucous gland adenomas represent a small percentage of primary lung neoplasms. The accurate diagnosis of these benign tumors can be challenging not only on resected specimens but also more challenging in small bronchoscopic biopsies. If to that problem we add the issue that these tumors may also exist in the ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2020, 27(6):371-379]

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Autopsy Services and Emergency Preparedness of a Tertiary Academic Hospital Mortuary for the COVID-19 Public Health Emergency: The Yale Plan.

Declan McGuone, John Sinard, James R Gill, Amanda Masters, Chen Liu, Raffaella Morotti, Vinita Parkash,

Pathology Autopsy and Mortuary Services have been front and center in the severe acute respiratory syndrome coronavirus 2 (SARS-Co-V-2) pandemic. The sheer number of fatalities from the pandemic have been unlike any other in recent memory and needed the rapid creation of new protocols and paradigms to manage the situation. ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2020, 27(6):355-362]

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Desmoplastic Small Round Cell Tumor of the Kidney: Report of a Case, Literature Review, and Comprehensive Discussion of the Distinctive Morphologic, Immunohistochemical, and Molecular Features in the Differential Diagnosis of Small Round Cell Tumors Affecting the Kidney.

Carlos A Galliani, Michele Bisceglia, Antonio Del Giudice, Giuseppe Cretì,

Desmoplastic small round cell tumor (DSRCT) is a rare, highly aggressive neoplasm typically presenting with widespread involvement of the abdominopelvic peritoneum of adolescent males, usually without organ-based primary. Although it is believed to originate from the serous (mainly peritoneal) membranes, intracranial, sinonasal, intraosseous, and other soft tissue sites are also ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2020, 27(6):408-421]

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Cardiac Myxoma: Review and Update of Contemporary Immunohistochemical Markers and Molecular Pathology.

Jaylou M Velez Torres, Ernesto Martinez Duarte, Julio A Diaz-Perez, Andrew E Rosenberg,

Cardiac myxoma is an uncommon benign mesenchymal neoplasm of the heart. It usually arises in the left atrium, near the valve of the fossa ovalis, and most frequently affects adults in the third through the sixth decades of life. It is hypothesized to arise from subendothelial vasoformative reserve cells or ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2020, 27(6):380-384]

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Artificial Intelligence in Pathology: A Simple and Practical Guide.

Keluo Yao, Amol Singh, Kaushik Sridhar, John L Blau, Robert S Ohgami,

Artificial intelligence (AI) is having an increasing impact on the field of pathology, as computation techniques allow computers to perform tasks previously performed by people. Here, we offer a simple and practical guide to AI methods used in pathology, such as digital image analysis, next-generation sequencing, and natural language processing. ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2020, 27(6):385-393]

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Adenomatoid Tumor: A Review of Pathology With Focus on Unusual Presentations and Sites, Histogenesis, Differential Diagnosis, and Molecular and Clinical Aspects With a Historic Overview of Its Description.

Georgia Karpathiou, Kenzo Hiroshima, Michel Peoc'h,

Adenomatoid tumors have been described almost a century ago, and their nature has been the subject of debate for decades. They are tumors of mesothelial origin usually involving the uterus, the Fallopian tubes, and the paratesticular region. Adenomatoid tumors of the adrenal gland, the liver, the extragenital peritoneum, the pleura, ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2020, 27(6):394-407]

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Histopathologic and Autopsy Findings in Patients Diagnosed With Coronavirus Disease 2019 (COVID-19): What We Know So Far Based on Correlation With Clinical, Morphologic and Pathobiological Aspects.

Areej Al Nemer,

In response to the current outbreak of Coronavirus Disease-2019 (COVID-19), a fast body of literature emerged providing insights into the clinical and radiologic aspects of the novel disease, while the pathologic manifestations on tissue are yet to be sufficiently characterized mainly due to paucity of autopsy and biopsy of these ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2020, 27(6):363-370]

Cited: 6 times

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Renal Hypoplasia, From Grossly Insufficient to Not Quite Enough: Consideration for Expanded Concepts Based Upon the Author's Perspective With Historical Review.

Stephen M Bonsib,

Hypoplasia is defined in the Merriman-Webster dictionary as "a condition of arrested development in which an organ, or part, remains below the normal size, or in an immature state." The degree of reduced size is not definitional. Renal hypoplasia, however, has historically been defined as a more marked reduction in ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2020, 27(5):311-330]

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