Full Text Journal Articles in
Journal Adipocyte

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Reliability and variation in mitochondrial respiration in human adipose tissue.

Ronni Eg Sahl, Eva Frederikke Høy Helms, Malte Schmücker, Mathias Flensted-Jensen, Arthur Ingersen, Thomas Morville, Flemming Dela, Jørn Wulff Helge, Steen Larsen,

Adipose tissue mitochondrial function is gaining increasing interest since it is a good marker of overall health. Methodological challenges and variability in assessing mitochondrial respiration in fresh adipose tissue with high-resolution respirometry are unknown and should be explored. Mitochondrial respiratory capacity (MRC) in human adipose tissue declines in a gradual ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):605-611]

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Verapamil induces autophagy to improve liver regeneration in non-alcoholic fatty liver mice.

Jian-Lin Lai, Yuan-E Lian, Jun-Yi Wu, Yao-Dong Wang, Yan-Nan Bai,

Verapamil can restore intracellular calcium homeostasis, increase the fusion of autophagosomes and lysosomes, reduce lipid droplet accumulation and inhibit inflammation and insulin resistance in high-fat-fed mice. The present study aimed to investigate verapamil's effect and its underlying liver regeneration mechanism in mice with non-alcoholic fatty liver. After 50% hepatectomy was ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):532-545]

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Polymorphisms analysis for association between ADIPO signaling pathway and genetic susceptibility to T2DM in Chinese han population.

Haibing Yu, Wei Hu, Chunwen Lin, Lin Xu, Hao Liu, Ling Luo, Rong Chen, Jialu Huang, Weiying Chen, Chen Yang, Danli Kong, Yuanlin Ding,

The aim of the present study is to explored the relationship between ADIPO signalling pathway and T2DM, to provide clues for further study of the pathogenesis of T2DM and to determine the possible drug targets. This study employed a case-control study design. Twenty-three single nucleotide polymorphisms (SNPs) of 13 genes ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):463-474]

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Matrigel® enhances 3T3-L1 cell differentiation.

Chitmandeep Josan, Sachin Kakar, Sandeep Raha,

Culturing cells on bio-gels are believed to provide a more <i>in vivo</i>-like extracellular matrix. 3T3-L1 cells cultured on Matrigel® significantly alteregd their proliferation and differentiation as compared to growth on tissue culture-coated polystyrene surfaces. Growth on a 250-μm thick layer of Matrigel® facilitated the formation of cellular aggregates of 3T3-L1 ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):361-377]

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The characterization of metabolites alterations in white adipose tissue of diabetic GK Rats after ileal transposition surgery by an untargeted metabolomics approach.

Xiaorui Lyu, Kemin Yan, Weijie Chen, Yujie Wang, Huijuan Zhu, Hui Pan, Guole Lin, Linjie Wang, Hongbo Yang, Fengying Gong,

Dysfunction of adipose tissue could lead to insulin resistance, obesity and type 2 diabetes. Thus, our present study aimed to investigate metabolites alterations in white adipose tissue (WAT) of diabetic GK rats after IT surgery. Ten-week-old male diabetic GK rats were randomly subjected to IT and Sham-IT surgery. Six weeks ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):275-284]

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MicroRNA-29b/29c targeting CTRP6 influences porcine adipogenesis via the AKT/PKA/MAPK Signalling pathway.

Wenjing Wu, Ke Xu, Meng Li, Jin Zhang, Yizhen Wang,

Porcine fat deposition is an important economic trait of pig breeds, and understanding the gene regulatory network in adipocytes is essential for modern pig breeding. In a previous study, we demonstrated that miR-29a negatively regulates the differentiation of porcine adipocytes. In this study, we investigated the roles of miR-29b/c in ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):264-274]

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Cleavage of the vaspin N-terminus releases cell-penetrating peptides that affect early stages of adipogenesis and inhibit lipolysis in mature adipocytes.

Catherine A Tindall, Estelle Erkner, Jan Stichel, Annette G Beck-Sickinger, Anne Hoffmann, Juliane Weiner, John T Heiker,

Vaspin expression and function is related to metabolic disorders and comorbidities of obesity. In various cellular and animal models of obesity, diabetes and atherosclerosis vaspin has shown beneficial, protective and/or compensatory action. While testing proteases for inhibition by vaspin, we noticed specific cleavage within the vaspin N-terminus and sequence analysis ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):216-231]

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MiR-33a plays an crucial role in the proliferation of bovine preadipocytes.

Wenzhen Zhang, Li Wang, Sayed Haidar Abbas Raza, Xiaoyu Wang, Guohu Wang, Chengcheng Liang, Gong Cheng, Bingzhi Li, Linsen Zan,

Preadipocyte proliferation is a critical and precisely orchestrated procedure in adipogenesis, which is highly regulated by microRNAs (miRNAs). A previous study identified that the expression of miR-33a is different in intramuscular fat (IMF) tissues from steers and bulls. In the present study, miR-33a was overexpressed in bovine preadipocytes, and a ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):189-200]

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No evidence for change in expression of TBC1D1 and TBC1D4 genes in cultured human adipocytes stimulated by myokines and adipokines.

Łukasz Kępczyński, Szymon Wcisło, Irmina Korzeniewska-Dyl, Katarzyna Połatyńska, Agnieszka Gach, Dariusz Moczulski,

TBC1D1 and TBC1D4 proteins play analogous, but not identical role in governing insulin-signalling pathway. Little is known about changes in expression levels of <i>TBC1D1</i> and <i>TBC1D4</i> genes in mammals, including humans. Number of factors were studied, but data remain controversial. The aim of this study was to evaluate the effect ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):153-159]

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Measurement of human abdominal and femoral intravascular adipose tissue blood flow using percutaneous Doppler ultrasound.

Ioannis G Lempesis, Gijs H Goossens, Konstantinos N Manolopoulos,

Adipose tissue blood flow (ATBF) is an important determinant of adipose tissue (AT) function. <sup>133</sup>Xenon wash-out technique is considered the gold-standard for human ATBF measurements. However, decreasing <sup>133</sup>Xenon clinical use and costly production and preservation, make alternative (non-invasive) methods necessary. Here, we explored percutaneous Doppler ultrasound as a proxy method ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):119-123]

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MicroRNA-378 regulates adipogenic differentiation in bovine intramuscular preadipocytes by targeting CaMKK2.

Dongwei Li, Heng Wang, Yongmin Li, Changqing Qu, Yunhai Zhang, Hongyu Liu, Xiaorong Zhang,

Intramuscular fat, as one of the most important palatability attribute of beef carcase, is the primary determinant of beef quality. The research of adipogenesis mechanism would provide new insight into intramuscular fatty deposition. Here, the role of microRNA-378 was investigated during bovine adipogenic differentiation. It was revealed that miR-378 expression ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):483-492]

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FAM13A promotes proliferation of bovine preadipocytes by targeting Hypoxia-Inducible factor-1 signaling pathway.

Chengcheng Liang, Guohua Wang, Sayed Haidar Abbas Raza, Xiaoyu Wang, Bingzhi Li, Wenzhen Zhang, Linsen Zan,

The family with sequence similarity 13 member A (FAM13A) gene has been discovered in recent years and is related to metabolism. In this study, the function of FAM13A in precursor adipocyte proliferation in Qinchuan cattle was investigated using fluorescence quantitative polymerase chain reaction (PCR), western blotting, 5-ethynyl-2'-deoxyuridine staining, and other ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):546-557]

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Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity.

Chenxuan Wang, Jessica Murphy, Kerri Z Delaney, Natalie Khor, José A Morais, Michael A Tsoukas, Dana E Lowry, David M Mutch, Sylvia Santosa,

Fatty acid desaturase 1 (<i>FADS1</i>) polymorphisms alter fatty acid content in subcutaneous adipose tissue (SAT); however, existing evidence is limited and conflicting regarding the association between <i>FADS1</i> variants and SAT inflammatory status. To advance this area, we conducted an exploratory study to investigate whether the common rs174537 polymorphism in <i>FADS1</i> ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):124-130]

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Cafeteria diet induces global and Slc27a3-specific hypomethylation in male Wistar rats.

Amsha Viraragavan, Tarryn Willmer, Oelfah Patel, Albertus Basson, Rabia Johnson, Carmen Pheiffer,

Increased visceral adipose tissue (VAT) is associated with metabolic dysfunction, while subcutaneous adipose tissue (SAT) is considered protective. The mechanisms underlying these differences are not fully elucidated. This study aimed to investigate molecular differences in VAT and SAT of male Wistar rats fed a cafeteria diet (CD) or a standard ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):108-118]

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Identification of the transgene insertion site for an adipocyte-specific adiponectin-cre model and characterization of the functional consequences.

Jared S Farrar, Joseph C Lownik, Grayson W Way, Matthew C Rodriguez, Francesco S Celi, Rebecca K Martin,

The <i>Adipoq-Cre</i> transgenic mouse is widely used in the development of adipocyte-specific genetic manipulations for the study of obesity and type 2 diabetes. In the process of developing a new mouse model utilizing the adipocyte selective <i>Adipoq-Cre</i> transgenic mouse, strong genetic linkage between a gene of interest, <i>Adam10</i>, and the ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):91-100]

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Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus.

Long Cheng, Jingkang Wang, Hongyu Dai, Yuhui Duan, Yongcheng An, Lu Shi, Yinglan Lv, Huimin Li, Chen Wang, Quantao Ma, Yaqi Li, Pengfei Li, Haifeng Du, Baosheng Zhao,

Mammalian adipose tissue can be divided into two major types, namely, white adipose tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function of WAT is to store excess energy in the form of triglycerides, while BAT is a thermogenic tissue that acts a pivotal part ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):48-65]

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The paracrine effects of adipocytes on lipid metabolism in doxorubicin-treated triple negative breast cancer cells.

Ilze Mentoor, Anna-Mart Engelbrecht, Mari van de Vyver, Paul J van Jaarsveld, Theo Nell,

Adipocytes in the breast tumour microenvironment promotes acquired treatment resistance. We used an in vitro adipocyte-conditioned media approach to investigate the direct paracrine effects of adipocyte secretory factors on MDA-MB-231 breast cancer cells treated with doxorubicin to clarify the underlying treatment resistance mechanisms. Cell-viability assays, and Western blots were performed ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):505-523]

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Association of cell death mechanisms and fibrosis in visceral white adipose tissue with pathological alterations in the liver of morbidly obese patients with NAFLD.

Anna-Sophia Leven, Robert K Gieseler, Martin Schlattjan, Thomas Schreiter, Marco Niedergethmann, Theodor Baars, Hideo A Baba, Mustafa K Özçürümez, Jan-Peter Sowa, Ali Canbay,

The role of visceral white adipose tissue (vWAT) in the progression of non-alcoholic liver disease (NAFLD) with its sub entities non-alcoholic fatty liver and steatohepatitis (NAFL; NASH) is underinvestigated. We thus explored mechanisms of fibrosis and regulated cell death in vWAT and liver tissue. In NAFLD, women displayed significantly more ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):558-573]

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Hematopoietic stem cells produce intermediate lineage adipocyte progenitors that simultaneously express both myeloid and mesenchymal lineage markers in adipose tissue.

Kathleen M Gavin, Timothy M Sullivan, Joanne K Maltzahn, Jeremy T Rahkola, Alistair S Acosta, Wendy M Kohrt, Susan M Majka, Dwight J Klemm,

Some adipocytes are produced from bone marrow hematopoietic stem cells. <i>In vitro</i> studies previously indicated that these bone marrow-derived adipocytes (BMDAs) were generated from adipose tissue macrophage (ATM) that lose their hematopoietic markers and acquire mesenchymal markers prior to terminal adipogenic differentiation. Here we interrogated whether this hematopoietic-to-mesenchymal transition drives ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):394-407]

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Resveratrol supplementation reduces ACE2 expression in human adipose tissue.

Marlies de Ligt, Matthijs K C Hesselink, Johanna Jorgensen, Nicole Hoebers, Ellen E Blaak, Gijs H Goossens,

Angiotensin converting enzyme-2 (ACE2) is the cell-surface receptor enabling cellular entry of SARS-CoV-2. ACE2 is highly expressed in adipose tissue (AT), rendering AT a potential SARS-CoV-2 reservoir contributing to massive viral spread in COVID-19 patients with obesity. Although rodent and cell studies suggest that the polyphenol resveratrol alters ACE2, human ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):408-411]

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Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis.

Zhiyong Dong, Xinyi Lei, Stacy A Kujawa, NaciEmre Bolu, Hong Zhao, Cunchuan Wang,

<b>Objectives</b> Adipocytes and adipocyte lipid metabolism are closely related with obesity and type 2 diabetes, but the molecular mechanism still needs further investigation. The aim of this study is to discover the adipocyte genes and pathways involved in obesity and type 2 diabetes using bioinformatics analysis.<b>Methods</b> The GSE27951 gene expression ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):310-321]

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Autologous decellularized extracellular matrix promotes adipogenic differentiation of adipose derived stem cells in low serum culture system by regulating the ERK1/2-PPARγ pathway.

Yao Qian, Hao Chen, Tianyun Pan, Tian Li, Zikai Zhang, Xuling Lv, Jingping Wang, Ziwan Ji, Yucang He, Liqun Li, Ming Lin,

High viability and further adipogenic differentiation of adipose-derived stem cells (ADSCs) are fundamental for engraftment and growth of the transplanted adipose tissue. It has been demonstrated that extracellular matrix (ECM) regulates cell proliferation and differentiation by interacting with ERK1/2 signalling pathway. In this study, we prepared autologous decellularized extracellular matrix ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):174-188]

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Swertiamarin supplementation prevents obesity-related chronic inflammation and insulin resistance in mice fed a high-fat diet.

Liang Xu, Dandan Li, Yuqin Zhu, Suili Cai, Xue Liang, Ying Tang, Shengnan Jin, Chunming Ding,

Obesity is characterized by low-grade chronic inflammation, which underlies insulin resistance and non-alcoholic fatty liver disease (NAFLD). Swertiamarin is a secoiridoid glycoside that has been reported to ameliorate diabetes and NAFLD in animal models. However, the effects of swertiamarin on obesity-related inflammation and insulin resistance have not been fully elucidated. ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):160-173]

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Fat grafting and platelet-rich plasma in wound healing: a review of histology from animal studies.

Grant S Nolan, Oliver J Smith, Gavin Jell, Afshin Mosahebi,

Stem cells could form the basis of a novel, autologous treatment for chronic wounds like diabetic foot ulcers. Fat grafts contain adipose-derived stem cells (ADSC) but low survival of cells within the grafts is a major limitation. Platelet-rich plasma (PRP) may increase graft survival. This review examines the histology from ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):80-90]

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Application of a deep learning-based image analysis and live-cell imaging system for quantifying adipogenic differentiation kinetics of adipose-derived stem/stromal cells.

Patrick Terrence Brooks, Lea Munthe-Fog, Klaus Rieneck, Frederik Banch Clausen, Olga Ballesteros Rivera, Eva Kannik Haastrup, Anne Fischer-Nielsen, Jesper Dyrendom Svalgaard,

Quantitative methods for assessing differentiative potency of adipose-derived stem/stromal cells may lead to improved clinical application of this multipotent stem cell, by advancing our understanding of specific processes such as adipogenic differentiation. Conventional cell staining methods are used to determine the formation of adipose areas during adipogenesis as a qualitative ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):621-630]

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