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Journal Addict Biol

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Daily and intermittent smoking are associated with low prefrontal volume and low concentrations of prefrontal glutamate, creatine, myo-inositol, and N-acetylaspartate.

Paul Faulkner, Susanna Lucini Paioni, Petya Kozhuharova, Natasza Orlov, David J Lythgoe, Yusuf Daniju, Elenor Morgenroth, Holly Barker, Paul Allen,

Cigarette smoking is still the largest contributor to disease and death worldwide. Successful cessation is hindered by decreases in prefrontal glutamate concentrations and gray matter volume due to daily smoking. Because nondaily, intermittent smoking also contributes greatly to disease and death, understanding whether infrequent tobacco use is associated with reductions ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12986]

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Susceptibility to interference between Pavlovian and instrumental control is associated with early hazardous alcohol use.

Hao Chen, Stephan Nebe, Negin Mojtahedzadeh, Sören Kuitunen-Paul, Maria Garbusow, Daniel J Schad, Michael A Rapp, Quentin J M Huys, Andreas Heinz, Michael N Smolka,

Pavlovian-to-instrumental transfer (PIT) tasks examine the influence of Pavlovian stimuli on ongoing instrumental behaviour. Previous studies reported associations between a strong PIT effect, high-risk drinking and alcohol use disorder. This study investigated whether susceptibility to interference between Pavlovian and instrumental control is linked to risky alcohol use in a community ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12983]

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Neural representation of prediction error signals in substance users.

Serenella Tolomeo, Zachary A Yaple, Rongjun Yu,

Abnormal decision making can result in detrimental outcomes of clinical importance, and decision making is strongly linked to neural prediction error signalling. Activation likelihood estimation (ALE) meta-analyses were used to examine the neural correlates of prediction error signals of individuals taking different types of substances and healthy controls with contrast ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12976]

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Reduced frontostriatal functional connectivity and associations with severity of Internet gaming disorder.

Haohao Dong, Min Wang, Jialin Zhang, Yuzheng Hu, Marc N Potenza, Guang-Heng Dong,

Cognitive, functional, and structural brain factors involving frontal executive and striatal reward networks have been implicated in Internet gaming disorder (IGD). However, frontostriatal network connectivity and its association with addiction severity are poorly understood in IGD. Resting-state fMRI data from 337 subjects (130 with IGD, 207 with recreational game use ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12985]

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Behavioral effects of four novel synthetic cathinone analogs in rodents.

Michael B Gatch, Ritu A Shetty, Nathalie Sumien, Michael J Forster,

A new generation of novel cathinone compounds has been developed as stimulant substitutes to avoid drug control laws and detection of use by blood tests. Dipentylone, N-ethylhexedrone, 4-chloroethcathinone (4-CEC), and 4'-methyl-α-pyrrolidinohexiophenone (MPHP) were tested for in vivo psychostimulant-like effects to assess their abuse liability. Locomotor activity was assessed in an ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12987]

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Cannabis use-related working memory deficit mediated by lower left hippocampal volume.

Subhadip Paul, Sagnik Bhattacharyya,

The association between cannabis exposure and working memory impairment and its neural substrates remain unclear. In this cross-sectional observational study, we investigated this by examining the relationship between frequency of exposure to cannabis, working memory performance and regional brain volumes and tested whether lower volumes of cortical and subcortical structures ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12984]

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Impaired hypothalamic feedback dysregulates brain glucocorticoid signaling in genetically-selected Marchigian Sardinian alcohol-preferring rats.

Luis A Natividad, Michael Q Steinman, M Adrienne McGinn, Suhas Sureshchandra, Tony M Kerr, Roberto Ciccocioppo, Ilhem Messaoudi, Scott Edwards, Marisa Roberto,

Genetically-selected Marchigian Sardinian alcohol-preferring (msP) rats display comorbid symptoms of increased alcohol preference and elevated anxiety-like behavior. Heightened stress sensitivity in msPs is influenced by genetic polymorphisms of the corticotropin-releasing factor receptor in the central nucleus of the amygdala (CeA), as well as reduced influence of anti-stress mechanisms that normally ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12978]

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The dopaminergic alterations induced by 4-F-PCP and 4-Keto-PCP may enhance their drug-induced rewarding and reinforcing effects: Implications for abuse.

Darlene Mae Ortiz, Raly James Perez Custodio, Arvie Abiero, Chrislean Jun Botanas, Leandro Val Sayson, Mikyung Kim, Hyun Jun Lee, Hee Jin Kim, Youngdo Jeong, Sulmin Yoon, Yong Sup Lee, Jae Hoon Cheong,

Novel psychoactive substances remain the popular recreational drugs of use over the years. They continue to bypass government restrictions due to their synthesis and modifications. Recent additions to the lists are the 4-F-PCP and 4-Keto-PCP, analogs of the drug phencyclidine (PCP) known to induce adverse effects and abuse potential. However, ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12981]

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Assessing effect of long-term abstinence on coupling of three core brain networks in male heroin addicts: A resting-state functional magnetic resonance imaging study.

Jiajie Chen, Fan Wang, Jia Zhu, Yongbin Li, Wei Liu, Jiuhua Xue, Hong Shi, Wei Li, Qiang Li, Wei Wang,

Abstinence is one of the important measures for heroin addiction. However, it is unknown whether long-term abstinence (LA) would improve the coupling among three core brain networks (salience, default mode, and executive control) and decrease craving in treated heroin addicts. Forty-three heroin addicts with LA, 27 heroin addicts with short-term ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12982]

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Disturbed sensory physiology underlies poor balance and disrupts activities of daily living in alcohol use disorder.

Edith V Sullivan, Natalie M Zahr, Stephanie A Sassoon, Adolf Pfefferbaum,

Postural stability is a multi-factorial skill maintained implicitly. Components of quiet standing can decline with Alcohol Use Disorder (AUD), cause instability, and disrupt activities of daily living (ADL). To examine how stability factors contribute to ADL and balance, 638 force platform testing sessions measured sway paths acquired during quiet standing ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12966]

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Gut dysbiosis associated with the rats' responses in methamphetamine-induced conditioned place preference.

Cheng Yang, Xiaoya Fu, Wei Hao, Xiaojun Xiang, Tieqiao Liu, Bao-Zhu Yang, Xiaojie Zhang,

Methamphetamine (MA) is a potent stimulant and notoriously addictive. Individuals respond to MA effects differently and thus have a varying susceptible risk of developing MA use disorder. Cumulative evidence has indicated that gut dysbiosis contributes to behavioral response to drug effects. However, the role of gut microbiota in the susceptible ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12975]

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Resting activity of the hippocampus and amygdala in obese individuals predicts their response to food cues.

Guanya Li, Yang Hu, Wenchao Zhang, Yueyan Ding, Yuanyuan Wang, Jia Wang, Yang He, Ganggang Lv, Karen M von Deneen, Yu Zhao, Antao Chen, Yu Han, Guangbin Cui, Gang Ji, Peter Manza, Dardo Tomasi, Nora D Volkow, Yongzhan Nie, Gene-Jack Wang, Yi Zhang,

Obese individuals exhibit brain functional abnormalities in multiple regions implicated in reward/motivation, emotion/memory, homeostatic regulation, and executive control when exposed to food cues and during rest. However, it remains unclear whether abnormal brain responses to food cues might account for or relate to their abnormal activity in resting state. This ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12974]

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The role of withdrawal in mesocorticolimbic drug cue reactivity in opioid use disorder.

Zhenhao Shi, Kanchana Jagannathan, James H Padley, An-Li Wang, Victoria P Fairchild, Charles P O'Brien, Anna Rose Childress, Daniel D Langleben,

Opioid use disorder (OUD) is characterized by heightened cognitive, physiological, and neural responses to opioid-related cues that are mediated by mesocorticolimbic brain pathways. Craving and withdrawal are key symptoms of addiction that persist during physiological abstinence. The present study evaluated the relationship between the brain response to drug cues in ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12977]

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Chronic opioid exposure differentially modulates oxycodone self-administration in male and female rats.

Maria Mavrikaki, Tania Lintz, Nick Constantino, Sarah Page, Elena Chartoff,

Withdrawal from opioid painkillers can produce short-lived physical symptoms and protracted psychological symptoms including anxiety and depressive-like states that often lead to opioid misuse and opioid use disorder (OUD). Studies testing the hypothesis that opioid withdrawal potentiates the reinforcing effects of opioid self-administration (SA) are largely inconclusive and have focused ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12973]

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Exercise craving potentiates excitatory inputs to ventral tegmental area dopaminergic neurons.

Maria-Carmen Medrano, Imane Hurel, Emma Mesguich, Bastien Redon, Christopher Stevens, François Georges, Miriam Melis, Giovanni Marsicano, Francis Chaouloff,

Physical exercise, which can be addictogenic on its own, is considered a therapeutic alternative for drug craving. Exercise might thus share with drugs the ability to strengthen excitatory synapses onto ventral tegmental area (VTA) dopaminergic neurones, as assessed by the ratio of AMPA receptor (AMPAR)-mediated excitatory postsynaptic currents (EPSCs) to ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12967]

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Low-dose alcohol: Interoceptive and molecular effects and the role of dentate gyrus in rats.

Patrick A Randall, Dennis F Lovelock, Kalynn VanVoorhies, Verda E Agan, Thomas L Kash, Joyce Besheer,

Alcohol abuse and dependence are world-wide health problems. Most research on alcohol use focuses on the consequences of moderate to high levels of alcohol. However, even at low concentrations, alcohol is capable of producing effects in the brain that can ultimately affect behavior. The current studies seek to understand the ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12965]

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Resting-state connectome-based support-vector-machine predictive modeling of internet gaming disorder.

Kun-Ru Song, Marc N Potenza, Xiao-Yi Fang, Gao-Lang Gong, Yuan-Wei Yao, Zi-Liang Wang, Lu Liu, Shan-Shan Ma, Cui-Cui Xia, Jing Lan, Lin-Yuan Deng, Lu-Lu Wu, Jin-Tao Zhang,

Internet gaming disorder (IGD), a worldwide mental health issue, has been widely studied using neuroimaging techniques during the last decade. Although dysfunctions in resting-state functional connectivity have been reported in IGD, mapping relationships from abnormal connectivity patterns to behavioral measures have not been fully investigated. Connectome-based predictive modeling (CPM)-a recently ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12969]

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Stress induces reinstatement of extinguished cocaine conditioned place preference by a sequential signaling via neuropeptide S, orexin, and endocannabinoid.

Yu-Hsien Chou, Chia Chun Hor, Ming Tatt Lee, Hsin-Jung Lee, Remo Guerrini, Girolamo Calo, Lih-Chu Chiou,

Neurons containing neuropeptide S (NPS) and orexins are activated during stress. Previously, we reported that orexins released during stress, via orexin OX1 receptors (OX1 Rs), contribute to the reinstatement of cocaine seeking through endocannabinoid/CB1 receptor (CB1 R)-mediated dopaminergic disinhibition in the ventral tegmental area (VTA). Here, we further demonstrated that ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12971]

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Brain volume changes after long-term injectable opioid treatment: A longitudinal voxel-based morphometry study.

André Schmidt, Marc Vogel, Sophie Baumgartner, Gerhard A Wiesbeck, Undine Lang, Stefan Borgwardt, Marc Walter,

Clinical research has demonstrated the efficacy of injectable opioid treatment for long-term, treatment-refractory opioid-dependent patients. It has been hypothesized that compulsive drug use is particularly associated with neuroplasticity changes in the networks corresponding to withdrawal/negative affect and preoccupation/anticipation rather than binge/intoxication. However, as yet, no study has investigated the effect ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12970]

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Effects of pituitary adenylate cyclase-activating polypeptide isoforms in nucleus accumbens subregions on ethanol drinking.

Andrew T Gargiulo, Breanne E Pirino, Genevieve R Curtis, Jessica R Barson,

While limited research has implicated the neuropeptide, pituitary adenylate cyclase-activating polypeptide (PACAP), in problematic alcohol use, the brain regions and isoforms involved in this effect remain to be determined. One region that has been found both to exhibit PACAP binding and, separately, to be involved in ethanol drinking is the ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12972]

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Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta-analysis with implications for drug development.

Joao P De Aquino, José M Flores, Victor J Avila-Quintero, Peggy Compton, Mehmet Sofuoglu,

The clinical features and neurobiology of pain and opioid use disorder (OUD) are inextricably linked. Despite emerging evidence supporting the negative impact of ongoing pain in the treatment of OUD, the pharmacological management of pain in the presence of OUD has received limited attention. We sought to systematically review the ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12964]

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Sex differences in the acute effects of oral and vaporized cannabis among healthy adults.

Dennis J Sholler, Justin C Strickland, Tory R Spindle, Elise M Weerts, Ryan Vandrey,

Policy changes have increased access to cannabis for individuals with little or no prior exposure. Few studies have examined sex differences in cannabis effects among individuals with sporadic cannabis use or for nonsmoked routes of cannabis administration. Data from four double-blind, placebo-controlled studies were pooled to compare the acute pharmacodynamic ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12968]

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Nalmefene alleviates the neuroimmune response to repeated binge-like ethanol exposure: A TSPO PET imaging study in adolescent rats.

Nicolas Tournier, Géraldine Pottier, Fabien Caillé, Christine Coulon, Maud Goislard, Benoit Jégo, Julia Negroni, Claire Leroy, Wadad Saba,

A large body of preclinical research has shown that neuroimmunity plays a key role in the deleterious effects of alcohol (ethanol) to the brain. Translational imaging techniques are needed to monitor the efficacy of strategies to prevent or mitigate neuroinflammation and alleviate ethanol-induced neurotoxicity. Opioid receptor antagonists such as nalmefene ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12962]

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Compensatory neuroadaptation to binge drinking: Human evidence for allostasis.

Angeles Correas, Pablo Cuesta, Burke Q Rosen, Fernando Maestu, Ksenija Marinkovic,

Animal studies have established that acute alcohol increases neural inhibition and that frequent intoxication episodes elicit neuroadaptive changes in the excitatory/inhibitory neurotransmission balance. To compensate for the depressant effects of alcohol, neural hyperexcitability develops in alcohol use disorder and is manifested through withdrawal symptoms. It is unclear, however, whether neuroadaptive ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12960]

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Glutamatergic input from the insula to the ventral bed nucleus of the stria terminalis controls reward-related behavior.

Kasey S Girven, Sonia Aroni, Jovana Navarrete, Rosa A M Marino, Paige N McKeon, Joseph F Cheer, Dennis R Sparta,

Individuals suffering from substance use disorder often experience relapse events that are attributed to drug craving. Insular cortex (IC) function is implicated in processing drug-predictive cues and is thought to be a critical substrate for drug craving, but the downstream neural circuit effectors of the IC that mediate reward processing ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12961]

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