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Japanese Encephalitis

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Tick-borne encephalitis virus NS4A ubiquitination antagonizes type I interferon-stimulated STAT1/2 signalling pathway.

Qi Yang, Jia You, Yuan Zhou, Yun Wang, Rongjuan Pei, Xinwen Chen, Min Yang, Jizheng Chen,

Tick-borne encephalitis virus (TBEV) accounts for approximately 10,000 annual cases of severe encephalitis in Europe and Asia and causes encephalitis in humans. In this study, we demonstrate TBEV appears to activate the interferon (IFN)-β dependent on RIG-I/MDA5. Both the IFN-β accumulation and the IFN stimulated genes (ISGs) transcription greatly delay. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):714-726]

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Transcriptomic Analysis Suggests the M1 Polarization and Launch of Diverse Programmed Cell Death Pathways in Japanese Encephalitis Virus-Infected Macrophages.

Zhao-Yang Wang, Zi-Da Zhen, Dong-Ying Fan, Pei-Gang Wang, Jing An,

The Japanese encephalitis virus (JEV) is a Culex mosquito-borne flavivirus and is the pathogenic agent of Japanese encephalitis, which is the most important type of viral encephalitis in the world. Macrophages are a type of pivotal innate immunocyte that serve as sentinels and respond quickly to pathogen invasions. However, some ... Read more >>

Viruses (Viruses)
[2020, 12(3):]

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An Autopsy Case of Varicella Zoster Virus Encephalitis with Multiple Brain Lesions.

Tomohiro Suzuki, Syuichi Tetsuka, Tomoko Ogawa, Ritsuo Hashimoto, Shinya Okada, Hiroyuki Kato,

VZV encephalitis in the absence of vasculopathy may rarely occur in association with herpes zoster. We herein report the case of a 67-year-old woman with non-Hodgkin' s lymphoma undergoing chemotherapy who presented with an acute alteration in consciousness. Magnetic resonance imaging of the brain revealed multiple and nonspecific lesions of ... Read more >>

Intern. Med. (Internal medicine (Tokyo, Japan))
[2020, :]

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Study of the association of seventeen single nucleotide polymorphisms and their haplotypes in the TNF-α, IL-2, IL-4 and IL-10 genes with the antibody response to inactivated Japanese encephalitis vaccine.

Yufeng Yao, Xiuwen Xu, Yaheng Li, Xiaona Wang, Huijuan Yang, Jun Chen, Shuyuan Liu, Yan Deng, Zhimei Zhao, Qiongzhou Yin, Mingbo Sun, Li Shi,

To investigate whether the TNF-α, IL-2, IL-4 and IL-10 genes contribute to variations in vaccine-induced immune responses after immunization with the inactivated Japanese encephalitis vaccine (IJEV), a total of 369 individuals who received the IJEV were enrolled. Based on Japanese encephalitis virus (JEV) neutralization antibodies (NAbs), the individuals were divided ... Read more >>

Hum Vaccin Immunother (Human vaccines & immunotherapeutics)
[2020, :1-7]

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A need to raise the bar - A systematic review of temporal trends in diagnostics for Japanese encephalitis virus infection, and perspectives for future research.

Tehmina Bharucha, Freya M Shearer, Manivanh Vongsouvath, Mayfong Mayxay, Xavier de Lamballerie, Paul N Newton, Nicole Zitzmann, Ernest Gould, Audrey Dubot-Pérès,

OBJECTIVE:Japanese encephalitis virus infection (JEV) remains a leading cause of neurological infection in Asia, largely involving individuals living in remote areas with limited access to treatment centres and diagnostic facilities. Laboratory confirmation is fundamental for the justification and implementation of vaccination programmes. We sought to review the literature on historical ... Read more >>

Int. J. Infect. Dis. (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2020, :]

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Parechovirus-A3 encephalitis presenting with focal seizure mimicking herpes simplex virus infection.

Sakiko Arai, Takayuki Yamanaka, Masashi Kasai, Tetsuhiro Fukuyama, Yuta Aizawa, Ko Matsui, Masanori Sato, Hiroko Matsui, Akihiko Saitoh,

BACKGROUND:Febrile neonates and young infants presenting with seizure require immediate evaluation and treatment. Herein we experienced two young infants with parechovirus-A3 (PeV-A3) encephalitis, initially presented with focal seizure suspecting herpes simplex virus (HSV) encephalitis. CASES:We have experienced 2 infantile cases, initially presented with focal seizure. At presentation, HSV encephalitis was ... Read more >>

J. Infect. Chemother. (Journal of Infection and Chemotherapy)
[2020, :]

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Utility of enzyme immunoassays to diagnose subacute sclerosing panencephalitis.

Hajime Maeda, Koichi Hashimoto, Kyohei Miyazaki, Shuto Kanno, Hayato Go, Kazuhide Suyama, Masatoki Sato, Yukihiko Kawasaki, Mitsuaki Hosoya,

BACKGROUND:Subacute sclerosing panencephalitis (SSPE) is a progressive neurologic disorder caused by the measles virus (MV) and is identified by positive MV-specific antibody titers detected mainly by hemagglutination inhibition (HI) tests in the cerebrospinal fluid (CSF). However, an alternative method, the enzyme immunoassay (EIA), has become an increasingly preferred method for ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, :]

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Japanese encephalitis virus and its mechanisms of neuroinvasion.

Justin T Hsieh, Ashley L St John,

PLoS Pathog. (PLoS pathogens)
[2020, 16(4):e1008260]

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Cerebrospinal fluid MOG-antibodies in anti-NMDA receptor encephalitis with leptomeningeal enhancement.

Eiichiro Amano, Akira Machida, Naomi Kanazawa, Takahiro Iizuka,

Neurol. Sci. (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, :]

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Comparative economic analysis of strategies for Japanese encephalitis vaccination of U.S. travelers.

Cristina Carias, Susan L Hills, Emily B Kahn, Bishwa B Adhikari, Marc Fischer, Martin I Meltzer,

BACKGROUND:Japanese encephalitis (JE) virus is the leading vaccine-preventable cause of encephalitis in Asia. For most travelers, JE risk is very low but varies based on several factors, including travel duration, location, and activities. To aid public health officials, health care providers, and travelers evaluate the worth of administering/ receiving pre-travel ... Read more >>

Vaccine (Vaccine)
[2020, 38(17):3351-3357]

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Limbic encephalitis with antibodies to N-methyl-D-aspartate (NMDA)-type glutamate receptor after allogeneic transplantation.

Jun Toda, Tetsuo Maeda, Keigo Akuta, Shinsuke Kusakabe, Tomoaki Ueda, Jiro Fujita, Hirohiko Shibayama, Kenji Oritani, Yukitoshi Takahashi, Yuzuru Kanakura,

Various central nervous system (CNS) complications may occur after allogeneic hematopoietic stem cell transplantation (allo-HSCT), which can result in severe clinical problems. Diagnosis is often difficult, as distinctive clinical symptoms may be absent and different neurological disorders may exhibit similar symptoms. Despite the fact that antibodies responding to brain cell ... Read more >>

Int. J. Hematol. (International journal of hematology)
[2020, :]

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A case series of inactivated Japanese encephalitis virus vaccination associated with positive West Nile virus blood donor screening nucleic acid tests.

Steven J Drews, Kai Makowski, Heidi Wood, Kristina Dimitrova, Matthew T S Yan, Dale Young, Robert Skeate, Michiko Ng, Gordon Hawes, Margaret Fearon, Mark Bigham,

BACKGROUND:West Nile Virus (WNV) is a member of the Japanese Encephalitis (JE) serocomplex within the Flaviviridae family. We report four whole blood donors and one plasma donor with WNV nucleic acid test (NAT)-reactive donations between September 2018 and November 2019, following recent Japanese Encephalitis virus (JEV) vaccination. CASE SERIES:Cases 1 ... Read more >>

Transfusion (Transfusion)
[2020, :]

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Discordant Activity of Kaempferol Towards Dengue Virus and Japanese Encephalitis Virus.

Chit Care, Wannapa Sornjai, Janejira Jaratsittisin, Atitaya Hitakarun, Nitwara Wikan, Kanokporn Triwitayakorn, Duncan R Smith,

Kaempferol, a plant-derived flavonoid, has been reported to have activity against Japanese encephalitis virus (JEV) in BHK-21 cells. To determine the broader utility of this compound, we initially evaluated the activity of kaempferol against JEV and dengue virus (DENV) in HEK293T/17 cells. Results showed no significant antiviral activity against either ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(5):]

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Identification and characterization of long noncoding RNAs and their association with acquisition of blood meal in Culex quinquefasciatus

Azali Azlan, Mardani Abdul Halim, Faisal Mohamad, Ghows Azzam,

Abstract The Southern house mosquito, Culex quinquefasciatus ( Cx. quinquefasciatus ) is an important vector that transmit multiple diseases including West Nile encephalitis, Japanese encephalitis, St. Louis encephalitis and lymphatic filariasis. Long noncoding RNAs (lncRNAs) involve in many biological processes such development, infection, and virus-host interaction. However, there is no ... Read more >>

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Antiviral Activity of Benzavir-2 against Emerging Flaviviruses.

Yong-Dae Gwon, Mårten Strand, Richard Lindqvist, Emma Nilsson, Michael Saleeb, Mikael Elofsson, Anna K Överby, Magnus Evander,

Most flaviviruses are arthropod-borne viruses, transmitted by either ticks or mosquitoes, and cause morbidity and mortality worldwide. They are endemic in many countries and have recently emerged in new regions, such as the Zika virus (ZIKV) in South-and Central America, the West Nile virus (WNV) in North America, and the ... Read more >>

Viruses (Viruses)
[2020, 12(3):]

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Just for Chinese people's stood up-Prof. Fangzhou Gu, father of "sugar pills".

Jun Wu, Dexiang Dong, Ying Li,

Protein Cell (Protein & cell)
[2020, 11(4):231-234]

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[Coverage rate and adverse reactions of National Immunization Program vaccines in children with spinal muscular atrophy: a cross-sectional retrospective cohort study].

Y J Qu, Y L Tian, F Song, J Wang, J L Bai, Y Y Cao, Y W Jin, H Wang, M M Cheng,

Objective: To investigate the coverage rate and the adverse reactions of National Immunization Program vaccines in children with spinal muscular atrophy (SMA). Methods: A cross-sectional retrospective cohort study was carried out from July 2016 to June 2019, 192 children (116 boys and 76 girls) with SMA registered by Capital Institute ... Read more >>

Zhonghua Er Ke Za Zhi (Zhonghua er ke za zhi = Chinese journal of pediatrics)
[2020, 58(4):308-313]

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Neutralizing antibody persistence in pediatric travelers from non-JE-endemic countries following vaccination with IXIARO® Japanese encephalitis vaccine: An uncontrolled, open-label phase 3 follow-up study.

Christian Taucher, Elizabeth D Barnett, Jakob P Cramer, Susanne Eder-Lingelbach, Tomas Jelinek, Vera Kadlecek, Sigrid Kiermayr, Deborah J Mills, Duellyn Pandis, Daniela Reiner, Katrin L Dubischar,

BACKGROUND:In an initial study among children from non-Japanese encephalitis (JE)-endemic countries, seroprotection rates remained high 6 months after completion of the primary series with IXIARO®. METHODS:In this open-label follow-up study, a subset of 23 children who received a 2-dose primary series of IXIARO® in the parent study, were evaluated for ... Read more >>

Travel Med Infect Dis (Travel medicine and infectious disease)
[2020, :101616]

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The burden of Japanese encephalitis, the catch-up vaccination campaign, and health service providers' perceptions in Myanmar: 2012-2017.

Aung Ye Naung Win, Khin Thet Wai, Anthony D Harries, Nang Thu Thu Kyaw, Tin Oo, Wint Phyo Than, Htar Htar Lin, Zaw Lin,

Background:Myanmar is endemic for Japanese encephalitis (JE) and has experienced several outbreaks in recent years. The vector-borne disease control (VBDC) program has collected hospital-based surveillance data since 1974. There is an urgent need to collate, analyze, and interpret the most recent information. The study aimed to describe (i) hospital-based JE ... Read more >>

Trop Med Health (Tropical medicine and health)
[2020, 48:13]

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Comparison of clinical presentation and out-comes of Chikungunya and Dengue virus infections in patients with acute undifferentiated febrile illness from the Sindh region of Pakistan.

Uzma Shahid, Joveria Q Farooqi, Kelli L Barr, S Faisal Mahmood, Bushra Jamil, Kehkashan Imitaz, Zahida Azizullah, Faisal R Malik, Dhani Prakoso, Maureen T Long, Erum Khan,

BACKGROUND:Arboviruses are a cause of acute febrile illness and outbreaks worldwide. Recent outbreaks of Chikungunya virus (CHIKV) in dengue endemic areas have alarmed clinicians as unique clinical features differentiating CHIKV from Dengue virus (DENV) are limited. This has complicated diagnostic efforts especially in resource limited countries where lab testing is ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2020, 14(3):e0008086]

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Vaccination against Japanese encephalitis with IC51: systematic review on immunogenicity, duration of protection and safety.

Kerstin Kling, Thomas Harder, Zane Younger, Gerd Burchard, Jonas Schmidt-Chanasit, Ole Wichmann,

Japanese encephalitis is a disease caused by a flavivirus which is transmitted by mosquitos in endemic countries. Considering the potentially severe outcomes of the disease, vaccination is recommended for those at risk of exposure. During recent years, IC51 (IXIARO®, JESPECT®, JEVAL®) has increasingly been used to protect travellers from Europe ... Read more >>

J Travel Med (Journal of travel medicine)
[2020, 27(2):]

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Natural chemical entities from Arisaema genus might be a promising break-through against Japanese encephalitis virus infection: a molecular docking and dynamics approach.

V Navyashree, Kamal Kant, Anoop Kumar,

Japanese encephalitis virus (JEV) infection affects millions of population worldwide whose incidence is increasing year by year and currently, no specific drugs are available for its treatment. However, vaccines are available for its prevention but not effective against all the clinical isolates. Thus, there is an urgent need for new ... Read more >>

J. Biomol. Struct. Dyn. (Journal of biomolecular structure & dynamics)
[2020, :1-13]

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Biochemical and molecular resistance mechanisms to DDT and some pyrethroid insecticides in vector of West Nile virus, Culex pipiens

Hassan Vatandoost, Yaser Salim-Abadi, Mohammad Oshaghi, Mohamad Abai, Ahmad Enayati, Mohammad Gorouhi,

<title>Abstract</title> <p> Objectives : Culex pipiens complex act as an important vector of several vector-borne diseases such as filariasis, West Nile virus, Japanese encephalitis and bird malaria. This study was designed in order to clarify the molecular and biochemical resistance mechanisms in Cx. pipiens to DDT and some ... Read more >>

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Self-remitting cerebral cortical encephalitis associated with myelin oligodendrocyte glycoprotein antibody mimicking acute viral encephalitis: A case report.

Tai Otani, Takashi Irioka, Susumu Igarashi, Kimihiko Kaneko, Toshiyuki Takahashi, Takanori Yokota,

A 22-year-old woman acutely developed recurrent convulsive seizures followed by fever and headache. Cerebrospinal fluid study showed leukocytosis without hypoglycorrhachia. These clinical features suggested acute viral or aseptic encephalitis. The patient was treated only with an antiviral agent and improved immediately with good prognosis. Afterwards, the characteristic brain MRI findings ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 41:102033]

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The Effects of Japanese Encephalitis Vaccine and Accelerated Dosing Scheduling on the Immunogenicity of the Chimeric Yellow Fever Derived Tetravalent Dengue Vaccine: A Phase II, Randomized, Open-Label, Single-Center Trial in Adults Aged 18 to 45 Years in the United States.

Aaron Glass, Mark Polhemus, Dongliang Wang, Richard G Jarman, Stephen J Thomas, Heather Friberg, Jeffrey R Currier, Matthew Bonaparte, Rafael De La Barra, Michael F Princiotta, Mark Abbott, Brian Cuzzo, Tifany Machabert, Saranya Sridhar, Timothy P Endy,

BACKGROUND:Dengue is a global health problem requiring an effective, safe dengue vaccine. METHODS:We report the results of a phase II, randomized, open-label, single-center trial in adults aged 18 to 45 years in the United States designed to explore the effects of the Chimeric Yellow Fever Derived Tetravalent Dengue Vaccine (CYD-TDV, ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2020, 221(7):1057-1069]

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