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Cost burden of breakthrough hemolysis in patients with paroxysmal nocturnal hemoglobinuria receiving ravulizumab versus eculizumab.

Ioannis Tomazos, J Rafael Sierra, Karissa M Johnston, Antoinette Cheung, Robert A Brodsky, Ilene C Weitz,

Objectives: Although complement inhibition is highly effective, patients with paroxysmal nocturnal hemoglobinuria (PNH) may experience intravascular breakthrough hemolysis (BTH). Underlying causes may include elevated free C5, pregnancy, or non-pregnancy complement-activating conditions (e.g. infections). This study compared BTH-related resource utilization and costs in PNH patients treated with eculizumab versus ravulizumab. Methods: ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2020, 25(1):327-334]

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CRISPR-cas system in the acquisition of virulence genes in dental-root canal and hospital-acquired isolates of Enterococcus faecalis.

Pourya Gholizadeh, Mohammad Aghazadeh, Reza Ghotaslou, Mohammad Ahangarzadeh Rezaee, Tahereh Pirzadeh, Şükran Köse, Khudaverdi Ganbarov, Mehdi Yousefi, Hossein Samadi Kafil,

Enterococcus faecalis is one of the important causative agents of nosocomial and life-threatening infections in human. Several studies have demonstrated that the presence of CRISPR-cas is associated with antibiotic susceptibility and lack of virulence traits. In this study, we aimed to assess the phenotypic and genotypic virulence determinants in relation to CRISPR ... Read more >>

Virulence (Virulence)
[2020, 11(1):1257-1267]

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Rsp promotes the transcription of virulence factors in an agr-independent manner in Staphylococcus aureus.

Banghui Liu, Baolin Sun,

Staphylococcus aureus is a major human pathogen that causes a great diversity of community- and hospital-acquired infections. Rsp, a member of AraC/XylS family of transcriptional regulators (AFTRs), has been reported to play an important role in the regulation of virulence determinants in S. aureus via an agr-dependent pathway. Here we ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):796-812]

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High-mobility Group Box 1 Protein in Pediatric Trauma Patients With Acute Traumatic Coagulopathy or Disseminated Intravascular Coagulation.

Emel Ulusoy, Murat Duman, Aykut Çağlar, Tuncay Küme, Anil Er, Fatma Akgül, Hale Çitlenbik, Durgül Yilmaz, Hale Ören,

OBJECTIVES:Trauma can induce the release of high-mobility group box 1 (HMGB1), which plays an important role in the activation of coagulation. In this study, we aimed to evaluate the role of HMGB1 in the early diagnosis of acute traumatic coagulopathy (ATC), disseminated intravascular coagulation, and clinical course. MATERIALS AND METHODS:One ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2020, 42(8):e712-e717]

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Drug-induced disseminated intravascular coagulation: a pharmacovigilance study on World Health Organization's database.

Giulia Bonaldo, Alberto Vaccheri, Mauro Melis, Domenico Motola,

BACKGROUND:Disseminated intravascular coagulation (DIC) occurs in several clinical conditions, including drug therapy. We aim to investigate the association between the administration of several drug classes and the onset of DIC by using the reports of Adverse Drug Reactions (ADR) collected in Vigibase, the World Health Organization (WHO) database of ADR. ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2020, 50(4):763-771]

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Nafamostat mesylate attenuates the pathophysiologic sequelae of neurovascular ischemia.

George Zaki Ghali, Michael George Zaki Ghali,

Nafamostat mesylate, an apparent soi-disant panacea of sorts, is widely used to anticoagulate patients undergoing hemodialysis or cardiopulmonary bypass, mitigate the inflammatory response in patients diagnosed with acute pancreatitis, and reverse the coagulopathy of patients experiencing the commonly preterminal disseminated intravascular coagulation in the Far East. The serine protease inhibitor ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(12):2217-2234]

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Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia.

Ling Lin, Lianfeng Lu, Wei Cao, Taisheng Li,

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with droplets and contact as the main means of transmission. Since the first case appeared in Wuhan, China, in December 2019, the outbreak has gradually spread nationwide. Up to now, according to official ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):727-732]

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Rare association of consumptive coagulopathy in visceral leishmaniasis: A case report.

Eric de Santana Ferreira, Valter Romão de Souza Júnior, Jefferson Filipe Silva de Oliveira, Manuela Freire Hazin Costa, Maria da Conceição de Barros Correia, Alessandra Ferraz de Sá,

Visceral leishmaniasis is a tropical parasitic disease caused by the species of the genus Leishmania infantum. The clinical picture includes fever, splenomegaly, leucopenia, anaemia and hypergammaglobulinaemia. There may also be a drop in plasma fibrinogen levels or an increase in plasma fibrinolytic activity. Furthermore, visceral leishmaniasis may be the trigger ... Read more >>

Trop Doct (Tropical doctor)
[2020, :49475520967239]

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Vascular injury in acute infections and COVID-19: everything old is new again

Jerrold H. Levy, Toshiaki Iba, Jean M. Connors,

Trends Cardiovasc Med (Trends in cardiovascular medicine)
[2020, :]

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Combinational dual drug delivery system to enhance the care and treatment of gastric cancer patients.

Ying Xiao, Yuewen Gao, Fajuan Li, Zhihe Deng,

Gastric cancer is a frequently occurring cancer with high mortality each year worldwide. Finding new and effective therapeutic strategy against human gastric cancer is still urgently required. Hence, we have established a new method to achieve treatment-actuated modifications in a tumor microenvironment by utilizing synergistic activity between two potential anticancer ... Read more >>

Drug Deliv (Drug delivery)
[2020, 27(1):1491-1500]

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First description of Weissella ceti associated with mortalities in farmed rainbow trout (Oncorhynchus mykiss) in Peru

Marco Medina, Carla Fernandez-Espinel, Giovanna Sotil, Jefferson Yunis-Aguinaga, Violeta Flores-Dominick,

Mortalities of up to 60% farmed rainbow trout (Oncorhynchus mykiss) were recorded in six floating cages farms in the Lake Titicaca during the wet season (December to April) of 2018. Fish presented uni or bilateral exophthalmia, ocular hemorrhages and melanosis. Necropsy showed severe hemorrhage in swim bladder, brain, liver and ... Read more >>

Aquaculture (Aquaculture (Amsterdam, Netherlands))
[2020, 529:Not Available]

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A novel compound heterozygous mutation in DGKE in a Chinese patient causes atypical hemolytic uremic syndrome.

Jitong Li, Yinsen Song, Yaodong Zhang, Hongjiang Li, Ming Tian, Di Li, Shufeng Zhang, Guanghai Cao, Cuihua Liu,

Objectives: DGKE mutations can lead to hemolysis and thrombus in patients with atypical hemolytic uremic syndrome (aHUS). However, the sequence variants of DGKE in Chinese patients with aHUS have not been reported, and the protein function and crystal structure of DGKE remain unresolved.Methods: Targeted exome sequencing was accomplished in one ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2020, 25(1):101-107]

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The utility of a monocyte monolayer assay in the assessment of intravenous immunoglobulin-associated hemolysis.

Tik Nga Tong, Megan Blacquiere, Darinka Sakac, Emeralda Burke-Murphy, Qilong Yi, Jeannie Callum, Christine Cserti-Gazdewich, Nagina Parmar, Nadine Shehata, Katerina Pavenski, Wendy Lau, Yulia Lin, Lani Lieberman, Donald R Branch, Jacob Pendergrast,

BACKGROUND:Hemolysis following the administration of intravenous immunoglobulin (IVIG) is an important adverse event (AE). While the monocyte monolayer assay (MMA) has been used to predict in vivo hemolysis when serologically incompatible blood may be transfused, it has also been shown to correlate with IVIG-associated hemolysis. In this study, the MMA ... Read more >>

Transfusion (Transfusion)
[2020, :]

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Impact of different syringe pumps on red cells during paediatric simulated transfusion.

Larissa Perez Pardo, Maria Angélica Sorgini Peterlini, Lyvonne Nicole Tume, Mavilde Luz Gonçalves Pedreira,

BACKGROUND:Critically ill patients frequently need blood transfusions. For safety, blood must be delivered via syringe infusion pumps, yet this can cause red cell damage and increase the rate of haemolysis. AIMS AND OBJECTIVES:To evaluate biochemical and haemolytic markers of red blood cells transfused in three different types of syringe infusion ... Read more >>

Nurs Crit Care (Nursing in critical care)
[2020, :]

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Exacerbation of Neonatal Hemolysis and Impaired Renal Iron Handling in Heme Oxygenase 1-Deficient Mice.

Aleksandra Bednarz, Paweł Lipiński, Rafał R Starzyński, Mateusz Tomczyk, Izabela Kraszewska, Sylwia Herman, Kacper Kowalski, Ewelina Gruca, Aneta Jończy, Rafał Mazgaj, Mateusz Szudzik, Zenon Rajfur, Zbigniew Baster, Alicja Józkowicz, Małgorzata Lenartowicz,

In most mammals, neonatal intravascular hemolysis is a benign and moderate disorder that usually does not lead to anemia. During the neonatal period, kidneys play a key role in detoxification and recirculation of iron species released from red blood cells (RBC) and filtered out by glomeruli to the primary urine. ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(20):]

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Global Metabolomic and Lipidomic Analysis Reveals the Potential Mechanisms of Hemolysis Effect of Ophiopogonin D and Ophiopogonin D’ in vivo

Xu Huan-Hua, Zhen-Hong Jiang, Cong-Shu Huang, Yu-Ting Sun, Long-Long Xu, Xiang-Ling Tang, Hong-Ling Tan, Zeng-Chun Ma, Yue Gao,

Abstract Background : OPD and OPD' are the two main active components of Ophiopogon japonicas in Shenmai injection (SMI). Being isomers of each other, they are supposed to have similar pharmacological activities, but the actual situation is complicated. The difference of hemolytic behavior between OPD and OPD' in vivo and ... Read more >>

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Global guidelines: An unjustified supporter of the endovascular procedures.

Andreas M Lazaris, Konstantinos Moulakakis, George Geroulakos,

J Vasc Surg (Journal of vascular surgery)
[2020, 72(5):1830-1831]

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Ovine red cell concentrates for transfusion research - is the storage lesion comparable to human red cell concentrates?

Gabriela Simonova, Rebecca Wellburn, Yoke Lin Fung, John F Fraser, John-Paul Tung,

BACKGROUND AND OBJECTIVES:Sheep are increasingly being used as a large in vivo animal model of blood transfusion because they provide several advantages over small animals. Understanding the effects of storage duration on ovine (ov) red cell concentrates (RCCs) and how these changes compare with stored human (hu) RCCs is necessary ... Read more >>

Vox Sang (Vox sanguinis)
[2020, :]

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Prominent coagulation disorder is closely related to inflammatory response and could be as a prognostic indicator for ICU patients with COVID-19.

Yang Liu, Weibo Gao, Wei Guo, Yang Guo, Maojing Shi, Guiying Dong, Qinggang Ge, Jihong Zhu, Jin Lu,

The new outbreak of Coronavirus Disease 2019 (COVID-19) has emerged as a serious global public health concern. A more in-depth study of blood coagulation abnormality is needed. We retrospectively analyzed 147 consecutive patients with COVID-19 who were admitted to three ICUs in Wuhan from February 9th, 2020 to March 20th, ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2020, 50(4):825-832]

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Disseminated intravascular coagulation: new identity as endotheliopathy-associated vascular microthrombotic disease based on in vivo hemostasis and endothelial molecular pathogenesis.

Jae C Chang,

Disseminated intravascular coagulation (DIC) can be correctly redefined as disseminated intravascular microthrombosis based on "two-path unifying theory" of in vivo hemostasis. "DIC" is a form of vascular microthrombotic disease characterized by "microthrombi" composed of platelets and unusually large von Willebrand factor multimers (ULVWF). Microthrombotic disease includes not only "DIC", but ... Read more >>

Thromb J (Thrombosis journal)
[2020, 18:25]

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Evaluation of the prophylaxis and treatment of COVID-associated coagulopathy.

Ali Elbeddini, Rachel Gerochi, Ahmed Elshahawi,

Most of the current "literature" surrounding the presence of thrombosis in COVID-19 disease and appropriate prophylaxis/treatment modalities is certainly retrospective at best, and anecdotal at worst. But in these times of rapidly changing information and perspective, an assessment of all available data (including expert opinion) is the goal of this ... Read more >>

J Pharm Policy Pract (Journal of pharmaceutical policy and practice)
[2020, 13:73]

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Plasmodium falciparum parasites exit the infected erythrocyte after haemolysis with saponin and streptolysin O.

Katharina A Quadt, Xanthoula Smyrnakou, Friedrich Frischknecht, Guido Böse, Markus Ganter,

Malaria is caused by unicellular parasites of the genus Plasmodium, which reside in erythrocytes during the clinically relevant stage of infection. To separate parasite from host cell material, haemolytic agents such as saponin are widely used. Previous electron microscopy studies on saponin-treated parasites reported both, parasites enclosed by the erythrocyte ... Read more >>

Parasitol Res (Parasitology research)
[2020, :]

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Testosterone replacement therapy in blood donors modulates erythrocyte metabolism and susceptibility to hemolysis in cold storage.

Keisha Alexander, Kelsey Hazegh, Fang Fang, Derek Sinchar, Joseph E Kiss, Grier P Page, Angelo DʼAlessandro, Tamir Kanias,

BACKGROUND:Red blood cells (RBCs) derived from patients who receive testosterone replacement therapy (TRT) may be considered eligible for component production and transfusion. The aim of this study was to identify testosterone-dependent changes in RBC metabolism and to evaluate its impact on susceptibility to hemolysis during cold storage. STUDY DESIGN AND ... Read more >>

Transfusion (Transfusion)
[2020, :]

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Case Report: Hemolysis in a G6PD-deficient patient, a dose-dependent effect of metformin

Yusra Irshad, Mahum Nadeem, Usman Khan, Ezza Tariq, Aemen Khakwani,

Glucose-6-phosphate deficiency is an X-linked genetic disorder, which predisposes erythrocytes to oxidative stress, resulting in hemolysis. It is the most common enzymatic deficiency, and typically affects African, Asian, Mediterranean, and Middle Eastern lineages. It can be induced by some medications, chemicals, and foods. Metformin is an uncommon drug to cause ... Read more >>

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Clinical results of transarterial embolization for post-partum hemorrhage in 62 patients.

Yasuyuki Ono, Shuji Kariya, Miyuki Nakatani, Yutaka Ueno, Asami Yoshida, Takuji Maruyama, Atsushi Komemushi, Noboru Tanigawa,

AIM:The pathology of post-partum hemorrhage (PPH) differs depending on its cause, background and timing of bleeding, and the effectiveness of transarterial embolization (TAE) is thought to vary based on these characteristics. The aim of this study is to evaluate the treatment outcomes of TAE for PPH. METHODS:Technical success, initial clinical ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2020, :]

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