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Full Text Journal Articles about
Interstitial Lung Disease Associated With Collagen Vascular Disease

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Etiology, Risk Factors, and Biomarkers in Systemic Sclerosis with Interstitial Lung Disease.

Dinesh Khanna, Donald P Tashkin, Christopher P Denton, Elisabetta A Renzoni, Sujal R Desai, John Varga,

Systemic sclerosis (SSc) is a complex, multiorgan, autoimmune disease. Lung fibrosis occurs in ∼80% of patients with SSc; 25% to 30% develop progressive interstitial lung disease (ILD). The pathogenesis of fibrosis in SSc-associated ILD (SSc-ILD) involves cellular injury, activation/differentiation of mesenchymal cells, and morphological/biological changes in epithelial/endothelial cells. Risk factors ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, 201(6):650-660]

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Prominence of IL6, IGF, TLR, and Bioenergetics Pathway Perturbation in Lung Tissues of Scleroderma Patients With Pulmonary Fibrosis.

Ludivine Renaud, Willian A da Silveira, Naoko Takamura, Gary Hardiman, Carol Feghali-Bostwick,

Scleroderma-associated pulmonary fibrosis (SSc-PF) and idiopathic pulmonary fibrosis (IPF) are two of many chronic fibroproliferative diseases that are responsible for nearly 45% of all deaths in developed countries. While sharing several pathobiological characteristics, they also have very distinct features. Currently no effective anti-fibrotic treatments exist that can halt the progression ... Read more >>

Front Immunol (Frontiers in Immunology)
[2020, 11:383]

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Genome-Wide Association Studies in Idiopathic Pulmonary Fibrosis: Bridging the Gap between Sequence and Consequence.

Paolo Spagnolo, Jonathan A Kropski,

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, 201(5):508-509]

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Adjunctive corticosteroids may be associated with better outcome for non-HIV Pneumocystis pneumonia with respiratory failure: a systemic review and meta-analysis of observational studies.

Lin Ding, Huixue Huang, Heyan Wang, Hangyong He,

BACKGROUND:Evidence supporting corticosteroids adjunctive treatment (CAT) for Pneumocystis jirovecii pneumonia (PCP) in non-HIV patients is highly controversial. We aimed to systematically review the literature and perform a meta-analysis of available data relating to the effect of CAT on mortality of PCP in non-HIV patients. METHODS:We searched Pubmed, Medline, Embase, and ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2020, 10(1):34]

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The Association Between MUC5B Mutations and Clinical Outcome in Patients with Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Retrospective Exploratory Study in China.

Na Wang, Qian Zhang, Xiaoyan Jing, Jian Guo, Hui Huang, Zuojun Xu,

BACKGROUND Patients with rheumatoid arthritis (RA) who develop interstitial lung disease (RA-ILD), show features of usual interstitial pneumonia (UIP) on high-resolution computed tomography (HRCT). This retrospective exploratory clinical study aimed to investigate the association between mutations in the MUC5B gene and clinical outcome in patients with RA, with or without ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e920137]

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Endothelial-specific Loss of IFT88 Promotes Endothelial-to-Mesenchymal Transition and Exacerbates Bleomycin-induced Pulmonary Fibrosis.

Shweta Singh, Mohamed Adam, Pratiek N Matkar, Antoinette Bugyei-Twum, Jean-Francois Desjardins, Hao H Chen, Hien Nguyen, Hannah Bazinet, David Michels, Zongyi Liu, Elizabeth Mebrahtu, Lillian Esene, Jameela Joseph, Mehroz Ehsan, Mohammad Qadura, Kim A Connelly, Howard Leong-Poi, Krishna K Singh,

Intraflagellar transport protein 88 (Ift88) is required for ciliogenesis and shear stress-induced dissolution of cilia in embryonic endothelial cells coincides with endothelial-to-mesenchymal transition (EndMT) in the developing heart. EndMT is also suggested to underlie heart and lung fibrosis, however, the mechanism linking endothelial Ift88, its effect on EndMT and organ ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):4466]

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Mitochondria dysfunction and metabolic reprogramming as drivers of idiopathic pulmonary fibrosis.

Marta Bueno, Jazmin Calyeca, Mauricio Rojas, Ana L Mora,

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown etiology. It is characterized by deposition of extracellular matrix proteins, like collagen and fibronectin in the lung interstitium leading to respiratory failure. Our understanding of the pathobiology underlying IPF is still incomplete; however, it is accepted that aging is ... Read more >>

Redox Biol (Redox biology)
[2020, :101509]

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Successful Use of Hyperbaric Oxygen as Adjunctive Therapy for a Nonhealing Venous Ulcer in a Patient with Systemic Sclerosis and Pulmonary Arterial Hypertension: A Case Report and Review of the Literature.

Isaac Biney, Tina Dudney, Mitchell Goldman, Lee Carder, Elise Schriver,

Skin ulcers are a common complication of systemic sclerosis (SSc) that can significantly impact the quality of life. There have been recent reports on the use of hyperbaric oxygen therapy (HBO2T) in the management of nonhealing systemic sclerosis skin ulcers. The effect of HBO2T on pulmonary arterial hypertension (PAH), another ... Read more >>

Case Rep Pulmonol (Case reports in pulmonology)
[2020, 2020:4750375]

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Thrombospondin-1 mediates muscle damage in brachio-cervical inflammatory myopathy and systemic sclerosis.

Xavier Suárez-Calvet, Jorge Alonso-Pérez, Ivan Castellví, Ana Carrasco-Rozas, Esther Fernández-Simón, Carlos Zamora, Laura Martínez-Martínez, Alicia Alonso-Jiménez, Ricardo Rojas-García, Joana Turón, Luis Querol, Noemi de Luna, Ana Milena-Millan, Héctor Corominas, Diego Castillo, Elena Cortés-Vicente, Isabel Illa, Eduard Gallardo, Jordi Díaz-Manera,

OBJECTIVE:To describe the clinical, serologic and histologic features of a cohort of patients with brachio-cervical inflammatory myopathy (BCIM) associated with systemic sclerosis (SSc) and unravel disease-specific pathophysiologic mechanisms occurring in these patients. METHODS:We reviewed clinical, immunologic, muscle MRI, nailfold videocapillaroscopy, muscle biopsy, and response to treatment data from 8 patients ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(3):]

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Semaphorins in Angiogenesis and Autoimmune Diseases: Therapeutic Targets?

Vijaya Iragavarapu-Charyulu, Ewa Wojcikiewicz, Alexandra Urdaneta,

The axonal guidance molecules, semaphorins, have been described to function both physiologically and pathologically outside of the nervous system. In this review, we focus on the vertebrate semaphorins found in classes 3 through 7 and their roles in vascular development and autoimmune diseases. Recent studies indicate that while some of ... Read more >>

Front Immunol (Frontiers in Immunology)
[2020, 11:346]

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CD151 in Respiratory Diseases.

Amanda H Wong, Thai Tran,

The tetraspanin, Cluster of Differentiation 151 (CD151), is ubiquitously expressed in adult tissue, especially in the lungs where it has been implicated in lung cancer, asthma, influenza, and idiopathic pulmonary fibrosis (IPF). CD151 interacts with laminin-binding integrins and growth factor receptors, and is reported in cancer-promoting processes such as tumor ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2020, 8:64]

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Genetic Interactions Affect Lung Function in Patients with Systemic Sclerosis.

Anna Tyler, J Matthew Mahoney, Gregory W Carter,

Scleroderma, or systemic sclerosis (SSc), is an autoimmune disease characterized by progressive fibrosis of the skin and internal organs. The most common cause of death in people with SSc is lung disease, but the pathogenesis of lung disease in SSc is insufficiently understood to devise specific treatment strategies. Developing targeted ... Read more >>

G3 (Bethesda) (G3 (Bethesda, Md.))
[2020, 10(1):151-163]

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The Role of the Anti-Inflammatory Cytokine Interleukin-10 in Tissue Fibrosis.

Emily H Steen, Xinyi Wang, Swathi Balaji, Manish J Butte, Paul L Bollyky, Sundeep G Keswani,

Significance: Fibrosis is the endpoint of chronic disease in multiple organs, including the skin, heart, lungs, intestine, liver, and kidneys. Pathologic accumulation of fibrotic tissue results in a loss of structural integrity and function, with resultant increases in morbidity and mortality. Understanding the pathways governing fibrosis and identifying therapeutic targets ... Read more >>

Adv Wound Care (New Rochelle) (Advances in wound care)
[2020, 9(4):184-198]

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Desquamative interstitial pneumonia in a non-smoker with neurofibromatosis type 1 (Von Recklinghausen syndrome).

Gustavo Ferrer, Alwiya Omar Saleh, Henry D Tazelaar, Andrea V Arrossi,

Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with multiple systemic manifestations. Pulmonary involvement has been reported in the form of interstitial fibrosis, emphysema, pulmonary hypertension and thoracic neoplasm. We report a case of desquamative interstitial pneumonia in a non-smoker with NF1. ... Read more >>

BMJ Case Rep (BMJ case reports)
[2020, 13(1):]

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Current Pharmacological Approach to ARDS: The Place of Bosentan.

Omer Araz,

Acute respiratory distress syndrome is characterized by dyspnea at presentation, tachypnea on physical examination, findings of bilateral infiltration in chest radiography, refractory hypoxia, and high mortality. Although the main treatment approach is to address the underlying disease, there are also pharmacological and nonpharmacological options for supportive treatment. There is currently ... Read more >>

Eurasian J Med (The Eurasian journal of medicine)
[2020, 52(1):81-85]

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Regulation of Macrophage and Dendritic Cell Function by Chondroitin Sulfate in Innate to Antigen-Specific Adaptive Immunity.

Sonoko Hatano, Hideto Watanabe,

Chondroitin sulfate (CS), a type of glycosaminoglycan (GAG), is a linear acidic polysaccharide comprised of repeating disaccharides, modified with sulfate groups at various positions. Except for hyaluronan (HA), GAGs are covalently bound to core proteins, forming proteoglycans (PGs). With highly negative charges, GAGs interact with a variety of physiologically active ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:232]

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Autoimmunity in Acute Myocarditis: How Immunopathogenesis Steers New Directions for Diagnosis and Treatment.

Karina Bruestle, Klaus Hackner, Gudrun Kreye, Bettina Heidecker,

PURPOSE OF REVIEW:Over the last decade, myocarditis has been increasingly recognized as common cause of sudden cardiac death in young adults and heart failure overall. The purpose of this review is to discuss hypothesis of development of non-infectious myocarditis, to provide a description of the immunopathogenesis and the most common ... Read more >>

Curr Cardiol Rep (Current cardiology reports)
[2020, 22(5):28]

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Natural Autoantibodies in Chronic Pulmonary Diseases.

Kiyoharu Fukushima, Kazuyuki Tsujino, Shinji Futami, Hiroshi Kida,

In autoantibody-mediated autoimmune diseases, pathogenic autoantibodies generated by a failure of central or peripheral tolerance, have different effects mediated by a variety of mechanisms. Interestingly, even non-autoimmune chronic diseases have a set of disease-specific natural autoantibodies that are maintained for a long time. Because most of these natural autoantibodies target ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(3):]

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Surfactant protein A as a biomarker of outcomes of anti-fibrotic drug therapy in patients with idiopathic pulmonary fibrosis.

Takumi Yoshikawa, Mitsuo Otsuka, Hirofumi Chiba, Kimiyuki Ikeda, Yuki Mori, Yasuaki Umeda, Hirotaka Nishikiori, Koji Kuronuma, Hiroki Takahashi,

BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a progressive and fibrosing lung disease with poor prognosis. Pirfenidone and nintedanib are anti-fibrotic drugs used for patients with IPF. These drugs reduce the rate of decline in forced vital capacity (FVC). Serum surfactant protein (SP)-A, SP-D, and Krebs von den Lungen-6 (KL-6) are monitoring ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20(1):27]

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IL-20 in Acute Kidney Injury: Role in Pathogenesis and Potential as a Therapeutic Target.

Tian-Yu Lin, Yu-Hsiang Hsu,

Acute kidney injury (AKI) causes over 1 million deaths worldwide every year. AKI is now recognized as a major risk factor in the development and progression of chronic kidney disease (CKD). Diabetes is the main cause of CKD as well. Renal fibrosis and inflammation are hallmarks in kidney diseases. Various ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(3):]

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The uses of overnight pulse oximetry.

Shruti Singh, Sara Z Khan, Dilbagh Singh, Sameer Verma, Arunabh Talwar,

Overnight pulse oximetry (OPO) has proven to be an effective and beneficial technique to determine the cardiorespiratory status of patients in both the inpatient and outpatient settings. It is a cheap, safe, reliable, simple, and accurate method of patient monitoring as compared to the expensive and labor-intensive method of multichannel ... Read more >>

Lung India (Lung India : official organ of Indian Chest Society)
[2020, 37(2):151-157]

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The autocrine CXCR4/CXCL12 axis contributes to lung fibrosis through modulation of lung fibroblast activity.

Fei Li, Xuefeng Xu, Jing Geng, Xuan Wan, Huaping Dai,

The C-X-C Motif Chemokine Receptor 4/C-X-C Motif Chemokine Ligand 12 (CXCR4/CXCL12) axis has been implicated in the pathogenesis of pulmonary fibrosis. However, the mechanisms governing this remain to be determined. The current study demonstrated that human lung fibroblasts (HLFs) exhibit high CXCL12 expression and also exhibit high expression of its ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2020, 19(3):1844-1854]

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Platelet activation in experimental murine neonatal pulmonary hypertension.

Pavel Davizon-Castillo, Ayed Allawzi, Matthew Sorrells, Susan Fisher, Kristina Baltrunaite, Keith Neeves, Eva Nozik-Grayck, Jorge DiPaola, Cassidy Delaney,

Serotonin (5-HT) contributes to the pathogenesis of experimental neonatal pulmonary hypertension (PH) associated with bronchopulmonary dysplasia (BPD). Platelets are the primary source of circulating 5-HT and is released upon platelet activation. Platelet transfusions are associated with neonatal mortality and increased rates of BPD. As BPD is often complicated by PH, ... Read more >>

Physiol Rep (Physiological Reports)
[2020, 8(5):e14386]

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Upregulation of Potassium Voltage-Gated Channel Subfamily J Member 2 Levels in the Lungs of Patients with Idiopathic Pulmonary Fibrosis.

Jong-Uk Lee, Hun Soo Chang, Chang An Jung, Ryun Hee Kim, Choon-Sik Park, Jong-Sook Park,

Background:Fibroblast dysfunction is the main pathogenic mechanism underpinning idiopathic pulmonary fibrosis (IPF). Potassium voltage-gated channel subfamily J member 2 (KCNJ2) plays critical roles in the proliferation of myofibroblasts and in the development of cardiac fibrosis. Objectives:This study aimed to evaluate the role of KCNJ2 in IPF. Methods:KCNJ2 mRNA expression was ... Read more >>

Can. Respir. J. (Canadian respiratory journal)
[2020, 2020:3406530]

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Buyang Huanwu Tang inhibits cellular epithelial-to-mesenchymal transition by inhibiting TGF-β1 activation of PI3K/Akt signaling pathway in pulmonary fibrosis model in vitro.

Zi-Fei Yin, Yang-Lin Wei, Xuan Wang, Li-Na Wang, Xia Li,

BACKGROUND:Pulmonary fibrosis (PF) is a chronic and progressive interstitial lung disease. Buyang Huanwu Tang (BYHWT), a classical traditional Chinese medicine formula, has been widely utilized for the treatment of PF in China. This present study aimed to explore the mechanism of BYHWT in the treatment of PF in vitro. METHODS:TGF-β1 ... Read more >>

BMC Complement Med Ther (BMC complementary medicine and therapies)
[2020, 20(1):13]

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