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The role of cellular prion protein in lipid metabolism in the liver.

Amandeep Singh Arora, Saima Zafar, Umair Latif, Franc Llorens, Mihm Sabine, Prateek Kumar, Waqas Tahir, Katrin Thüne, Mohsin Shafiq, Matthias Schmitz, Inga Zerr,

Cellular prion protein (PrPC) is a plasma membrane glycophosphatidylinositol-anchored protein and it is involved in multiple functions, including neuroprotection and oxidative stress. So far, most of the PrPC functional research is done in neuronal tissue or cell lines; the role of PrPC in non-neuronal tissues such as liver is only ... Read more >>

Prion (Prion)
[2020, 14(1):95-108]

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Discovery of a multipotent chaperone, 1-(2,6-Difluorobenzylamino)-3-(1,2,3,4-tetrahydrocarbazol-9-yl)-propan-2-ol with the inhibitory effects on the proliferation of prion, cancer as well as influenza virus.

Satoshi Yamashita, Ryo Honda, Mayuko Fukuoka, Tsutomu Kimura, Junji Hosokawa-Muto, Kazuo Kuwata,

We previously discovered three carbazole derivatives, GJP14 (1-piperidinylmethyl-2-(1-oxo-6-methyl-1,2,3,4-tetrahydrocarbazol-9-yl)-ethan-1-ol) with anti-prion activity, GJC29 (benzylamino-3-(1,2,3,4-tetrahydrocarbazol-9-yl)-propan-2-ol) with anti-cancer activity, and THC19 (1-piperidinylmethyl-2-(1,2,3,4-tetrahydrocarnazol-9-yl)-ethan-1-ol) with anti-influenza virus activity. During optimization of GJP14 for the anti-prion activity, we discovered a compound, 1-(2,6-difluorobenzylamino)-3-(1,2,3,4-tetrahydrocarbazol-9-yl)-propan-2-ol, termed 5Y, had the most strong anti-prion activity among a series of newly synthesized ... Read more >>

Prion (Prion)
[2020, 14(1):42-46]

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The cellular prion protein promotes neuronal regeneration after acute nasotoxic injury.

Lindsay E Parrie, Jenna A E Crowell, Julie A Moreno, Stephanie S Suinn, Glenn C Telling, Richard A Bessen,

Adult neurogenesis, analogous to early development, is comprised of several, often concomitant, processes including proliferation, differentiation, and formation of synaptic connections. However, due to continual, asynchronous turn-over, newly-born adult olfactory sensory neurons (OSNs) must integrate into existing circuitry. Additionally, OSNs express high levels of cellular prion protein (PrPC), particularly in ... Read more >>

Prion (Prion)
[2020, 14(1):31-41]

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Cloning and analysis of PRNP gene of Vulpes corsac in Qinghai plateau, China.

Xue-Hua Yang, Kang Xiao, Yuezhang Wu, Liping Gao, Dongdong Chen, Xiao-Ping Dong, Qi Shi,

PRNP gene encodes PrP protein, which is conservative among different species and associates with the susceptibility of prion disease. In this report, we cloned and sequenced the full-length PRNP gene of Vulpes corsac in Qinghai plateau, China. The amino acid sequence of Vulpes corsac PrP showed 100% homology with those ... Read more >>

Prion (Prion)
[2020, 14(1):20-23]

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RT-QuIC-based detection of alpha-synuclein seeding activity in brains of dementia with Lewy Body patients and of a transgenic mouse model of synucleinopathy.

Jung-Youn Han, Hyung-Sup Jang, Alison J E Green, Young Pyo Choi,

RT-QuIC is a shaking-based cyclic amplification technique originally developed in the prion field to detect minute amounts of scrapie prion protein (PrPSc). In this study, we applied the RT-QuIC assay to investigate a-synuclein (a-syn) seeding activity in brains of Dementia with Lewy Body (DLB) patients and in brains of G2-3 ... Read more >>

Prion (Prion)
[2020, 14(1):88-94]

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Chronic wasting disease associated with prion protein gene (PRNP) variation in Norwegian wild reindeer (Rangifer tarandus).

Mariella E Güere, Jørn Våge, Helene Tharaldsen, Sylvie L Benestad, Turid Vikøren, Knut Madslien, Petter Hopp, Christer M Rolandsen, Knut H Røed, Michael A Tranulis,

The emergence of CWD in Europe in 2016 and the first natural infection in wild reindeer warranted disease management. This led to the testing of 2424 hunted or culled reindeer during 2016-2018, from the infected subpopulation in the Nordfjella mountain range in Southern Norway. To identify any association between PRNP ... Read more >>

Prion (Prion)
[2020, 14(1):1-10]

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An enigmatic case of cortical anopsia: Antemortem diagnosis of a 14-3-3 negative Heidenhain-variant MM1-sCJD.

Julius Obergassel, Lisa Lohmann, Sven G Meuth, Heinz Wiendl, Oliver Grauer, Christopher Nelke,

Sporadic Creutzfeldt-Jakob disease is the predominant type of human prion disease. While routine diagnostic in phenotypic cases has advanced considerably, the clinical heterogeneity and rarity of subtypes continue to constitute a major clinical and diagnostic challenge. Here, we report a peculiar case of the Heidenhain-variant of MM1 sporadic Creutzfeldt-Jakob disease ... Read more >>

Prion (Prion)
[2020, 14(1):24-28]

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Causal relationships between substance use and insomnia

Joelle Pasman, Dirk J.A. Smit, Lilian Kingma, Jacqueline Vink, Jorien Treur, Karin J.H. Verweij,

Background: Poor sleep quality and insomnia have been associated with the use of tobacco, alcohol, and cannabis, but it is unclear if there is a causal link. In this Mendelian Randomization (MR) study we examine if insomnia causes substance use and/or if substance use causes insomnia. Methods: MR uses summary ... Read more >>

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iTRAQ based proteomics analysis on insomnia rats treated with Mongolian medical warm acupuncture.

Yanan Xu, Xian Li, Duriwa Man, Xiulan Su, Gula A,

Objective To explore the proteomic changes in the hypothalamus of rats treated with Mongolian medical warm acupuncture for insomnia therapy based proteomics. Method We used an iTRAQ-based quantitative proteomic approach to identify proteins that potential molecular mechanisms involved in the treatment of insomnia by Mongolian medical warm acupuncture. Result In ... Read more >>

Biosci. Rep. (Bioscience reports)
[2020, :]

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The Relationship Between Military Occupation and Diagnosed Insomnia Following Combat Deployment.

Andrew J MacGregor, Rachel R Markwald, Amber L Dougherty, Gilbert Seda,

STUDY OBJECTIVES:Our objective was to investigate the relationship between military occupation and diagnosed insomnia following combat deployment. METHODS:This retrospective cohort study was conducted using existing electronic military databases. Eligible participants were military personnel with a deployment to Iraq, Afghanistan, or Kuwait between 2005 and 2009. A total of 66,869 US ... Read more >>

J Clin Sleep Med (Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine)
[2020, :]

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Clinical Correlates of Insomnia in Patients with Persistent Post-Traumatic Headache Compared with Migraine

Todd Schwedt, Soo-Kyoung Kim, Catherine Chong, Gina Dumkrieger, Katherine Ross, Visar Berisha,

<title>Abstract</title> <p> Background Close associations between insomnia with other clinical factors have been identified in migraine, but there have been few studies investigating associations between insomnia and clinical factors in patients with persistent post-traumatic headache (PPTH). The study objective was to contrast the severity of insomnia symptoms in ... Read more >>

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The Impact of Maternal Symptoms of Perinatal Insomnia on Social-emotional Child Development: A Population-based, 2-year Follow-up Study.

Ida Adler, Kerstin Weidner, Malin Eberhard-Gran, Susan Garthus-Niegel,

Background: Poor sleep quality is a common problem in pregnant women, however there is scarce research evidence regarding the association between maternal perinatal insomnia and later social-emotional child development. Participants: This study is part of the Akershus Birth Cohort, a longitudinal population-based study. Birth record and questionnaire data of 1,346 ... Read more >>

Behav Sleep Med (Behavioral sleep medicine)
[2020, :1-15]

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[Cognitive-behavioural group therapy for insomnia: evaluation of the results after its implementation in a health department].

M de Entrambasaguas, M Aiko-Gesler, E Luciano, E M Domínguez-Cabañero, B Terrés, S Diego-Castaño, C González-Vivas, B García-Parreño, E Lorente-Rovira, B Herraiz, R Victorio, P Cases-Bergón,

INTRODUCTION:Cognitive-behavioural therapy (CBT) is the preferred treatment in cases of chronic insomnia disorder in adults. PATIENTS AND METHODS:Open pragmatic study of 32 patients after eight sessions of group CBT for insomnia. RESULTS:Remission (insomnia severity index: 0-7 points) and response (insomnia severity index drops to > 8) were 31.3% and 46.9% ... Read more >>

Rev Neurol (Revista de neurologia)
[2020, 70(7):246-250]

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Music to improve sleep quality in adults with depression-related insomnia (MUSTAFI): study protocol for a randomized controlled trial.

Helle Nystrup Lund, Inge Nygaard Pedersen, Søren Paaske Johnsen, Agnieszka M Heymann-Szlachcinska, Maryla Tuszewska, Gustav Bizik, Jens Ivar Larsen, Eszter Kulhay, Anelia Larsen, Bettina Grønbech, Helle Østermark, Heidi Borup, Jan Brink Valentin, Jan Mainz,

BACKGROUND:Insomnia is a common sleep disorder for adults with depression, with major impact on their quality of life. Previous trials suggest that listening to music may be helpful in the treatment of sleep disturbances in healthy populations, including students and elderly. In addition, small studies with clinical populations of traumatized ... Read more >>

Trials (Trials)
[2020, 21(1):305]

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The role of insomnia in the association between posttraumatic stress disorder and hypertension.

Allison E Gaffey, Nancy S Redeker, Lindsey Rosman, Janet M Mullington, Cynthia A Brandt, Sally G Haskell, Matthew M Burg,

OBJECTIVE:Posttraumatic stress disorder (PTSD) is associated with incident hypertension. Although this relationship is poorly understood, PTSD is also associated with insomnia symptoms, which increases the risk for hypertension. Whether insomnia contributes to PTSD-associated risk for hypertension is unknown. METHODS:We examined self-report survey and electronic health record data from 1109 participants ... Read more >>

J. Hypertens. (Journal of hypertension)
[2020, 38(4):641-648]

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Mid-Pregnancy Insomnia and its Association with Perinatal Depressive Symptoms: A Prospective Cohort Study.

Rannveig S Osnes, Malin Eberhard-Gran, Turid Follestad, Håvard Kallestad, Gunnar Morken, John Olav Roaldset,

Objective/Background: Insomnia and depression are disorders that affect many perinatal women and that often are interrelated. The present study aimed to examine concurrent and prospective associations between mid-pregnancy insomnia and depression during mid-pregnancy and 8 weeks postpartum. Furthermore, differences in depression and in the sleep-related characteristics insomnia, chronotype, and sleep efficiency ... Read more >>

Behav Sleep Med (Behavioral sleep medicine)
[2020, :1-18]

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The Prevalence of Insomnia Subtypes in Relation to Demographic Characteristics, Anxiety, Depression, Alcohol Consumption and Use of Hypnotics.

Ingrid Bjorøy, Vilde Aanesland Jørgensen, Ståle Pallesen, Bjørn Bjorvatn,

Objective:The aim of the present study was to examine the prevalence of insomnia subtypes in relation to several demographic characteristics, as well as to investigate the prevalence of possible anxiety and depression, alcohol consumption and use of hypnotics within the different insomnia subtypes. Methods:The present study was based on an ... Read more >>

Front Psychol (Frontiers in Psychology)
[2020, 11:527]

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Efficacy of a Theory-Based Cognitive Behavioral Technique App-Based Intervention for Patients With Insomnia: Randomized Controlled Trial.

Nilofar Rajabi Majd, Anders Broström, Martin Ulander, Chung-Ying Lin, Mark D Griffiths, Vida Imani, Daniel Kwasi Ahorsu, Maurice M Ohayon, Amir H Pakpour,

BACKGROUND:Sleep hygiene is important for maintaining good sleep and reducing insomnia. OBJECTIVE:This study examined the long-term efficacy of a theory-based app (including cognitive behavioral therapy [CBT], theory of planned behavior [TPB], health action process approach [HAPA], and control theory [CT]) on sleep hygiene among insomnia patients. METHODS:The study was a ... Read more >>

J. Med. Internet Res. (Journal of medical Internet research)
[2020, 22(4):e15841]

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Efficacy and Safety of Electro-Acupuncture (EA) on Insomnia in Patients with Lung Cancer: Study Protocol of a Randomized Controlled Trial

Shifen Xu, Hongyu Yue, Shuang Zhou, Huangan Wu, Xuan Yin, Shanshan Li, Tingting Liang, Yan Li, Zhihong Fang, Xufeng Zhang, Linglin Wang, Min Han, Xiaolei Chen, Ming Zhang, Wei Zhang, Zhangjin Zhang,

<title>Abstract</title> <p> Background : Cancer-related insomnia (CRI) is one of the most prevalent complaints among cancer survivors and severely impairs patients’ quality of life. As a popular non-pharmacological alternative treatment, acupuncture provides a good clinical curative effect on insomnia. The aim of this trial is to evaluate efficacy ... Read more >>

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Sedative and Hypnotic Effects and Transcriptome Analysis of Polygala tenuifolia in Aged Insomnia Rats.

Xiao-Juan Ren, Guan-Ying Wang, Xing-Ping Zhang, Qing-Quan Wang, Zhi-Peng Peng,

OBJECTIVE:To study the sedative and hypnotic effects and underlying mechanisms of Polygala tenuifolia (PT) on treating aged insomnia rats. METHODS:Sixty Sprague-Dawley male rats were divided into 6 groups by a random number table, including control group, model group, diazepam group (0.92 mg/kg), as well as PT low-, medium- and high-dose ... Read more >>

Chin J Integr Med (Chinese journal of integrative medicine)
[2020, :]

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A feasibility study of a mobile app to treat insomnia.

Melissa Aji, Nick Glozier, Delwyn Bartlett, Dorian Peters, Rafael A Calvo, Yizhong Zheng, Ronald Grunstein, Christopher Gordon,

Insomnia is a major public health concern. Sleep restriction therapy (SRT) is an effective behavioral treatment but its delivery is impeded by a shortage of trained clinicians. We developed a mobile app delivering SRT to individuals with insomnia. This feasibility study employed a mixed-methods design to examine the engagement, acceptability, ... Read more >>

Transl Behav Med (Translational behavioral medicine)
[2020, :]

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Jiao-tai-wan for insomnia symptoms caused by the disharmony of the heart and kidney: a study protocol for a randomized, double-blind, placebo-controlled trial

Zhengzhong Yuan, Congcong Zeng, Xi Liu, Lufeng Hu, Yuan Feng, Nengzhi Xia, Haihuan Zeng, Lin Luo, Ren Ye,

<title>Abstract</title> <p> Background: Insomnia seriously affects people’s normal lives and work. However, effective treatment strategies are scarce. The purpose of this study is to explore the efficacy and safety of Jiao-tai-wan (JTW) for ameliorating insomnia symptoms caused by disharmony of the heart and kidney. Design: This is a ... Read more >>

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Insomnia and caregiver burden in chronic pain patients: A cross-sectional clinical study.

Masahiro Yamaguchi, Keiko Yamada, Masako Iseki, Yusuke Karasawa, Yasuko Murakami, Tatsuya Enomoto, Nobuko Kikuchi, Satoko Chiba, Atsuko Hara, Keisuke Yamaguchi, Eiichi Inada,

Insomnia is a major comorbid symptom of chronic pain and is likely to affect caregiver burden. This cross-sectional study investigated the association between insomnia in chronic pain patients and family caregiver burden. Participants were 60 patients with chronic pain of ≥3 months duration. Demographic and clinical information were collected using ... Read more >>

PLoS ONE (PloS one)
[2020, 15(4):e0230933]

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A Study on the Mechanism of Lavender in the treatment of Insomnia based on Network Pharmacology.

Yao Wang, Junbo Zou, Yanzhuo Jia, Yulin Liang, Xiaofei Zhang, ChangLi Wang, Xiao Wang, Dongyan Guo, Yajun Shi, Ming Yang,

AIM AND OBJECTIVE:The common disease of insomnia has complex and diverse clinical manifestations. Lavender represents an effective treatment of insomnia, but the molecular mechanism underlying the effectiveness of this treatment is not clear. The purpose of this study is to investigate the active components, target proteins and molecular pathways of ... Read more >>

Comb. Chem. High Throughput Screen. (Combinatorial chemistry & high throughput screening)
[2020, :]

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Tardive dystonia improved with discontinuation of trazodone in an elderly schizophrenia patient: a case report.

Yoshinori Kadota, Hikaru Hori, Michiko Takayama, Chikako Okabe, Naotoshi Ohara,

BackgroundTardive dystonia associated with antidepressant use is rare and often under-recognized. We had an experience with trazodone, which is used for delirium and insomnia prescribed in general hospital, inducing tardive dystonia.Case presentationA 61-year-old Japanese woman had been treated for schizophrenia. She was moved to general hospital because of consciousness disturbance. ... Read more >>

Ann Gen Psychiatry (Annals of General Psychiatry)
[2020, 19:]

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