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Annotating Putative D. discoideum Proteins Using I-TASSER.

Jacquelyn McCullough, Petra Fey, Ryan J Rahman, Morgan Wallace, Seeta Morey, Kyle Sahlberg, Ethan McGonagle, Danielle Hess, Chance Hatfield, Michaela-Romina Sarmiento, Jordi Velasquez, Richard H Gomer,

Using Gene Ontology annotation in any aspect or using any evidence code, we found that approximately 14% percent of predicted <i>D. discoideum</i> proteins have no GO annotations and no obvious similarity to any annotated protein across diverse organisms. We have been systematically examining these unannotated protein sequences using software that ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Cross-protective immunity of the haemagglutinin stalk domain presented on the surface of Lactococcus lactis against divergent influenza viruses in mice.

Han Lei, Tong Gao, Qianhong Cen,

Most of the current approaches to influenza vaccine design focus on antibodies against influenza (HA). However, these influenza vaccines typically provide strain-specific protection against mostly homologous subtypes. There is an urgent need to develop a universal vaccine that confers cross-protection against influenza viruses. Of note, the HA stalk domain (HAsd) ... Read more >>

Virulence (Virulence)
[2021, 12(1):12-19]

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Mink is a highly susceptible host species to circulating human and avian influenza viruses.

Honglei Sun, Fangtao Li, Qingzhi Liu, Jianyong Du, Litao Liu, Haoran Sun, Chong Li, Jiyu Liu, Xin Zhang, Jizhe Yang, Yuhong Duan, Yuhai Bi, Juan Pu, Yipeng Sun, Qi Tong, Yongqiang Wang, Xiangjun Du, Yuelong Shu, Kin-Chow Chang, Jinhua Liu,

Pandemic influenza, typically caused by the reassortment of human and avian influenza viruses, can result in severe or fatal infections in humans. Timely identification of potential pandemic viruses must be a priority in influenza virus surveillance. However, the range of host species responsible for the generation of novel pandemic influenza ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):472-480]

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A host-based whole genome sequencing study reveals novel risk loci associated with severity of influenza A(H1N1)pdm09 infection.

Mo Li, Yongkun Chen, Tao Chen, Shixiong Hu, Luan Chen, Lu Shen, Fangcai Li, Jing Yang, Yan Sun, Dayan Wang, Lin He, Shengying Qin, Yuelong Shu,

Influenza A(H1N1)pdm09 virus has remained in a seasonal circulation since being recognized in 2009. Although it followed a mild course in most patients, in others it caused a series of severe clinical illnesses. Epidemiologic studies have implicated that host factors have a major influence on the disease severity of influenza ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):123-131]

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PB1 S524G mutation of wild bird-origin H3N8 influenza A virus enhances virulence and fitness for transmission in mammals.

Xinghai Zhang, Yuanguo Li, Song Jin, Yiming Zhang, Leiyun Sun, Xinyu Hu, Menglin Zhao, Fangxu Li, Tiecheng Wang, Weiyang Sun, Na Feng, Hongmei Wang, Hongbin He, Yongkun Zhao, Songtao Yang, Xianzhu Xia, Yuwei Gao,

Influenza H3N8 viruses have been recovered frequently from wild bird species, including Anseriformes (primarily from migratory ducks) and Charadriiformes (primarily from shorebirds). However, little attention has been given to the transmission ability of H3N8 avian influenza viruses among mammals. Here, we study the potential human health threat and the molecular ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1038-1051]

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Identification of key residues involved in the neuraminidase antigenic variation of H9N2 influenza virus.

Fei Wang, Jinsen Wu, Yajuan Wang, Zhimin Wan, Hongxia Shao, Kun Qian, Jianqiang Ye, Aijian Qin,

Influenza A H9N2 virus causes economic loss to the poultry industry and has likely contributed to the genesis of H5N1 and H7N9 viruses. The neuraminidase (NA) of H9N2 virus, like haemagglutinin, is under antibody selective pressure and may undergo antigenic change; however, its antigenic structure remains to be elucidated. In ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):210-219]

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Intra-species sialic acid polymorphism in humans: a common niche for influenza and coronavirus pandemics?

Xi Jiang, Ming Tan, Ming Xia, Pengwei Huang, Michael A Kennedy,

The ongoing COVID-19 pandemic has led to more than 159 million confirmed cases with over 3.3 million deaths worldwide, but it remains mystery why most infected individuals (∼98%) were asymptomatic or only experienced mild illness. The same mystery applies to the deadly 1918 H1N1 influenza pandemic, which has puzzled the ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1191-1199]

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Support among healthcare workers for the new mandatory seasonal influenza vaccination policy and its effects on vaccination coverage.

Aleksi Hämäläinen, Riitta-Liisa Patovirta, Ella Mauranen, Sari Hämäläinen, Irma Koivula,

<h4>Introduction</h4>Finland was the first European country to introduce a nation-wide mandatory seasonal influenza vaccination policy for healthcare workers (HCWs) by mandating that administrators of health care institutions only employ vaccinated HCWs. In this study, we examine the effects of the new policy and the view of HCWs on the new ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):384-390]

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Novel dual multiplex real-time RT-PCR assays for the rapid detection of SARS-CoV-2, influenza A/B, and respiratory syncytial virus using the BD MAX open system.

Hsing-Yi Chung, Ming-Jr Jian, Chih-Kai Chang, Jung-Chung Lin, Kuo-Ming Yeh, Chien-Wen Chen, Sheng-Kang Chiu, Yi-Hui Wang, Shu-Jung Liao, Shih-Yi Li, Shan-Shan Hsieh, Shih-Hung Tsai, Cherng-Lih Perng, Ji-Rong Yang, Ming-Tsan Liu, Feng-Yee Chang, Hung-Sheng Shang,

SARS-CoV-2 has spread rapidly, causing deaths worldwide. In this study, we evaluated the performance of the BD MAX Open System module for identifying viral pathogens, including SARS-CoV-2, in nasopharyngeal specimens from individuals with symptoms of upper respiratory tract infection. We developed and validated a rapid total nucleic acid extraction method ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):161-166]

Cited: 4 times

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Estimating the risk of pandemic avian influenza.

Amita Tripathi, Harish Chandra Dhakal, Khagendra Adhikari, Ramesh Chandra Timsina, Lindi M Wahl,

Outbreaks of highly pathogenic strains of avian influenza (HPAI) cause high mortality in avian populations worldwide. When spread from avian reservoirs to humans, HPAI infections cause mortality in about 50% of human infections. Cases of human-to-human transmission of HPAI are relatively rare, and have, to date, only been reported in ... Read more >>

J Biol Dyn (Journal of biological dynamics)
[2021, 15(1):327-341]

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Assessing the effects of a two-amino acid flexibility in the Hemagglutinin 220-loop receptor-binding domain on the fitness of Influenza A(H9N2) viruses.

Yixue Sun, Yulin Cong, Haiying Yu, Zhuang Ding, Yanlong Cong,

The enzootic and zoonotic nature of H9N2 avian influenza viruses poses a persistent threat to the global poultry industry and public health. In particular, the emerging sublineage h9.4.2.5 of H9N2 viruses has drawn great attention. In this study, we determined the effects of the flexibility at residues 226 and 227 ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):822-832]

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Emergence and spread of novel H5N8, H5N5 and H5N1 clade 2.3.4.4 highly pathogenic avian influenza in 2020.

Nicola S Lewis, Ashley C Banyard, Elliot Whittard, Talgat Karibayev, Thamer Al Kafagi, Ilya Chvala, Alex Byrne, Saduakassova Meruyert Akberovna, Jacqueline King, Timm Harder, Christian Grund, Steve Essen, Scott M Reid, Adam Brouwer, Nikolay G Zinyakov, Azimkhan Tegzhanov, Victor Irza, Anne Pohlmann, Martin Beer, Ron A M Fouchier, Sultanov Akhmetzhan Akievich, Ian H Brown,

Analyses of HPAI H5 viruses from poultry outbreaks across a wide Eurasian region since July 2020 including the Russian Federation, Republics of Iraq and Kazakhstan, and recent detections in migratory waterfowl in the Netherlands, revealed undetected maintenance of H5N8, likely in galliform poultry since 2017/18 and both H5N5 and H5N1. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):148-151]

Cited: 5 times

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Bacterial and viral infections and related inflammatory responses in chronic obstructive pulmonary disease.

Silvestro Ennio D'Anna, Mauro Maniscalco, Francesco Cappello, Mauro Carone, Andrea Motta, Bruno Balbi, Fabio L M Ricciardolo, Gaetano Caramori, Antonino Di Stefano,

In chronic obstructive pulmonary disease (COPD) patients, bacterial and viral infections play a relevant role in worsening lung function and, therefore, favour disease progression. The inflammatory response to lung infections may become a specific indication of the bacterial and viral infections. We here review data on the bacterial-viral infections and ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):135-150]

Cited: 1 time

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H1N1 exposure during the convalescent stage of SARS-CoV-2 infection results in enhanced lung pathologic damage in hACE2 transgenic mice.

Heng Li, Xin Zhao, Yurong Zhao, Jing Li, Huiwen Zheng, Mengyi Xue, Lei Guo, Jian Zhou, Jinling Yang, Yuanyuan Zuo, Yanli Chen, Zening Yang, Qiqi Fan, Li Qin, Haijing Shi, Longding Liu,

<b>ABSTRACT</b>The risk of secondary infection with SARS-CoV-2 and influenza A virus is becoming a practical problem that must be addressed as the flu season merges with the COVID-19 pandemic. As SARS-CoV-2 and influenza A virus have been found in patients, understanding the in vivo characteristics of the secondary infection between ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1156-1168]

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Pathogenic assessment of avian influenza viruses in migratory birds.

Eun-Ha Kim, Young-Ll Kim, Se Mi Kim, Kwang-Min Yu, Mark Anthony B Casel, Seung-Gyu Jang, Philippe Noriel Q Pascua, Richard J Webby, Young Ki Choi,

<b>ABSTRACT</b>Several subtypes of avian influenza (AI) viruses have caused human infections in recent years; however, there is a severe knowledge gap regarding the capacity of wild bird viruses to infect mammals. To assess the risk of mammalian infection by AI viruses from their natural reservoirs, a panel of isolates from ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):565-577]

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The role of glycosylation in the N-terminus of the hemagglutinin of a unique H4N2 with a natural polybasic cleavage site in virus fitness in vitro and in vivo.

Marcel Gischke, Ola Bagato, Angele Breithaupt, David Scheibner, Claudia Blaurock, Melina Vallbracht, Axel Karger, Beate Crossley, Jutta Veits, Eva Böttcher-Friebertshäuser, Thomas C Mettenleiter, Elsayed M Abdelwhab,

To date, only low pathogenic (LP) H5 and H7 avian influenza viruses (AIV) have been observed to naturally shift to a highly pathogenic (HP) phenotype after mutation of the monobasic hemagglutinin (HA) cleavage site (HACS) to polybasic motifs. The LPAIV monobasic HACS is activated by tissue-restricted trypsin-like enzymes, while the ... Read more >>

Virulence (Virulence)
[2021, 12(1):666-678]

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Comparative pathogenicity and environmental transmission of recent highly pathogenic avian influenza H5 viruses.

Nancy Beerens, Evelien A Germeraad, Sandra Venema, Eline Verheij, Sylvia B E Pritz-Verschuren, Jose L Gonzales,

Strategies to control spread of highly pathogenic avian influenza (HPAI) viruses by wild birds appear limited, hence timely characterization of novel viruses is important to mitigate the risk for the poultry sector and human health. In this study we characterize three recent H5-clade 2.3.4.4 viruses, the H5N8-2014 group A virus ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):97-108]

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Disparities in case frequency and mortality of coronavirus disease 2019 (COVID-19) among various states in the United States.

Rohit S Loomba, Gaurav Aggarwal, Saurabh Aggarwal, Saul Flores, Enrique G Villarreal, Juan S Farias, Carl J Lavie,

<h4>Objective</h4>To utilize publicly reported, state-level data to identify factors associated with the frequency of cases, tests, and mortality in the USA.<h4>Materials and methods</h4>Retrospective study using publicly reported data collected included the number of COVID-19 cases, tests and mortality from March 14th through April 30th. Publicly available state-level data was collected ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):151-159]

Cited: 6 times

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Establishment of an anti-inflammation-based bioassay for the quality control of the 13-component TCM formula (Lianhua Qingwen).

Shuaishuai Chen, Xiaojuan Yang, Ziying Wei, Yanru Zhang, Ying Huang, Zhuo Shi, Ziteng Zhang, Jiabo Wang, Haizhu Zhang, Jianli Ma, Xiaohe Xiao, Ming Niu,

<h4>Context</h4>Owing to the complexity of chemical ingredients in traditional Chinese medicine (TCM), it is difficult to maintain quality and efficacy by relying only on chemical markers.<h4>Objective</h4>Lianhua Qingwen capsule (LHQW) was selected as an example to discuss the feasibility of a bioassay for quality control.<h4>Materials and methods</h4>Network pharmacology was used to ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):537-545]

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First Nations' hospital readmission ending in death: a potential sentinel indicator of inequity?

Josée Lavoie, Wanda Phillips-Beck, Kathi Avery Kinew, Grace Kyoon-Achan, Alan Katz,

In this study, we focused on readmissions for Ambulatory Care Sensitive Conditions (ACSC) ending in death, to capture those admissions and readmissions that might have been prevented if responsive primary healthcare was accessible. We propose this as a sentinel indicator of equity. We conducted analyses of Manitoba-based 30-day hospital readmission ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1859824]

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Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients.

Qihong Yan, Ping He, Xiaohan Huang, Kun Luo, Yudi Zhang, Haisu Yi, Qian Wang, Feng Li, Ruitian Hou, Xiaodi Fan, Pingchao Li, Xinglong Liu, Huan Liang, Yijun Deng, Zhaoming Chen, Yunfei Chen, Xiaoneng Mo, Liqiang Feng, Xiaoli Xiong, Song Li, Jian Han, Linbing Qu, Xuefeng Niu, Ling Chen,

Monoclonal antibodies (mAbs) encoded by IGHV3-53 (VH3-53) targeting the spike receptor-binding domain (RBD) have been isolated from different COVID-19 patients. However, the existence and prevalence of shared VH3-53-encoded antibodies in the antibody repertoires is not clear. Using antibody repertoire sequencing, we found that the usage of VH3-53 increased after SARS-CoV-2 ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1097-1111]

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A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques.

Yuzhong Li, Yanwei Bi, Hongjian Xiao, Yueting Yao, Xiaojuan Liu, Zhengrong Hu, Jinmei Duan, Yaoyun Yang, Zhihua Li, Yadong Li, Heng Zhang, Chen Ding, Jianbo Yang, Haiwei Li, Zhanlong He, Longding Liu, Guangnan Hu, Shuying Liu, Yanchun Che, Shixia Wang, Qihan Li, Shan Lu, Wei Cun,

The current study aims to develop a safe and highly immunogenic COVID-19 vaccine. The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine induced high level neutralizing antibody and T cell immune responses in both small and large animal ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):342-355]

Cited: 2 times

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Isolation and characterization of novel reassortant mammalian orthoreovirus from pigs in the United States.

Liping Wang, Yan Li, Timothy Walsh, Zhenyu Shen, Yonghai Li, Nirmalendu Deb Nath, Jinhwa Lee, Baoliang Zheng, Ying Tao, Clinton R Paden, Krista Queen, Shuping Zhang, Suxiang Tong, Wenjun Ma,

Mammalian orthoreovirus (MRV) infects multiple mammalian species including humans. A United States Midwest swine farm with approximately one thousand 3-month-old pigs experienced an event, in which more than 300 pigs showed neurological signs, like "down and peddling", with approximately 40% mortality. A novel MRV was isolated from the diseased pigs. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1137-1147]

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The cardiovascular aspect of COVID-19.

Joseph Adu-Amankwaah, Richard Mprah, Adebayo Oluwafemi Adekunle, Marie Louise Ndzie Noah, Gabriel Komla Adzika, Jeremiah Ong'achwa Machuki, Hong Sun,

The coronavirus disease-2019 (COVID-19), an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2), has hit the world very hard by affecting millions of people across countries hence posing a major health threat on a global scale. This novel virus is thought to enter and cause infection in its ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):227-236]

Cited: 2 times

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Mitigating the threat of emerging infectious diseases; a coevolutionary perspective.

Cock Van Oosterhout,

Virulence (Virulence)
[2021, 12(1):1288-1295]

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