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The autophagy gene product BEC-1 supports normal aging and neurodevelopment in Caenorhabditis elegans: Integration.

Nicholas Ashley, Andrea Holgado,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 0 times

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Diagnostic value and key features of computed tomography in Coronavirus Disease 2019.

Bingjie Li, Xin Li, Yaxuan Wang, Yikai Han, Yidi Wang, Chen Wang, Guorui Zhang, Jianjun Jin, Hongxia Jia, Feifei Fan, Wang Ma, Hong Liu, Yue Zhou,

On 31 December 2019, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, Hubei province, China, and caused the outbreak of the Coronavirus Disease 2019 (COVID-19). To date, computed tomography (CT) findings have been recommended as major evidence for the clinical diagnosis of COVID-19 in Hubei, China. This ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):787-793]

Cited: 1 time

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Adult outcomes of childhood bronchiectasis.

Dawn Sibanda, Rosalyn Singleton, John Clark, Christine Desnoyers, Ellen Hodges, Gretchen Day, Gregory Redding,

Recent literature has highlighted the importance of transition from paediatric to adult care for children with chronic conditions. Non-cystic fibrosis bronchiectasis is an important cause of respiratory morbidity in low-income countries and in indigenous children from affluent countries; however, there is little information about adult outcomes of childhood bronchiectasis. We ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1731059]

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Trends and health burden of hospitalized acute respiratory infections and impact of Haemophilus influenza immunization in a Tunisian university hospital: a twelve-year study.

Manel Ben Fredj, Wafa Dhouib, Meriem Kacem, Cyrine Bennasrallah, Ons Mehrez, Hela Abroug, Imen Zemni, Aicha Gardabou, Koubaa Jamel, Slaheddine Chouchene, Naceur Rouatbi, Asma Belguith Sriha,

BACKGROUND:We aimed to describe the episodes and trends of admissions for community-acquired Respiratory Infections (RI) over a 12-year period and to assess the impact of Haemophilus influenza type b (Hib) vaccine on RI admissions in children aged up to 3 years. METHODS:We conducted a twelve-year retrospective observational study on all community-acquired ... Read more >>

Libyan J Med (The Libyan journal of medicine)
[2020, 15(1):1783048]

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A case series describing the epidemiology and clinical characteristics of COVID-19 infection in Jilin Province.

Na Du, Haiying Chen, Qing Zhang, Lihe Che, Lixin Lou, Xiaohua Li, Kaiyu Zhang, Wanguo Bao,

Since its outbreak in Wuhan, Hubei Province China, 2019-coronavirus infected disease (COVID-19) had been widely spread all over the world, the control of which calls for a better understanding of its epidemiology and clinical characteristics. We included 12 confirmed cases of COVID-19 in First Affiliated Hospital of Jilin University from ... Read more >>

Virulence (Virulence)
[2020, 11(1):482-485]

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Long non-coding RNA NKILA weakens TNF-α-induced inflammation of MRC-5 cells by miR-21 up-regulation.

Dandan Wang, Jiajie Zhang, Yan Sun, Nan Lv, Jianwei Sun,

Background: Infantile pneumonia (IP) seriously affects the health of children. This article mainly discussed the protective effect of long non-coding RNA NKILA (lnc NKILA) on IP by detecting cell viability, apoptosis and inflammatory response of MRC5 cells.Methods: Cell counting kit-8 (CCK-8) was used to detect cell viability, while flow cytometry ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):498-505]

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Therapeutic sildenafil inhibits pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats.

Zhouxin Ren, Jiansheng Li, Junling Shen, Haibin Yu, Xiaofeng Mei, Peng Zhao, Zhenya Xiao, Wanliu Wu,

Context: Clinical reports showed sildenafil beneficial therapy on severe chronic obstructive pulmonary disease (COPD) with pulmonary hypertension (PH) patients.Objective: The study investigated therapeutic effects of silenafil on pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats.Materials and methods: Female Sprague-Dawley rats (200-250 g) were divided into control group ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):116-123]

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Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia.

Ling Lin, Lianfeng Lu, Wei Cao, Taisheng Li,

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with droplets and contact as the main means of transmission. Since the first case appeared in Wuhan, China, in December 2019, the outbreak has gradually spread nationwide. Up to now, according to official ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):727-732]

Cited: 31 times

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Epidemiology and clinical course of COVID-19 in Shanghai, China.

Yinzhong Shen, Fang Zheng, Danfeng Sun, Yun Ling, Jun Chen, Feng Li, Tao Li, Zhiping Qian, Yuyi Zhang, Qingnian Xu, Li Liu, Qin Huang, Fei Shan, Lie Xu, Jun Wu, Zhaoqin Zhu, Zhigang Song, Shenyang Li, Yuxin Shi, Jianliang Zhang, Xueyun Wu, Joshua B Mendelsohn, Tongyu Zhu, Hongzhou Lu,

Background: Novel coronavirus pneumonia (COVID-19) is prevalent around the world. We aimed to describe epidemiological features and clinical course in Shanghai. Methods: We retrospectively analysed 325 cases admitted at Shanghai Public Health Clinical Center, between January 20 and February 29, 2020. Results: 47.4% (154/325) had visited Wuhan within 2 weeks ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1537-1545]

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Organic dust-induced lung injury and repair: Bi-directional regulation by TNFα and IL-10.

T A Wyatt, M Nemecek, D Chandra, J M DeVasure, A J Nelson, D J Romberger, J A Poole,

Exposure to organic dust increases chronic airway inflammatory disorders. Effective treatment strategies are lacking. It has been reported that hog barn dust extracts (HDE) induce TNFα through protein kinase C (PKC) activation and that lung inflammation is enhanced in scavenger receptor A (SRA/CD204) knockout (KO) mice following HDE. Because interleukin ... Read more >>

J Immunotoxicol (Journal of immunotoxicology)
[2020, 17(1):153-162]

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Diagnosing Balamuthia mandrillaris encephalitis via next-generation sequencing in a 13-year-old girl.

Xia Wu, Gangfeng Yan, Shuzhen Han, Yingzi Ye, Xunjia Cheng, Hairong Gong, Hui Yu,

Balamuthia amoebic encephalitis has a subacute-to-chronic course and is almost invariably fatal owing to delayed diagnosis and a lack of effective therapy. Here, we report a 13-year-old girl with cutaneous lesions and multifocal granulomatous encephalitis. The patient underwent a series of tests and was suspected as having tuberculosis. She was ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1379-1387]

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Non-active antibiotic and bacteriophage synergism to successfully treat recurrent urinary tract infection caused by extensively drug-resistant Klebsiella pneumoniae.

Juan Bao, Nannan Wu, Yigang Zeng, Liguang Chen, Linlin Li, Lan Yang, Yiyuan Zhang, Mingquan Guo, Lisha Li, Jie Li, Demeng Tan, Mengjun Cheng, Jingmin Gu, Jinghong Qin, Jiazheng Liu, Shiru Li, Guangqiang Pan, Xin Jin, Bangxin Yao, Xiaokui Guo, Tongyu Zhu, Shuai Le,

We report a case of a 63-year-old female patient who developed a recurrent urinary tract infection (UTI) with extensively drug-resistant Klebsiella pneumoniae (ERKp). In the initial two rounds of phage therapy, phage resistant mutants developed within days. Although ERKp strains were completely resistant to sulfamethoxazole-trimethoprim, the combination of sulfamethoxazole-trimethoprim with ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):771-774]

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Donor CMV-specific cytotoxic T lymphocytes successfully treated drug-resistant cytomegalovirus encephalitis after allogeneic hematopoietic stem cell transplantation.

Peng Ke, Xiebing Bao, Jihao Zhou, Xiaoli Li, Juan Zhuang, Xuefeng He, Depei Wu, Xinyou Zhang, Xiao Ma,

Background: Cytomegalovirus (CMV) infection of the central nervous system (CNS) is a rare but life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT).Cases presentation: Two patients with drug-resistant CMV encephalitis after allo-HSCT were successfully treated with donor CMV-specific cytotoxic T lymphocytes (CTLs). In the first case, a 27-year-old male who ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2020, 25(1):43-47]

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Measles in Romania - clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic.

Daniela Pițigoi, Oana Săndulescu, Maria Dorina Crăciun, Anca Drăgănescu, Gheorghiță Jugulete, Anca Streinu-Cercel, Angelica Vișan, Claudia Rîciu, Alexandru Rafila, Victoria Aramă, Monica Luminos, Adrian Streinu-Cercel,

A large measles epidemic has been ongoing in Romania and many European countries, since 2016. We report case-based surveillance data for all patients (n = 1371) with laboratory-confirmed and epidemiologically-confirmed measles hospitalized in a major infectious diseases hospital in Bucharest Romania during the first three years of the current measles epidemic (July ... Read more >>

Virulence (Virulence)
[2020, 11(1):686-694]

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Genetic cluster analysis of SARS-CoV-2 and the identification of those responsible for the major outbreaks in various countries.

Xuemei Yang, Ning Dong, Edward Wai-Chi Chan, Sheng Chen,

A newly emerged coronavirus, SARS-CoV-2, caused severe pneumonia outbreaks in China in December 2019 and has since spread to various countries around the world. To trace the evolution route and probe the transmission dynamics of this virus, we performed phylodynamic analysis of 247 high quality genomic sequences available in the ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1287-1299]

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Narciclasine attenuates LPS-induced acute lung injury in neonatal rats through suppressing inflammation and oxidative stress.

Qingning Duan, Yin Jia, Yan Qin, Yingji Jin, Haozhong Hu, Jiebin Chen,

Acute lung injury (ALI) is a life-threatening disorder related to serious pulmonary inflammation. Narciclasine exhibits strong anti-inflammation activity and attenuates the reactive oxygen species (ROS) production. The present study aims to investigate the underlying mechanism related to the effect of narciclasine on the pathogenesis of neonatal acute lung injury (ALI). ... Read more >>

Bioengineered (Bioengineered)
[2020, 11(1):801-810]

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XingNaoJing injection ameliorates cerebral ischaemia/reperfusion injury via SIRT1-mediated inflammatory response inhibition.

Yue-Ming Zhang, Xiao-Yu Qu, Li-Na Tao, Jing-Hui Zhai, Huan Gao, Yan-Qing Song, Si-Xi Zhang,

Context: XingNaoJing injection (XNJ), extracted from a traditional compound Chinese medicine Angong niuhuang pill, is well known for treating stroke in the clinic, but the specific effects and mechanisms remain unclear.Objective: We investigated the mechanistic basis for the protective effect of XNJ on cerebral ischaemia/reperfusion (I/R) injury.Materials and methods: Five ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):16-24]

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In silico data mining of large-scale databases for the virtual screening of human interleukin-2 inhibitors.

Sobia Ahsan Halim, , Ajmal Khan, Ahmed Al-Rawahi, Ahmed Al-Harrasi,

Interleukin-2 (IL-2) is involved in the activation and differentiation of T-helper cells. Uncontrolled activated T cells play a key role in the pathophysiology by stimulating inflammation and autoimmune diseases like arthritis, psoriasis and Crohn's disease. T cells activation can be suppressed either by preventing IL-2 production or blocking the IL-2 ... Read more >>

Acta Pharm (Acta pharmaceutica (Zagreb, Croatia))
[2021, 71(1):33-56]

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Clostridium difficile toxin B induces colonic inflammation through the TRIM46/DUSP1/MAPKs and NF-κB signalling pathway.

Ying Li, Su Xu, Qingqing Xu, Yijian Chen,

Clostridium difficile (C. difficile) infection results in toxin-induced epithelial injury and marked colonic inflammation. Mitogen-activated protein kinase (MAPK) and NF-κB which regulated by MAP kinase phosphatase (MKP, also known as dual specificity phosphatases, DUSP) are fundamental signalling pathways that mediate multiple cellular processes. However, the regulation of DUSP/MAPKs and NF-κB ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):452-462]

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Matrine protects PC12 cells from lipopolysaccharide-evoked inflammatory injury via upregulation of miR-9.

Jinsong Jiang, Guangji Wang,

Context: Matrine is a well-known anti-inflammatory quinolizidine alkaloid derived from leguminous plant Sophora flavescens Ait. (Leguminosae).Objective: This study was designed to uncover the potential application of matrine in treating spinal cord injury (SCI).Materials and methods: Neuron-like PC12 cells in experimental groups were pre-treated with/without matrine (200 μM) for 24 h and then ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):314-320]

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Inhibition of SARS-CoV 3CL protease by flavonoids.

Seri Jo, Suwon Kim, Dong Hae Shin, Mi-Sun Kim,

There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these viruses have been required. Coronaviruses (CoVs) have been rising targets of some flavonoids. The antiviral activity of some flavonoids against CoVs is presumed directly caused by inhibiting 3C-like protease (3CLpro). Here, ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):145-151]

Cited: 16 times

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Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.

Yong Xiong, Yuan Liu, Liu Cao, Dehe Wang, Ming Guo, Ao Jiang, Dong Guo, Wenjia Hu, Jiayi Yang, Zhidong Tang, Honglong Wu, Yongquan Lin, Meiyuan Zhang, Qi Zhang, Mang Shi, Yingle Liu, Yu Zhou, Ke Lan, Yu Chen,

Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):761-770]

Cited: 23 times

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Comparative proteomics analysis indicates that palmatine contributes to transepithelial migration by regulating cellular adhesion.

Wang Hui, Yang Feng, Xin Ruihua, He Jiongjie, Cui Dongan, Sun Yan, Zhang Shidong,

CONTEXT:Palmatine, a biologically active isoquinoline alkaloid, possesses multiple pharmaceutical activities against mucosal infection and inflammation. OBJECTIVE:There are no reports about the influence of palmatine on uterine mucosal epithelial cells. MATERIALS AND METHODS:We used proteomics to analyse differentially expressed proteins (DEPs) in goat endometrial epithelial cells (EECs) stimulated by lipopolysaccharide (LPS, ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):646-654]

Cited: 0 times

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Histological and functional outcomes in a rat model of hemisected spinal cord with sustained VEGF/NT-3 release from tissue-engineered grafts.

Zi-Xing Xu, Li-Qun Zhang, Yi-Nan Zhou, Xue-Min Chen, Wei-Hong Xu,

Microvascular disturbance, excessive inflammation and gliosis are key pathophysiologic changes in relation to functional status following the traumatic spinal cord injury (SCI). Continuous release of vascular endothelial growth factor (VEGF) to the lesion site was proved be able to promote the vascular remodelling, whereas the effects on reduction of inflammation ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):362-376]

Cited: 1 time

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Burden of respiratory infections and otitis media in the Inuit population of Nunavik, Quebec, Canada.

Philippe De Wals, Z Zhou, J B LeMeur, J F Proulx,

BACKGROUND:Respiratory infections are a major health problem in the Inuit population of Nunavik, province of Quebec, Canada. OBJECTIVES:A study was undertaken to assess the burden of lower (LRTI) and upper respiratory tract infections (URTI) and otitis media (OM) and to explore some of their determinants including the pneumococcal conjugate vaccine ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1799688]

Cited: 0 times

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