Full Text Journal Articles about
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Neuronal expression of Ca2+ oscillation initiator is linked to rapid neonatal growth in mice.

Woojin Kang, Kenji Yamatoya, Kenji Miyado, Mami Miyado, Yoshitaka Miyamoto,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Caspar SUMOylation regulates Drosophila lifespan.

Bhagyashree Kaduskar, Deepti Trivedi, Girish S Ratnaparkhi,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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The autophagy gene product BEC-1 supports normal aging and neurodevelopment in Caenorhabditis elegans: Integration.

Nicholas Ashley, Andrea Holgado,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

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The mechanism behind activation of the Nod-like receptor family protein 3 inflammasome in Parkinson's disease.

Jing Wang, Xiao-Na Zhang, Jin-Ni Fang, Fei-Fei Hua, Jing-Yang Han, Zeng-Qiang Yuan, An-Mu Xie,

Previous studies have shown that the ATP-P2X4 receptor signaling pathway mediates the activation of the Nod-like receptor family protein 3 (NLRP3) inflammasome. The NLRP3 inflammasome may promote renal interstitial inflammation in diabetic nephropathy. As inflammation also plays an important role in the pathogenesis of Parkinson's disease, we hypothesized that the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):898-904]

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HOTTIP downregulation reduces neuronal damage and microglial activation in Parkinson's disease cell and mouse models.

Peng Lun, Tao Ji, De-Hong Wan, Xia Liu, Xiao-Dong Chen, Shuai Yu, Peng Sun,

HOXA transcript at the distal tip (HOTTIP), a newly identified long noncoding RNA, has been shown to exhibit anti-inflammatory effects and inhibit oxygen-glucose deprivation-induced neuronal apoptosis. However, its role in Parkinson's disease (PD) remains unclear. 1-Methyl-4-phenylpyridium (MPP<sup>+</sup>) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were used to establish PD models in SH-SY5Y and BV2 ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):887-897]

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Glial decline and loss of homeostatic support rather than inflammation defines cognitive aging.

Alexei Verkhratsky, Natalia Lazareva, Alexey Semyanov,

Neural Regen Res (Neural regeneration research)
[2022, 17(3):565-566]

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Profile of the RNA in exosomes from astrocytes and microglia using deep sequencing: implications for neurodegeneration mechanisms.

Hui-Min Xie, Xing Su, Feng-Yuan Zhang, Chao-Lun Dai, Rong-Hua Wu, Yan Li, Xiao-Xiao Han, Xing-Mei Feng, Bin Yu, Shun-Xing Zhu, Song-Lin Zhou,

Glial cells play an important role in signal transduction, energy metabolism, extracellular ion homeostasis and neuroprotection of the central nervous system. However, few studies have explained the potential effects of exosomes from glial cells on central nervous system health and disease. In this study, the genes expressed in exosomes from ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(3):608-617]

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Vietnamese Medicinal Plants as Potential Resources to Explore New Anticancer and Anti-inflammation: Established Assays for Pharmacological Tests.

Trang Thi Phuong Nguyen, Dieu Thi Xuan Nguyen, Triet Thanh Nguyen,

Cancer is one of the most serious health problems in the world, which annually increases in incidence and mortality rates. Among therapies for cancer, chemical treatments are widespread. However, the benefit of these compounds remains limited due to high cytotoxicity, resistances, and non-selectivity. In addition to cancer, inflammation is also ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2343:271-286]

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Celeboxib-mediated neuroprotection in focal cerebral ischemia: an interplay between unfolded protein response and inflammation.

María Santos-Galdiano, Diego Pérez-Rodríguez, Arsenio Fernández-López,

Neural Regen Res (Neural regeneration research)
[2022, 17(2):302-303]

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Microglia regulation of synaptic plasticity and learning and memory.

Jessica Cornell, Shelbi Salinas, Hou-Yuan Huang, Miou Zhou,

Microglia are the resident macrophages of the central nervous system. Microglia possess varied morphologies and functions. Under normal physiological conditions, microglia mainly exist in a resting state and constantly monitor their microenvironment and survey neuronal and synaptic activity. Through the C1q, C3 and CR3 "Eat Me" and CD47 and SIRPα ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):705-716]

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Neutrophil-to-lymphocyte ratio in sporadic amyotrophic lateral sclerosis.

Qian-Qian Wei, Yan-Bing Hou, Ling-Yu Zhang, Ru-Wei Ou, Bei Cao, Yong-Ping Chen, Hui-Fang Shang,

The neutrophil-to-lymphocyte ratio (NLR) is considered a robust prognostic biomarker for predicting patient survival outcomes in many diseases. However, it remains unclear whether it can be used as a biomarker for amyotrophic lateral sclerosis (ALS). To correlate NLR with disease progression and survival in sporadic ALS, 1030 patients with ALS ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):875-880]

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Orientin mediates protection against MRSA-induced pneumonia by inhibiting Sortase A.

Li Wang, Shisong Jing, Han Qu, Kai Wang, Yajing Jin, Ying Ding, Lin Yang, Hangqian Yu, Yan Shi, Qianxue Li, Dacheng Wang,

Drug-resistant pathogenic <i>Staphylococcus aureus</i> (<i>S. aureus</i>) has severely threatened human health and arouses widespread concern. Sortase A (SrtA) is an essential virulence factor of <i>S. aureus</i>, which is responsible for the covalent anchoring of a variety of virulence-related proteins to the cell wall. SrtA has always been regarded as an ... Read more >>

Virulence (Virulence)
[2021, 12(1):2149-2161]

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Genome-wide interrogation of transfer RNA-derived small RNAs in a mouse model of traumatic brain injury.

Xiao-Jian Xu, Meng-Shi Yang, Bin Zhang, Qian-Qian Ge, Fei Niu, Jin-Qian Dong, Yuan Zhuang, Bai-Yun Liu,

Transfer RNA (tRNA)-derived small RNAs (tsRNAs) are a recently established family of regulatory small non-coding RNAs that modulate diverse biological processes. Growing evidence indicates that tsRNAs are involved in neurological disorders and play a role in the pathogenesis of neurodegenerative disease. However, whether tsRNAs are involved in traumatic brain injury-induced ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(2):386-394]

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Testing the Effects of Cinnamon Extract Supplementation on Inflammation and Oxidative Stress Induced by Acrylamide.

Fatemeh Haidari, Majid Mohammadshahi, Behnaz Abiri, Paul C Guest, Mehdi Zarei, Mojdeh Fathi,

We investigated the effects of cinnamon water extract supplementation on inflammation and oxidative stress induced by acrylamide in rats. This revealed acrylamide-intoxicated control group had significant higher levels of malondialdehyde, tumor necrosis factor-alpha (TNF-α), high-sensitive C-reactive protein (hs-CRP), leptin and alanine transaminase, and lower levels of total antioxidant capacity compared ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2343:179-190]

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Protective effects of Re-yan-ning mixture on Streptococcus pneumonia in rats based on network pharmacology.

Lizhu Han, Jing Kou, Kunxia Hu, Yunlan Wang, Zhishu Tang, Zhisheng Wu, Xiao Song,

<h4>Context</h4>Re-yan-ning mixture (RYNM) is a new national drug approved by China's State Food and Drug Administration for the treatment of colds, simple pneumonia and acute bronchitis.<h4>Objective</h4>To determine the mechanism of action of RYNM in the treatment of bacterial pneumonia.<h4>Materials and methods</h4>Using the network pharmacology approach, the multiple components, component candidate ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):209-221]

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Metagenomic next-generation sequencing in the family outbreak of psittacosis: the first reported family outbreak of psittacosis in China under COVID-19.

Na Li, Shengjin Li, Wanmei Tan, Hanghang Wang, Huan Xu, Daoxing Wang,

<i>Chlamydia psittaci</i> infection in humans, also known as psittacosis, is usually believed to be an uncommon disease which mainly presents as community-acquired pneumonia (CAP). It is usually sporadic, but outbreaks of infection may occasionally occur. In outbreaks, diagnosis and investigations were usually hampered by the non-specificity of laboratory testing methods ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1418-1428]

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The roles of T cells in obese adipose tissue inflammation.

Qiong Wang, Yurong Wang, Danyan Xu,

Adipose tissue inflammation in obese patients can cause a series of metabolic diseases. There are a variety of immune cells in adipose tissue, and studies have shown that T cells are associated with adipose tissue inflammation. This review aims to describe the current understanding of the relationship between T cells ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):435-445]

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An Organ System-Based Synopsis of Pseudomonas aeruginosa Virulence.

Charles D Morin, Eric Déziel, Jeff Gauthier, Roger C Levesque, Gee W Lau,

Driven in part by its metabolic versatility, high intrinsic antibiotic resistance, and a large repertoire of virulence factors, <i>Pseudomonas aeruginosa</i> is expertly adapted to thrive in a wide variety of environments, and in the process, making it a notorious opportunistic pathogen. Apart from the extensively studied chronic infection in the ... Read more >>

Virulence (Virulence)
[2021, 12(1):1469-1507]

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Incidence of invasive Group B Streptococcus (iGBS) infections and the factors associated with iGBS mortality in adults during 2013-2017: a retrospective study at Thailand's largest national tertiary referral center.

Pakpoom Phoompoung, Nantaporn Pirogard, Amornrut Leelaporn, Nasikarn Angkasekwinai,

<h4>Objectives</h4>To determine the incidence of invasive Group B streptococcal (iGBS) diseases and the factors significantly associated with iGBS mortality in adult patients.<h4>Material and methods</h4>This retrospective study included adults with a positive culture for GBS isolated from a sterile site at Siriraj Hospital - Thailand's largest tertiary care hospital - during ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):715-721]

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Procalcitonin kinetics to guide sequential invasive-noninvasive mechanical ventilation weaning in patients with acute exacerbation of chronic obstructive pulmonary disease and respiratory failure: procalcitonin's adjunct role.

Shao-Hua Lin, Ying-Ping He, Jun-Jie Lian, Cun-Kun Chu,

How to identify the optimum switch point of sequential invasive and noninvasive ventilation is the focus of clinical attention on the patients suffering from acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated by acute respiratory failure (ARF). This study aims to explore the clinical significance of taking the change ... Read more >>

Libyan J Med (The Libyan journal of medicine)
[2021, 16(1):1961382]

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Bacterial and viral infections and related inflammatory responses in chronic obstructive pulmonary disease.

Silvestro Ennio D'Anna, Mauro Maniscalco, Francesco Cappello, Mauro Carone, Andrea Motta, Bruno Balbi, Fabio L M Ricciardolo, Gaetano Caramori, Antonino Di Stefano,

In chronic obstructive pulmonary disease (COPD) patients, bacterial and viral infections play a relevant role in worsening lung function and, therefore, favour disease progression. The inflammatory response to lung infections may become a specific indication of the bacterial and viral infections. We here review data on the bacterial-viral infections and ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):135-150]

Cited: 2 times

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Clinical descriptive analysis of severe Pneumocystis jirovecii pneumonia in renal transplantation recipients.

Dan Xie, Wen Xu, Jingya You, Xiaofeng Yuan, Mingliang Li, Xiaogang Bi, Kouxing Zhang, Heng Li, Ying Xian,

<i>Pneumocystis jirovecii (P. jirovecii)</i> pneumonia (PJP) is an opportunistic fungal infection after renal transplantation, which is always severe, difficult to diagnose, combined with multiple complications and have poor prognosis. We retrospectively analyzed clinical data, including risk factors, diagnosis, treatment and complications of seven clinical cases suffered with severe PJP after ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1264-1272]

Cited: 1 time

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Oral administration of Clostridium butyricum rescues streptomycin-exacerbated respiratory syncytial virus-induced lung inflammation in mice.

Wenwen Zhu, Jia Wang, Na Zhao, Rui Zheng, Dalu Wang, Weiwei Liu, Beixing Liu,

Changes in the intestinal microbiota indirectly impact the health of mucosa distal to the intestine, particularly the respiratory tract. However, the effects of intestinal microbiota dysbiosis on the regulation of respiratory syncytial virus (RSV) infection are not clear. In this study, we examined the effects of altering the intestinal microbiota ... Read more >>

Virulence (Virulence)
[2021, 12(1):2133-2148]

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Profiling the immune response to Mycobacterium tuberculosis Beijing family infection: a perspective from the transcriptome.

Cerezo-Cortés María Irene, Rodríguez-Castillo Juan Germán, López-Leal Gamaliel, Mata-Espinosa Dulce Adriana, Bini Estela Isabel, Marquina-Casitllo Brenda Nohemí, Barrios Payan Jorge, Zatarain-Barrón Zyanya Lucía, Bobadilla Del Valle Myriam, Cornejo-Granados Fernanda, Ochoa-Leyva Adrian, Murcia Martha Isabel, Hernández-Pando Rogelio,

Tuberculosis continues to be an important public health problem. Particularly considering Beijing-family strains of <i>Mycobacterium tuberculosis</i>, which have been associated with drug-resistance and hypervirulence. The Beijing-like SIT190 (BL) is the most prevalent Beijing strain in Colombia. The pathogenic mechanism and immune response against this pathogen is unknown. Thus, we compared ... Read more >>

Virulence (Virulence)
[2021, 12(1):1689-1704]

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The genetic feature and virulence determinant of highly virulent community-associated MRSA ST338-SCCmec Vb in China.

Ye Jin, Wangxiao Zhou, Zhidong Yin, Shuntian Zhang, Yunbo Chen, Ping Shen, Jinru Ji, Weiwei Chen, Beiwen Zheng, Yonghong Xiao,

ST59 is the predominant pathotype of community-associated methicillin-resistant <i>Staphylococcus aureus</i> (CA-MRSA) in China. As a variant of ST59, there is relatively little known about the detailed information of ST338. To address this issue, here, we described thirteen ST338 CA-MRSA strains isolated from severe bloodstream infection cases, and focused on their ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1052-1064]

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