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Induction of Tolerance

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A Novel Heat Shock Transcription Factor (ZmHsf08) Negatively Regulates Salt and Drought Stress Responses in Maize

Jing Wang, Li Chen, Yun Long, Weina Si, Beijiu Cheng, Haiyang Jiang,

Heat shock transcription factors (HSFs) play important roles in plant growth, development, and stress responses. However, the function of these transcription factors in abiotic stress responses in maize (Zea mays) remains largely unknown. In this study, we characterized a novel HSF transcription factor gene, ZmHsf08, from maize. ZmHsf08 was highly ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(21):]

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A Review of Cyclophosphamide-Induced Transplantation Tolerance in Mice and Its Relationship With the HLA-Haploidentical Bone Marrow Transplantation/Post-Transplantation Cyclophosphamide Platform.

Hisanori Mayumi,

The bone marrow transplantation (BMT) between haplo-identical combinations (haploBMT) could cause unacceptable bone marrow graft rejection and graft-versus-host disease (GVHD). To cross such barriers, Johns Hopkins platform consisting of haploBMT followed by post-transplantation (PT) cyclophosphamide (Cy) has been used. Although the central mechanism of the Johns Hopkins regimen is Cy-induced ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:744430]

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Elevated RIF1 Participates in the Epigenetic Abnormalities of Zygotes by Regulating Histone Modifications on MuERV-L in Obese Mice

Jiliang Huang, Gaizhen Ru, Jiajia Sun, Luying Sun, Zhiling Li,

<h4>Background: </h4> Maternal obesity impairs embryonic developmental potential and has significantly increases metabolic risks in offspring. However, the epigenetic transmission mechanism of maternal metabolic abnormalities is still poorly understood. Methods We induced an obesity model in female mice by high-fat diet (HFD) feeding. The effects of a HFD on ... Read more >>

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Cannabinoid Receptor Type 2 Agonist Reduces Morphine Tolerance via Mitogen Activated Protein Kinase Phosphatase Induction and Mitogen Activated Protein Kinase Dephosphorylation.

Qingling Kong, Songyu Tian, Chao Ma, Guonian Wang, Mingyue Zhang,

Morphine is an opioid drug often used in treating moderate to severe pain. However, morphine tolerance in patients limits its used in clinical settings. Our previous study showed that a cannabinoid type 2 (CB2) receptor agonist attenuated morphine tolerance. However, the exact mechanism by which CB2 agonists reduce morphine tolerance ... Read more >>

Neuroscience (Neuroscience)
[2021, :]

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Predictors of inhibitor eradication by primary immune tolerance induction in severe haemophilia A with high responding inhibitors.

Giovanni Di Minno, Antonio Coppola, Maurizio Margaglione, Angiola Rocino, Maria Elisa Mancuso, Annarita Tagliaferri, Silvia Linari, Ezio Zanon, Cristina Santoro, Chiara Biasoli, Giancarlo Castaman, Elena Santagostino, Pier Mannuccio Mannucci, ,

<h4>Background</h4>Immune tolerance induction (ITI) is the only proven strategy to eradicate factor VIII inhibitors in patients with haemophilia A (HA).<h4>Aim</h4>To identify patients and treatment options with the highest chance of inhibitor eradication by primary ITI.<h4>Patients and methods</h4>In the frame of the Italian ITI Registry, carried out from 1995 to 2015 ... Read more >>

Haemophilia (Haemophilia : the official journal of the World Federation of Hemophilia)
[2021, :]

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Critical Protein-Protein Interactions Determine the Biological Activity of Elk-1, a Master Regulator of Stimulus-Induced Gene Transcription.

Gerald Thiel, Tobias M Backes, Lisbeth A Guethlein, Oliver G Rössler,

Elk-1 is a transcription factor that binds together with a dimer of the serum response factor (SRF) to the serum-response element (SRE), a genetic element that connects cellular stimulation with gene transcription. Elk-1 plays an important role in the regulation of cellular proliferation and apoptosis, thymocyte development, glucose homeostasis and ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(20):]

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First successful concomitant therapy of immune tolerance induction therapy and desensitization in a CRIM-negative infantile Pompe patient.

Merve Emecen Sanli, Hacer Ilbilge Ertoy Karagol, Ayse Kilic, Ekin Aktasoglu, Asli Inci, Ilyas Okur, Fatih Ezgu, Leyla Tumer,

<h4>Objectives</h4>Enzyme replacement therapy (ERT) with alglucosidase alfa (rhGAA) has changed the fatal course of infantile Pompe disease, however, development of anti rhGAA antibodies and infusion-associated reactions (IAR) restrict the tolerability and effectiveness of the treatment.<h4>Case presentation</h4>We describe a successful concomitant immune tolerance induction (ITI) and desensitization protocols in a cross-reactive ... Read more >>

J Pediatr Endocrinol Metab (Journal of pediatric endocrinology & metabolism : JPEM)
[2021, :]

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Targeting DCs for Tolerance Induction: Don't Lose Sight of the Neutrophils.

Florianne M J Hafkamp, Tom Groot Kormelink, Esther C de Jong,

Chronic inflammatory disorders (CID), such as autoimmune diseases, are characterized by overactivation of the immune system and loss of immune tolerance. T helper 17 (Th17) cells are strongly associated with the pathogenesis of multiple CID, including psoriasis, rheumatoid arthritis, and inflammatory bowel disease. In line with the increasingly recognized contribution ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:732992]

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The self-peptide repertoire plays a critical role in transplant tolerance induction.

Eric T Son, Pouya Faridi, Moumita Paul-Heng, Mario L Leong, Kieran English, Sri H Ramarathinam, Asolina Braun, Nadine L Dudek, Ian E Alexander, Leszek Lisowski, Patrick Bertolino, David G Bowen, Anthony W Purcell, Nicole A Mifsud, Alexandra F Sharland,

While direct allorecognition underpins both solid organ allograft rejection and tolerance induction, the specific molecular targets of most directly alloreactive CD8+ T cells have not been defined. In this study, we used a combination of genetically engineered major histocompatibility complex class I (MHC I) constructs, mice with a hepatocyte-specific mutation ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2021, 131(21):]

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Home-based graded exposure to egg to treat egg allergy.

Sarah Cotter, Dhanis Lad, Aideen Byrne, Jonathan O'B Hourihane,

Clin Transl Allergy (Clinical and translational allergy)
[2021, 11(8):e12068]

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The Transcription Factor FRA-1/AP-1 Controls Lipocalin-2 Expression and Inflammation in Sepsis Model.

Shan Cao, Anne Schnelzer, Nicole Hannemann, Georg Schett, Didier Soulat, Aline Bozec,

Sepsis is a life-threatening condition characterized by excessive inflammation in its early phase. This is followed by an aberrant resolution phase associated to a prolonged period of immune suppression that can ultimately lead to multiple organ dysfunctions. This immunosuppression can be mediated by the functional reprogramming of gene transcription in ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:701675]

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Approaches to Establishing Tolerance in Immune Mediated Diseases.

Michelle F Huffaker, Srinath Sanda, Sindhu Chandran, Sharon A Chung, E William St Clair, Gerald T Nepom, Dawn E Smilek,

The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that have evolved from the clinical trial experience of the Immune Tolerance Network, with an emphasis on lessons learned ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:744804]

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Exploiting the preferential phagocytic uptake of nanoparticle-antigen conjugates for the effective treatment of autoimmunity.

Prashant Sadanandan, Natalie L Payne, Guizhi Sun, Anusha Ashokan, Siddaramana G Gowd, Arsha Lal, M K Satheesh Kumar, Sreeranjini Pulakkat, Shantikumar V Nair, Krishnakumar N Menon, Claude C A Bernard, Manzoor Koyakutty,

Tolerance induction is central to the suppression of autoimmunity. Here, we engineered the preferential uptake of nano-conjugated autoantigens by spleen-resident macrophages to re-introduce self-tolerance and suppress autoimmunity. The brain autoantigen, myelin oligodendrocyte glycoprotein (MOG), was conjugated to 200 or 500nm silica nanoparticles (SNP) and delivered to the spleen and liver-resident ... Read more >>

Nanomedicine (Nanomedicine : nanotechnology, biology, and medicine)
[2021, :102481]

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Overexpression of ADAM9 decreases radiosensitivity of hepatocellular carcinoma cell by activating autophagy.

Lijin Zhu, Yuanyuan Zhao, Li Yu, Xinjia He, Yingju Wang, Peng Jiang, Rong Yu, Wei Li, Bin Dong, Xiang Wang, Yinying Dong,

A disintegrin and a metalloprotease (ADAM)9 upregulated within human hepatocellular carcinoma (HCC) cells, but its effect on HCC radiosensitivity remains unknown. The present work aimed to examine the effect of ADAM9 on HCC radiosensitivity and to reveal its possible mechanism, which may be helpful in identifying a potential therapeutic strategy. ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):5516-5528]

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Update on polycystic ovary syndrome.

Jin Ju Kim,

Polycystic ovary syndrome (PCOS) is a common disorder in reproductive-age women. In 2018, an international evidence-based guideline announced recommendations spanning a wide range of issues on the assessment and management of PCOS. From the 166 recommendations, the present study reviews those that are of particular clinical relevance for daily practice ... Read more >>

Clin Exp Reprod Med (Clinical and experimental reproductive medicine)
[2021, 48(3):194-197]

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Adipose-Derived Stem/Stromal Cells in Kidney Transplantation: Status Quo and Future Perspectives.

Gabriele Storti, Evaldo Favi, Francesca Albanesi, Bong-Sung Kim, Valerio Cervelli,

Kidney transplantation (KT) is the gold standard treatment of end-stage renal disease. Despite progressive advances in organ preservation, surgical technique, intensive care, and immunosuppression, long-term allograft survival has not significantly improved. Among the many peri-operative complications that can jeopardize transplant outcomes, ischemia-reperfusion injury (IRI) deserves special consideration as it is ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(20):]

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The soybean TGA transcription factor GmTGA13 plays important roles in the response to salinity stress.

D Ke, Y He, L Fan, R Niu, L Cheng, L Wang, Z Zhang,

Soybean (Glycine max L.) is an important oil, food and economic crop in the world. High salinity severely affects the growth and yield of soybean. Overexpressing a specific anti-retroviral transcription factor by biotechnology is an effective way to cultivate new stress-tolerant varieties of soybean. TGA transcription factor is a subfamily ... Read more >>

Plant Biol (Stuttg) (Plant biology (Stuttgart, Germany))
[2021, :]

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Embryogenic Calli Induction and Salt Stress Response Revealed by RNA-Seq in Diploid Wild Species Gossypium sturtianum and Gossypium raimondii.

Hushuai Nie, Yali Wang, Chengcheng Wei, Corrinne E Grover, Ying Su, Jonathan F Wendel, Jinping Hua,

Wild cotton species can contribute to a valuable gene pool for genetic improvement, such as genes related to salt tolerance. However, reproductive isolation of different species poses an obstacle to produce hybrids through conventional breeding. Protoplast fusion technology for somatic cell hybridization provides an opportunity for genetic manipulation and targeting ... Read more >>

Front Plant Sci (Frontiers in plant science)
[2021, 12:715041]

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Peripheral immune tolerance by prolactin-induced protein originated from human invariant natural killer T cells.

Hyeong-Woo Lee, Juhyun Shin, Brian S Wilson, Jae-Wook Oh,

invariant natural killer T (iNKT) cells have been reported to regulate a diverse set of immunological responses. iNKT cell dysfunction in cytokine secretion is linked to the development of autoimmunity, an immune response against its own tissue. Interestingly, CD4<sup>+</sup> iNKT cells preferentially secrete regulatory cytokines. Here we investigated what kind ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):461-475]

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The Positive Impact of Donor Bone Marrow Cells Transplantation into Immunoprivileged Compartments on the Survival of Vascularized Skin Allografts.

Arkadiusz Jundziłł, Aleksandra Klimczak, Erhan Sonmez, Grzegorz Brzezicki, Maria Siemionow,

Using the vascularized skin allograft (VSA) model, we compared the tolerogenic effects of different allogeneic bone marrow transplantation (BMT) delivery routes into immunoprivileged compartments under a 7-day protocol immunosuppressive therapy. Twenty-eight fully MHC mismatched VSA transplants were performed between ACI (RT1<sup>a</sup>) donors and Lewis (RT1<sup>1</sup>) recipients in four groups of ... Read more >>

Arch Immunol Ther Exp (Warsz) (Archivum immunologiae et therapiae experimentalis)
[2021, 69(1):28]

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Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice.

Christopher S Wilson, Blair T Stocks, Emilee M Hoopes, Jillian P Rhoads, Kelsey L McNew, Amy S Major, Daniel J Moore,

Autoimmune disease has presented an insurmountable barrier to restoration of durable immune tolerance. Previous studies indicate that chronic therapy with metabolic inhibitors can reduce autoimmune inflammation, but it remains unknown whether acute metabolic modulation enables permanent immune tolerance to be established. In an animal model of lupus, we determined that ... Read more >>

JCI Insight (JCI insight)
[2021, 6(19):]

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The role of CD8+ T-cell systemic lupus erythematosus pathogenesis: an update.

Ping-Min Chen, George C Tsokos,

<h4>Purpose of review</h4>Systemic lupus erythematosus (SLE) is a serious autoimmune disease with a wide range of organ involvement. In addition to aberrant B-cell responses leading to autoantibody production, T-cell abnormalities are important in the induction of autoimmunity and the ensuing downstream organ damage. In this article, we present an update ... Read more >>

Curr Opin Rheumatol (Current opinion in rheumatology)
[2021, 33(6):586-591]

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Genome-wide analysis of ZAT gene family revealed GhZAT6 regulates salt stress tolerance in G. hirsutum.

Guoquan Chen, Zhao Liu, Shengdong Li, Ghulam Qanmber, Le Liu, Mengzhen Guo, Lili Lu, Shuya Ma, Fuguang Li, Zuoren Yang,

High salt environments can induce stress in different plants. The genes containing the ZAT domain constitute a family that belongs to a branch of the C<sub>2</sub>H<sub>2</sub> family, which plays a vital role in responding to abiotic stresses. In this study, we identified 169 ZAT genes from seven plant species, including ... Read more >>

Plant Sci (Plant science : an international journal of experimental plant biology)
[2021, 312:111055]

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Dietary Conjugated Linoleic Acid Modulates the Hepatic Circadian Clock Program via PPARα/REV-ERBα-Mediated Chromatin Modification in Mice.

Hao-Yu Liu, Haotian Gu, Yanwei Li, Ping Hu, Yatian Yang, Kaiqi Li, Hao Li, Kexin Zhang, Bo Zhou, Huaxing Wu, Wenbin Bao, Demin Cai,

<b>Scope:</b> Disruptions of circadian rhythm cause metabolic disorders and are closely related to dietary factors. In this study, we investigated the interplays between the dietary conjugated linoleic acid (CLA)-induced hepatic steatosis and the circadian clock regulation, in association with lipid homeostasis. <b>Methods and Results:</b> Exposure of mice to 1.5% dietary ... Read more >>

Front Nutr (Frontiers in nutrition)
[2021, 8:711398]

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Strigolactones positively regulate abscisic acid-dependent heat and cold tolerance in tomato.

Cheng Chi, Xuechen Xu, Mengqi Wang, Hui Zhang, Pingping Fang, Jie Zhou, Xiaojian Xia, Kai Shi, Yanhong Zhou, Jingquan Yu,

Strigolactones are carotenoid-derived phytohormones that impact plant growth and development in diverse ways. However, the roles of strigolactones in the responses to temperature stresses are largely unknown. Here, we demonstrated that strigolactone biosynthesis is induced in tomato (Solanum lycopersicum) by heat and cold stresses. Compromised strigolactone biosynthesis or signaling negatively ... Read more >>

Hortic Res (Horticulture research)
[2021, 8(1):237]

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