Full Text Journal Articles about
Inclusion Body Myositis

Advertisement

Find full text journal articles






[Idiopathic Inflammatory Myopathies].

Stylianos Tomaras, Jörn Kekow, Eugen Feist,

Myositis is a rare and an extremely heterogeneous autoimmune disease, that causes muscle weakness. Currently, "idiopathic inflammatory myopathies (IIM)" is the preferred umbrella-term used to describe the disease complexity within individuals. IIM include dermatomyositis, polymyositis, inclusion body myositis, autoimmune necrotizing myopathy, overlap myositis and antisynthetase syndrome. Research activity concerning myositis ... Read more >>

Dtsch. Med. Wochenschr. (Deutsche medizinische Wochenschrift (1946))
[2020, 145(13):903-910]

Cited: 0 times

View full text PDF listing >>



Trends in idiopathic inflammatory myopathies: cross-sectional data from the German National Database.

Katinka Albrecht, Dörte Huscher, Johanna Callhoff, Jutta G Richter, Tobias Alexander, Jörg Henes, Angela Zink,

OBJECTIVE:To describe trends in outcomes among patients with idiopathic inflammatory myopathies (IIM) over two decades. METHODS:From 1997 to 2017, a total of 1079 IIM patients were documented in the National Database of the German Collaborative Arthritis Centers. Annual cross-sectional data on treatment, disease activity, patient-reported outcomes, hospitalization and employment were ... Read more >>

Rheumatol. Int. (Rheumatology international)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Inclusion body myositis in patients with spinocerebellar ataxia types 3 and 6.

Anke Rietveld, Judith van Gaalen, Christiaan Saris, Kees Okkersen, Benno Küsters, Bart van de Warrenburg, Baziel van Engelen, Sabrina Sacconi, Joost Raaphorst,

OBJECTIVES:To describe the combination of spinocerebellar ataxia (SCA) types 3 and 6 and sporadic inclusion body myositis (IBM). METHODS:A description of five patients with SCA type 3 and 6 who were diagnosed with IBM. We explore possible mechanisms explaining the coexistence of both diseases. RESULTS:The patients with SCA-3 (n=4) and ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, :]

Cited: 0 times

View full text PDF listing >>



MicroRNA and mRNA profiling in the idiopathic inflammatory myopathies.

Joanna E Parkes, Anastasia Thoma, Adam P Lightfoot, Philip J Day, Hector Chinoy, Janine A Lamb,

Background:The idiopathic inflammatory myopathies (IIMs) are heterogeneous autoimmune conditions of skeletal muscle inflammation and weakness. MicroRNAs (miRNAs) are short, non-coding RNA which regulate gene expression of target mRNAs. The aim of this study was to profile miRNA and mRNA in IIM and identify miRNA-mRNA relationships which may be relevant to ... Read more >>

BMC Rheumatol (BMC Rheumatology)
[2020, 4:25]

Cited: 0 times

View full text PDF listing >>



Machine learning algorithms reveal unique gene expression profiles in muscle biopsies from patients with different types of myositis.

Iago Pinal-Fernandez, Maria Casal-Dominguez, Assia Derfoul, Katherine Pak, Frederick W Miller, Jose César Milisenda, Josep Maria Grau-Junyent, Albert Selva-O'Callaghan, Carme Carrion-Ribas, Julie J Paik, Jemima Albayda, Lisa Christopher-Stine, Thomas E Lloyd, Andrea M Corse, Andrew L Mammen,

OBJECTIVES:Myositis is a heterogeneous family of diseases that includes dermatomyositis (DM), antisynthetase syndrome (AS), immune-mediated necrotising myopathy (IMNM), inclusion body myositis (IBM), polymyositis and overlap myositis. Additional subtypes of myositis can be defined by the presence of myositis-specific autoantibodies (MSAs). The purpose of this study was to define unique gene ... Read more >>

Ann. Rheum. Dis. (Annals of the rheumatic diseases)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Myopathies featuring early or prominent dysphagia.

James D Triplett, Marcus V Pinto, Emily A Hosfield, Margherita Milone, Teerin Liewluck,

BACKGROUND:Limited data exist regarding myopathies with early or prominent dysphagia. METHODS:A retrospective study was performed (January 2003 to August 2019) to identify myopathy patients in whom dysphagia was the initial symptom or was disproportionately severe compared with limb weakness. RESULTS:Thirty-two patients were identified. The median age at diagnosis was 65 ... Read more >>

Muscle Nerve (Muscle & nerve)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Myopathies with finger flexor weakness: Not only inclusion-body myositis.

Stefan Nicolau, Teerin Liewluck, Margherita Milone,

Muscle disorders are characterized by differential involvement of various muscle groups. Among these, weakness predominantly affecting finger flexors is an uncommon pattern, most frequently found in sporadic inclusion-body myositis. This finding is particularly significant when the full range of histopathological findings of inclusion-body myositis is not found on muscle biopsy. ... Read more >>

Muscle Nerve (Muscle & nerve)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Efficacy of Botulinum Toxin for Treating Sialorrhea in Neuromuscular Conditions.

Harsh Singh, Yash Nene, Tejas R Mehta, Raghav Govindarajan,

Background: Drooling related to bulbar weakness and dysfunction is a common concern in patients with neuromuscular disease. While there are numerous medications to manage sialorrhea, they are often limited by side effects and lack of efficacy. Botulinum toxin has shown to benefit ALS patients in a few studies, but there ... Read more >>

Front Neurol (Frontiers in Neurology)
[2020, 11:513]

Cited: 0 times

View full text PDF listing >>



Attitudes Toward Noninterventional Observational Studies in US and Australian Patients With Sporadic Inclusion Body Myositis.

Veena Mathew, Marie Wencel, Ali Aamer Habib, Namita A Goyal, Merrilee Needham, Tahseen Mozaffar,

J Clin Neuromuscul Dis (Journal of clinical neuromuscular disease)
[2020, 21(4):246-247]

Cited: 0 times

View full text PDF listing >>



Inclusion Body Myositis. Genetics, Biomarkers and Muscle Biopsy.

Ioannis Mavroudis, Foivos Petridis, Dimitrios Kazis,

Sporadic inclusion body myositis is the most common idiopathic inflammatory myopathy over the age of 50, with a male-to-female ratio of 3:1. Symptoms onset before age of 60 occurs in 18-20% of patients, with a delay in diagnosis of 5 to 8 years.The classic clinical presentation of SIBM consists of ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-10]

Cited: 0 times

View full text PDF listing >>



MON-LB70 The Association of Paget’s Disease With Inclusion Body Myositis and Fronto Temporal Dementia (IBMFTD).

Clare Miller, Siobhan E Mcquaid,

Abstract Background: Inclusion body myopathy associated with Paget disease of bone (PDB) and/or frontotemporal dementia (IBMPFD) is a rare, autosomal dominant condition, characterized by adult-onset muscle weakness, early-onset PDB, and premature frontotemporal dementia. Paget’s disease is a chronic disorder of bone resulting in increased bone resorption, followed by a disorganized ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2020, 4(Suppl 1):]

Cited: 0 times

View full text PDF listing >>



Mitochondrial Dysfunction: A Common Hallmark Underlying Comorbidity between sIBM and Other Degenerative and Age-Related Diseases.

Marc Catalán-García, Francesc Josep García-García, Pedro J Moreno-Lozano, Gema Alcarraz-Vizán, Adrià Tort-Merino, José César Milisenda, Judith Cantó-Santos, Tamara Barcos-Rodríguez, Francesc Cardellach, Albert Lladó, Anna Novials, Glòria Garrabou, Josep M Grau-Junyent,

Sporadic inclusion body myositis (sIBM) is an inflammatory myopathy associated, among others, with mitochondrial dysfunction. Similar molecular features are found in Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM), underlying potential comorbidity. This study aims to evaluate common clinical and molecular hallmarks among sIBM, AD, and T2DM. Comorbidity with ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(5):]

Cited: 0 times

View full text PDF listing >>



Ultrasound can differentiate inclusion body myositis from disease mimics.

Kristofoor E Leeuwenberg, Nens van Alfen, Lisa Christopher-Stine, Julie J Paik, Eleni Tiniakou, Christopher Mecoli, Jonne Doorduin, Christiaan G J Saris, Jemima Albayda,

INTRODUCTION:The diagnosis of inclusion body myositis (IBM) can be challenging, and its presentation can be confused with other forms of myositis or neuromuscular disorders. In this study we evaluate the ability of quantitative muscle ultrasound to differentiate between IBM and mimicking diseases. METHODS:Patients 50 years of age and older were included ... Read more >>

Muscle Nerve (Muscle & nerve)
[2020, 61(6):783-788]

Cited: 0 times

View full text PDF listing >>



Diving into the Heterogeneity of Inclusion Body Myositis.

Hani Kushlaf,

Muscle Nerve (Muscle & nerve)
[2020, 62(1):7-9]

Cited: 0 times

View full text PDF listing >>



Comparison of rapamycin and methylprednisolone for treating inflammatory muscle disease in a murine model of experimental autoimmune myositis.

Juan Kang, Dongyun Feng, Feng Yang, Xiaojia Tian, Wenjuan Han, Hongge Jia,

Idiopathic inflammatory myopathies (IIMs) are a group of autoimmune inflammatory muscle diseases. Rapamycin has been shown to ameliorate inflammation and improve muscle function in a mouse model of experimental autoimmune myositis (EAM). In the present study, the therapeutic effect of rapamycin was compared with methylprednisolone (MP) on EAM. Mice were ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2020, 20(1):219-226]

Cited: 0 times

View full text PDF listing >>



Bioinformatics analysis of gene expression profiles of Inclusion body myositis.

Jiuchang Zhang, Elona Khasanova, Liming Zhang,

Inclusion body myositis (IBM) is a disease with a poor prognosis and limited treatment options. This study aimed at exploring gene expression profile alterations, investigating the underlying mechanisms and identifying novel targets for IBM. We analysed two microarray datasets (GSE39454 and GSE128470) derived from the Gene Expression Omnibus (GEO) database. ... Read more >>

Scand. J. Immunol. (Scandinavian journal of immunology)
[2020, 91(6):e12887]

Cited: 0 times

View full text PDF listing >>



Juvenile Dermatomyositis and the Inflammatory Myopathies.

Collin Swafford, E Steve Roach,

The inflammatory myopathies comprise disorders of immune-mediated muscle injury. The histopathology and clinical features help distinguish them. Juvenile dermatomyositis (JDM) is the most common form of myositis in children and adolescents. Children with JDM present with proximal muscle weakness and characteristic rashes. The presentation is similar in children and adults, ... Read more >>

Semin Neurol (Seminars in neurology)
[2020, 40(3):342-348]

Cited: 0 times

View full text PDF listing >>



Aberrant Expression of High Mobility Group Box Protein 1 in the Idiopathic Inflammatory Myopathies.

Jessica Day, Sophia Otto, Kathy Cash, Preethi Eldi, Pravin Hissaria, Susanna Proudman, Vidya Limaye, John D Hayball,

Introduction:High Mobility Group Box Protein 1 (HMGB1) is a DNA-binding protein that exerts inflammatory or pro-repair effects upon translocation from the nucleus. We postulate aberrant HMGB1 expression in immune-mediated necrotising myopathy (IMNM). Methods:Herein, we compare HMGB1 expression (serological and sarcoplasmic) in patients with IMNM with that of other myositis subtypes ... Read more >>

Front Cell Dev Biol (Frontiers in Cell and Developmental Biology)
[2020, 8:226]

Cited: 0 times

View full text PDF listing >>



[A rare case of inclusion body myositis associated with anti-PM/Scl-75 antibodies].

Masayoshi Yamamoto, Koji Tsuzaki, Kumi Itani, Naoko Tachibana, Manabu Inoue, Toshiaki Hamano,

A 71-year-old man presented with progressive muscle weakness of the four limbs in November 2014. His symptoms had started from the left leg in 2008, resulting in frequent falls. In 2011, he became unable to stand up without a handrail due to weakness of the both legs. Physical examination showed ... Read more >>

Rinsho Shinkeigaku (Rinsho shinkeigaku = Clinical neurology)
[2020, 60(4):264-267]

Cited: 0 times

View full text PDF listing >>



Myo-Inositol Transporter SLC5A3 Associates with Degenerative Changes and Inflammation in Sporadic Inclusion Body Myositis.

Boel De Paepe, Caroline Merckx, Jana Jarošová, Miryam Cannizzaro, Jan L De Bleecker,

Myo-inositol exerts many cellular functions, which include osmo-protection, membrane functioning, and secondary messaging. Its Na+/myo-inositol co-transporter SLC5A3 is expressed in muscle tissue and further accumulates in myositis. In this study we focused on the peculiar subgroup of sporadic inclusion body myositis (IBM), in which auto-inflammatory responses and degenerative changes co-exist. ... Read more >>

Biomolecules (Biomolecules)
[2020, 10(4):]

Cited: 0 times

View full text PDF listing >>



Bar None: A Rare Cause of Oropharyngeal Dysphagia.

Vaishnavi Boppana, Karen SantaCruz, Manish Shrestha, Nicholas Volpicelli, Denis McCarthy,

Dig. Dis. Sci. (Digestive diseases and sciences)
[2020, 65(6):1656-1660]

Cited: 0 times

View full text PDF listing >>



Myositis associated anti-NT5C1A autoantibody in clinical practice

Chiseko Ikenaga, Andrew Findlay, Namita Goyal, Sarah Robinson, Jonathan Cauchi, Yessar Hussain, Leo Wang, Joshua Kershen, Brent Beson, Michael Wallendorf, Robert Bucelli, Tahseen Mozaffar, Alan Pestronk, Conrad Weihl,

Objective: To define the diagnostic utility and clinicopathologic features correlating with anti- cytosolic 5'-nucleotidase 1A (NT5C1A) antibody positivity in idiopathic inflammatory myopathies (IIMs). Methods: 4987 patients had anti-NT5C1A status clinically tested between 2014 and 2019 in the Washington University neuromuscular clinical laboratory. Using clinicopathologic information available for 630 of ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Increased intra-mitochondrial lipofuscin aggregates with spherical dense body formation in mitochondrial myopathy.

Jian-Qiang Lu, Cynthia M F Monaco, Thomas J Hawke, Chuanzhu Yan, Mark A Tarnopolsky,

Lipofuscin aggregation may result from incomplete degradation of damaged mitochondria by autophagy-lysosome pathway, and intra-mitochondrial lipofuscin aggregation may exacerbate mitochondrial abnormalities in mitochondrial myopathy (MM) and mitochondrial disease. We examined vastus lateralis muscle biopsies from 24 patients with pathologically diagnosed MM and clinically diagnosed chronic progressive external ophthalmoplegia, in comparison ... Read more >>

J. Neurol. Sci. (Journal of the Neurological Sciences)
[2020, 413:116816]

Cited: 0 times

View full text PDF listing >>



Mitochondrial dysfunction underlying sporadic inclusion body myositis is ameliorated by the mitochondrial homing drug MA-5

Yoshitsugu Oikawa, Rumiko Izumi, Masashi Koide, Yoshihiro Hagiwara, Makoto Kanzaki, Naoki Suzuki, Koichi Kikuchi, Tetsuro Matsuhashi, Yukako Akiyama, Mariko Ichijo, Takafumi Toyohara, Takehiro Suzuki, Eikan Mishima, Yasutoshi Akiyama, Yoshiaki Ogata, Chitose Suzuki, Masashi Aoki, Eiji Itoi, Shigeo Kure, Ken-ichiro Hayashi, Takaaki Abe,

Abstract Sporadic inclusion body myositis (sIBM) is the most common idiopathic inflammatory myopathy, and several reports have suggested that mitochondrial abnormalities are involved in its etiology. We recruited 9 sIBM patients and found significant histological changes and an elevation of growth differential factor 15 (GDF15), a marker of mitochondrial disease, ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Mitochondrial DNA 10158T>C mutation in a patient with mitochondrial encephalomyopathy with lactic acidosis, and stroke-like episodes syndrome: A case-report and literature review (CARE-complaint).

Shuai Wang, Tao Song, Suping Wang,

RATIONALE:Mitochondrial encephalomyopathy with lactic acidosis and stroke- like episodes (MELAS) syndrome is caused by mitochondrial respiratory chain dysfunction and oxidative phosphorylation disorder. It is a rare clinical metabolic disease involved with multiple systems. PATIENT CONCERNS:A 22-year-old patient presented with limb convulsion accompanied by loss of consciousness, headache, partial blindness, blurred ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(24):e20310]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
2.2489 s