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Oncogenic Ras cooperates with knockdown of the tumor suppressor Lkb1 by RNAi to override organ size limits in Drosophila wing tissue.

Briana Brown Rackley, Evan Kiely, Chang-Soo Seong, Manali Rupji, Melissa Gilbert-Ross,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Establishing functional lentiviral vector production in a stirred bioreactor for CAR-T cell therapy.

Qu-Lai Tang, Li-Xing Gu, Yao Xu, Xing-Hua Liao, Yong Zhou, Tong-Cun Zhang,

As gene delivery tools, lentiviral vectors (LV) have broad applications in chimeric antigen receptor therapy (CAR-T). Large-scale production of functional LV is limited by the adherent, serum-dependent nature of HEK293T cells used in the manufacturing. HEK293T adherent cells were adapted to suspension cells in a serum-free medium to establish large-scale ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2095-2105]

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Identification of mast cells as a candidate significant target of immunotherapy for acute myeloid leukemia.

Mingfeng Jia, Hao Zhang, Lina Wang, Long Zhao, Shengxuan Fan, Yaming Xi,

<h4>Objection</h4>Immunotherapy based on T cells is a new therapy for Acute myeloid leukemia (AML). However, there has not been considerable improvement compared with traditional chemotherapeutics. This study aimed to identify important immune cells, genes, and drugs associated with the immunotherapy of AML.<h4>Methods</h4>The gene expression profile and clinical data of patients ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):284-294]

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A genomic instability-derived risk index predicts clinical outcome and immunotherapy response for clear cell renal cell carcinoma.

Sha Wu, Xiaoning Li,

This study aims to originate agenomic instability-derived risk index (GIRI) for prognostic analysis of clear cell renal cell carcinoma (ccRCC) and explore the mutation characteristics, immune characteristics, and immunotherapy response defined by GIRI. Differentially expressed genome instability-associated genes were obtained from the genomic unstable (GU) group and the genomic stable ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1642-1662]

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The intra-class heterogeneity of immunophenotyping and immune landscape in oesophageal cancer and clinical implications.

Yujie Xie, Xiaoshun Shi, Ying Chen, Bomeng Wu, Xiaolin Gong, Weicheng Lu, Wanli Lin,

<h4>Background</h4>The response rate and survival benefit of immunotherapy vary among patients, implying specific immune status of an individual could be associated with the effect of immunotherapy. However, in-depth studies of immune subtypes (ISs), immune landscape and tumour microenvironment of oesophageal cancer (ESCA) and their clinical implications are less reported.<h4>Methods</h4>We first ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):626-638]

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Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis.

Tao Xu, Jiahao Liu, Yu Xia, Zhi Wang, Xingrui Li, Qinglei Gao,

<h4>Background</h4>The overall response rate of immunotherapy in triple-negative breast cancer (TNBC) remains unsatisfactory. Accumulating evidence indicated that glucose metabolic reprogramming could modulate immunotherapy efficacy. However, transcriptomic evidence remains insufficient.<h4>Methods</h4>Genes' relationship with glucose metabolism and TNBC-specific immune was demonstrated by weighted gene co-expression network analysis (WGCNA). The glucose metabolic capability was ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):916-928]

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Targeting CD155 by rediocide-A overcomes tumour immuno-resistance to natural killer cells.

Wanyi Ng, Chenyuan Gong, Xuewei Yan, Guifan Si, Chen Fang, Lixin Wang, Xiaowen Zhu, Zihang Xu, Chao Yao, Shiguo Zhu,

<h4>Context</h4>Therapeutic benefits of immunotherapy are restricted by cancer immune-resistance mechanisms. Rediocide-A (Red-A), a natural product extracted from Traditional Chinese Medicine, is a promising agent to battle against cancer which acts as an immune checkpoint inhibitor.<h4>Objective</h4>To investigate the effect of Red-A on NK-cell tumouricidal activity.<h4>Materials and methods</h4>NK cells were co-cultured with ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):47-53]

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Solute carrier transporter superfamily member SLC16A1 is a potential prognostic biomarker and associated with immune infiltration in skin cutaneous melanoma.

Jiaheng Xie, Zhechen Zhu, Yuan Cao, Shujie Ruan, Ming Wang, Jingping Shi,

Melanoma is a type of cancer with a relatively poor prognosis. The development of immunotherapy for the treatment of patients with melanoma has drawn considerable attention in recent years. It is of great clinical significance to identify novel promising prognostic biomarkers and to explore their roles in the immune microenvironment. ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2021, 15(1):483-495]

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M2 subtype tumor associated macrophages (M2-TAMs) infiltration predicts poor response rate of immune checkpoint inhibitors treatment for prostate cancer.

Zhou JiaWei, Dou ChunXia, Liu CunDong, Liu Yang, Yang JianKun, Duan HaiFeng, Yang Cheng, Huang ZhiPeng, Wang HongYi, Liao DeYing, Liang ZhiJian, Xie Xiao, Zhou QiZhao, Xue KangYi, Guo WenBing, Xia Ming, Zhou JunHao, Bao JiMing, Zhao ShanChao, Chen MingKun,

<h4>Background</h4>Prostate cancer (PCa) is poor response to the immunotherapy for its high heterogeneity of immune microenvironment. In this study, we aim to introduce a new immune subtype for PCa involving M2 tumour associated macrophages <b>(</b>M2-TAMs).<h4>Methods</h4>Three hundred and sixty-two PCa patients and matched normal prostate tissues were selected from the Cancer ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):730-740]

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MiRNA based tumor mutation burden diagnostic and prognostic prediction models for endometrial cancer.

Nan Lu, Jinhui Liu, Chengjian Ji, Yichun Wang, Zhipeng Wu, Shuning Yuan, Yan Xing, Feiyang Diao,

Uterus Corpus Endometrial cancer (UCEC) is the sixth most common malignant tumor worldwide. In this research, we identified diagnostic and prognostic biomarkers to reflect patients' immune microenvironment and prognostic. Various data of UCEC patients from the TCGA database were obtained. Firstly, patients were divided into a high tumor mutation burden ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3603-3620]

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The screening of immune-related biomarkers for prognosis of lung adenocarcinoma.

Zhonghui Liu, Dan Sun, Qing Zhu, Xinmin Liu,

Lung adenocarcinoma (LUAD) accounts for a frequently seen non-small cell lung cancer (NSCLC) histological subtype, and it is associated with dismal prognostic outcome. However, the benefits of traditional treatment are still limited, and the efficacies of immunotherapy are quite different. Therefore, it is of great significance to identify novel immune-related ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1273-1285]

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Comprehensive Analysis of Monocarboxylate Transporter 4 (MCT4) expression in breast cancer prognosis and immune infiltration via integrated bioinformatics analysis.

Chen Yuan, Jie Zhang, Jianjuan Lou, Siqi Wang, Yanni Jiang, Feiyun Wu, Shouju Wang,

Lactate blunts the anticancer immune response in breast cancer (BC). However, little is known about the exact effect of lactate transporters such as monocarboxylate transporter 4 (MCT4) on immunotherapy. In this study, we investigated the expression status and prognostic value of MCT4 in BC through large-scale transcriptome data. Our results ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3850-3863]

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Analysis of RNA m6A methylation regulators and tumour immune cell infiltration characterization in prostate cancer.

Yue Zhao, Huimin Sun, Jianzhong Zheng, Chen Shao,

Potential roles of RNA N6-methyladenosine (m<sup>6</sup>A) modification in tumour microenvironment (TME) cell infiltration has been demonstrated in recent studies. Nonetheless, the mechanism of its regulation remains unknown and immunotherapy has been marginal in prostate cancer. We demonstrated the expression of different m<sup>6</sup>A regulators within prostate cancer related to genetic variation, ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2021, 49(1):407-435]

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Bioinformatics reveal macrophages marker genes signature in breast cancer to predict prognosis.

Ying Li, Xin Zhao, Qiang Liu, Yujie Liu,

<b>Background:</b> Breast cancer is a pivotal cause of global women cancer death. Immunotherapy has become a promising means to cure breast cancer. As constitutes of immune microenvironment of breast cancer, macrophages exert complicated functions in the tumour development and treatment. This study aims to develop a prognostic macrophage marker genes ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1019-1031]

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Multi-omics reveals novel prognostic implication of SRC protein expression in bladder cancer and its correlation with immunotherapy response.

Wenhao Xu, Aihetaimujiang Anwaier, Chunguang Ma, Wangrui Liu, Xi Tian, Maierdan Palihati, Xiaoxin Hu, Yuanyuan Qu, Hailiang Zhang, Dingwei Ye,

<h4>Purpose</h4>This study aims to identify potential prognostic biomarkers of bladder cancer (BCa) based on large-scale multi-omics data and investigate the role of SRC in improving predictive outcomes for BCa patients and those receiving immune checkpoint therapies (ICTs).<h4>Methods</h4>Large-scale multi-comic data were enrolled from the Cancer Proteome Atlas, the Cancer Genome Atlas ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):596-610]

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Nanovesicles released by OKT3 hybridoma express fully active antibodies.

Mariantonia Logozzi, Rossella Di Raimo, Francesca Properzi, Stefano Barca, Daniela F Angelini, Davide Mizzoni, Mario Falchi, Luca Battistini, Stefano Fais,

Recent findings have shown that nanovesicles preparations from either primary immune cells culture supernatants or plasma contain immunoglobulins, suggesting that a natural way of antibody production may be through exosome release. To verify this hypothesis, we used the OKT3 hybridoma clone, which produces a murine IgG2a monoclonal antibody used to ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):175-182]

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Construction of a novel risk model based on the random forest algorithm to distinguish pancreatic cancers with different prognoses and immune microenvironment features.

Yalan Lei, Rong Tang, Jin Xu, Bo Zhang, Jiang Liu, Chen Liang, Qingcai Meng, Jie Hua, Xianjun Yu, Wei Wang, Si Shi,

Immune-related long noncoding RNAs (irlncRNAs) are actively involved in regulating the immune status. This study aimed to establish a risk model of irlncRNAs and further investigate the roles of irlncRNAs in predicting prognosis and the immune landscape in pancreatic cancer. The transcriptome profiles and clinical information of 176 pancreatic cancer ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3593-3602]

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Infiltrating T-cell abundance combined with EMT-related gene expression as a prognostic factor of colon cancer.

Xiaowei Huang, Chan Chen, Yajing Xu, Lanxiao Shen, Yi Chen, Huafang Su,

EMT-related gene expression reportedly exhibits correlation with the anti-tumor immunity of T cells. In the present study, we explored the factors that might affect the efficacy of immunotherapy in colon cancer with treatment. In this regard, RNA-seq and clinical data of 469 colon cancer samples derived from the Cancer Genome ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2688-2701]

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A novel immune-related long non-coding RNA signature improves the prognosis prediction in the context of head and neck squamous cell carcinoma.

Lin Chen, Zhimou Cai, Kexing Lyu, Zhiwei Cai, Wenbin Lei,

The tumor immune microenvironment plays an important role in head and neck squamous cell carcinoma (HNSCC). Reliable prognostic signatures able to accurately predict the immune landscape and survival rate of HNSCC patients are crucial to ensure an individualized/effective treatment. Here, we used HNSCC transcriptomic and clinical data retrieved from The ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2311-2325]

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Interleukin-18 promotes the antitumor ability of natural killer cells in colorectal cancer via the miR-574-3p/TGF-β1 axis.

Yin-Peng Li, Xian-Rong Du, Ru Zhang, Qiu Yang,

Interleukin (IL)-18 has a clear antitumor effect; however, its mechanisms of action are not understood in patients with colorectal cancer (CRC). Here, we investigated the potential mechanism of IL-18 in CRC. The results showed that IL-18 treatment alone had no effect on HCT116 cells apoptosis, whereas IL-18 in the presence ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):763-778]

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Optimization of GPC3-specific chimeric antigen receptor structure and its effect on killing hepatocellular carcinoma cells.

Jianfeng Zhao, Lijuan Lin, Yihua Luo, Qinghe Cai, Xiaojie Jiang, Changxi Liao, Huimin Wei,

To investigate the effect of optimized GPC3-specific chimeric antigen receptor (GPC3-CAR) structure on killing hepatocellular carcinoma (HCC) cells. We constructed three lentiviral expression vectors with different CAR structures by genetic engineering and molecular cloning techniques. These three CAR structures shared the same intracellular signaling region consisting of 4-1BB and CD3ζ, ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3674-3683]

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Prediction of clinical prognosis in cutaneous melanoma using an immune-related gene pair signature.

Yu Yang, Xuan Long, Guiyun Li, Xiaohong Yu, Yu Liu, Kun Li, Xiaobin Tian,

Cutaneous melanoma (CM) is a malignant and aggressive skin cancer that is the leading cause of skin cancer-related deaths. Increasing evidence shows that immunity plays a vital role in the prognosis of CM. In this study, we developed an immune-related gene pair (IRGP) signature to predict the clinical prognosis of ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1803-1812]

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Anti-glomerular basement membrane disease mediated by IgG and IgA: a case report.

Guming Zou, Haitao Lu, Li Zhuo, Wanzhong Zou, Wenge Li,

<h4>Background</h4>Anti-glomerular basement membrane (anti-GBM) disease is a rare autoimmune condition responsible for rapidly progressive glomerulonephritis. This disease is usually mediated by IgG autoantibodies against the noncollagenous domain of the α3(IV) collagen chain. In rare cases, IgA or IgM anti-GBM antibodies are involved. This raises the question of whether there are ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):774-778]

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A hypoxia related long non-coding RNA signature could accurately predict survival outcomes in patients with bladder cancer.

Facai Zhang, Xiaoming Wang, Huan Hu, Yubo Yang, Jiahao Wang, Yin Tang, Dengxiong Li, Yunjin Bai, Ping Han,

Hypoxia plays a significant role in tumor progression. This study aimed to develop a hypoxia-related long noncoding RNA (lncRNA) signature for predicting survival outcomes of patients with bladder cancer (BC). The transcriptome and clinicopathologic data were downloaded from The Cancer Genome Atlas (TCGA) database. Univariate Cox regression analysis and Lasso ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3802-3823]

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Immune activation by microbiome shapes the colon mucosa: Comparison between healthy rat mucosa under conventional and germ-free conditions.

Fabián Čaja, Dmitry Stakheev, Oleksander Chernyavskiy, Jiří Křížan, Jiří Dvořák, Pavel Rossmann, Renata Štěpánková, Peter Makovický, Pavol Makovický, Hana Kozáková, Luca Vannucci,

Germ-free animals (GF) are those without a microbiome since birth. This particular biological model has become one of special interest with the growing evidence of importance of the microbiome in the life, development, adaptation, and immunity of humans and animals in the environments in which they live. Anatomical differences observed ... Read more >>

J Immunotoxicol (Journal of immunotoxicology)
[2021, 18(1):37-49]

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