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Long intergenic non-coding RNA 1939 eliminates proliferation and migration of human renal cell carcinoma (RCC) cells by down-regulation of miR-154.

Rongyuan Zhang, Weijie Zhang, Baocai Xu, Chuan Lv, Jianquan Hou, Guangbo Zhang,

Renal carcinoma (RCC) is widely accepted as a malignant tumour of urinary system. Long intergenic non-coding RNA 1939 (LINC01939) is a novel lncRNA which was found to be down-regulated in RCC. Thus, we set out to explore the effect and regulation mechanism of LINC01939 in RCC. LINC01939 and miR-154 in ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):695-702]

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Contribution of NKT cells to the immune response and pathogenesis triggered by respiratory viruses.

Emma Rey-Jurado, Karen Bohmwald, Nicolás M S Gálvez, Daniela Becerra, Steven A Porcelli, Leandro J Carreño, Alexis M Kalergis,

Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) cause acute respiratory tract infections in children worldwide. Natural killer T (NKT) cells are unconventional T lymphocytes, and their TCRs recognize glycolipids bound to the MHC-I-like molecule, CD1d. These cells modulate the inflammatory response in viral infections. Here, we evaluated the ... Read more >>

Virulence (Virulence)
[2020, 11(1):580-593]

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Delayed specific IgM antibody responses observed among COVID-19 patients with severe progression.

Liang Shen, Chunhua Wang, Jianzhong Zhao, Xiaoyong Tang, Ying Shen, Mingqing Lu, Zhe Ding, Canping Huang, Ji Zhang, Shichao Li, Jiaming Lan, Gary Wong, Yufang Zhu,

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly worldwide since it was confirmed as the causative agent of COVID-19. Molecular diagnosis of the disease is typically performed via nucleic acid-based detection of the virus from swabs, sputum or bronchoalveolar lavage fluid (BALF). However, the positive rate from the ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1096-1101]

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Cross-validation of the RT-QuIC assay for the antemortem detection of chronic wasting disease in elk.

N J Haley, R Donner, D M Henderson, J Tennant, E A Hoover, M Manca, B Caughey, N Kondru, S Manne, A Kanthasamay, S Hannaoui, S C Chang, S Gilch, S Smiley, G Mitchell, A D Lehmkuhl, B V Thomsen,

Chronic wasting disease is a progressively fatal, horizontally transmissible prion disease affecting several members of the cervid species. Conventional diagnosis relies on ELISA or IHC evaluation using tissues collected post-mortem; however, recent research has focused on newly developed amplification techniques using samples collected antemortem. The present study sought to cross-validate ... Read more >>

Prion (Prion)
[2020, 14(1):47-55]

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Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial.

Viola Poeschel, Gerhard Held, Marita Ziepert, Mathias Witzens-Harig, Harald Holte, Lorenz Thurner, Peter Borchmann, Andreas Viardot, Martin Soekler, Ulrich Keller, Christian Schmidt, Lorenz Truemper, Rolf Mahlberg, Reinhard Marks, Heinz-Gert Hoeffkes, Bernd Metzner, Judith Dierlamm, Norbert Frickhofen, Mathias Haenel, Andreas Neubauer, Michael Kneba, Francesco Merli, Alessandra Tucci, Peter de Nully Brown, Massimo Federico, Eva Lengfelder, Alice di Rocco, Ralf Trappe, Andreas Rosenwald, Christian Berdel, Martin Maisenhoelder, Ofer Shpilberg, Josif Amam, Konstantinos Christofyllakis, Frank Hartmann, Niels Murawski, Stephan Stilgenbauer, Maike Nickelsen, Gerald Wulf, Bertram Glass, Norbert Schmitz, Bettina Altmann, Markus Loeffler, Michael Pfreundschuh, , ,

BACKGROUND:Six cycles of R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) are the standard treatment for aggressive B-cell non-Hodgkin lymphoma. In the FLYER trial, we assessed whether four cycles of CHOP plus six applications of rituximab are non-inferior to six cycles of R-CHOP in a population of patients with B-cell ... Read more >>

Lancet (Lancet (London, England))
[2020, 394(10216):2271-2281]

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Recent advances on the role of long non-coding RNAs in Alzheimer's disease.

Kyle Doxtater, Manish K Tripathi, Mohammad Moshahid Khan,

Neural Regen Res (Neural regeneration research)
[2020, 15(12):2253-2254]

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LncRNA SNHG4 regulates miR-10a/PTEN to inhibit the proliferation of acute myeloid leukemia cells.

Zhongtao Yuan, Wei Wang,

ABSTRACTObjectives: Long non-coding RNA (lncRNA) small nucleolar RNA host gene 4 (SNHG4) is a characterized oncogenic lncRNA in osteosarcoma. The analysis of the TCGA dataset suggested the downregulation of SNHG4 in acute myeloid leukemia (AML), indicating its possible involvement in this disease. Therefore, this study was performed to analyze the ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2020, 25(1):160-164]

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Implementation and evaluation of a self-directed learning activity for first-year medical students.

Molly Hill, Megan Peters, Michelle Salvaggio, Jay Vinnedge, Alix Darden,

Background: It is critical that medical students develop self-directed, life-long learning skills to navigate medical school successfully and to become competent healthcare professionals. Moreover, the Liaison Committee on Medical Education (LCME), the USA medical school accrediting body, requires activities designed to help students develop self-directed learning (SDL) skills in the ... Read more >>

Med Educ Online (Medical education online)
[2020, 25(1):1717780]

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Management of chronic wasting disease in ranched elk: conclusions from a longitudinal three-year study.

N J Haley, D M Henderson, R Donner, S Wyckoff, K Merrett, J Tennant, E A Hoover, D Love, E Kline, A D Lehmkuhl, B V Thomsen,

Chronic wasting disease is a fatal, horizontally transmissible prion disease of cervid species that has been reported in free-ranging and farmed animals in North America, Scandinavia, and Korea. Like other prion diseases, CWD susceptibility is partly dependent on the sequence of the prion protein encoded by the host's PRNP gene; ... Read more >>

Prion (Prion)
[2020, 14(1):76-87]

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Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors.

Huan Han, Qingfeng Ma, Cong Li, Rui Liu, Li Zhao, Wei Wang, Pingan Zhang, Xinghui Liu, Guosheng Gao, Fang Liu, Yingan Jiang, Xiaoming Cheng, Chengliang Zhu, Yuchen Xia,

Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly spread across many other countries. While the majority of patients were considered mild, critically ill patients involving respiratory failure and multiple organ dysfunction syndrome are not uncommon, which could result death. We hypothesized that cytokine storm ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1123-1130]

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Protocatechuic acid inhibits proliferation, migration and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes.

Huiqiang Wu, Jing Wang, Qing Zhao, Yanjie Ding, Bingyi Zhang, Lingli Kong,

Rheumatoid arthritis (RA) is a chronic joint inflammatory disease that is closely associated with dysregulation of fibroblast-like synoviocytes (FLSs). Protocatechuic acid (PCA), a phenolic compound of anthocyanins, has been proven to possess anti-inflammatory activity. However, the role of PCA in RA has not been investigated. In the present study, we ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):969-976]

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The interaction between flagellin and the glycosphingolipid Gb3 on host cells contributes to Bacillus cereus acute infection.

Song Gao, Chengpei Ni, Wenhua Huang, Huaijie Hao, Hua Jiang, Qingyu Lv, Yuling Zheng, Peng Liu, Decong Kong, Yongqiang Jiang,

BACILLUS CEREUS:is an opportunistic pathogen that can cause emetic or diarrheal foodborne illness. Previous studies have identified multiple pathogenic B. cereus strains and characterized a variety of virulence factors. Here, we demonstrate that the virulence and lethality of B. cereus for mammalian cells and host animals involve the interaction of ... Read more >>

Virulence (Virulence)
[2020, 11(1):769-780]

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Colostrum fails to prevent bovine/camelid neonatal neutrophil damage from AFB1.

Sajad Najafi, Gholamreza Mohammadi, Mehrdad Mohri, Saman Hosseinkhani, Jalil Mehrzad,

Exposure to environmental toxicants that affect the immune system and overall health of many mammals is mostly unavoidable. One of the more common substances is the mycotoxins, especially carcinogenic aflatoxin (AF)B1 which also causes immune suppression/dysregulation in exposed hosts. The present study analyzed the effects of naturally occurring levels of ... Read more >>

J Immunotoxicol (Journal of immunotoxicology)
[2020, 17(1):43-50]

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Preclinical evaluation of antigen-specific nanotherapy based on phosphatidylserine-liposomes for type 1 diabetes.

Adrian Villalba, Silvia Rodriguez-Fernandez, Rosa-Maria Ampudia, Mary Cano-Sarabia, David Perna-Barrull, Cesc Bertran-Cobo, Clara Ehrenberg, Daniel Maspoch, Marta Vives-Pi,

Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of insulin-producing cells. Due to the ability of apoptotic cells clearance to induce tolerance, we previously generated liposomes rich in phophatidylserine (PS) -a feature of apoptotic cells- loaded with insulin peptides to mimic apoptotic beta-cells. PS-liposomes arrested autoimmunity ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):77-83]

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Hypoxia regulates human mast cell adhesion to fibronectin via the PI3K/AKT signaling pathway.

Joanna Pastwińska, Aurelia Walczak-Drzewiecka, Magdalena Łukasiak, Marcin Ratajewski, Jarosław Dastych,

A decrease in oxygen concentration is a hallmark of inflammatory reactions resulting from infection or homeostasis disorders. Mast cells interact with extracellular matrix and other cells by adhesion receptors. We investigated the effect of hypoxia on integrin-mediated mast cell adhesion to fibronectin. We found that it was mediated by the ... Read more >>

Cell Adh Migr (Cell adhesion & migration)
[2020, 14(1):106-117]

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Potential classification of chemical immunologic response based on gene expression profiles.

Stacey E Anderson, Rachel Baur, Michael Kashon, Ewa Lukomska, Lisa Weatherly, Hillary L Shane,

Occupational immune diseases are a serious public health burden and are often a result of exposure to low molecular weight (LMW) chemicals. The complete immunological mechanisms driving these responses are not fully understood which has made the classification of chemical allergens difficult. Antimicrobials are a large group of immunologically-diverse LMW ... Read more >>

J Immunotoxicol (Journal of immunotoxicology)
[2020, 17(1):122-134]

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Relevance of inducible nitric oxide synthase for immune control of Mycobacterium avium subspecies paratuberculosis infection in mice.

Ketema Abdissa, Nanthapon Ruangkiattikul, Wiebke Ahrend, Andreas Nerlich, Andreas Beineke, Kristin Laarmann, Nina Janze, Ulrike Lobermeyer, Abdulhadi Suwandi, Christine Falk, Ulrike Schleicher, Siegfried Weiss, Christian Bogdan, Ralph Goethe,

Mycobacterium avium subspecies paratuberculosis (MAP) causes Johne's disease (JD), an incurable chronic intestinal bowel disease in ruminants. JD occurs worldwide and causes enormous economic burden in dairy industry. Research on JD pathobiology is hampered by its complexity which cannot completely be mimicked by small animal models. As a model the ... Read more >>

Virulence (Virulence)
[2020, 11(1):465-481]

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BST2 regulates interferon gamma-dependent decrease in invasion of HTR-8/SVneo cells via STAT1 and AKT signaling pathways and expression of E-cadherin.

Sonam Verma, Amandeep Kaur Kang, Rahul Pal, Satish Kumar Gupta,

The mechanism by which interferon-gamma (IFN-γ) downregulates trophoblast invasion needs further investigation. Treatment of HTR-8/SVneo cells with IFN-γ led to a decrease in their invasion concomitant with an increased expression of BST2. Silencing of BST2 by siRNA showed a significant increase in their invasion and spreading after treatment with IFN-γ ... Read more >>

Cell Adh Migr (Cell adhesion & migration)
[2020, 14(1):24-41]

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Prenatal arsenic exposure interferes in postnatal immunocompetence despite an absence of ongoing arsenic exposure.

Mainak Chakraborty, Moumita Bhaumik,

Arsenic (As) readily crosses the placenta and exposure of the fetus may cause adverse consequences later in life, including immunomodulation. In the current study, the question was asked how the immune repertoire might respond in postnatal life when there is no further As exposure. Here, pregnant mice (Balb/c [H-2d]) were ... Read more >>

J Immunotoxicol (Journal of immunotoxicology)
[2020, 17(1):135-143]

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Activation of aryl hydrocarbon receptor (AhR) in mesenchymal stem cells modulates macrophage polarization in asthma.

Zhuang Cui, Yuan Feng, Danqing Li, Taoping Li, Peisong Gao, Ting Xu,

Macrophage polarization has been demonstrated to exert a vital role on asthma pathogenesis. Mesenchymal stem cells (MSC) have the capacity to modulate macrophage differentiation from a pro-inflammatory M1 phenotype toward an anti-inflammatory M2 phenotype. However, the impact of MSC-macrophage interactions on asthma development and underlying mechanisms responsible for this interaction ... Read more >>

J Immunotoxicol (Journal of immunotoxicology)
[2020, 17(1):21-30]

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Identification of conditionally essential genes for Streptococcus suis infection in pigs.

Jesús Arenas, Aldert Zomer, Jose Harders-Westerveen, Hester J Bootsma, Marien I De Jonge, Norbert Stockhofe-Zurwieden, Hilde E Smith, Astrid De Greeff,

Streptococcus suis is a Gram-positive bacterium and zoonotic pathogen that causes meningitis and sepsis in pigs and humans. The aim of this study was to identify genes required for S. suis infection. We created Tn-Seq libraries in a virulent S. suis strain 10, which was used to inoculate pigs in ... Read more >>

Virulence (Virulence)
[2020, 11(1):446-464]

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Effect of lead exposure and nutritional iron-deficiency on immune response: A vaccine challenge study in rats.

Srinivasa Reddy Yathapu, Narendra Babu Kondapalli, Sarath Babu Srivalliputturu, Rajkumar Hemalatha, Dinesh Kumar Bharatraj,

The prevalence of iron (Fe) deficiency and subclinical lead (Pb) toxicity is high in developing countries like India, and information on their potential additive effects on immune responses is scant. The current study assessed immune parameters in dual Pb-exposed\Fe-deficient weanling SD rats. Rats were fed a control (CD) or Fe-deficient ... Read more >>

J Immunotoxicol (Journal of immunotoxicology)
[2020, 17(1):144-152]

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Serological differentiation between COVID-19 and SARS infections.

Wan Ni Chia, Chee Wah Tan, Randy Foo, Adrian Eng Zheng Kang, Yilong Peng, Velraj Sivalingam, Charles Tiu, Xin Mei Ong, Feng Zhu, Barnaby E Young, Mark I-C Chen, Yee-Joo Tan, David C Lye, Danielle E Anderson, Lin-Fa Wang,

In response to the coronavirus disease 2019 (COVID-19) outbreak, caused by SARS-CoV-2, multiple diagnostic tests are required for acute disease diagnosis, contact tracing, monitoring asymptomatic infection rates and assessing herd immunity. While PCR remains the frontline test of choice in the acute diagnostic setting, serological tests are urgently needed. Unlike ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1497-1505]

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Active and prospective latent tuberculosis are associated with different metabolomic profiles: clinical potential for the identification of rapid and non-invasive biomarkers.

A Albors-Vaquer, A Rizvi, M Matzapetakis, P Lamosa, A V Coelho, A B Patel, S C Mande, S Gaddam, A Pineda-Lucena, S Banerjee, L Puchades-Carrasco,

Although 23% of world population is infected with Mycobacterium tuberculosis (M. tb), only 5-10% manifest the disease. Individuals surely exposed to M. tb that remain asymptomatic are considered potential latent TB (LTB) cases. Such asymptomatic M. tb.-exposed individuals represent a reservoir for active TB cases. Although accurate discrimination and early ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1131-1139]

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Unbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis.

Icaro Bonyek-Silva, Sara Nunes, Reinan L Santos, Filipe R Lima, Alexsandro Lago, Juliana Silva, Lucas P Carvalho, Sergio M Arruda, Henrique C Serezani, Edgar M Carvalho, Claudia I Brodskyn, Natalia M Tavares,

Poorly controlled diabetes mellitus leads to several comorbidities, including susceptibility to infections. Hyperglycemia increases phagocyte responsiveness, however immune cells from people with diabetes show inadequate antimicrobial functions. We and others have shown that aberrant production of leukotriene B4 (LTB4) is detrimental to host defense in models of bacterial infection. Here, ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1275-1286]

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