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Immunology of Transplant Rejection

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Functional and immunological peculiarities of peripheral nerve allografts.

Kelly C S Roballo, Jason P Gigley, Tyler A Smith, George D Bittner, Jared S Bushman,

This review addresses the accumulating evidence that live (not decellularized) allogeneic peripheral nerves are functionally and immunologically peculiar in comparison with many other transplanted allogeneic tissues. This is relevant because live peripheral nerve allografts are very effective at promoting recovery after segmental peripheral nerve injury via axonal regeneration and axon ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):721-727]

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Microbiota in heart and lung transplantation: implications for innate-adaptive immune interface.

Yun Zhu Bai, Sophia H Roberts, Daniel Kreisel, Ruben G Nava,

<h4>Purpose of review</h4>Transplantation continues to be the only treatment option for end-stage organ failure when other interventions have failed. Although short-term outcomes have improved due to advances in perioperative care, long-term outcomes continue to be adversely affected by chronic rejection. Little is known about the role microbiota play in modulating ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):609-614]

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Immunology and Donor-Specific Antibodies in Corneal Transplantation.

Joanna Major, Bartosz Foroncewicz, Jacek Paweł Szaflik, Krzysztof Mucha,

The first human corneal transplantation was performed in 1905 by Eduard Zirm in the Olomouc Eye Clinic, now Czech Republic. However, despite great advancements in microsurgical eye procedures, penetrating keratoplasty in high-risk patients (e.g., vascularized or inflamed corneal tissue, consecutive transplants) remains a challenge. The difficulty is mainly due to ... Read more >>

Arch Immunol Ther Exp (Warsz) (Archivum immunologiae et therapiae experimentalis)
[2021, 69(1):32]

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Intra-Organ Delivery of Nanotherapeutics for Organ Transplantation.

Bilal Hussain, Vivek Kasinath, Joren C Madsen, Jonathan Bromberg, Stefan G Tullius, Reza Abdi,

Targeted delivery of therapeutics through the use of nanoparticles (NPs) has emerged as a promising method that increases their efficacy and reduces their side effects. NPs can be tailored to localize to selective tissues through conjugation to ligands that bind cell-specific receptors. Although the vast majority of nanodelivery platforms have ... Read more >>

ACS Nano (ACS nano)
[2021, :]

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Multicenter Experience of Hematopoietic Stem Cell Transplantation in WHIM Syndrome.

Alexandra Laberko, Ekaterina Deordieva, Gergely Krivan, Vera Goda, Saleh Bhar, Yuta Kawahara, Kanchan Rao, Austen Worth, David H McDermott, Dmitry Balashov, Alexey Maschan, Anna Shcherbina,

<h4>Purpose</h4>WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is a rare disease, caused by CXCR4 gene mutations, which incorporates features of combined immunodeficiency, congenital neutropenia, and a predisposition to human papillomavirus infection. Established conventional treatment for WHIM syndrome does not fully prevent infectious complications in these patients. Only single case reports ... Read more >>

J Clin Immunol (Journal of clinical immunology)
[2021, :]

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Chronic rejection as a persisting phantom menace in organ transplantation: a new hope in the microbiota?

Emmanuel F Mongodin, Vikas Saxena, Jegan Iyyathurai, Ram Lakhan, Bing Ma, Emma Silverman, Zachariah L Lee, Jonathan S Bromberg,

<h4>Purpose of review</h4>The microbiota plays an important role in health and disease. During organ transplantation, perturbations in microbiota influence transplant outcome. We review recent advances in characterizing microbiota and studies on regulation of intestinal epithelial barrier function and mucosal and systemic immunity by microbiota and their metabolites. We discuss implications ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(6):567-581]

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Personalized Medicine for Kidney Transplantation: Association of Graft Survival and Acute Transplant Rejection with Genetic Variation in B Cell Activating Factor System Signaling.

Rafael Alfaro, El Kaaoui El Band Jaouad, Santiago Llorente, Victor Jimenez-Coll, Helios Martínez-Banaclocha, José Antonio Galián, Carmen Botella, María Rosa Moya-Quiles, Jesús de la Peña-Moral, Alfredo Minguela, Isabel Legaz, Manuel Muro,

Kidney transplantation (KT) clinical outcomes are highly variable across patients and would benefit from predictive biomarkers to achieve personalized/precision medicine. The B cell activating factor (BAFF) system signaling plays an essential role in B lymphocytes' homeostasis, and is implicated in activation and survival of B lymphocytes. Single nucleotide polymorphisms (SNPs) ... Read more >>

OMICS (Omics : a journal of integrative biology)
[2021, 25(11):725-737]

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Effect of donor-to-recipient HLA matching in low-immunological risk kidney transplant recipients without induction therapy on acute rejection, graft survival, infections, and surgical complications at 3 years: The road towards new recommendations.

Maroun Abou-Jaoudé, Said El Hage, Dany Akiki, Rita Araman,

<h4>Background</h4>Donor-to-recipient human leukocyte antigen mismatching is considered one of the strongest determinants for graft and patient survival in kidney transplant recipients (KTR).<h4>Objective</h4>This retrospective study discusses the impact of HLA matching as low immunological risk KTR without induction therapy.<h4>Material and methods</h4>Records of 80 adult kidney transplant patients were reviewed with 3 years ... Read more >>

Transpl Immunol (Transplant immunology)
[2021, :101490]

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Dual JAK2/Aurora kinase A inhibition prevents human skin graft rejection by allo-inactivation and ILC2-mediated tissue repair.

Kelly Walton, Kirsti Walker, Megan Riddle, Brent H Koehn, Jordan Reff, Elizabeth M Sagatys, Michael A Linden, Joseph Pidala, Jongphil Kim, Marie C Lee, John V Kiluk, Jane Yuet Ching Hui, Sang Y Yun, Yan Xing, Heather Stefanski, Harshani R Lawrence, Nicholas J Lawrence, Jakub Tolar, Claudio Anasetti, Bruce R Blazar, Said M Sebti, Brian C Betts,

Prevention of allograft rejection often requires lifelong immune suppression, risking broad impairment of host immunity. Nonselective inhibition of host T cell function increases recipient risk of opportunistic infections and secondary malignancies. Here we demonstrate that AJI-100, a dual inhibitor of JAK2 and Aurora kinase A, ameliorates skin graft rejection by ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2021, :]

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Prospective Tracking of Donor-Reactive T-Cell Clones in the Circulation and Rejecting Human Kidney Allografts.

Constantin Aschauer, Kira Jelencsics, Karin Hu, Andreas Heinzel, Mariella Gloria Gregorich, Julia Vetter, Susanne Schaller, Stephan M Winkler, Johannes Weinberger, Lisabeth Pimenov, Guido A Gualdoni, Michael Eder, Alexander Kainz, Anna Regina Troescher, Heinz Regele, Roman Reindl-Schwaighofer, Thomas Wekerle, Johannes Bernhard Huppa, Megan Sykes, Rainer Oberbauer,

<h4>Background</h4>Antigen recognition of allo-peptides and HLA molecules leads to the activation of donor-reactive T-cells following transplantation, potentially causing T-cell-mediated rejection (TCMR). Sequencing of the T-cell receptor (TCR) repertoire can be used to track the donor-reactive repertoire in blood and tissue of patients after kidney transplantation.<h4>Methods/design</h4>In this prospective cohort study, 117 ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:750005]

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Acute Endothelial Graft Rejection Following COVID-19 Infection.

Geeta Behera, Tanmay Gokhale, Krishna R Babu,

Here, we report a case of acute endothelial graft rejection following coronavirus disease 2019 (COVID-19). A 57-year-old woman who underwent therapeutic penetrating keratoplasty for a perforated infectious corneal ulcer in her right eye developed severe acute respiratory syndrome coronavirus 2 infection, which required intensive care and treatment with steroids. Acute endothelial ... Read more >>

Cureus (Cureus)
[2021, 13(10):e19084]

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Case Report: Combined Liver-Kidney Transplantation to Correct a Mutation in Complement Factor B in an Atypical Hemolytic Uremic Syndrome Patient.

Margarita López-Trascasa, Ángel Alonso-Melgar, Marta Melgosa-Hijosa, Laura Espinosa-Román, María Dolores Lledín-Barbancho, Eugenia García-Fernández, Santiago Rodríguez de Córdoba, Pilar Sánchez-Corral,

Pathogenic gain-of-function variants in complement Factor B were identified as causative of atypical Hemolytic Uremic syndrome (aHUS) in 2007. These mutations generate a reduction on the plasma levels of complement C3. A four-month-old boy was diagnosed with hypocomplementemic aHUS in May 2000, and he suffered seven recurrences during the following ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:751093]

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Complement in ischaemia-reperfusion injury and transplantation.

Mark C Howard, Christopher L Nauser, Conrad A Farrar, Steven H Sacks,

Until recently, the only known condition in which complement could mediate transplant injury was the rare occurrence of antibody-mediated rejection, in which the original concept of antibody immunity against the transplant was supported by complementary proteins present in the serum. This has changed within the last two decades because of ... Read more >>

Semin Immunopathol (Seminars in immunopathology)
[2021, :]

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Hyperacute rejection in ABO-incompatible kidney transplantation: Significance of isoagglutinin subclass.

John Jeongseok Yang, Chung Hee Baek, Hyosang Kim, Hyunwook Kwon, Sung Shin, Young Hoon Kim, Sang-Hyun Hwang, Heung-Bum Oh, Su-Kil Park, Duck Cho, Dae-Hyun Ko,

<h4>Introduction</h4>ABO-incompatible transplantation has expanded the limited donor pool for kidney transplantation. Despite the successful desensitization protocols and immunosuppression, undesirable cases of hyperacute rejection occurs.<h4>Objective</h4>Flow cytometry was used to measure isoagglutinin titer and its IgG subclasses in assessment of the cause of hyperacute rejection in ABO-incompatible kidney transplantation.<h4>Materials and methods</h4>The recipient ... Read more >>

Transpl Immunol (Transplant immunology)
[2021, 69:101484]

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Corneal Allografts: Factors for and against Acceptance.

Justyna Sakowska, Paulina Glasner, Maciej Zieliński, Piotr Trzonkowski, Leopold Glasner,

Cornea is one of the most commonly transplanted tissues worldwide. However, it is usually omitted in the field of transplantology. Transplantation of the cornea is performed to treat many ocular diseases. It restores eyesight significantly improving the quality of life. Advancements in banking of explanted corneas and progressive surgical techniques ... Read more >>

J Immunol Res (Journal of immunology research)
[2021, 2021:5372090]

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Evaluation of rejection, infection, and malignancy outcomes in elderly liver transplant recipients receiving a similar level of immunosuppression compared to a younger group.

Bassem Almalki, Clare Kane, Kathleen Cunningham, Carly D'Agostino, Antonia Novak, Michelle Kapugi, Daniela Ladner, Jamie Schulte,

Elderly liver transplant (LTx) recipients at a lower risk of acute rejection compared to younger recipients due to immunosenescence. As such, they may benefit from reduced immunosuppression (IS) to minimize infectious and malignant complications. We aimed to evaluate outcomes in LTx recipients ≥60 years compared to a younger group of LTx ... Read more >>

Transpl Immunol (Transplant immunology)
[2021, 69:101485]

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Efficacy and tolerability of a third dose of an mRNA anti-SARS-CoV-2 vaccine in patients with rheumatoid arthritis with absent or minimal serological response to two previous doses.

Kristin Schmiedeberg, Nicolas Vuilleumier, Sabrina Pagano, Werner C Albrich, Burkhard Ludewig, Johannes von Kempis, Andrea Rubbert-Roth,

Lancet Rheumatol (The Lancet. Rheumatology)
[2021, :]

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Blockade of IL-6/IL-6R Signaling Attenuates Acute Antibody-Mediated Rejection in a Mouse Cardiac Transplantation Model.

Maolin Ma, Qipeng Sun, Xiujie Li, Gengguo Deng, Yannan Zhang, Zhe Yang, Fei Han, Zhengyu Huang, Youqiang Fang, Tao Liao, Qiquan Sun,

Acute antibody-mediated rejection (AAMR) is an important cause of cardiac allograft dysfunction, and more effective strategies need to be explored to improve allograft prognosis. Interleukin (IL)-6/IL-6R signaling plays a key role in the activation of immune cells including B cells, T cells and macrophages, which participate in the progression of ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:778359]

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COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue.

Xi Yongzhi,

SARS-CoV-2 has claimed 2,137,908 lives in more than a year. Some COVID-19 patients experience sudden and rapid deterioration with the onset of fatal cytokine storm syndrome (CSS), which have increased interest in CSS's mechanisms, diagnosis and therapy. Although the prototypic concept of CSS was first proposed 116 years ago, we ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):266-276]

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Cytokines in Liver Transplantation.

Sara Assadiasl, Nuala Mooney, Mohammad Hossein Nicknam,

Cytokines, soluble mediators of the immune system, play a critical role in the pathogenesis of autoimmune, allergic and infectious diseases. They are also implicated in the initiation and development of allograft rejection. During recent years, there have been considerable advances in generating novel anti-cytokine agents with promoted efficacy and safety, ... Read more >>

Cytokine (Cytokine)
[2021, 148:155705]

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SARS-CoV-2 Anti-Spike Antibodies After Vaccination in Pediatric Heart Transplantation: A First Report

Joseph A Spinner, Christopher L Julien, Lily Olayinka, William J Dreyer, Claire E Bocchini, Flor M Munoz, Sridevi Devaraj,

There is a paucity of data regarding the antibody response to SARS-CoV-2 vaccination in children after solid organ transplant. We retrospectively reviewed the SARS-CoV-2 Anti-Spike IgG antibodies measured following SARS-CoV-2 vaccination at our pediatric heart transplant (HTx) center. Among patients (median age 17.1 years) in whom antibody testing was performed ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2021, :]

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Antibody response to COVID-19 booster vaccine in rituximab treated patients with ANCA associated vasculitis

Sam Kant, Antoine Azar, Duvuru Geetha,

Kidney Int (Kidney international)
[2021, :]

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The Presence of Activated T Cell Subsets prior to Transplantation Is Associated with Increased Rejection Risk in Pancreas Transplant Recipients.

Stalin Chellappa, Kushi Kushekhar, Morten Hagness, Rune Horneland, Kjetil Taskén, Einar Martin Aandahl,

Pancreas and islet transplantation (PTx) are currently the only curative treatment options for type 1 diabetes. CD4<sup>+</sup> and CD8<sup>+</sup> T cells play a pivotal role in graft function, rejection, and survival. However, characterization of immune cell status from patients with and without rejection of the pancreas graft is lacking. We ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2021, 207(10):2501-2511]

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Advanced Genomics-Based Approaches for Defining Allograft Rejection With Single Cell Resolution.

Tiffany Shi, Krishna Roskin, Brian M Baker, E Steve Woodle, David Hildeman,

Solid organ transplant recipients require long-term immunosuppression for prevention of rejection. Calcineurin inhibitor (CNI)-based immunosuppressive regimens have remained the primary means for immunosuppression for four decades now, yet little is known about their effects on graft resident and infiltrating immune cell populations. Similarly, the understanding of rejection biology under specific ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:750754]

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Risk of Breakthrough SARS-CoV-2 Infections in Adult Transplant Recipients.

Caroline X Qin, Linda W Moore, Shweta Anjan, Ruth Rahamimov, Costi D Sifri, Nicole M Ali, Megan K Morales, Demetra S Tsapepas, Nikolina Basic-Jukic, Rachel A Miller, David van Duin, Robert N Santella, Hani M Wadei, Pali D Shah, Nikki Gage, Maricar Malinis, Saima Aslam, Eve Todesco, William A Werbel, Robin K Avery, Dorry L Segev,

Transplantation (Transplantation)
[2021, 105(11):e265-e266]

Cited: 3 times

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