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Identification of Potential Epilepsy Surgery Candidates

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Investigatory pathway and principles of patient selection for epilepsy surgery candidates: a systematic review.

Arash Ghaffari-Rafi, Jose Leon-Rojas,

BACKGROUND:The predominant treatment for epilepsy is pharmacotherapy, yet 20-40% do not respond to anti-epileptic drugs. After becoming pharmacoresistant, some patients are worked-up to determine candidacy for epilepsy surgery. Despite the 2009 American Epilepsy Society guidelines, there is no broadly accepted criteria for the investigatory pathway and principles of patient selection ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):100]

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The cognitive costs, contraindications and complications of epilepsy surgery in adults.

Sallie Baxendale,

PURPOSE OF REVIEW:Access to epilepsy surgery is rapidly growing throughout the world. While it is an established and effective treatment for seizures, epilepsy surgery has the potential to exacerbate cognitive comorbidities of the condition. RECENT FINDINGS:Not all surgical patients experience a postoperative decline in cognitive function. Postoperative cognitive function depends ... Read more >>

Curr. Opin. Neurol. (Current opinion in neurology)
[2020, 33(2):207-212]

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Guideline for advanced neuroimaging in pediatric epilepsy.

Yun Jung Hur,

Clin Exp Pediatr (Clinical and experimental pediatrics)
[2020, 63(3):100-101]

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LncRNAs Predicted to Interfere With the Gene Regulation Activity of miR-637 and miR-196a-5p in GBM.

Jingfang Zheng, Zhiying Su, Yang Kong, Qingping Lin, Hongli Liu, Yanlong Wang, Jian Wang,

Rigorous molecular characterization of biological systems has uncovered a variety of gene variations underlying normal and disease states and a remarkable complexity in the forms of RNA transcripts that exist. A recent concept, competitive endogenous RNA, suggests that some non-coding RNAs can bind to miRNAs to modulate their role in ... Read more >>

Front Oncol (Frontiers in Oncology)
[2020, 10:303]

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The Potential of Stereotactic-EEG for Brain-Computer Interfaces: Current Progress and Future Directions.

Christian Herff, Dean J Krusienski, Pieter Kubben,

Stereotactic electroencephalogaphy (sEEG) utilizes localized, penetrating depth electrodes to measure electrophysiological brain activity. It is most commonly used in the identification of epileptogenic zones in cases of refractory epilepsy. The implanted electrodes generally provide a sparse sampling of a unique set of brain regions including deeper brain structures such as ... Read more >>

Front Neurosci (Frontiers in Neuroscience)
[2020, 14:123]

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Pediatric Adenotonsillectomy Trial for Snoring (PATS): protocol for a randomised controlled trial to evaluate the effect of adenotonsillectomy in treating mild obstructive sleep-disordered breathing.

Rui Wang, Jessie P Bakker, Ronald D Chervin, Susan L Garetz, Fauziya Hassan, Stacey L Ishman, Ron B Mitchell, Michael G Morrical, Syed K Naqvi, Jerilynn Radcliffe, Emily I Riggan, Carol L Rosen, Kristie Ross, Michael Rueschman, Ignacio E Tapia, H Gerry Taylor, David A Zopf, Susan Redline,

INTRODUCTION:Mild obstructive sleep-disordered breathing (oSDB), characterised by habitual snoring without frequent apnoeas and hypopnoeas on polysomnography, is prevalent in children and commonly treated with adenotonsillectomy (AT). However, the absence of high-level evidence addressing the role of AT in improving health and behavioural outcomes has contributed to significant geographical variations in ... Read more >>

BMJ Open (BMJ open)
[2020, 10(3):e033889]

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An update on pediatric surgical epilepsy: Part I.

Nisha Gadgil, Melissa A LoPresti, Matthew Muir, Jeffrey M Treiber, Marc Prablek, Patrick J Karas, Sandi K Lam,

Epilepsy affects many children worldwide, with drug-resistant epilepsy affecting 20-40% of all children with epilepsy. This carries a significant burden for patients and their families and is strongly correlated with poor cognitive outcomes, depression, anxiety, developmental delay, and impaired activities of daily living. For this reason, we sought to explore ... Read more >>

Surg Neurol Int (Surgical Neurology International)
[2019, 10:257]

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Epilepsy Benchmarks Area IV: Limit or Prevent Adverse Consequence of Seizures and Their Treatment Across the Life Span.

Jana E Jones, Miya R Asato, Mesha-Gay Brown, Julia L Doss, Elizabeth A Felton, Jennifer A Kearney, Delia Talos, Penny A Dacks, Vicky Whittemore, Annapurna Poduri, ,

Epilepsy represents a complex spectrum disorder, with patients sharing seizures as a common symptom and manifesting a broad array of additional clinical phenotypes. To understand this disorder and treat individuals who live with epilepsy, it is important not only to identify pathogenic mechanisms underlying epilepsy but also to understand their ... Read more >>

Epilepsy Curr (Epilepsy currents)
[2020, 20(1_suppl):31S-39S]

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Utility of Absolute Quantification in Non-lesional Extratemporal Lobe Epilepsy Using FDG PET/MR Imaging.

Tatjana Traub-Weidinger, Otto Muzik, Lalith Kumar Shiyam Sundar, Susanne Aull-Watschinger, Thomas Beyer, Marcus Hacker, Andreas Hahn, Gregor Kasprian, Eva-Maria Klebermass, Rupert Lanzenberger, Markus Mitterhauser, Magdalena Pilz, Ivo Rausch, Lucas Rischka, Wolfgang Wadsak, Ekaterina Pataraia,

The purpose of this study was to establish a non-invasive clinical PET/MR protocol using [18F]-labeled deoxyglucose (FDG) that provides physicians with regional metabolic rate of glucose (MRGlc) values and to clarify the contribution of absolute quantification to clinical management of patients with non-lesional extratemporal lobe epilepsy (ETLE). The study included ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:54]

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Subtraction Ictal SPECT coregistered to MRI (SISCOM) as a guide in localizing childhood epilepsy.

Thomas Foiadelli, Lieven Lagae, Karolien Goffin, Tom Theys, Mara De Amici, Lucia Sacchi, Johannes Van Loon, Salvatore Savasta, Katrien Jansen,

Objective:To assess feasibility and efficacy of subtraction ictal SPECT coregistered to MRI (SISCOM) for epilepsy localization in children who are candidates for resective surgery. Methods:We retrospectively reviewed all patients ≤16 years with drug-resistant epilepsy screened for epilepsy surgery in the University Hospital of Leuven from January 2009 to January 2018. Fifty-eight ... Read more >>

Epilepsia Open (Epilepsia open)
[2020, 5(1):61-72]

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Advanced neuroimaging techniques for evaluating pediatric epilepsy.

Yun Jeong Lee,

Accurate localization of the seizure onset zone is important for better seizure outcomes and preventing deficits following epilepsy surgery. Recent advances in neuroimaging techniques have increased our understanding of the underlying etiology and improved our ability to noninvasively identify the seizure onset zone. Using epilepsy-specific magnetic resonance imaging (MRI) protocols, ... Read more >>

Clin Exp Pediatr (Clinical and experimental pediatrics)
[2020, 63(3):88-95]

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Discovery of Novel Animal-Based Medicinal Products with Therapeutic Potential in Evidence-Based Traditional Medicine.

Gunhyuk Park, Yong-Ung Kim, Irawan W Kusuma,

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2019, 2019:1626543]

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A Long Short-Term Memory neural network for the detection of epileptiform spikes and high frequency oscillations.

A V Medvedev, G I Agoureeva, A M Murro,

Over the last two decades, the evidence has been growing that in addition to epileptic spikes high frequency oscillations (HFOs) are important biomarkers of epileptogenic tissue. New methods of artificial intelligence such as deep learning neural networks can provide additional tools for automated analysis of EEG. Here we present a ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):19374]

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Presurgical epilepsy evaluation and epilepsy surgery.

Christoph Baumgartner, Johannes P Koren, Martha Britto-Arias, Lea Zoche, Susanne Pirker,

With a prevalence of 0.8 to 1.2%, epilepsy represents one of the most frequent chronic neurological disorders; 30 to 40% of patients suffer from drug-resistant epilepsy (that is, seizures cannot be controlled adequately with antiepileptic drugs). Epilepsy surgery represents a valuable treatment option for 10 to 50% of these patients. ... Read more >>

F1000Res (F1000Research)
[2019, 8:]

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An integrated analysis of rare CNV and exome variation in Autism Spectrum Disorder using the Infinium PsychArray.

Elena Bacchelli, Cinzia Cameli, Marta Viggiano, Roberta Igliozzi, Alice Mancini, Raffaella Tancredi, Agatino Battaglia, Elena Maestrini,

Autism spectrum disorder (ASD) is a neurodevelopmental condition with a complex and heterogeneous genetic etiology. While a proportion of ASD risk is attributable to common variants, rare copy-number variants (CNVs) and protein-disrupting single-nucleotide variants (SNVs) have been shown to significantly contribute to ASD etiology. We analyzed a homogeneous cohort of ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):3198]

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Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma.

Cristiano Guttà, Arman Rahman, Claudia Aura, Peter Dynoodt, Emilie M Charles, Elodie Hirschenhahn, Jesuchristopher Joseph, Jasper Wouters, Ciaran de Chaumont, Mairin Rafferty, Madhuri Warren, Joost J van den Oord, William M Gallagher, Markus Rehm,

Despite the introduction of novel targeted therapies, chemotherapy still remains the primary treatment for metastatic melanoma in poorly funded healthcare environments or in case of disease relapse, with no reliable molecular markers for progression-free survival (PFS) available. As chemotherapy primarily eliminates cancer cells by apoptosis, we here evaluated if the ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(2):124]

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Evolution of concepts in epilepsy surgery.

Jerome Engel,

At the time of the first meeting of the International League Against Epilepsy (ILAE) in 1909, surgical treatment for epilepsy had been accepted as an alternative therapy for over two decades, but was rarely practiced, considered a last resort for carefully selected patients. Localization was based on ictal semiology and ... Read more >>

Epileptic Disord (Epileptic disorders : international epilepsy journal with videotape)
[2019, 21(5):391-409]

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Implications of genetic diagnostics in epilepsy surgery candidates: A single-center cohort study.

Maurits W C B Sanders, Cynthia M C Lemmens, Floor E Jansen, Eva H Brilstra, Bobby P C Koeleman, Kees P J Braun, ,

Objective:Genetic causes are increasingly identified in patients with focal epilepsy. These genetic causes may be related to the effectiveness of epilepsy surgery. We aimed to assess the use and yield of genetic testing in a large cohort of patients who were evaluated for epilepsy surgery. Methods:We performed a retrospective single-center ... Read more >>

Epilepsia Open (Epilepsia open)
[2019, 4(4):609-617]

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Stratified analyses of genome wide association study data reveal haplotypes for a candidate gene on chromosome 2 (KIAA1211L) is associated with opioid use in patients of Arabian descent.

Hiba Alblooshi, Habiba Al Safar, Ahmed El Kashef, Hamad Al Ghaferi, Mansour Shawky, Gary K Hulse, Guan K Tay,

BACKGROUND:Genome Wide Association Studies (GWAS) have been conducted to identify genes and pathways involved in development of opioid use disorder. This study extends the first GWAS of substance use disorder (SUD) patients from the United Arab Emirates (UAE) by stratifying the study group based on opioid use, which is the ... Read more >>

BMC Psychiatry (BMC psychiatry)
[2020, 20(1):41]

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Recording Electrical Brain Activity with Novel Stretchable Electrodes Based on Supersonic Cluster Beam Implantation Nanotechnology on Conformable Polymers.

Vadym Gnatkovsky, Alessandro Cattalini, Alessandro Antonini, Laura Spreafico, Matteo Saini, Francesco Noè, Camilla Alessi, Laura Librizzi, Laura Uva, Carlo Efisio Marras, Marco de Curtis, Sandro Ferrari,

Background:Multielectrodes are implanted in central and peripheral nervous systems for rehabilitation and diagnostic purposes. The physical resistance of intracranial devices to mechanical stress is critical and fractures or electrode displacement may occur. We describe here a new recording device with stretchable properties based on Supersonic Cluster Beam Implantation (SCBI) technology ... Read more >>

Int J Nanomedicine (International journal of nanomedicine)
[2019, 14:10079-10089]

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Genetic variations associated with pharmacoresistant epilepsy.

Noemí Cárdenas-Rodríguez, Liliana Carmona-Aparicio, Diana L. Pérez-Lozano, Daniel Ortega-Cuellar, Saúl Gómez-Manzo, Iván Ignacio-Mejía,

Epilepsy is a common, serious neurological disorder worldwide. Although this disease can be successfully treated in most cases, not all patients respond favorably to medical treatments, which can lead to pharmacoresistant epilepsy. Drug-resistant epilepsy can be caused by a number of mechanisms that may involve environmental and genetic factors, as ... Read more >>

Mol Med Rep (Molecular Medicine Reports)
[2020, 21(4):1685-1701]

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Somatosensory evoked fields predict response to vagus nerve stimulation.

Karim Mithani, Simeon M Wong, Mirriam Mikhail, Haatef Pourmotabbed, Elizabeth Pang, Roy Sharma, Ivanna Yau, Ayako Ochi, Hiroshi Otsubo, O Carter Snead, Elizabeth Donner, Cristina Go, Elysa Widjaja, Abbas Babajani-Feremi, George M Ibrahim,

There is an unmet need to develop robust predictive algorithms to preoperatively identify pediatric epilepsy patients who will respond to vagus nerve stimulation (VNS). Given the similarity in the neural circuitry between vagus and median nerve afferent projections to the primary somatosensory cortex, the current study hypothesized that median nerve ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2020, 26:102205]

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Imaging epilepsy in larval zebrafish.

D R W Burrows, É Samarut, J Liu, S C Baraban, M P Richardson, M P Meyer, R E Rosch,

Our understanding of the genetic aetiology of paediatric epilepsies has grown substantially over the last decade. However, in order to translate improved diagnostics to personalised treatments, there is an urgent need to link molecular pathophysiology in epilepsy to whole-brain dynamics in seizures. Zebrafish have emerged as a promising new animal ... Read more >>

Eur. J. Paediatr. Neurol. (European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society)
[2020, 24:70-80]

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Cost-Effectiveness of Advanced Imaging Technologies in the Presurgical Workup of Epilepsy.

Churl-Su Kwon, Edward F Chang, Nathalie Jetté,

The cost-effectiveness and benefit of many diagnostic tests used in the presurgical evaluation for persons with epilepsy is for the most part uncertain as is their influence on decision-making. The options we have at our disposal are ever increasing. Advanced imaging modalities aim to improve surgical candidacy by helping us ... Read more >>

Epilepsy Curr (Epilepsy currents)
[2020, 20(1):7-11]

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Epileptogenicity Maps of Intracerebral Fast Activities (60-100 Hz) at Seizure Onset in Epilepsy Surgery Candidates.

Anne-Sophie Job, Olivier David, Lorella Minotti, Fabrice Bartolomei, Stephan Chabardès, Philippe Kahane,

Fast activities (FA) at seizure onset have been increasingly described as a useful signature of the epileptogenic zone (EZ) in patients undergoing intracranial EEG recordings. Different computer-based signal analysis methods have thus been developed for objectively quantifying ictal FA. Whether these methods detect FA in all forms of focal epilepsies, ... Read more >>

Front Neurol (Frontiers in neurology)
[2019, 10:1263]

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