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Hypoxic Ischemic Encephalopathy

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Offspring of rats with cerebral hypoxia-ischemia manifest cognitive dysfunction in learning and memory abilities.

Lu-Lu Xue, Fang Wang, Rui-Ze Niu, Ya-Xin Tan, Jia Liu, Yuan Jin, Zheng Ma, Zi-Bin Zhang, Ya Jiang, Li Chen, Qing-Jie Xia, Jun-Jie Chen, Ting-Hua Wang, Liu-Lin Xiong,

Neonatal hypoxic-ischemic encephalopathy is a serious neurological disease, often resulting in long-term neurodevelopmental disorders among surviving children. However, whether these neurodevelopmental issues can be passed to offspring remains unclear. The right common carotid artery of 7-day-old parental-generation rats was subjected to permanent ligation using a vessel electrocoagulator. Neonatal hypoxic-ischemic rat ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(9):1662-1670]

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Corrigendum: Single-nucleotide polymorphism screening and RNA sequencing of key messenger RNAs associated with neonatal hypoxic-ischemia brain damage.

[This corrects the article DOI: 10.4103/1673-5374.264469]. ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1325]

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Resatorvid protects against hypoxic-ischemic brain damage in neonatal rats.

Li-Jun Jiang, Zhen-Xing Xu, Ming-Fu Wu, Gai-Qin Dong, Li-Li Zhang, Jun-Yan Gao, Chen-Xi Feng, Xing Feng,

Secondary brain damage caused by hyperactivation of autophagy and inflammatory responses in neurons plays an important role in hypoxic-ischemic brain damage (HIBD). Although previous studies have implicated Toll-like receptor 4 (TLR4) and nuclear factor kappa-B (NF-κB) in the neuroinflammatory response elicited by brain injury, the role and mechanisms of the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1316-1325]

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Brain-derived neurotrophic factor mediates macrophage migration inhibitory factor to protect neurons against oxygen-glucose deprivation.

Su Hwan Bae, Mi Ran Yoo, Ye Yeong Kim, In Kyung Hong, Mi Hee Kim, Seung Hak Lee, Dae Yul Kim,

Macrophage migration inhibitory factor (MIF) is a chemokine that plays an essential role in immune system function. Previous studies suggested that MIF protects neurons in ischemic conditions. However, few studies are reported on the role of MIF in neurological recovery after ischemic stroke. The purpose of this study is to ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1483-1489]

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Perinatal Risk Factors Influencing Neonatal Hypoxic Ischemic Encephalopathy in Southern China: A Case-Control Study.

Junrong Wang, Enfu Tao, Miaojun Mo, Weimin Ding, Junhui Yuan, Min Wang, Changhua Zheng, Haixiao Zheng,

OBJECTIVE: In this study, our objective was to explore the relevant influencing factors of neonatal hypoxic-ischemic encephalopathy (HIE) in Southern China and provide scientific basis for improving the quality of life for neonates. STUDY DESIGN: A retrospective analysis of 306 cases with HIE neonates who were admitted during April 2015 to October ... Read more >>

Am J Perinatol (American journal of perinatology)
[2020, :]

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Therapeutic hypothermia in severe hypoxic-ischemic encephalopathy: a cost-effectiveness analysis.

Claire H Packer, Alyssa R Hersh, James A Sargent, Aaron B Caughey,

Background: The incidence of hypoxic-ischemic encephalopathy (HIE) is 0.5 per 1,000 live births. Current standard treatment is therapeutic hypothermia (cooling) begun within 6 hours of life. In infants with severe HIE, this results in fewer deaths; however, more infants survive with major neurodevelopmental disability.Objective: We sought to determine whether cooling is ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-8]

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Neonatal Vitamin D Status Is Associated with the Severity of Brain Injury in Neonatal Hypoxic-Ischemic Encephalopathy: A Pilot Study.

Elizabeth A McGinn, Andria Powers, Madeline Galas, Elizabeth Lyden, Eric S Peeples,

OBJECTIVE: The primary aim of this study was to evaluate the association between 25-hydroxyvitamin D (25OHD) concentration at birth and the short-term outcomes in neonatal hypoxic-ischemic encephalopathy (HIE). Our secondary aim was to evaluate the effect of postnatal vitamin D supplementation on outcomes in the perinatal period after hypoxic injury. STUDY ... Read more >>

Neuropediatrics (Neuropediatrics)
[2020, :]

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Assessing pupil reaction to light using ultrasound in a sick neonate with Hypoxic Ischemic Encephalopathy.

K Mohammad,

Examining pupil reaction to light is an important component of the neurological examination in infants with hypoxic ischemic encephalopathy (HIE) to determine eligibility for therapeutic hypothermia (TH) and as part of serial neurological assessment for prognostication. Pupil examination can be challenging in critically ill infants with generalized edema. In this ... Read more >>

J Neonatal Perinatal Med (Journal of neonatal-perinatal medicine)
[2020, :]

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Brain Hypoxia Secondary to Diffusion Limitation in Hypoxic Ischemic Brain Injury Postcardiac Arrest.

Mypinder S Sekhon, Philip N Ainslie, David K Menon, Sharanjit S Thiara, Danilo Cardim, Arun K Gupta, Ryan Leo Hoiland, Peter Gooderham, Donald E Griesdale,

OBJECTIVES:We sought to characterize 1) the difference in the diffusion gradient of cellular oxygen delivery and 2) the presence of diffusion limitation physiology in hypoxic-ischemic brain injury patients with brain hypoxia, as defined by parenchymal brain tissue oxygen tension less than 20 mm Hg versus normoxia (brain tissue oxygen tension ... Read more >>

Crit. Care Med. (Critical care medicine)
[2020, 48(3):378-384]

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Early Electroencephalogram Background Could Guide Tailored Duration of Monitoring for Neonatal Encephalopathy Treated with Therapeutic Hypothermia.

Giulia M Benedetti, Rebecca J Vartanian, Harlan McCaffery, Renée A Shellhaas,

OBJECTIVE:To evaluate whether features of the early electroencephalographic (EEG) background could guide the optimal duration of continuous video EEG monitoring for seizure detection in newborn infants treated with therapeutic hypothermia for hypoxic ischemic encephalopathy (HIE). STUDY DESIGN:Retrospective cohort study of 114 consecutive infants treated with therapeutic hypothermia for moderate to ... Read more >>

J. Pediatr. (The Journal of pediatrics)
[2020, :]

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Pathophysiology of hypoxic-ischemic encephalopathy: a review of the past and a view on the future.

P Greco, G Nencini, I Piva, M Scioscia, C A Volta, S Spadaro, M Neri, G Bonaccorsi, F Greco, I Cocco, F Sorrentino, F D'Antonio, L Nappi,

Hypoxic-ischemic encephalopathy, also referred as HIE, is a type of brain injury or damage that is caused by a lack of oxygen to the brain during neonatal period. The incidence is approximately 1.5 cases per 1000 live births in developed countries. In low and middle-income countries, the incidence is much ... Read more >>

Acta Neurol Belg (Acta neurologica Belgica)
[2020, 120(2):277-288]

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Predictors of Long-Term Neurodevelopmental Outcome of Hypoxic-Ischemic Encephalopathy Treated with Therapeutic Hypothermia.

Ipsita Goswami, Mireille Guillot, Emily W Y Tam,

Hypoxic-ischemic encephalopathy (HIE) is a manifestation of perinatal asphyxial insult that continues to evolve over days to weeks following the initial injury. Therapeutic hypothermia has demonstrated that a proportion of this secondary brain injury may indeed be preventable. However, therapeutic hypothermia has also altered the prognostic utility of many bedside ... Read more >>

Semin Neurol (Seminars in neurology)
[2020, :]

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Metabolic Phenotypes of Hypoxic-Ischemic Encephalopathy with Normal vs. Pathologic Magnetic Resonance Imaging Outcomes.

José David Piñeiro-Ramos, Antonio Núñez-Ramiro, Roberto Llorens-Salvador, Anna Parra-Llorca, Ángel Sánchez-Illana, Guillermo Quintás, Nuria Boronat-González, Juan Martínez-Rodilla, Julia Kuligowski, Máximo Vento, The Hypotop Study Group,

Hypoxic-Ischemic Encephalopathy (HIE) is one of the most relevant contributors to neurological disability in term infants. We hypothesized that clinical outcomes of newborns with (HIE) can be associated with changes at plasma metabolic level enabling the detection of brain injury. Plasma samples of a cohort of 55 asphyxiated infants who ... Read more >>

Metabolites (Metabolites)
[2020, 10(3):]

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Patterns of neurobehavioral functioning in school-aged survivors of neonatal jaundice and hypoxic-ischemic encephalopathy in Kilifi, Kenya: A cross-sectional study

Dorcas Magai, Charles Newton, Paul Mwangi, Hans Koot, Amina Abubakar,

Background: Studies in high-income countries have reported that school-aged children who survive neonatal jaundice (NNJ) and hypoxic-ischemic encephalopathy (HIE) develop long-term neurocognitive problems. However, less is known about the patterns of functioning in school-aged survivors of NNJ and HIE in sub-Saharan Africa. This study examined patterns of functioning in school-aged ... Read more >>

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Advances in the Evaluation and Management of Cortical/Cerebral Visual Impairment in Children.

Melinda Y Chang, Mark S Borchert,

Cortical/cerebral visual impairment (CVI) is the most frequent cause of pediatric visual impairment in developed countries and is increasing in prevalence in developing nations. The most common underlying etiology is hypoxic-ischemic encephalopathy (HIE), particularly in premature children; other causes include seizures, hydrocephalus, trauma, and infections. Because of neurologic comorbidities, children ... Read more >>

Surv Ophthalmol (Survey of ophthalmology)
[2020, :]

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Latent Phase Identification of High-Frequency Micro-Scale Gamma Spike Transients in the Hypoxic Ischemic EEG of Preterm Fetal Sheep Using Spectral Analysis and Fuzzy Classifiers.

Hamid Abbasi, Alistair J Gunn, Laura Bennet, Charles P Unsworth,

Premature babies are at high risk of serious neurodevelopmental disabilities, which in many cases are related to perinatal hypoxic-ischemic encephalopathy (HIE). Studies of neuroprotection in animal models consistently suggest that treatment must be started as early as possible in the first 6 h after hypoxia-ischemia (HI), the so-called latent phase ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2020, 20(5):]

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COX5A over-expression protects cortical neurons from hypoxic ischemic injury in neonatal rats associated with TPI up-regulation

Tinghua Wang, Ya Jiang, Xue Bai, Ting-Ting Li, Mohammed Hawwas, Yuan Jin, Yu Zou, Yue Hu, Lin-Yi Liu, Ying Zhang, Qing Liu, Hao Yang, Jun Ma, Jia Liu, Liu-Lin Xiong,

<title>Abstract</title> <p> Background: Neonatal hypoxic-ischemic encephalopathy (HIE) represents as a major cause of neonatal morbidity and mortality. However, the underlying molecular mechanisms in brain damage are still not fully elucidated. This study was conducted to determine the specific potential molecular mechanism in the hypoxic-ischemic induced cerebral injury. Methods: ... Read more >>

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Aggravated brain injury after neonatal hypoxic ischemia in microglia depleted mice

Shunichiro Tsuji, Elena Martino, Takeo Mukai, Shoko Tsuji, Takashi Murakami, Robert Harris, Klas Blomgren, Ulrika Aden,

<title>Abstract</title> <p> Background: Neuroinflammation plays an important role in neonatal hypoxic-ischemic encephalopathy (HIE). Although microglia are largely responsible for injury-induced inflammatory response, they play beneficial roles in both normal and disease states. However, the effects of microglial depletion on neonatal HIE remain unclear. Methods: Tamoxifen was administered to ... Read more >>

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[Role of JAK2/STAT3 signaling pathway in microglia activation after hypoxic-ischemic brain damage].

Jie Zeng, Ya-Lin Zhao, Bo-Wen Deng, Xiao-Ye Li, Jie Xu, Le Wang, Xiao-Hong Mu,

Hypoxic-ischemic encephalopathy (HIE) is the leading cause of neonatal death and neurodevelopmental disorders in infants. Part of patients have different degrees of neurological sequelae, such as cerebral palsy, cognitive and motor function development disorders. Hypoxia-ischemia may activate JAK2/STAT3 signaling pathway, which leads to the microglia activation and neuroinflammation. Down-Regulating JAK2/STAT3 ... Read more >>

Zhongguo Gu Shang (Zhongguo gu shang = China journal of orthopaedics and traumatology)
[2020, 33(2):190-194]

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Plasma vasopressin levels are closely associated with fetal hypotension and neuronal injury after hypoxia-ischemia in near-term fetal sheep.

Christopher A Lear, Michi Kasai, Paul P Drury, Joanne O Davidson, Etsuko Miyagi, Laura Bennet, Alistair J Gunn,

BACKGROUND:Sensitive biomarkers are needed to rapidly identify high-risk infants after hypoxia-ischemia for neuroprotective treatment. Hypotension is a key determinant of hypoxic-ischemic neural injury, and a potent stimulus of humoral pressors including angiotensin-II and arginine vasopressin. We therefore aimed to quantify the relationship between vasopressin and angiotensin-II levels in the latent ... Read more >>

Pediatr. Res. (Pediatric Research)
[2020, :]

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Cooling and immunomodulation for treating hypoxic-ischemic brain injury.

Kenta H T Cho, Joanne O Davidson, Justin M Dean, Laura Bennet, Alistair J Gunn,

Therapeutic hypothermia is now well established to partially reduce disability in term and near-term infants with moderate-severe hypoxic-ischemic encephalopathy. Subsequent preclinical and clinical studies have confirmed that current protocols for therapeutic hypothermia are near-optimal. The challenge is now to identify complementary therapies that can further improve outcomes, in combination with ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, :]

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Diffusion Kurtosis Imaging of Leptin Intervention in Early Hypoxic-Ischemic Brain Edema.

Xiaoning He, Juan Xiao, Juan Tian, Honghai Chen, Jing Liu, Chao Yang,

The role of leptin in neuroprotection has recently been recognized. However, there are few reports on the use of imaging methods to dynamically evaluate the neuroprotection role of leptin. Diffusion kurtosis imaging (DKI), which is a method used to measure non-Gaussian water diffusion, can reflect the real water diffusion in ... Read more >>

Neuroscience (Neuroscience)
[2020, 431:176-183]

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The Phenomenon of Trombley-Brennan Terminal Tissue Injury in a Neonate: A Case Study.

Ani Jacob, Deborah Grabher,

BACKGROUND:Trombley-Brennan terminal tissue injury (TB-TTI), also known as skin failure, was first identified in 2009 among critically ill adults receiving palliative care. Identification of this skin injury can be misinterpreted as a pressure ulcer. However, this phenomenon is now accepted as an early sign of impending death among critically ill ... Read more >>

Adv Neonatal Care (Advances in neonatal care : official journal of the National Association of Neonatal Nurses)
[2020, 20(2):171-175]

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Perinatal asphyxia and its associated factors in Ethiopia: a systematic review and meta-analysis.

Fikadu Waltengus Sendeku, Getnet Gedefaw Azeze, Selamawit Lake Fenta,

BACKGROUND:Despite different preventive strategies that have been implemented in different health institutions in the country, neonatal mortality and morbidity are still significantly increasing in Ethiopia. Perinatal asphyxia is the leading cause of neonatal morbidity and mortality worldwide. As a result, this systematic review and meta-analysis aimed to assess the prevalence ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):135]

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Anti-apoptotic and Immunomodulatory Effect of CB2 Agonist, JWH133, in a Neonatal Rat Model of Hypoxic-Ischemic Encephalopathy.

Bhavna Gupta, Mary G Hornick, Seema Briyal, Ramona Donovan, Preetha Prazad, Anil Gulati,

Introduction: Neonatal HIE is associated with high morbidity and mortality. Current research, is focused on developing alternative treatments to therapeutic hypothermia for treatment of HIE. The endocannabinoid system is known to be influential in neuronal protection. Activation of brain CB2 receptors, has been shown to reduce inflammatory markers and decrease ... Read more >>

Front Pediatr (Frontiers in Pediatrics)
[2020, 8:65]

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