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A T231E Mutant that Mimics Pathologic Phosphorylation of Tau in Alzheimer's disease Causes Activation of the Mitochondrial Unfolded Protein Response in C. elegans touch neurons.

Sanjib Guha, Sarah Fischer, Anson Cheng, Gail V W Johnson, Keith Nehrke,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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New mutants defective in RMED/V neuron specification are alleles of EOR-1 and EOR-2.

Xun Huang, Yishi Jin,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 2 times

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EOR-1 and EOR-2 act independently of RAS and WNT signaling pathways in RMED/V neuron specification.

Xun Huang, Yishi Jin,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

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EOR-1 and EOR-2 function in RMED/V neuron specification.

Xun Huang, Yishi Jin,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 2 times

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Loss of eif-2alpha phosphorylation on S49 (mammalian S51) associated with the integrated stress response hastens development in C. elegans.

Jarod Rollins, Noah Lind, Aric N Rogers,

MicroPubl Biol (microPublication biology)
[2017, 2017:]

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High-altitude Illnesses and Air Travel: Pediatric Considerations.

Nelson Villca, Adriana Asturizaga, Alexandra Heath-Freudenthal,

Healthy children may present acute mountain sickness (AMS) within a few hours after arrival at high altitudes. In few cases, serious complications may occur, including high-altitude pulmonary edema and rarely high-altitude cerebral edema. Those with preexisting conditions especially involving hypoxia and pulmonary hypertension shall not risk travelling to high altitudes. ... Read more >>

Pediatr Clin North Am (Pediatric clinics of North America)
[2021, 68(1):305-319]

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Hypoxia in Alzheimer's disease: effects of hypoxia inducible factors.

Halimatu Hassan, Ruoli Chen,

Neural Regen Res (Neural regeneration research)
[2021, 16(2):310-311]

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Preparation of Gold Nanoparticles and Its Effect on Autophagy and Oxidative Stress in Chronic Kidney Disease Cell Model.

Ping Zhao, Ting Li, Zhi Li, Lei Cao, Youliang Wang, Yong Wang, Weikai Wang, Togo Shinonaga, Maneesha A Rajora,

Gold nanoparticles (GNPs) are widely used in life sciences and medicine due to their simple preparation, stable physical and chemical properties, controllable optical properties and no significant toxicity. However, in recent years, studies have found that there are still many uncertain factors in the application of gold nanoparticles in the ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):1266-1271]

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Detection of Hypoxic Regions in the Bone Microenvironment.

Wendi Guo, Colleen Wu,

Oxygen serves as a critical environmental factor essential for maintaining the physiological state of a tissue. Hypoxia, or low oxygen, triggers a cascade of events which allows for cells to adapt to low oxygen tensions and to facilitate oxygen delivery required to maintain tissue homeostasis. In the bone microenvironment (BME), ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2230:345-356]

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Role of apoptosis-inducing factor in perinatal hypoxic-ischemic brain injury.

Juan Rodriguez, Tao Li, Yiran Xu, Yanyan Sun, Changlian Zhu,

Perinatal complications, such as asphyxia, can cause brain injuries that are often associated with subsequent neurological deficits, such as cerebral palsy or mental retardation. The mechanisms of perinatal brain injury are not fully understood, but mitochondria play a prominent role not only due to their central function in metabolism but ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(2):205-213]

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Experimental Hypoxia as a Model for Cardiac Regeneration in Mice.

Yuji Nakada, Hesham A Sadek,

Experimental hypoxia has been used for decades to examine the adaptive response to low-oxygen environments. Various models have been studied, including flies, worms, fish, rodents, and humans. Our lab has recently used this technology to examine the effect of environmental hypoxia on mammalian heart regeneration. In this chapter, we describe ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2158:337-344]

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Measurement of Superoxide Production in Acute Hypoxia by Fixed-Cell Microscopy.

Pablo Hernansanz-Agustín, Carmen Choya-Foces, Antonio Martínez-Ruiz,

Redox signaling implication in cell adaptation to hypoxia has been studied for a long time, both in long-term and acute responses. However, measurement of superoxide and other reactive oxygen species (ROS) in acute hypoxia is technically challenging, for example, because of the need to overcome the effect of cell reoxygenation ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2202:43-50]

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Dietary arginine modulates nonspecific immune responses in Indian Major Carp, Cirrhinus mrigala exposed to hypoxia

Tincy Varghese, V Rejish Kumar, Amrutha Gopan, Rajendran Kooloth Valappil, K A Sajina, Puthiyottil Mishal, Asim Kumar Pal,

Hypoxia in aquatic environment is often a recurrent stressor which can affect growth and health of fishes. However, nutritional intervention can help aquatic animals to cope up with environmental stressors so as to alleviate the adverse effects. Here, we examined the impact of L-Arginine (Arg) supplementation on hypoxia-induced changes in ... Read more >>

Aquaculture (Aquaculture (Amsterdam, Netherlands))
[2020, 529:Not Available]

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Hypoxia regulates human mast cell adhesion to fibronectin via the PI3K/AKT signaling pathway.

Joanna Pastwińska, Aurelia Walczak-Drzewiecka, Magdalena Łukasiak, Marcin Ratajewski, Jarosław Dastych,

A decrease in oxygen concentration is a hallmark of inflammatory reactions resulting from infection or homeostasis disorders. Mast cells interact with extracellular matrix and other cells by adhesion receptors. We investigated the effect of hypoxia on integrin-mediated mast cell adhesion to fibronectin. We found that it was mediated by the ... Read more >>

Cell Adh Migr (Cell adhesion & migration)
[2020, 14(1):106-117]

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Long non-coding RNA DANCR alleviates hypoxia-caused H9c2 cells damage through up regulation of HIF-1α.

Libin Qiu, Qian Zhao, Lingli Dai, Aoshuang Zhu, Xiaofei Xu, Shanshan Zhao, Jingcheng Chen,

Hypoxia is an important cause of myocardial cell loss, further inducing various heart illnesses, including acute myocardial infraction (AMI). Long non-coding RNA (LncRNA) discrimination antagonising non-protein coding RNA (DANCR) was firstly identified as epidermal cell differentiation suppressor. Here, we aimed to explore the effects and mechanism of DNACR in hypoxia-induced ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):533-541]

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Histamine H2 receptor negatively regulates oligodendrocyte differentiation in neonatal hypoxic-ischemic white matter injury.

Lei Jiang, Li Cheng, Han Chen, Haibin Dai, Dadao An, Qianyi Ma, Yanrong Zheng, Xiangnan Zhang, Weiwei Hu, Zhong Chen,

Neonatal hypoxic-ischemic encephalopathy (HIE) with the pathological characteristic of white matter injury often leads to lifelong cognitive and neurobehavioral dysfunction, but relevant therapies to promote remyelination are still unavailable. We found that histamine H2 receptor (H2R) negatively regulated the oligodendrocyte differentiation rate without affecting the oligodendrocytes at the oligodendrocyte precursor ... Read more >>

J Exp Med (The Journal of experimental medicine)
[2021, 218(1):]

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Inhibiting NTRK2 signaling causes endometriotic lesion regression.

Hsiu-Chi Lee, Shih-Chieh Lin, Meng-Hsing Wu, Shaw-Jenq Tsai,

Endometriosis is a common gynecological disease in reproductive-age women. Although the hormone-dependent therapy is the first line treatment for endometriosis, it is not a curative regimen and associated with severe side-effects, which significantly decrease the life quality of affected individuals. To seek a target for treatment of endometriosis, we focused ... Read more >>

Reproduction (Reproduction (Cambridge, England))
[2021, 161(1):11-19]

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Normobaric hypoxia training in military aviation and subsequent hypoxia symptom recognition.

Antti Leinonen, Nikke Varis, Hannu Kokki, Tuomo K Leino,

Altitude hypoxia episodes are increasingly common in military aviation. Hypoxia training is mandatory for fighter pilots, but evidence-based data on the effects of training are scarce. The purpose of this study was to validate the normobaric hypoxia (NH) training effect. Data were collected from 89 pilots from the Finnish Air ... Read more >>

Ergonomics (Ergonomics)
[2020, :1-8]

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Possible silent hypoxemia in a COVID-19 patient: A case report

Siswanto, Munawar Gani, Aditya Rifqi Fauzi, Ririn Enggy Yuliyanti, Maria Patricia Inggriani, Bagus Nugroho, Denny Agustiningsih, Gunadi,

Introduction It has been hypothesized that silent hypoxemia is the cause of rapid progressive respiratory failure with severe hypoxia that occurs in some COVID-19 patients without warning. Presentation of case A 60-year-old male presented cough without any breathing difficulty. Vital signs showed blood pressure 130/75 mmHg, pulse 84x/minute, respiratory rate (RR) ... Read more >>

Ann Med Surg (Lond) (Annals of medicine and surgery (2012))
[2020, 60:583-586]

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Silencing MEG3 protects PC12 cells from hypoxic injury by targeting miR-21.

Dan Deng, Hui Liang,

Increasing number of literatures highlighted lncRNA maternally expressed gene 3 (MEG3) as an emerging target for hypoxic-ischaemic brain damage (HIBD). This study attempted to assess the role of MEG3 in a cell model of HIBD. Expression of MEG3 in PC12 cells was suppressed by siRNA-mediated transfection, after which the cells ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):610-619]

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Hypoxia induces sorafenib resistance mediated by autophagy via activating FOXO3a in hepatocellular carcinoma.

Chao Liang, Zhebin Dong, Xianlei Cai, Jie Shen, Yuan Xu, Miaozun Zhang, Hong Li, Weiming Yu, Wei Chen,

Sorafenib, a multikinase inhibitor, is considered as the only approved drug to cure the advanced hepatocellular carcinoma (HCC); however, the acquired chemoresistance caused by intratumoral hypoxia through sorafenib long term therapy induces sorafenib inefficacy. We demonstrated here that hypoxia significantly attenuated sensitivity of HCC cells to sorafenib treatment and reduced ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(11):1017]

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The effect of hypoxia on the proteomic signature of pig adipose-derived stromal/stem cells (pASCs).

Joanna Bukowska, Mariola Słowińska, Patrycja Cierniak, Marta Kopcewicz, Katarzyna Walendzik, Trivia Frazier, Barbara Gawrońska-Kozak,

Human adipose-derived stem cells (ASCs) have potential to improve wound healing; however, their equivalents from domestic animals have received less attention as an alternative cell-based therapy for animals or even humans. Hypoxia is essential for maintaining stem cell functionality in tissue-specific niches. However, a cellular response to low oxygen levels ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):20035]

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Cirbp-PSD95 Axis Protects Against Hypobaric Hypoxia-Induced Aberrant Morphology of Hippocampal Dendritic Spines and Cognitive Deficits

Yang Zhou, Huanyu Lu, Ying Liu, Zaihua Zhao, Qian Zhang, Chong Xue, Yuankang Zou, Zipeng Cao, Wenjing Luo,

Abstract Hypobaric hypoxia (HH) is a typical characteristic of high altitude environment and causes a spectrum of pathophysiological effects, including headaches, gliovascular dysfunction and cognitive slowing. Here, we sought to understand the mechanisms underlying cognitive deficits under HH exposure. Our results showed that HH exposure impaired cognitive function and suppressed ... Read more >>

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Early-life hypoxia alters adult physiology and reduces stress resistance and lifespan in Drosophila.

Danielle M Polan, Mohammed Alansari, Byoungchun Lee, Savraj S Grewal,

In many animals, short-term fluctuations in environmental conditions in early life often exert long-term effects on adult physiology. In Drosophila, one ecologically relevant environmental variable is hypoxia. Drosophila larvae live on rotting, fermenting food rich in microorganisms, an environment characterized by low ambient oxygen. They have therefore evolved to tolerate ... Read more >>

J Exp Biol (The Journal of experimental biology)
[2020, 223(Pt 22):]

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Poloxamer 188 Protects Isolated Adult Mouse Cardiomyocytes from Reoxygenation Injury.

Michele M Salzman, Jason A Bartos, Demetris Yannopoulos, Matthias L Riess,

Reperfusion injury is a complex pathological event involving processes that can lead to further disruption of the cell membrane and function following an ischemic event. Return of blood flow allows for the needed reperfusion; however, for a period of time before remaining viable cells stabilize, reperfusion results in additional cellular ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2020, 8(6):e00639]

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