Full Text Journal Articles about
Hypertension

Advertisement

Find full text journal articles






Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster.

Heiko Meyer, Annika Buhr, Patrick Callaerts, Ronja Schiemann, Mariana F Wolfner, Steven J Marygold,

The neprilysin (M13) family of metalloendopeptidases comprises highly conserved ectoenzymes that cleave and thereby inactivate many physiologically relevant peptides in the extracellular space. Impaired neprilysin activity is associated with numerous human diseases. Here, we present a comprehensive list and classification of M13 family members in <i>Drosophila melanogaster</i>. Seven <i>Neprilysin</i> (<i>Nep</i>) ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

Cited: 0 times

View full text PDF listing >>



Retinal microglial activation in glaucoma: evolution over time in a unilateral ocular hypertension model.

José A Fernandez-Albarral, Ana I Ramírez, Rosa de Hoz, Juan J Salazar,

Neural Regen Res (Neural regeneration research)
[2022, 17(4):797-799]

Cited: 0 times

View full text PDF listing >>



Advertisement

Hemodynamically Unloading the Distal Pulmonary Circulation in Pulmonary Hypertension: A Modeling Study.

Rachelle Walter, Kendall Hunter, Kurt Stenmark, Vitaly O Kheyfets,

Pulmonary hypertension (PH) is a progressive disease that is characterized by a gradual increase in both resistive and reactive pulmonary arterial (PA) impedance. Previous studies in a rodent model of PH have shown that reducing the hemodynamic load in the left lung (by banding the left PA) reverses this remodeling ... Read more >>

J Biomech Eng (Journal of biomechanical engineering)
[2022, 144(2):]

Cited: 0 times

View full text PDF listing >>



Limitations in activities of daily living increase the risk of stroke in older Chinese adults: a population-based longitudinal study.

Zhuang-Sheng Wei, Yu-Sen Chen, Ying Wu, Chen-Yao Kang, Jia-Yuan Wu, Yu Yang, Hao Wu, Bin Zhao, Zhou Liu,

It remains unclear whether limitations in activities of daily living (ADL) increase the risk of stroke in older Chinese adults. This longitudinal study used data from the Chinese Longitudinal Healthy Longevity Survey to investigate the effects of limitations in ADL on the incidence of stroke in older adults. Between 2002 ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(3):643-648]

Cited: 0 times

View full text PDF listing >>



Effects of hypertension on the outcomes of COVID-19: a multicentre retrospective cohort study.

Li Zhong, Yuting Wu, Jinghua Gao, Jinxia Zhang, Qifeng Xie, Huang He, Jingjing Ji, Zheying Liu, Conglin Wang, Zhifeng Liu,

<b>Objectives:</b> Hypertension is thought to be a contributor to mortality in coronavirus disease 2019 patients; however, limited clinical data on the outcomes of COVID-19 in patients with hypertension are available.<b>Methods:</b> This study was designed to confirm whether hypertension affects the outcomes of COVID-19. <b>Results:</b> A total of 983 patients with ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):770-776]

Cited: 1 time

View full text PDF listing >>



Integrated weighted gene co-expression network analysis uncovers STAT1(signal transducer and activator of transcription 1) and IFI44L (interferon-induced protein 44-like) as key genes in pulmonary arterial hypertension.

Han Yang, Yang Lu, Hongmin Yang, Yaoxi Zhu, Yaohan Tang, Lixia Li, Changhu Liu, Jing Yuan,

Despite the multiple diagnostic and therapeutic strategies implemented in clinical practice, the mortality rate of patients with pulmonary arterial hypertension (PAH) remains high. Understanding the mechanisms and key genes involved could provide insight into the drivers of the pathogenesis of PAH. In this research, we aimed to examine the mechanisms ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):6021-6034]

Cited: 0 times

View full text PDF listing >>



Efficacy and safety of novel-targeted drugs in the treatment of pulmonary arterial hypertension: a Bayesian network meta-analysis.

Wenhai Fu, Wenjun He, Yuexin Li, Yangxiao Chen, Jingyi Liang, Hui Lei, Lin Fu, Yanghang Chen, Ni Ren, Qian Jiang, Yi Shen, Ran Ma, Tao Wang, Xinni Wang, Nuofu Zhang, Dakai Xiao, Chunli Liu,

<b>Background:</b> Pulmonary arterial hypertension (PAH) is a severe and fatal clinical syndrome characterized by high blood pressure and vascular remodeling in the pulmonary arterioles, which is also a rapidly progressing disease of the lung vasculature with a poor prognosis. Although PAH medication made great advances in recent years, the efficacy ... Read more >>

Drug Deliv (Drug delivery)
[2021, 28(1):1007-1019]

Cited: 0 times

View full text PDF listing >>



A Matter of Fat: Body Fat Distribution and Cardiometabolic Disease in Africa.

Nasrin Goolam Mahyoodeen, Nigel J Crowther,

Africa is a complex and diverse continent that faces numerous challenges. It is a region in epidemiological transition which is currently experiencing a dual burden of communicable and non-communicable diseases. The high prevalence of cardiometabolic disease (CMD) on the continent is driven largely by the increasing prevalence of obesity in ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2343:37-56]

Cited: 0 times

View full text PDF listing >>



Screening of key biomarkers and immune infiltration in Pulmonary Arterial Hypertension via integrated bioinformatics analysis.

Yu Zeng, Nanhong Li, Zhenzhen Zheng, Riken Chen, Wang Liu, Junfen Cheng, Jinru Zhu, Mingqing Zeng, Min Peng, Cheng Hong,

This study aimed to screen key biomarkers and investigate immune infiltration in pulmonary arterial hypertension (PAH) based on integrated bioinformatics analysis. The Gene Expression Omnibus (GEO) database was used to download three mRNA expression profiles comprising 91 PAH lung specimens and 49 normal lung specimens. Three mRNA expression datasets were ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2576-2591]

Cited: 0 times

View full text PDF listing >>



Bioinformatic exploration of the immune related molecular mechanism underlying pulmonary arterial hypertension.

Ruina Huang, Xifeng Zheng, Junxian Wang,

This study aimed to explore the molecular mechanisms related to immune and hub genes related to pulmonary arterial hypertension (PAH). The differentially expressed genes (DEGs) of GSE15197 were identified as filters with adjusted P value <0.05, and |Log2 fold change|> 1. Biofunctional and pathway enrichment annotation of DEGs indicated that ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3137-3147]

Cited: 0 times

View full text PDF listing >>



Xinmai 'an extract enhances the efficacy of sildenafil in the treatment of pulmonary arterial hypertension via inhibiting MAPK signalling pathway.

Yaolu Zhu, Yabin Sun, Shichang Zhang, Chuyuan Li, Yiwei Zhao, Boxin Zhao, Guofeng Li,

<h4>Context</h4>Xinmai 'an tablet has been used to improve myocardial blood supply. Recently, some compounds from its formula have shown that they can treat pulmonary arterial hypertension (PAH).<h4>Objective</h4>This study investigates the effects of Xinmai 'an extract (XMA) on PAH and further tests the co-therapeutic enhancement with sildenafil (SIL).<h4>Materials and methods</h4>Pulmonary artery ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):594-605]

Cited: 0 times

View full text PDF listing >>



Uncovering antiobesity-related hypertension targets and mechanisms of metformin, an antidiabetic medication.

Lu Yang, Jianxin Yang, Xiao Liang, Wenjun Huang, Xiaoxi Zhang, Rong Li,

Metformin, a common clinical drug used to treat diabetes mellitus, is found with potential antiobese actions as reported in increasing evidences. However, the detailed mechanisms of metformin-antiobesity-related hypertension remain unrevealed. We have utilized the bioinformatics strategy, including network pharmacology and molecular docking analyses, to uncover pharmacological targets and molecular pathways ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):4757-4767]

Cited: 0 times

View full text PDF listing >>



The association between hypertension and nonalcoholic fatty liver disease (NAFLD): literature evidence and systems biology analysis.

Chongyang Ma, Kai Yan, Zisong Wang, Qiuyun Zhang, Lianyin Gao, Tian Xu, Jiayang Sai, Fafeng Cheng, Yuqiong Du,

Nonalcoholic fatty liver disease (NAFLD) has become a major public health issue as its progression increases risks of multisystem morbidity and mortality. Recent evidence indicates a more complex relationship between hypertension and NAFLD than previously thought. In this study, a comprehensive literature search was used to gather information supporting the ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2187-2202]

Cited: 0 times

View full text PDF listing >>



MicroRNA 21 and microRNA 155 levels in resistant hypertension, and their relationships with aldosterone.

Sonat Pınar Kara, Gulsum Ozkan, Ahsen Yılmaz, Nergiz Bayrakçı, Savaş Güzel, Elif Geyik,

<h4>Aim</h4>MicroRNAs (miRNAs) are non-coding RNA molecules that serve as regulators following gene expression transcription. While studies have investigated the role of miRNAs in the pathogenesis of essential hypertension (HT), very few have considered their place in the pathogenesis of resistant hypertension (RH). The purpose of this study was to investigate ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):676-683]

Cited: 0 times

View full text PDF listing >>



Changes in the gut microbiome and metabolome in a rat model of pulmonary arterial hypertension.

Wei Hong, Qiudi Mo, Luyao Wang, Fang Peng, Yuming Zhou, Weifeng Zou, Ruiting Sun, Chunxiao Liang, Mengning Zheng, Haiqing Li, Dongxing Zhao, Mi Gao, Jinding Pu, Bing Li, Pixin Ran, Gongyong Peng,

The gut microbiota is widely considered to be involved in several diseases, including atherosclerosis, obesity, chronic obstructive pulmonary disease (COPD) and pulmonary arterial hypertension (PAH). This study aimed to determine if changes in the gut microbiome and metabolome play a major role in the early pathogenesis of PAH. Male Wistar ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):5173-5183]

Cited: 0 times

View full text PDF listing >>



Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension.

Yousef A Bin Jardan, Abdul Ahad, Mohammad Raish, Mohd Aftab Alam, Abdullah M Al-Mohizea, Fahad I Al-Jenoobi,

<h4>Context</h4>Garden cress (GC), fenugreek (FG), and black seed (BS) are traditional herbal medicine for managing hypertension.<h4>Objective</h4>The effects of the three herbs on the pharmacodynamics of metoprolol tartrate (MT) in hypertensive rats were investigated.<h4>Materials and methods</h4>Wistar rats were divided in five groups (<i>n</i> = 6). Group I served as normal control group and ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1088-1097]

Cited: 0 times

View full text PDF listing >>



Syndemics at play: chronic kidney disease, diabetes and COVID-19 in Pakistan.

Inayat Ali,

Although coronavirus disease 2019 (COVID-19) is a pandemic, it has several specificities influencing its outcomes due to the entwinement of several factors, which anthropologists have called "syndemics". Drawing upon Singer and Clair's syndemics model, I focus on synergistic interaction among chronic kidney disease (CKD), diabetes, and COVID-19 in Pakistan. I ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):581-586]

Cited: 1 time

View full text PDF listing >>



The promise of neuroprotection by dietary restriction in glaucoma.

Rossella Russo, Carlo Nucci, Annagrazia Adornetto,

Glaucoma, a progressive age-related optic neuropathy characterized by the death of retinal ganglion cells, is the most common neurodegenerative cause of irreversible blindness worldwide. The therapeutic management of glaucoma, which is limited to lowering intraocular pressure, is still a challenge since visual loss progresses in a significant percentage of treated ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):45-47]

Cited: 0 times

View full text PDF listing >>



Neonatal outcomes and congenital anomalies in pregnancies affected by hypothyroidism.

Zareen Kiran, Aisha Sheikh, Khadija Nuzhat Humayun, Najmul Islam,

<h4>Background</h4>Maternal hypothyroidism has been reported to have concerns over neonatal outcomes, not only in the context of neurocognitive development but also in the short term as birth weight and neonatal jaundice.<h4>Patients and methods</h4>We conducted a cross-sectional retrospective study on 638 cases who delivered live births in the Aga Khan University ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1560-1568]

Cited: 0 times

View full text PDF listing >>



Detection of occult atrial fibrillation with 24-hour ECG after cryptogenic acute stroke or transient ischaemic attack: A retrospective cross-sectional study in a primary care database in Israel.

Ori Liran, Tamar Banon, Alon Grossman,

<h4>Background</h4>Ischaemic stroke or cerebrovascular accident (CVA) due to occult atrial fibrillation (AF) may cause severe morbidity and mortality. Diagnosing occult AF can be challenging and there is no consensus regarding the optimal duration of screening. A 24-hour Holter electrocardiogram (ECG) is frequently employed to detect occult AF following ischaemic CVA.<h4>Objectives</h4>Demonstration ... Read more >>

Eur J Gen Pract (The European journal of general practice)
[2021, 27(1):152-157]

Cited: 0 times

View full text PDF listing >>



The association between pre-transfusion hemoglobin levels and thalassemia complications.

Wasuwit Wanchaitanawong, Adisak Tantiworawit, Pokpong Piriyakhuntorn, Thanawat Rattanathammethee, Sasinee Hantrakool, Chatree Chai-Adisaksopha, Ekarat Rattarittamrong, Lalita Norasetthada, Piangrawee Niprapan, Kanda Fanhchaksai, Pimlak Charoenkwan,

<h4>Objectives</h4>To evaluate any association between pre-transfusion hemoglobin (Hb) levels and thalassemia complications and to identify the Hb cutoff values to predict thalassemia complications.<h4>Methods</h4>We performed a cross-sectional study in thalassemia patients who attended the Adult Hematology Clinic of the tertiary care University Hospital from October 2017 to October 2018. A point-biserial ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):1-8]

Cited: 0 times

View full text PDF listing >>



The antihypertensive effect of irbesartan in spontaneously hypertensive rats is associated with improvement of the leptin-adiponectin imbalance.

Junting Weng, Min Chen, Rongjie Guo, Shuzhen Yang, Danjuan Liu, Dexiang Fang,

<h4>Objective</h4>This study aimed to investigate whether the antihypertensive effect of irbesartan (IRB) in spontaneously hypertensive rats (SHR) was achieved through improvement of insulin resistance and adjustment of the LPN-APN imbalance.<h4>Methods</h4>SHR rats were divided into SHAM, SHR-A and SHR-I group(8 per group). Homologous Wistar-Kyoto (WKY) rats were used as control group ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):101-107]

Cited: 0 times

View full text PDF listing >>



Inhibition of neprilysin with sacubitril without RAS blockage aggravates renal disease in Dahl SS rats.

Iuliia Polina, Morgan J Spicer, Mark Domondon, Ryan S Schibalski, Elizaveta Sarsenova, Regina F Sultanova, Daria V Ilatovskaya,

Salt-sensitive (SS) hypertension is accompanied with severe cardiorenal complications. In this condition, elevated blood pressure (BP) resulting from salt retention is associated with counterintuitively lower levels of atrial natriuretic peptide (ANP). In plasma, ANP is degraded by the neprilysin; therefore, pharmacological inhibition of this metalloprotease (i.e., with sacubitril) can be ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):315-324]

Cited: 1 time

View full text PDF listing >>



Association between an increase in blood urea nitrogen at 24 h and worse outcomes in COVID-19 pneumonia.

Bo Ye, Hongbin Deng, Hanwei Zhao, Jingjing Liang, Lu Ke, Weiqin Li,

Ren Fail (Renal failure)
[2021, 43(1):347-350]

Cited: 0 times

View full text PDF listing >>



Urinary calprotectin, NGAL, and KIM-1 in the differentiation of primarily inflammatory vs. non-inflammatory stable chronic kidney diseases.

Felix S Seibert, Maximilian Sitz, Jürgen Passfall, Martin Haesner, Peter Laschinski, Martin Buhl, Frederic Bauer, Benjamin Rohn, Nina Babel, Timm H Westhoff,

<h4>Introduction</h4>It has been demonstrated that urinary neutrophil gelatinase-associated lipocalin (NGAL) and calprotectin are helpful biomarkers in the differentiation of intrinsic and prerenal acute kidney injury.<h4>Objective</h4>The present cross-sectional study investigates, whether urinary biomarkers are able to differentiate primarily inflammatory from non-inflammatory entities in chronic kidney disease (CKD).<h4>Methods</h4>Urinary calprotectin, NGAL, and kidney ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):417-424]

Cited: 0 times

View full text PDF listing >>



Advertisement


Disclaimer

1.1893 s