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Hypersensitivity Pneumonitis

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Secondhand smoke from electronic cigarette resulting in hypersensitivity pneumonitis.

Panagis Galiatsatos, Erin Gomez, Cheng Ting Lin, Peter B Illei, Pali Shah, Enid Neptune,

Cases of vaping-induced lung injury have increased in the USA, resulting in a heterogeneous collection of pneumonitis patterns in persons who used electronic cigarettes. Hypersensitivity pneumonitis has been documented in several cases of first-hand electronic cigarette use; however, secondhand smoke health-related consequences have not been fully understood. We present a ... Read more >>

BMJ Case Rep (BMJ case reports)
[2020, 13(3):]

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Hospitalisation patterns of patients with interstitial lung disease in the light of comorbidities and medical treatment – a German claims data analysis.

Julia Wälscher, Sabine Witt, Larissa Schwarzkopf, Michael Kreuter,

BackgroundInterstitial lung disease (ILD) is a heterogeneous group of mainly chronic lung diseases differing in disease course and prognosis. For most subtypes, evidence on relevance and outcomes of hospitalisations is lacking.MethodsUsing German claims data we investigated number of hospitalisations (zero-inflated-negative-binomial models providing rate ratios (RR)) and time to first hospitalisation ... Read more >>

Respir. Res. (Respiratory research)
[2020, 21:]

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Current Diagnosis and Management of Hypersensitivity Pneumonitis.

Paolo Maria Leone, Luca Richeldi,

Hypersensitivity Pneumonitis (HP) one of the most common interstitial lung diseases (ILDs) is characterized by exposure to an inhaled inciting antigen that leads to a host immunologic reaction determining interstitial inflammation and architectural distortion. The underlying pathogenetic mechanisms are unclear. The absence of international shared diagnostic guidelines and the lack ... Read more >>

Tuberc Respir Dis (Seoul) (Tuberculosis and respiratory diseases)
[2020, :]

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Management issues in rheumatoid arthritis-associated interstitial lung disease.

Bryant R England, Daniel Hershberger,

PURPOSE OF REVIEW:Summarize recent evidence on the identification and management of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). RECENT FINDINGS:Clinical and subclinical interstitial lung disease (ILD) are frequent extra-articular manifestations of rheumatoid arthritis (RA). Better means of identifying and treating RA-ILD are needed to improve the prognosis, with a median survival ... Read more >>

Curr Opin Rheumatol (Current opinion in rheumatology)
[2020, 32(3):255-263]

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N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine, a zinc chelator, inhibits biofilm and hyphal formation in Trichosporon asahii.

Sanae Kurakado, Ryota Chiba, Chisato Sato, Yasuhiko Matsumoto, Takashi Sugita,

OBJECTIVE:Trichosporon asahii is the major causative fungus of disseminated or deep-seated trichosporonosis and forms a biofilm on medical devices. Biofilm formation leads to antifungal drug resistance, so biofilm-related infections are relatively difficult to treat and infected devices often require surgical removal. Therefore, prevention of biofilm formation is important in clinical ... Read more >>

BMC Res Notes (BMC research notes)
[2020, 13(1):142]

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COVID-19, A Clinical Syndrome Manifesting as Hypersensitivity Pneumonitis.

Young Goo Song, Hyoung Shik Shin,

Infect Chemother (Infection & chemotherapy)
[2020, :]

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Use Of Leflunomide In Patients With Hypersensitivity Pneumonitis

Aman Pande, Sungryong Noh, Ruchi Yadav, Manshi Li, Xiaofeng Wang, Debasis Sahoo, Daniel Culver,

<title>Abstract</title> <p> Prednisone has been shown to reverse lung function declines in hypersensitivity pneumonitis patients without established fibrosis. Second line immunosuppressants like azathioprine and mycophenolate mofetil have a steroid sparing effect and improve DLCO. There is no published literature on the use of leflunomide in such patients. We ... Read more >>

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Republished: Sertraline-induced hypersensitivity pneumonitis.

Gursharan Virdee, John Bleasdale, Mohammed Ikramullah, Emma Graham-Clarke,

Drug Ther Bull (Drug and therapeutics bulletin)
[2020, :]

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High-resolution CT features distinguishing usual interstitial pneumonia pattern in chronic hypersensitivity pneumonitis from those with idiopathic pulmonary fibrosis.

Tomoya Tateishi, Takeshi Johkoh, Fumikazu Sakai, Yasunari Miyazaki, Takashi Ogura, Kazuya Ichikado, Takafumi Suda, Yoshio Taguchi, Yoshikazu Inoue, Tamiko Takemura, Thomas V Colby, Hiromitsu Sumikawa, Kiminori Fujimoto, Hiroaki Arakawa, Suhail Raoof, Naohiko Inase,

PURPOSE:Radiologic diagnosis of chronic hypersensitivity pneumonitis (CHP) presenting a usual interstitial pneumonia (UIP) pattern is challenging. The aim of this study was to identify the high-resolution CT (HRCT) findings which are useful to discriminate CHP-UIP from idiopathic pulmonary fibrosis (IPF). MATERIALS AND METHODS:This study included 49 patients with well-established bird-related ... Read more >>

Jpn J Radiol (Japanese journal of radiology)
[2020, :]

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High resolution computed tomography patterns in interstitial lung disease (ILD): prevalence and prognosis.

Renata Fragomeni Almeida, Guilherme Watte, Edson Marchiori, Stephan Altmayer, Gabriel Sartori Pacini, Marcelo Cardoso Barros, Aldo Paza Junior, Adalberto Sperb Runin, Moacyr Christopher Garces Gamarra Salem, Bruno Hochhegger,

OBJECTIVE:To correlate the prevalence and prognosis of each HRCT pattern of typical, probable, and indeterminate usual interstitial pneumonia (UIP) with the clinical multidisciplinary diagnosis of interstitial lung disease (ILD). METHODS:We included all patients with a multidisciplinary diagnosis of ILD with an HRCT pattern of typical UIP, probable UIP, or indeterminate ... Read more >>

J Bras Pneumol (Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia)
[2020, 46(5):e20190153]

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Bronchoalveolar lavage and serum KL-6 concentrations in chronic hypersensitivity pneumonitis: correlations with radiological and immunological features.

Nicola Lanzarone, Francesco Gentili, Valerio Alonzi, Laura Bergantini, Miriana d'Alessandro, Paola Rottoli, Rosa Metella Refini, Maria Pieroni, Lucia Vietri, Francesco Bianchi, Maria Antonietta Mazzei, Luca Volterrani, Anna Perrone, Paolo Cameli, Elena Bargagli, Piersante Sestini,

Chronic hypersensitivity pneumonitis (cHP) is a fibrotic interstitial lung disease (ILD) resulting from inhalation of different organic substances and chemical compounds determining an inflammatory and immunological response in sensitized individuals. KL-6, a human mucin protein expressed by type 2 pneumocytes, has been proposed as a prognostic biomarker of cHP. Assessment ... Read more >>

Intern Emerg Med (Internal and emergency medicine)
[2020, :]

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Successful treatment of anti-MDA5 antibody-positive refractory interstitial lung disease with plasma exchange therapy.

Yoshiyuki Abe, Makio Kusaoi, Kurisu Tada, Ken Yamaji, Naoto Tamura,

OBJECTIVES:We examined the effectiveness of plasma exchange (PE) therapy to reduce the mortality of rapidly progressive interstitial lung disease (RP-ILD) in patients positive for anti-melanoma differentiation-associated gene 5 (MDA5) antibodies. METHODS:Among 142 patients newly diagnosed with PM/DM or clinically amyopathic DM from 2008 to 2019 at our hospital, 10 were ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, 59(4):767-771]

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Hypersensitivity Pneumonitis and (Idiopathic) Pulmonary Fibrosis Due to Feather Duvets and Pillows.

Ferran Morell, Ana Villar, Iñigo Ojanguren, Xavier Muñoz, María Jesús Cruz, Irene Sansano, Maria Antonia Ramon, Ganesh Raghu,

INTRODUCTION:Exposure to feather bedding may be an unnoticed cause of hypersensitivity pneumonitis (HP) and idiopathic pulmonary fibrosis (IPF). Thus, an in-depth clinical study of the diagnosis of patients with suspected HP and IPF is required in order to determine their etiologies. The objective of the present study is to raise ... Read more >>

Arch. Bronconeumol. (Archivos de bronconeumologia)
[2020, :]

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Nintedanib in patients with progressive fibrosing interstitial lung diseases-subgroup analyses by interstitial lung disease diagnosis in the INBUILD trial: a randomised, double-blind, placebo-controlled, parallel-group trial.

Athol U Wells, Kevin R Flaherty, Kevin K Brown, Yoshikazu Inoue, Anand Devaraj, Luca Richeldi, Teng Moua, Bruno Crestani, Wim A Wuyts, Susanne Stowasser, Manuel Quaresma, Rainer-Georg Goeldner, Rozsa Schlenker-Herceg, Martin Kolb, ,

BACKGROUND:The INBUILD trial investigated the efficacy and safety of nintedanib versus placebo in patients with progressive fibrosing interstitial lung diseases (ILDs) other than idiopathic pulmonary fibrosis (IPF). We aimed to establish the effects of nintedanib in subgroups based on ILD diagnosis. METHODS:The INBUILD trial was a randomised, double-blind, placebo-controlled, parallel ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2020, :]

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An unusual disease with an interesting sign.

Andreas Afthinos, Emmanouil Antonakis, Maria Horti, Eleftherios Markatis, Konstantinos Pagratis, Ilias C Papanikolaou,

Acute interstitial pneumonias mimic infectious pneumonias. Radiology signs point to, but usually don't establish, diagnosis. http://bit.ly/3b3P1iK. ... Read more >>

Breathe (Sheff) (Breathe (Sheffield, England))
[2020, 16(1):190302]

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Honeycomb lung-like structures resulting from clustering of traction bronchiectasis distally in sarcoidosis.

Michiru Sawahata, Noriharu Shijubo, Takeshi Johkoh, Koichi Hagiwara, Satoshi Konno, Tetsuo Yamaguchi,

Gene expression profiles of patients with progressive sarcoidosis, most of whom had evidence of fibrosis on imaging, have been reported to be similar to those of patients with inflammatory hypersensitivity pneumonitis, while expression profiles in progressive sarcoidosis did not resemble those of idiopathic pulmonary fibrosis. However, it is not known ... Read more >>

Respirol Case Rep (Respirology case reports)
[2020, 8(3):e00539]

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Pantoea agglomerans chronic exposure induces epithelial-mesenchymal transition in human lung epithelial cells and mice lungs.

Marta Kinga Lemieszek, Wojciech Rzeski, Marcin Golec, Barbara Mackiewicz, Jacek Zwoliński, Jacek Dutkiewicz, Janusz Milanowski,

Pantoea agglomerans is gram-negative bacteria widely distributed in nature. It predominates in inhalable dust from grain, herbs, and flax, and was identified as the most important cause of hypersensitivity pneumonitis (HP) in eastern Poland. To better understand the molecular mechanism of HP development studies focused on the interactions between P. ... Read more >>

Ecotoxicol. Environ. Saf. (Ecotoxicology and environmental safety)
[2020, 194:110416]

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Sentinel approach to detect emerging causes of work-related respiratory diseases.

A Y Zhou, M Seed, M Carder, A Money, M Van Tongeren, R Agius,

BACKGROUND:The world of work is continually changing, and this could result in new and emerging risks being introduced, including those that may cause work-related respiratory diseases (WRRD). AIMS:To describe recently emerging and new cases of WRRD and the relevant methodology using data in a national occupational respiratory disease surveillance scheme ... Read more >>

Occup Med (Lond) (Occupational medicine (Oxford, England))
[2020, 70(1):52-59]

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Change in Serum Biomarker CA 15-3 as an Early Predictor of Response to Treatment and Survival in Hypersensitivity Pneumonitis.

S A Moll, I A Wiertz, A D M Vorselaars, H J T Ruven, C H M van Moorsel, J C Grutters,

BACKGROUND:Hypersensitivity pneumonitis (HP) is an interstitial lung disease with a heterogeneous course of disease and treatment response. Cancer antigen 15-3 (CA 15-3), part of mucin 1, is believed to reflect epithelial cell injury and lung permeability and could be a potential biomarker for treatment response in HP. OBJECTIVE:To assess the ... Read more >>

Lung (Lung)
[2020, :]

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Chemotherapy-induced pneumonitis associated with transient CA 15-3 elevation.

Savas Comlek,

J Oncol Pharm Pract (Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners)
[2020, :1078155220904994]

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Chronic hypersensitivity pneumonitis in the southeastern United States: an assessment of how clinicians reached the diagnosis.

Jessie P Gu, Chen-Liang Tsai, Nicholas G Wysham, Yuh-Chin T Huang,

BACKGROUND:Chronic hypersensitivity pneumonitis (cHP) is a disease caused by exposure to inhaled environmental antigens. Diagnosis of cHP is influenced by the awareness of the disease prevalence, which varies significantly in different regions, and how clinicians utilize relevant clinical information. We conducted a retrospective study to evaluate how clinicians in the ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20(1):32]

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Occupational exposures and idiopathic pulmonary fibrosis.

Gareth I Walters,

PURPOSE OF REVIEW:A recent meta-analysis of data from international case-control studies reports a population attributable fraction of 16% for occupational factors in the cause of idiopathic pulmonary fibrosis (IPF). Smoking, genetic factors and other prevalent diseases only partly explain IPF, and so this review aims to summarize recent progress in ... Read more >>

Curr Opin Allergy Clin Immunol (Current opinion in allergy and clinical immunology)
[2020, 20(2):103-111]

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CX3CR1-fractalkine axis drives kinetic changes of monocytes in fibrotic interstitial lung diseases.

Flavia R Greiffo, Valeria Viteri-Alvarez, Marion Frankenberger, Daniela Dietel, Almudena Ortega-Gomez, Joyce S Lee, Anne Hilgendorff, Jürgen Behr, Oliver Soehnlein, Oliver Eickelberg, Isis E Fernandez,

Circulating immune cell populations have been shown to contribute to interstitial lung disease (ILD). In this study, we analysed circulating and lung resident monocyte populations, and assessed their phenotype and recruitment from the blood to the lung in ILD. Flow cytometry analysis of blood samples for quantifying circulating monocytes was ... Read more >>

Eur. Respir. J. (The European respiratory journal)
[2020, 55(2):]

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Hypersensitivity pneumonitis: Need for a better diagnostic evaluation.

Claudia Ravaglia,

Pulmonology (Pulmonology)
[2020, :]

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Human genetics of life-threatening influenza pneumonitis.

Qian Zhang,

Influenza viruses infect millions of people around the globe annually, usually causing self-limited upper respiratory tract infections. However, a small but non-negligible proportion of patients suffer from life-threatening pulmonary disease. Those affected include otherwise healthy individuals, and children with primary infections in particular. Much effort has been devoted to virological ... Read more >>

Hum. Genet. (Human genetics)
[2020, :]

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