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Hyperglycemia and Hypoglycemia in Stroke

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Is intensive glucose control bad for critically ill patients? A systematic review and meta-analysis.

Ren-Qi Yao, Chao Ren, Guo-Sheng Wu, Yi-Bing Zhu, Zhao-Fan Xia, Yong-Ming Yao,

Background: The monitoring and management of blood glucose concentration are standard practices in critical settings as hyperglycaemia has been shown close association with poorer outcomes. Several meta-analyses have revealed that intensive glucose control has no benefit in decreasing short-term mortality among critically ill patients, while the studies these meta-analyses have ... Read more >>

Int. J. Biol. Sci. (International journal of biological sciences)
[2020, 16(9):1658-1675]

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Risk of hypoglycemia associated with repaglinide combined with clopidogrel, a retrospective cohort study.

Yuuki Akagi, Akiko Iketaki, Haruna Kimura, Yuki Matsudaira, Takami Yoshida, Takahiro Nishimura, Yohei Kawano, Yasunari Mano, Erina Shigematsu, Makoto Ujihara,

Background:Repaglinide is widely prescribed to reduce postprandial hyperglycemia and elevated glycated hemoglobin (HbA1c) levels associated with type 2 diabetes, and clopidogrel is a thienopyridine antiplatelet agent and widely used in cardiovascular and cerebrovascular diseases. It has been suggested that the concomitant use of repaglinide with clopidogrel may inhibit repaglinide metabolism, ... Read more >>

J Pharm Health Care Sci (Journal of pharmaceutical health care and sciences)
[2020, 6:5]

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Prevalence of Diabetes Medication Intensifications in Older Adults Discharged From US Veterans Health Administration Hospitals.

Timothy S Anderson, Sei Lee, Bocheng Jing, Kathy Fung, Sarah Ngo, Molly Silvestrini, Michael A Steinman,

Importance:Elevated blood glucose levels are common in hospitalized older adults and may lead clinicians to intensify outpatient diabetes medications at discharge, risking potential overtreatment when patients return home. Objective:To assess how often hospitalized older adults are discharged with intensified diabetes medications and the likelihood of benefit associated with these intensifications. ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(3):e201511]

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Admission glucose level was associated with increased short-term mortality and length-of-stay irrespective of diagnosis, treating medical specialty or concomitant laboratory values.

Magnus Björk, Eva O Melin, Thomas Frisk, Maria Thunander,

BACKGROUND:Glucose is a routine emergency sample. General guidelines for inpatient hyperglycemia are scarce, except in myocardial infarction, stroke, and perioperative/ICU. Previous studies found admission glucose associated with increased mortality in specific conditions. Scandinavian data, and for general patients, are scarcer. We investigated admission glucose levels, 30-day mortality, and length-of-stay (LoS), ... Read more >>

Eur. J. Intern. Med. (European journal of internal medicine)
[2020, :]

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Time in range: a new parameter to evaluate blood glucose control in patients with diabetes.

Monica Andrade Lima Gabbay, Melanie Rodacki, Luis Eduardo Calliari, Andre Gustavo Daher Vianna, Marcio Krakauer, Mauro Scharf Pinto, Janice Sepúlveda Reis, Marcia Puñales, Leonardo Garcia Miranda, Ana Claudia Ramalho, Denise Reis Franco, Hermelinda Pedrosa Cordeiro Pedrosa,

The International Consensus in Time in Range (TIR) was recently released and defined the concept of the time spent in the target range between 70 and 180 mg/dL while reducing time in hypoglycemia, for patients using Continuous Glucose Monitoring (CGM). TIR was validated as an outcome measures for clinical Trials complementing ... Read more >>

Diabetol Metab Syndr (Diabetology & Metabolic Syndrome)
[2020, 12:22]

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Economic evaluation of dapagliflozin versus metformin in Chinese patients whose diabetes is inadequately controlled with diet and exercise.

Hua Nian, Xu Wan, Jing Ma, Fu Jie, Bin Wu,

Background:To investigate the long-term economic outcome of dapagliflozin versus metformin in Chinese patients with type 2 diabetes mellitus (T2DM) whose diet and exercise have not provided sufficient glycemic control. Methods:An economic analysis of dapagliflozin versus metformin was conducted by using the Chinese Outcomes Model for T2DM with a time horizon ... Read more >>

Cost Eff Resour Alloc (Cost effectiveness and resource allocation : C/E)
[2020, 18:12]

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Predictive value of random blood glucose versus fasting blood glucose on in-hospital adverse events in patients with ST-segment elevation acute myocardial infarction.

Yuhan Qin, Gaoliang Yan, Yong Qiao, Dong Wang, Erfei Luo, Jiantong Hou, Chengchun Tang,

BACKGROUND:We aim to find out the relationship between random blood glucose (RBG), fasting blood glucose (FBG) and in-hospital adverse events in ST-segment elevation acute myocardial infarction (STEMI) patients. We evaluate and compare the predictive value of RBG and FBG on in-hospital adverse events, and give an appropriate cut-off value of ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2020, 20(1):95]

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DAPA-HF trial: dapagliflozin evolves from a glucose-lowering agent to a therapy for heart failure.

Edgardo Kaplinsky,

Heart failure (HF) continues to be a major global health problem with a notable impact in terms of morbidity and mortality and so, in consequence, with a large unmet necessity for new therapies. The inhibition of sodium-glucose cotransporter 2 (SGLT2) causes glycosuria and natriuresis, leading to reductions in hyperglycemia (antidiabetic ... Read more >>

Drugs Context (Drugs in context)
[2020, 9:]

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Acute and chronic diabetes complications associated with self-reported oral health: a retrospective cohort study.

Kamini Kaura Parbhakar, Laura C Rosella, Sonica Singhal, Carlos R Quiñonez,

BACKGROUND:Oral health is associated with diabetes, but the chances of experiencing acute or chronic diabetes complications as per this association is unknown in Canada's most populous province, Ontario. This study assesses the impact of self-reported oral health on the likelihood of experiencing acute and chronic complications among a cohort of ... Read more >>

BMC Oral Health (BMC oral health)
[2020, 20(1):66]

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Insight Into the Perioperative Management of Type 2 Diabetes.

Syed Owais Zaidi, Yusra Khan, Bibi S Razak, Bilal Haider Malik,

Diabetic people are at risk of developing acute complications when exposed to stress. Surgery brings a stressful period when the patient is exposed not only to surgical stress but also the effects of medications used during that particular period. The patient's comorbidities can influence the perioperative management of diabetes. Poorly ... Read more >>

Cureus (Cureus)
[2020, 12(2):e6878]

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Clinical characteristics and outcomes of patients with end-stage renal disease hospitalized with diabetes ketoacidosis.

Rodolfo J Galindo, Francisco J Pasquel, Maya Fayfman, Katerina Tsegka, Neil Dhruv, Saumeth Cardona, Heqiong Wang, Priyathama Vellanki, Guillermo E Umpierrez,

INTRODUCTION:There is limited evidence to guide management in patients with end-stage renal disease (ESRD) on chronic hemodialysis admitted with diabetes ketoacidosis. Thus, we investigated the clinical characteristics and outcomes of patients with ESRD admitted with diabetic ketoacidosis (DKA). METHODS:In this observational study, we used International Classification of Diseases Ninth/Tenth Revision ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2020, 8(1):]

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Intensive Versus Standard Glucose Control in Patients with Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials.

Dandan Zheng, Xianjing Zhao,

BACKGROUND:Hyperglycemia is common in patients with ischemic stroke (IS) and has been proven to be associated with worse clinical outcomes. However, it is controversial whether intensive glucose control (IGC) is superior to standard glucose control (SGC). Therefore, we carried out this meta-analysis based on randomized controlled trials (RCTs). METHODS:We systematically ... Read more >>

World Neurosurg (World neurosurgery)
[2020, 136:e487-e495]

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Acute Complications of Diabetes Among Pilgrims During Hajj 2017: A Brief Report.

Zikra Khogeer, Razan Alnifaee, Sarah Alyamani, Khalid Alharbi, Sarah Hanbzaza, Abdulrahman Mashhor, Mohammad Alfelali, Osamah Barasheed,

INTRODUCTION:Diabetes mellitus (DM) was reported as one of the most common non-communicable diseases during Hajj. However, few studies evaluated acute complications of DM during Hajj. Therefore, this study aims to explore the most common acute complications among pilgrims with DM during Hajj 2017 and its clinical presentations. METHODS:This is a ... Read more >>

Diabetes Ther (Diabetes therapy : research, treatment and education of diabetes and related disorders)
[2020, 11(3):747-751]

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Insulin in the Management of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.

Christian D Cerecedo-Lopez, Alejandra Cantu-Aldana, Nirav J Patel, M Ali Aziz-Sultan, Kai U Frerichs, Rose Du,

OBJECTIVE:The role of tight glycemic control in the management of acute ischemic stroke remains uncertain. Our goal is to evaluate the effects of tight glucose control with insulin therapy after acute ischemic stroke. METHODS:We searched PubMed, CENTRAL, and Embase for randomized controlled trials (RCTs) that evaluated the effects of tight ... Read more >>

World Neurosurg (World neurosurgery)
[2020, 136:e514-e534]

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Effects of Preoperative HbA1c Levels on the Postoperative Outcomes of Coronary Artery Disease Surgical Treatment in Patients with Diabetes Mellitus and Nondiabetic Patients: A Systematic Review and Meta-Analysis.

Jinjing Wang, Xufei Luo, Xinye Jin, Meng Lv, Xueqiong Li, Jingtao Dou, Jing Zeng, Ping An, Yaolong Chen, Kang Chen, Yiming Mu,

Aims:To investigate the effect of preoperative HbA1c levels on the postoperative outcomes of coronary artery disease surgery in diabetic and nondiabetic patients. Methods and Results:The MEDLINE (via PubMed), Cochrane Library, Web of Science, Embase, Wanfang Data, China National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) databases were used to ... Read more >>

J Diabetes Res (Journal of diabetes research)
[2020, 2020:3547491]

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Effects of Glucose Fluctuation Targeted Intervention on the Prognosis of Patients with Type 2 Diabetes following the First Episode of Cerebral Infarction.

Qingqing Lou, Xiaodan Yuan, Shujie Hao, Joshua D Miller, Juan Yan, Panpan Zuo, Jianing Li, Lihong Yang, Hong Li,

Objective:The purpose of this study was to assess the effects of glucose fluctuation targeted intervention on neurologic function, independent living skills, and quality of life in type 2 diabetes patients following the first episode of cerebral infarction (CI). Methods:This was a randomized control trial. Following confirmed cerebral infarction, 75 patients ... Read more >>

J Diabetes Res (Journal of diabetes research)
[2020, 2020:2532171]

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Hippocampal Neurochemical Profile and Glucose Transport Kinetics in Patients With Type 1 Diabetes.

Petr Bednařík, Pierre-Gilles Henry, Amir Khowaja, Nathan Rubin, Anjali Kumar, Dinesh Deelchand, Lynn E Eberly, Elizabeth Seaquist, Gülin Öz, Amir Moheet,

CONTEXT:Longstanding type 1 diabetes (T1D) may lead to alterations in hippocampal neurochemical profile. Upregulation of hippocampal glucose transport as a result of recurrent exposure to hypoglycemia may preserve cognitive function during future hypoglycemia in subjects with T1D and impaired awareness of hypoglycemia (IAH). The effect of T1D on hippocampal neurochemical ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2020, 105(2):]

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Management of type 2 diabetes: consensus of diabetes organizations.

Elaena Quattrocchi, Tamara Goldberg, Nino Marzella,

Despite the advances in diabetes management, people with diabetes are not reaching their target glycemic goals. Healthcare professionals often fail to initiate, escalate, or de-intensify therapy when indicated. There are several organizations that provide guidance on the management of diabetes to assist the practitioner in achieving improved glycemic control, and ... Read more >>

Drugs Context (Drugs in context)
[2020, 9:212607]

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Association of Longitudinal Values of Glycated Hemoglobin With Cardiovascular Events in Patients With Type 2 Diabetes and Multivessel Coronary Artery Disease.

Paulo Cury Rezende, Mark Andrew Hlatky, Whady Hueb, Rosa Maria Rahmi Garcia, Luciano da Silva Selistre, Eduardo Gomes Lima, Cibele Larrosa Garzillo, Thiago Luis Scudeler, Gustavo Andre Boeing Boros, Fernando Faglioni Ribas, Carlos Vicente Serrano, Jose Antonio Franchini Ramires, Roberto Kalil Filho,

Importance:Glycated hemoglobin (HbA1c) values are used to guide glycemic control, but in patients with type 2 diabetes and multivessel coronary artery disease (CAD), the association of the longitudinal values of HbA1c with cardiovascular outcomes is unclear. Objective:To assess whether longitudinal variation of HbA1c is associated with cardiovascular events in long-term ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(1):e1919666]

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GIP as a Potential Therapeutic Target for Atherosclerotic Cardiovascular Disease-A Systematic Review.

Yusaku Mori, Takanori Matsui, Tsutomu Hirano, Sho-Ichi Yamagishi,

Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are gut hormones that are secreted from enteroendocrine L cells and K cells in response to digested nutrients, respectively. They are also referred to incretin for their ability to stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner. Furthermore, GLP-1 ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(4):]

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Effectiveness and safety of pulsatile intravenous insulin therapy for the improvement of respiratory quotient in Chinese patients with diabetes mellitus.

Nan Gu, Aimei Dong, Lei Gao, Chenying Xie, Peiyi Hou, Wenbo Wang, Sainan Zhu, Chen Yao, Junqing Zhang, Xiaohui Guo,

Pulsatile intravenous insulin therapy (PIVIT) is a means of imitating naturally occurring insulin pulses artificially. It is thought to improve carbohydrate metabolism, which can be assessed using the respiratory quotient (RQ). The aim of this present study was to assess the efficacy and safety of PIVIT for the improvement of ... Read more >>

(Experimental and Therapeutic Medicine)
[2020, 19(4):3069-3075]

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The Use of GLP1R Agonists for the Treatment of Type 2 Diabetes in Kidney Transplant Recipients.

Aleksandra Kukla, Jennifer Hill, Massini Merzkani, Andrew Bentall, Elizabeth C Lorenz, Walter D Park, Matthew D'Costa, Yogish C Kudva, Mark D Stegall, Pankaj Shah,

Glucagon-like peptide-1 receptor agonists (GLP1RA) have been shown to improve glucose control and diabetes-related comorbidities in patients without solid organ transplants. The effectiveness, safety, and tolerability of GLP1RA after kidney transplantation have not been adequately studied. Methods:We retrospectively reviewed data on kidney transplant recipients performed in our institution, who were ... Read more >>

Transplant Direct (Transplantation direct)
[2020, 6(2):e524]

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Beneficial Effects of Ipragliflozin on the Renal Function and Serum Uric Acid Levels in Japanese Patients with Type 2 Diabetes: A Randomized, 12-week, Open-label, Active-controlled Trial.

Masashi Tanaka, Hajime Yamakage, Takayuki Inoue, Shinji Odori, Toru Kusakabe, Akira Shimatsu, Noriko Satoh-Asahara,

Objective To examine the add-on effects, compared to the existing antidiabetes treatment, of the sodium-glucose cotransporter 2 inhibitor ipragliflozin on glycemic control and the risk factors of cardiovascular disease (CVD) and chronic kidney disease (CKD) in patients with inadequately controlled type 2 diabetes. Methods This 12-week, randomized, open-label, active-controlled trial ... Read more >>

Intern. Med. (Internal medicine (Tokyo, Japan))
[2020, 59(5):601-609]

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The effect of wuling capsule on depression in Type 2 diabetic patients.

Huanping Wang, Huizhen Chen, Yang Gao, Shengju Wang, Xian Wang, Xiaomei Tang, Wei Fang, Xiaoyan Shi, Jia Yao, Qiu Chen,

OBJECTIVE:Depression is a common complication in Type 2 diabetes mellitus (T2DM); however, it has long been underrecognized and undertreated. In the present study, we aimed to evaluate the clinical effects of Wuling capsule, a compound traditional Chinese herbal medicine, on T2DM complicated with depression. METHOD:66 patients were enrolled and randomly ... Read more >>

Biosci. Rep. (Bioscience reports)
[2020, 40(2):]

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Educational Case: Etiologies, Mechanisms, and Treatment of Stroke.

Lymaries Velez, Steven Toffel, Jorge Trejo-Lopez, Jesse L Kresak, Stacy G Beal,

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and ... Read more >>

Acad Pathol (Academic pathology)
[2020, 7:2374289520901817]

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