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Hyperandrogenism

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Ameliorative effects of Cuscuta reflexa and Peucedanum grande on letrozole induced polycystic ovary syndrome in Wistar rats.

Firdaus Kausar, Muzafar Ahmad Rather, Showkeen Muzamil Bashir, Rana M Alsaffar, Showkat Ul Nabi, Sofi Imtiyaz Ali, Pankaj Goswami, Ansar Ahmad, Summya Rashid, Adil Farooq Wali,

<h4>Objectives</h4>The current study was designed to examine the therapeutic role of hydroalcoholic extract of <i>Cuscuta reflexa</i> Roxb (CRE) and <i>Peucedanum grande</i> C.B. Clarke (PGE) on letrozole (1 mg/kg) induced polycystic ovary syndrome (PCOS) in female Wistar albino rats.<h4>Methods</h4>PCOS rats were treated with CRE (280 mg/kg), PGE (140 mg/kg) or CRE + PGE p.o. for 3 ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2021, 26(1):94-104]

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Investigation of common risk factors between polycystic ovary syndrome and Alzheimer's disease: a narrative review.

Nahid Sarahian, Hosna Sarvazad, Elham Sajadi, Nasrin Rahnejat, Narges Eskandari Roozbahani,

<h4>Background</h4>The most common endocrine and metabolic disorders in premenopausal women is polycystic ovary syndrome (PCOS), characterized by hyperandrogenism, chronic anovulation, and/or ultrasound evidence of small ovarian cysts. Obesity and insulin resistance are also the main factors influencing the clinical manifestations of this syndrome. Alzheimer's disease (AD) is the most typical ... Read more >>

Reprod Health (Reproductive health)
[2021, 18(1):156]

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Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice.

Emmi Rotgers, Barbara Nicol, Karina Rodriguez, Saniya Rattan, Jodi A Flaws, Humphrey Hung-Chang Yao,

Steroid hormones regulate various aspects of physiology, from reproductive functions to metabolic homeostasis. Steroidogenic factor-1 (NR5A1) plays a central role in the development of steroidogenic tissues and their ability to produce steroid hormones. Inactivation of Nr5a1 in the mouse results in a complete gonadal and adrenal agenesis, absence of gonadotropes ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(8):e21770]

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The Effects of Statins on Hyperandrogenism In Women With Polycystic Ovary Syndrome: A Systematic Review And Meta-analysis of Randomized Controlled Trials

Jianguo Chen, Chaoran Huan, Tongtong Zhang, Wuqing Gong, Xiaofeng Deng, Hua Liu, Jinbo Liu, Yuanbiao Guo,

Several clinical studies showed that statins were potential to treat polycystic ovary syndrome (PCOS). Through comprehensive search PubMed, EMBASE, the Web of Science, BIOSIS, the ClinialTrails.gov, and the Cochrane Library database up to 14 Feb 2020, we identified the randomized controlled trials about the treatment of statins on hyperandrogenism in ... Read more >>

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MIF-mediated NF-κB signaling pathway regulates the pathogenesis of polycystic ovary syndrome in rats.

Zhenlin He, Yuelong Wang, Li Zhuan, Yunxiu Li, Z-Ouyin Tang, Ze Wu, Yanping Ma,

Polycystic ovary syndrome (PCOS) resulting from abnormal glucose metabolism is a relatively common and complex endocrine disorder among women in their reproductive years, However, the pathogenesis of PCOS is still unclear. The purpose of this study is to investigate the macrophage migration inhibitory factor (MIF) involvement of the nuclear factor ... Read more >>

Cytokine (Cytokine)
[2021, 146:155632]

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Impact of rs2414096 polymorphism of CYP19 gene on susceptibility of polycystic ovary syndrome and hyperandrogenism in Kashmiri women.

Sairish Ashraf, Shayaq Ul Abeer Rasool, Mudasar Nabi, Mohd Ashraf Ganie, Shariq R Masoodi, Shajrul Amin,

Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder in pre-menopausal women having complex pathophysiology. Several candidate genes have been shown to have association with PCOS. CYP19 gene encodes a key steroidogenic enzyme involved in conversion of androgens into estrogens. Previous studies have reported contradictory results with regard to association of SNP rs2414096 in CYP19 gene ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):12942]

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Polycystic Ovary Syndrome Phenotype Does Not Have Impact on Oocyte Morphology

Audrey Uk, Christine Decanter, Camille Grysole, Laura Keller, Hélène Béhal, Mauro Silva, Didier Dewailly, Geoffroy Robin, anne-laure barbotin,

<h4>Purpose: </h4> The primary objective of the present study of women participating in an ICSI program was to determine whether the morphologic quality of oocytes was related to the polycystic ovary syndrome (PCOS) phenotype. <h4>Methods: </h4> We performed a retrospective cohort study in the IVF unit at the Lille University ... Read more >>

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Challenges in diagnosis of polycystic ovary syndrome in adolescence.

Elene Asanidze, Jenaro Kristesashvili, Nino Parunashvili, Natalia Karelishvili, Nana Etsadashvili,

<h4>Objective</h4>we evaluated clinical features, the hormonal status, and ovarian morphological characteristics using ultrasound (US) in adolescents with polycystic ovary syndrome (PCOS) and an 'increased risk' of PCOS, and compared the data to age-matched controls.<h4>Methods</h4>the prospective study involved 154 adolescents (≥2 and <8 years post menarche): Group I-adolescents with PCOS (<i>n</i> = 60), Group ... Read more >>

Gynecol Endocrinol (Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology)
[2021, :1-4]

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Proxalutamide (GT0918) Reduces the Rate of Hospitalization in mild-to-moderate COVID-19 Female Patients: A Randomized Double-Blinded Placebo-Controlled Two-Arm Parallel Trial

Flávio Adsuara Cadegiani, Ricardo Ariel Zimerman, Daniel do Nascimento Fonseca, Michael do Nascimento Correia, John McCoy, Carlos Gustavo Wambier, Andy Goren,

<h4>Background</h4> Antiandrogens were shown to be effective in mild-tomoderate COVID-19 male patients, supported by the SARS-CoV-2 dependency on transmembrane protease, serine 2 (TMPRSS2), which is solely modulated by androgens, for cell entry. While women with hyperandrogenism experiment more symptoms in COVID-19 compared to women without hyperandrogenism, and the chronic use ... Read more >>

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Ovarian Hyperandrogenism and Response to Gonadotropin-releasing Hormone Analogues in Primary Severe Insulin Resistance.

Isabel Huang-Doran, Alexandra B Kinzer, Mercedes Jimenez-Linan, Kerrie Thackray, Julie Harris, Claire L Adams, Marc de Kerdanet, Anna Stears, Stephen O'Rahilly, David B Savage, Phillip Gorden, Rebecca J Brown, Robert K Semple,

<h4>Context</h4>Insulin resistance (IR) is associated with polycystic ovaries and hyperandrogenism, but underpinning mechanisms are poorly understood and therapeutic options are limited.<h4>Objective</h4>To characterize hyperandrogenemia and ovarian pathology in primary severe IR (SIR), using IR of defined molecular etiology to interrogate disease mechanism. To extend evaluation of gonadotropin-releasing hormone (GnRH) analogue therapy ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2021, 106(8):2367-2383]

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Let-7e modulates the proliferation and the autophagy of human granulosa cells by suppressing p21 signaling pathway in polycystic ovary syndrome without hyperandrogenism.

Ying Li, Yu-Dong Liu, Xing-Yu Zhou, Jun Zhang, Xiao-Min Wu, Yi-Zhen Yang, Ying-Xue Chen, Xiao-Fei Zhang, Xin Li, Lin-Zi Ma, Zhe Wang, Shi-Ling Chen,

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in reproductive-aged women, and its pathogenesis is still under debate. Recent studies suggest crucial roles for microRNAs (miRNAs) in PCOS development. The let-7 family miRNAs constitute the most abundant miRNAs in human granulosa cells (GCs), and plays an important ... Read more >>

Mol Cell Endocrinol (Molecular and cellular endocrinology)
[2021, 535:111392]

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Impact of vascular liver disease on the menstrual cycle and metabolic status in premenopausal women.

Tatiana Stempak-Droissart, Christine Rousset-Jablonski, Poli M Spritzer, Najiba Lalhou, Etienne Larger, Caroline Pichard, Aurélie Plessier, Anne Gompel,

<h4>Background</h4>Vascular liver disease (VLD) are rare liver diseases, which affect women at reproductive ages. Main complications are bleeding (portal hypertension, thrombopenia or anticoagulation related) and thromboembolism. Failure of liver function can occur. Thus endocrine abnormalities management and contraception are challenging.<h4>Purpose</h4>to evaluate the impact on the menstrual cycles and related endocrine ... Read more >>

Clin Res Hepatol Gastroenterol (Clinics and research in hepatology and gastroenterology)
[2021, :101756]

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Humanin Alleviates Insulin Resistance in Polycystic Ovary Syndrome: A Human and Rat Model-Based Study.

Yingying Wang, Zhengyan Zeng, Shuhua Zhao, Li Tang, Jin Yan, Nianyu Li, Liping Zou, Xiaorong Fan, Chengcheng Xu, Jin Huang, Wei Xia, Changhong Zhu, Meng Rao,

Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, is characterized by hyperandrogenism and insulin resistance (IR); however, the pathogenesis of local ovarian IR in PCOS remains largely unclear. Humanin, a mitochondria-derived peptide, has been reported to be associated with IR. Our previous study confirmed ... Read more >>

Endocrinology (Endocrinology)
[2021, 162(8):]

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The study of the pathogenesis of idiopathic central precocious puberty based on gut microbiota

Congfu Huang, Bin Wu, Wei Yang, Junru Chen, Zhenyu Yang, Yinhu Li, Shufen Chen, Xiangling Wu, Liping Wu, Haiying Liu,

Object To analyze the correlation between gut microbiota (GM) and hyperandrogenemia, insulin resistance, carbohydrate metabolism, and explore whether the pathogenesis of idiopathic central precocious puberty (ICPP) and polycystic ovary syndrome (PCOS) is consistent based on GM. Methods In this study, we have recruited 27 ICPP (ICPP group) and ... Read more >>

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Polycystic ovary syndrome and infertility: an update.

Mehrukh Zehravi, Mudasir Maqbool, Irfat Ara,

Polycystic ovarian syndrome is the most well-known endocrine condition among women of this generation (PCOS). Symptoms of hyperandrogenism, irregular menstrual periods, and insulin resistance are all traits associated with PCOS. In women with PCOS, the chance of having problems including infertility, insulin resistance, and type 2 diabetes increases. The PCOS ... Read more >>

Int J Adolesc Med Health (International journal of adolescent medicine and health)
[2021, :]

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Epigenetic inheritance of polycystic ovary syndrome - challenges and opportunities for treatment.

Elisabet Stener-Victorin, Qiaolin Deng,

Polycystic ovary syndrome (PCOS) is the main cause of female infertility worldwide and is associated with a substantially increased lifetime risk of comorbidities, including type 2 diabetes mellitus, psychiatric disorders and gynaecological cancers. Despite its high prevalence (~15%) and substantial economic burden, the aetiology of PCOS remains elusive. The genetic ... Read more >>

Nat Rev Endocrinol (Nature reviews. Endocrinology)
[2021, :]

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Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome.

Sebastião Freitas de Medeiros, Raymond Joseph Rodgers, Robert John Norman,

<h4>Background</h4>Metabolic and endocrine alterations in women with polycystic ovary syndrome (PCOS) affect adipose tissue mass and distribution. PCOS is characterised by hyperandrogenism, obesity and adipocyte dysfunction. Hyperandrogenism in PCOS drives dysfunctional adipocyte secretion of potentially harmful adipocytokines. Glucocorticoids and sex-steroids modulate adipocyte development and function. For their part, adipocyte products ... Read more >>

Hum Reprod Update (Human reproduction update)
[2021, 27(4):771-796]

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Postmenopausal hyperandrogenism.

T Yoldemir,

Postmenopausal hyperandrogenism is a state of relative or absolute androgen excess originating from the adrenal glands and/or ovaries clinically manifested by the presence of terminal hair in androgen-dependent areas of the body, and other manifestations of hyperandrogenism such as acne and alopecia or the development of virilization. In such circumstances, ... Read more >>

Climacteric (Climacteric : the journal of the International Menopause Society)
[2021, :1-9]

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Sex Hormones Related Ocular Dryness in Breast Cancer Women.

Antonella Grasso, Antonio Di Zazzo, Giuseppe Giannaccare, Jaemyoung Sung, Takenori Inomata, Kendrick Co Shih, Alessandra Micera, Daniele Gaudenzi, Sara Spelta, Maria Angela Romeo, Paolo Orsaria, Marco Coassin, Vittorio Altomare,

<h4>Background</h4>Dry eye syndrome (DES) is strictly connected to systemic and topical sex hormones. Breast cancer treatment, the subsequent hormonal therapy, the subsequent hyperandrogenism and the early sudden menopause, may be responsible for ocular surface system failure and its clinical manifestation as dry eye disease. This local dryness is part of ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(12):]

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Impact of Obesity on Anti-Mullerian Hormone (AMH) Levels in Women of Reproductive Age.

Alexis L Oldfield, Maryam Kazemi, Marla E Lujan,

Obesity negatively impacts reproductive health, including ovarian function. Obesity has been posited to alter Anti-Müllerian hormone (AMH) production. Understanding biological factors that could impact AMH levels is necessary given the increasing use of AMH for predicting reproductive health outcomes in response to controlled ovarian stimulation, diagnosing ovulatory disorders, onset of ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(14):]

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Increased uterine androgen receptor protein abundance results in implantation and mitochondrial defects in pregnant rats with hyperandrogenism and insulin resistance.

Yuehui Zhang, Min Hu, Fan Yang, Yizhuo Zhang, Shuting Ma, Dongqi Zhang, Xu Wang, Amanda Nancy Sferruzzi-Perri, Xiaoke Wu, Mats Brännström, Linus R Shao, Håkan Billig,

In this study, we show that during normal rat pregnancy, there is a gestational stage-dependent decrease in androgen receptor (AR) abundance in the gravid uterus and that this is correlated with the differential expression of endometrial receptivity and decidualization genes during early and mid-gestation. In contrast, exposure to 5α-dihydrotestosterone (DHT) ... Read more >>

J Mol Med (Berl) (Journal of molecular medicine (Berlin, Germany))
[2021, :]

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Polycystic ovary syndrome: epidemiologic assessment of prevalence of systemic rheumatic and autoimmune diseases.

Saika Sharmeen, Hafsa Nomani, Erin Taub, Harold Carlson, Qingping Yao,

<h4>Background</h4>Polycystic ovary syndrome (PCOS) causes anovulation and hyperandrogenism. Hormonal imbalance is known to contribute to systemic autoimmune diseases.<h4>Objective</h4>To examine the frequency of certain rheumatic diseases in PCOS.<h4>Methods</h4>This retrospective study utilized and analyzed electronic medical records from January 2004 through February 2020. A diagnosis of PCOS and specified rheumatic diseases was ... Read more >>

Clin Rheumatol (Clinical rheumatology)
[2021, :]

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Ovarian Hyperthecosis: Hyperandrogenism in a Post-Menopausal Woman

Christine Fayad, Amber Champion, Kenneth E Izuora,

Abstract Introduction: Ovarian Hyperthecosis (OH) is a disorder characterized by severe hyperandrogenism and insulin resistance. It is a rare cause of hyperandrogenism primarily among postmenopausal women. We present a case report about a patient with adrenal incidentalomas and later found to have ovarian hyperthecosis during her evaluation. Case Description: 62-year-old ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2021, 5(Suppl 1):A782-A783]

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Licogliflozin versus placebo in women with polycystic ovary syndrome: A randomized, double-blind, phase 2 trial.

Susanne Tan, Stanislav Ignatenko, Frank Wagner, Anuja Dokras, Jochen Seufert, Denise Zwanziger, Karin Dunschen, Marjorie Zakaria, Neda Huseinovic, Craig T Basson, Ping Mahling, Dagmar Fuhrer, Markus Hinder,

Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and insulin resistance. The dual sodium-glucose co-transporter 1/2 inhibitor (SGLT1/2i) licogliflozin (LIK066) ameliorates hyperinsulinism in patients with diabetes and obesity. This study examines the effect of licogliflozin on androgens in women with PCOS. In a multicentre, randomized, placebo-controlled, double-blind, 2-week trial, patients ... Read more >>

Diabetes Obes Metab (Diabetes, obesity & metabolism)
[2021, :]

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Post Menopausal Hyperandrogenism: A Case of a Steroid Cell Tumor of the Ovary

Lauren Juliette Hassan Nelson, Sarika Rao,

Abstract Introduction: Postmenopausal hyperandrogenism is a rare condition that causes hirsutism, virilization, and clitoromegaly that should be carefully evaluated in order to avoid overlooking an androgen secreting tumor (1). Case: A 48 year old African American female with a prior history of polycystic ovarian syndrome (PCOS) presented for evaluation of ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2021, 5(Suppl 1):A783-A783]

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