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Human Milk and Lactation

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A qualitative examination of barriers against effective medical education and practices related to breastfeeding promotion and support in Lebanon.

Sara Moukarzel, Christoforos Mamas, Antoine Farhat, Antoine Abi Abboud, Alan J Daly,

Background: Insufficient breastfeeding promotion and support by physicians contribute to suboptimal breastfeeding rates globally. Understanding setting-specific barriers against breastfeeding promotion and support from the perspective of medical students and addressing those that can be modified through undergraduate medical education may help improve learning outcomes, medical practice, and ultimately health outcomes ... Read more >>

Med Educ Online (Medical education online)
[2020, 25(1):1723950]

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Nuclear magnetic resonance (NMR)-based metabolome profile evaluation in dairy cows with and without displaced abomasum.

Abdullah Basoglu, Nuri Baspinar, Leonardo Tenori, Cristina Licari, Erdem Gulersoy,

Background: Displaced abomasum (DA) is a condition of dairy cows that severely impacts animal welfare and causes huge economic losses.Objective: To assess the metabolic status of the disease using metabolomics in serum, urine and liver samples aimed at both water soluble and lipid soluble fractions.Methods: Fifty Holstein multiparous cows with ... Read more >>

Vet Q (The veterinary quarterly)
[2020, 40(1):1-15]

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Differences in fatty acid profiles and desaturation indices of abdominal subcutaneous adipose tissue between pregnant women with and without PCOS.

Neda Emami, AliReza Alizadeh, Ashraf Moini, Parichehreh Yaghmaei, Maryam Shahhosseini,

The objective was to determine the differences in fatty acid (FA) profiles in subcutaneous adipose tissue (AT) between pregnant women with polycystic ovary syndrome (PCOS) and those without PCOS. FA profiles of AT samples from 13 PCOS and 32 non-PCOS, all of whom underwent caesarean section were compared using gas ... Read more >>

Adipocyte (Adipocyte)
[2020, 9(1):16-23]

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Quantitative Phosphoproteomics of Milk Fat Globule Membrane in Human Colostrum and Mature Milk: New Insights into Changes in Protein Phosphorylation during Lactation.

Mei Yang, Wei Deng, Xueyan Cao, Lijie Wang, Na Yu, Yan Zheng, Junrui Wu, Rina Wu, Xiqing Yue,

Phosphorylation is a widespread posttranslational protein modification and is important in various biological processes. However, milk fat globule membrane (MFGM) phosphoproteins have not been explored systematically in human milk. Here, we used quantitative phosphoproteomics to analyze phosphorylation sites in human MFGM proteins and their differences at different stages of lactation; ... Read more >>

J. Agric. Food Chem. (Journal of agricultural and food chemistry)
[2020, :]

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Genome-wide association study for genotype by lactation stage interaction of milk production traits in dairy cattle.

Haibo Lu, Yachun Wang, Henk Bovenhuis,

Substantial evidence demonstrates that the genetic background of milk production traits changes during lactation. However, most GWAS for milk production traits assume that genetic effects are constant during lactation and therefore might miss those quantitative trait loci (QTL) whose effects change during lactation. The GWAS for genotype by lactation stage ... Read more >>

J. Dairy Sci. (Journal of dairy science)
[2020, :]

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Quantitative Longitudinal Inventory of the N-Glycoproteome of Human Milk from a Single Donor Reveals the Highly Variable Repertoire and Dynamic Site-Specific Changes.

Jing Zhu, Yu-Hsien Lin, Kelly A Dingess, Marko Mank, Bernd Stahl, Albert J R Heck,

Protein N-glycosylation on human milk proteins assists in protecting an infant's health and functions among others as competitive inhibitors of pathogen binding and immunomodulators. Due to the individual uniqueness of each mother's milk and the overall complexity and temporal changes of protein N-glycosylation, analysis of the human milk N-glycoproteome requires ... Read more >>

J. Proteome Res. (Journal of proteome research)
[2020, :]

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Human Milk and Lactation.

Maria Lorella Gianni, Daniela Morniroli, Maria Enrica Bettinelli, Fabio Mosca,

Human milk is uniquely tailored to meet infants' specific nutritional requirements [...]. ... Read more >>

Nutrients (Nutrients)
[2020, 12(4):]

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Efficacy of leflunomide combined with prednisone for the treatment of PLA2R-associated primary membranous nephropathy.

Yaling Guo, Xueping Wu, Lei Liu, Haifeng Zhang, Lijuan Yang, Weidong Chen,

Objective: To evaluate the clinical efficacy and safety of leflunomide (LEF) combined with prednisone for the treatment of PLA2R-associated primary membranous nephropathy (PMN) and changes in anti-PLA2R antibody titers after treatment.Methods: Sixty patients with nephrotic syndrome, biopsy-proven MN and anti-PLA2R antibody positivity were included in this study conducted from December ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):122-130]

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Nuclear Magnetic Resonance Metabolomics Reveals Qualitative and Quantitative Differences in the Composition of Human Breast Milk and Milk Formulas.

Dorota Garwolińska, Weronika Hewelt-Belka, Agata Kot-Wasik, Ulrik Kræmer Sundekilde,

Commercial formula milk (FM) constitutes the best alternative to fulfill the nutritional requirements of infants when breastfeeding is precluded. Here, we present the comparative study of polar metabolite composition of human breast milk (HBM) and seven different brands of FM by nuclear magnetic resonance spectroscopy. The results of the multivariate ... Read more >>

Nutrients (Nutrients)
[2020, 12(4):]

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Genome‑wide integrated analysis demonstrates widespread functions of lncRNAs in mammary gland development and lactation in dairy goats.

Zhibin Ji, Tianle Chao, Zhaohua Liu, Lei Hou, Jin Wang, Aili Wang, Jie Zhou, Rong Xuan, Guizhi Wang, Jianmin Wang,

BackgroundThe mammary gland is a unique organ for milk synthesis, secretion and storage, and it undergoes cyclical processes of development, differentiation, lactation and degeneration. At different developmental periods, the biological processes governing mammary gland physiology and internal environmental homeostasis depend on a complex network of genes and regulatory factors. Emerging ... Read more >>

BMC Genomics (BMC Genomics)
[2020, 21:]

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A Systematic Review of Collection and Analysis of Human Milk for Macronutrient Composition.

Gabriela E Leghi, Philippa F Middleton, Merryn J Netting, Mary E Wlodek, Donna T Geddes, Beverly S Muhlhausler,

As human milk (HM) composition varies by time and across even a single feed, methods of sample collection can significantly affect the results of compositional analyses and complicate comparisons between studies. The aim was to compare the results obtained for HM macronutrient composition between studies utilizing different sampling methodologies. The ... Read more >>

J. Nutr. (The Journal of nutrition)
[2020, :]

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International Perspectives Concerning Donor Milk Banking During the SARS-CoV-2 (COVID-19) Pandemic.

Kathleen A Marinelli,

J Hum Lact (Journal of human lactation : official journal of International Lactation Consultant Association)
[2020, :890334420917661]

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Drug Exposure in Newborns: Effect of Selected Drugs Prescribed to Mothers During Pregnancy and Lactation.

Katharina M Rentsch,

The number of newborns exposed to therapeutic drugs during pregnancy is growing because of the increased use of drugs during pregnancy. In recent years, advances in our understanding of drug placental transfer have augmented the likelihood of a healthy baby in mothers with chronic diseases needing drug therapy. Globally, for ... Read more >>

Ther Drug Monit (Therapeutic drug monitoring)
[2020, 42(2):255-263]

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Human Milk Oligosaccharide Profile Variation Throughout Postpartum in Healthy Women in a Brazilian Cohort.

Ana Lorena Ferreira, Ronaldo Alves, Amanda Figueiredo, Nadya Alves-Santos, Nathalia Freitas-Costa, Mônica Batalha, Chloe Yonemitsu, Nadia Manivong, Annalee Furst, Lars Bode, Gilberto Kac,

Human milk oligosaccharide (HMO) composition varies throughout lactation and can be influenced by maternal characteristics. This study describes HMO variation up to three months postpartum and explores the influences of maternal sociodemographic and anthropometric characteristics in a Brazilian prospective cohort. We followed 101 subjects from 28-35 gestational weeks (baseline) and ... Read more >>

Nutrients (Nutrients)
[2020, 12(3):]

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The acute phase protein orosomucoid 1 is upregulated in early lactation but does not trigger appetite-suppressing STAT3 signaling via the leptin receptor.

M M McGuckin, S L Giesy, A N Davis, M A Abyeta, E A Horst, S Saed Samii, Y Zang, W R Butler, L H Baumgard, J W McFadden, Y R Boisclair,

Dairy cows consume inadequate amounts of feed in early lactation and during conditions and diseases such as excessive fatness, heat stress, and infectious diseases. Affected cows often experience increases in plasma concentrations of acute phase proteins consistent with the negative effect of inflammation on appetite. The acute phase protein orosomucoid ... Read more >>

J. Dairy Sci. (Journal of dairy science)
[2020, :]

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Immunology of Human Milk and Lactation: Historical Overview.

Pearay L Ogra,

The development of the mammary glands and the process of lactation is an integral component of mammalian evolution, and suckling has been essential for the survival of the neonates of most mammalian species. The colostrum and milk, the major products of lactation, contain a wealth of biologically active products derived ... Read more >>

Nestle Nutr Inst Workshop Ser (Nestle Nutrition Institute workshop series)
[2020, 94:11-26]

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The impact of maternal obesity on human milk macronutrient composition: A systematic review and meta-analysis.

Gabriela E Leghi, Merryn J Netting, Philippa F Middleton, Mary E Wlodek, Donna T Geddes, And Beverly S Muhlhausler,

Maternal obesity has been associated with changes in the macronutrient concentration of human milk (HM), which have the potential to promote weight gain and increase the long-term risk of obesity in the infant. This article aimed to provide a synthesis of studies evaluating the effects of maternal overweight and obesity ... Read more >>

Nutrients (Nutrients)
[2020, 12(4):]

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Negative Energy Balance Influences Nutritional Quality of Milk from Czech Fleckvieh Cows due Changes in Proportion of Fatty Acids.

Jaromír Ducháček, Luděk Stádník, Martin Ptáček, Jan Beran, Monika Okrouhlá, Matúš Gašparík,

The objective of this study was to evaluate the influence of negative energy balance on fatty acids proportion in the milk of Czech Fleckvieh cows after calving. Milk quality was determined based on fatty acid group proportion. Milk quality was evaluated in relation to selected negative energy balance (NEB) traits: ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2020, 10(4):]

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Is Cabergoline Safe and Effective for Postpartum Lactation Inhibition? A Systematic Review.

Yang Yang, Isabelle Boucoiran, Karen J Tulloch, Vanessa Poliquin,

Background:Despite its benefits, there are some situations where breastfeeding is impossible or not recommended. Breast milk secretion and engorgement can be distressing to these non-breastfeeding women. There is currently no universal guideline on the most appropriate management for these women. Our objective is to evaluate the effectiveness and safety of ... Read more >>

Int J Womens Health (International Journal of Women's Health)
[2020, 12:159-170]

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Measures of Secretory Activation for Research and Practice: An Integrative Review.

Clarisa Medina Poeliniz, Janet L Engstrom, Rebecca Hoban, Aloka L Patel, Paula Meier,

Background: Maternal concern about inadequate milk volume commonly emerges in the first 2 weeks postpartum, a critical lactation period that includes secretory activation. This review summarizes the biology of secretory activation and evaluates the accuracy and feasibility of published measures of secretory activation. Materials and Methods: A systematic search of ... Read more >>

Breastfeed Med (Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine)
[2020, :]

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Appropriate Infant and Young Child Feeding Practices in an Emergency for Non-Breastfed Infants Under Six Months: The Rohingya Experience.

Alice Burrell, Anne M Kueter, Sujan Ariful, Habibur Rahaman, Alessandro Iellamo, Golam Mothabbir,

BACKGROUND:Since 25 August, 2017 over 693,000 Rohingya have been forced from Myanmar due to mass violence, seeking refuge in neighboring Bangladesh. Nutritional surveys during 2017 revealed worrying levels of malnutrition and poor infant feeding practices, including high numbers of infants not exclusively breastfeeding. Infants under 6 months who are not ... Read more >>

J Hum Lact (Journal of human lactation : official journal of International Lactation Consultant Association)
[2020, :890334420906838]

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Impact of Intraoperative Infusion and Postoperative PCIA of Dexmedetomidine on Early Breastfeeding After Elective Cesarean Section: A Randomized Double-Blind Controlled Trial.

Yu Wang, Xiang Fang, Chao Liu, Xiaotong Ma, Yutong Song, Ming Yan,

Objective:Few studies have investigated the effects of dexmedetomidine (DEX) on breastfeeding after cesarean delivery. A randomized double-blind controlled trial was conducted to investigate whether the administration of DEX, immediately after delivery and for patient-controlled intravenous analgesia (PCIA), can be beneficial for breastfeeding. Patients and Methods:One hundred sixty parturients scheduled for ... Read more >>

Drug Des Devel Ther (Drug Design, Development and Therapy)
[2020, 14:1083-1093]

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Relationship between reproductive and productive traits in Holstein cattle using multivariate analysis.

Pablo Dominguez-Castaño, Matheus Henrique Vargas de Oliveira, Lenira El Faro, Josineudson Augusto Ii de Vasconcelos Silva,

Multivariate procedures are used for the extraction of variables from the correlation matrix of phenotypes in order to identify those traits that explain the largest proportion of phenotypic variation and to evaluate the relationship structure between these traits. The reproductive traits [days from calving to first estrus (CFE), days from ... Read more >>

Reprod. Domest. Anim. (Reproduction in domestic animals = Zuchthygiene)
[2020, :]

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Human Milk Microbiota: Origin and Potential Uses.

Leónides Fernández, Juan M Rodríguez,

At the beginning of the 21st century, some pioneer studies provided evidence of the existence of a site-specific human milk microbiota. Hygienically collected milk samples from healthy women contain a relatively low bacterial load, which consist mostly of Staphylococcus, Streptococcus, lactic acid bacteria, and other gram-positive bacteria (Corynebacterium, Propionibacterium, and ... Read more >>

Nestle Nutr Inst Workshop Ser (Nestle Nutrition Institute workshop series)
[2020, 94:1-11]

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Analyzing the genomic and transcriptomic architecture of milk traits in Murciano-Granadina goats.

Dailu Guan, Vincenzo Landi, María Gracia Luigi-Sierra, Juan Vicente Delgado, Xavier Such, Anna Castelló, Betlem Cabrera, Emilio Mármol-Sánchez, Javier Fernández-Alvarez, José Luis Ruiz de la Torre Casañas, Amparo Martínez, Jordi Jordana, Marcel Amills,

Background:In this study, we aimed to investigate the molecular basis of lactation as well as to identify the genetic factors that influence milk yield and composition in goats. To achieve these two goals, we have analyzed how the mRNA profile of the mammary gland changes in seven Murciano-Granadina goats at each ... Read more >>

J Anim Sci Biotechnol (Journal of animal science and biotechnology)
[2020, 11:35]

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