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Full Text Journal Articles about
Human Metapneumovirus

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Co-infection with SARS-CoV-2 and Human Metapneumovirus.

Francine Touzard-Romo, Chantal Tapé, John R Lonks,

The novel coronavirus (now called SARS-CoV-2) initially discovered in Wuhan, China, has now become a global pandemic. We describe a patient presenting to an Emergency Department in Rhode Island on March 12, 2020 with cough and shortness of breath after a trip to Jamaica. The patient underwent nasopharyngeal swab for ... Read more >>

R I Med J (2013) (Rhode Island medical journal (2013))
[2020, 103(2):75-76]

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Co-infection with SARS-CoV-2 and Human Metapneumovirus.

Francine Touzard-Romo, Chantal Tapé, John R Lonks,

The novel coronavirus (now called SARS-CoV-2) initially discovered in Wuhan, China, has now become a global pandemic. We describe a patient presenting to an Emergency Department in Rhode Island on March 12, 2020 with cough and shortness of breath after a trip to Jamaica. The patient underwent nasopharyngeal swab for ... Read more >>

R I Med J (2013) (Rhode Island medical journal (2013))
[2020, 103(3):48-49]

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Proteome Analysis in a Mammalian Cell line Reveals that PLK2 is Involved in Avian Metapneumovirus Type C (aMPV/C)-Induced Apoptosis.

Rong Quan, Li Wei, Lei Hou, Jing Wang, Shanshan Zhu, Zixuan Li, Moran Lv, Jue Liu,

Avian metapneumovirus subtype C (aMPV/C) causes an acute respiratory disease that has caused serious economic losses in the Chinese poultry industry. In the present study, we first explored the protein profile in aMPV/C-infected Vero cells using iTRAQ quantitative proteomics. A total of 921 of 7034 proteins were identified as significantly ... Read more >>

Viruses (Viruses)
[2020, 12(4):]

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Non-influenza respiratory viruses in adult patients admitted with influenza-like illness: a 3-year prospective multicenter study.

François Bénézit, Paul Loubet, Florence Galtier, Charlotte Pronier, Nezha Lenzi, Zineb Lesieur, Stéphane Jouneau, Gisèle Lagathu, Anne-Sophie L’Honneur, Vincent Foulongne, Christine Vallejo, Sophie Alain, Xavier Duval, Nawal Houhou, Yolande Costa, Philippe Vanhems, Sélilah Amour, Fabrice Carrat, Bruno Lina, Odile Launay, Pierre Tattevin,

PurposeTo describe the burden, and characteristics, of influenza-like illness (ILI) associated with non-influenza respiratory viruses (NIRV).MethodsWe performed a prospective, multicenter, observational study of adults admitted with ILI during three influenza seasons (2012–2015). Patients were screened for picornavirus, respiratory syncytial virus (RSV), coronavirus, human metapneumovirus, adenovirus, bocavirus, parainfluenza virus, and influenza, ... Read more >>

Infection (Infection)
[0, :1-7]

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Rapid viral diagnosis and ambulatory management of suspected COVID-19 cases presenting at the infectious diseases referral hospital in Marseille, France, - January 31st to March 1st, 2020: A respiratory virus snapshot.

Sophie Amrane, Hervé Tissot-Dupont, Barbara Doudier, Carole Eldin, Marie Hocquart, Morgane Mailhe, Pierre Dudouet, Etienne Ormières, Lucie Ailhaud, Philippe Parola, Jean-Christophe Lagier, Philippe Brouqui, Christine Zandotti, Laetitia Ninove, Léa Luciani, Céline Boschi, Bernard La Scola, Didier Raoult, Matthieu Million, Philippe Colson, Philippe Gautret,

BACKGROUND:Rapid virological diagnosis is needed to limit the length of isolation for suspected COVID-19 cases. METHOD:We managed the first 280 patients suspected to have COVID-19 through a rapid care circuit and virological diagnosis in our infectious disease reference hospital in Marseille, France. Rapid viral detection was performed on sputum and ... Read more >>

Travel Med Infect Dis (Travel medicine and infectious disease)
[2020, :101632]

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Engineering of Live Chimeric Vaccines against Human Metapneumovirus.

Daniela Ogonczyk Makowska, Marie-Ève Hamelin, Guy Boivin,

Human metapneumovirus (HMPV) is an important human pathogen that, along with respiratory syncytial virus (RSV), is a major cause of respiratory tract infections in young infants. Development of an effective vaccine against Pneumoviruses has proven to be particularly difficult; despite over 50 years of research in this field, no vaccine ... Read more >>

Pathogens (Pathogens (Basel, Switzerland))
[2020, 9(2):]

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High resolution metagenomic characterization of complex infectomes in paediatric acute respiratory infection.

Ci-Xiu Li, Wei Li, Jun Zhou, Bing Zhang, Yan Feng, Chang-Ping Xu, Yi-Yu Lu, Edward C Holmes, Mang Shi,

The diversity of pathogens associated with acute respiratory infection (ARI) makes diagnosis challenging. Traditional pathogen screening tests have a limited detection range and provide little additional information. We used total RNA sequencing ("meta-transcriptomics") to reveal the full spectrum of microbes associated with paediatric ARI. Throat swabs were collected from 48 ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):3963]

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Prevalence of Human Metapneumovirus Infections in Iran: A Systematic Review and Meta-Analysis.

Somayeh Shatizadeh Malekshahi, Jila Yavarian, Nazanin-Zahra Shafiei-Jandaghi, Talat Mokhtari-Azad, Mohammad Farahmand,

Background: We sought to systematically review the literature and perform a meta-analysis by assessing the prevalence of human metapneumovirus (hMPV) infections from a number of studies conducted in Iran. Methods: Entire studies addressing epidemiology of hMPV in Iran using data from PubMed, Scopus, Science Direct, Web of science, Google Scholar, ... Read more >>

Fetal Pediatr Pathol (Fetal and pediatric pathology)
[2020, :1-11]

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Respiratory syncytial virus and human metapneumovirus after allogeneic hematopoietic stem cell transplantation: impact of the immunodeficiency scoring index, viral load, and ribavirin treatment on the outcomes.

Mobil Akhmedov, Verena Wais, Elisa Sala, Adela Neagoie, Thanh Mai Nguyen, Andrea Gantner, Stephanie von Harsdorf, Florian Kuchenbauer, Axel Schubert, Detlef Michel, Hartmut Döhner, Donald Bunjes,

INTRODUCTION:Respiratory viral infections are a major cause of morbidity and mortality among stem cell transplant recipients. While there is a substantial amount of information on prognostic factors and response ribavirin therapy is available for RSV infections this information is largely lacking for hMPV. PATIENTS AND METHODS:In total 71 patients were ... Read more >>

Transpl Infect Dis (Transplant infectious disease : an official journal of the Transplantation Society)
[2020, :e13276]

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Nanopore metagenomic sequencing to investigate nosocomial transmission of human metapneumovirus from a unique genetic group among haematology patients in the United Kingdom.

Yifei Xu, Kuiama Lewandowski, Katie Jeffery, Louise O Downs, Dona Foster, Nicholas D Sanderson, James Kavanagh, Ali Vaughan, Claudia Salvagno, Richard Vipond, Miles Carroll, Robert Danby, Timothy Peto, Derrick Crook, A Sarah Walker, Philippa C Matthews, Steven T Pullan,

BACKGROUND:Human metapneumovirus (HMPV) infection causes a spectrum of respiratory tract disease, and may be a significant pathogen in the context of immunocompromise. Here, we report direct-from-sample metagenomic sequencing of HMPV using Oxford Nanopore Technology. METHODS:We applied this sequencing approach to 25 respiratory samples that had been submitted to a clinical ... Read more >>

J. Infect. (The Journal of infection)
[2020, :]

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The role of M2-2 PDZ-binding motifs in pulmonary innate immune responses to human metapneumovirus.

Eun-Jin Choi, Wenzhe Wu, Yu Chen, Weiyu Yan, Liqing Li, Atanu Choudhury, Xiaoyong Bao,

Human metapneumovirus (HMPV) is a leading cause of lower respiratory tract infection (LRTI) in pediatric and geriatric populations. We recently found that two PDZ-binding motifs of the M2-2 protein, 29-DEMI-32 and 39-KEALSDGI-46, play a significant role in mediating HMPV immune evasion in airway epithelial cells (AECs). However, their role in ... Read more >>

J. Med. Virol. (Journal of medical virology)
[2020, :]

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Human Metapneumovirus: A Largely Unrecognized Threat to Human Health.

Charles J Russell, Rhiannon R Penkert, Sonnie Kim, Julia L Hurwitz,

Human metapneumovirus (HMPV) infects most children by five years of age. The virus can cause both upper and lower respiratory tract disease and can be life threatening. High-risk populations include young children who are exposed to virus for the first time and the elderly. Currently, there is no standard treatment ... Read more >>

Pathogens (Pathogens (Basel, Switzerland))
[2020, 9(2):]

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Human Metapneumovirus Infection in Hospitalized Children.

Nicholas F Holzemer, Jennifer J Hasvold, Kyle J Pohl, Matthew J Ashbrook, Kathleen L Meert, Michael W Quasney,

BACKGROUND:Most children are exposed to human metapneumovirus (HMPV) by the age of 5 y. This study aimed to describe the morbidity associated with HMPV infections in a cohort of children in the Midwest of the United States. METHODS:This was a retrospective 2-center cohort study including children (0-17 y old) hospitalized ... Read more >>

Respir Care (Respiratory care)
[2020, :]

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Viral Etiology of Acute Lower Respiratory Tract Infections in Hospitalized Children in Nagasaki, a Regional City of Japan in 2013-2015.

Tomoyuki Hasuwa, Fumiko Kinoshita, Sadatomo Harada, Kazuhisa Nakashima, Keisuke Yoshihara, Yuichirou Toku, Hiroyuki Moriuchi, Lay Myint Yoshida,

BACKGROUND:Acute lower respiratory tract infections (ALRIs) are the most common disease for hospitalized children in Japan. The aim of this study was to identify viruses in children hospitalized for ALRIs and to demonstrate epidemiologic and clinical characteristics in Japan. METHODS:During a 2-year period from February 2013 to January 2015, we ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2020, :]

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Etiology of Pulmonary Infections in Human Immunodeficiency Virus-infected Inpatients Using Sputum Multiplex Real-time Polymerase Chain Reaction.

Gary Maartens, Rulan Griesel, Felix Dube, Mark Nicol, Marc Mendelson,

BACKGROUND:There are limited data on the etiology of respiratory infections in human immunodeficiency virus (HIV)-infected patients in resource-limited settings. METHODS:We performed quantitative multiplex real-time polymerase chain reaction (PCR) for Pneumocystis jirovecii and common bacterial and viral respiratory pathogens on sputum samples (spontaneous or induced) from a prospective cohort study of ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(6):1147-1152]

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Clinical Features of Human Metapneumovirus-Associated Community-Acquired Pneumonia Hospitalizations.

Leigh M Howard, Kathryn M Edwards, Yuwei Zhu, Carlos G Grijalva, Wesley H Self, Seema Jain, Krow Ampofo, Andrew T Pavia, Sandra R Arnold, Jonathan A McCullers, Evan J Anderson, Richard G Wunderink, Derek J Williams,

BACKGROUND:Human metapneumovirus (HMPV) is a leading cause of respiratory tract infections. Few studies have compared the clinical characteristics and severity of HMPV-associated pneumonia with other pathogens. METHODS:Active population-based surveillance was previously conducted for radiographically-confirmed community-acquired pneumonia hospitalizations among children and adults in eight United States hospitals. Clinical data and specimens ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Respiratory viruses in mechanically ventilated patients: a pilot study.

Raquel Nazareth, Maria-Jesus Chasqueira, Maria-Lúcia Rodrigues, Carolina Paulino, Catarina Conceição, Lia Lêdo, Úrsula Segura, Madalena Santos, António Messias, Pedro Póvoa, Paulo Paixão,

BACKGROUND:Respiratory virome is an integral part of the human microbiome and its characterization may contribute to a better understanding of the changes that arise in the disease and, consequently, influence the approach and treatment of patients with acute lower respiratory infections. The aim of this study was to evaluate the ... Read more >>

BMC Pulm Med (BMC Pulmonary Medicine)
[2020, 20(1):39]

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Human Metapneumovirus: Etiological Agent of Severe Acute Respiratory Infections in Hospitalized and Deceased Patients with a Negative Diagnosis of Influenza.

Gisela Barrera-Badillo, Beatriz Olivares-Flores, Adriana Ruiz-López, Miguel Ángel Fierro-Valdez, Rosaura Idania Gutiérrez-Vargas, Irma López-Martínez,

Human metapneumovirus (HMPV) is one of the four major viral pathogens associated with acute respiratory tract infections (ARI) and creates a substantial burden of disease, particularly in young children (<5 years) and older individuals (≥65 years). The objective of this study was to determine the epidemiological behavior of HMPV in ... Read more >>

Pathogens (Pathogens (Basel, Switzerland))
[2020, 9(2):]

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Inhibition of PI3Kδ Enhances Poly I:C-Induced Antiviral Responses and Inhibits Replication of Human Metapneumovirus in Murine Lungs and Human Bronchial Epithelial Cells.

Akitaka Fujita, Keiko Kan-O, Ken Tonai, Norio Yamamoto, Tomohiro Ogawa, Satoru Fukuyama, Yoichi Nakanishi, Koichiro Matsumoto,

Viral infections of the airway can exacerbate respiratory diseases, such as asthma or chronic obstructive pulmonary disease (COPD), and accelerate disease progression. Phosphoinositide 3-kinase (PI3K)δ, a class 1A PI3K, has been studied as a potential target for achieving anti-oncogenic and anti-inflammatory effects. However, the role of PI3Kδ in antiviral responses ... Read more >>

Front Immunol (Frontiers in Immunology)
[2020, 11:432]

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Comparison of the AllplexTM Respiratory Panel Assays and the automated Fast Track Diagnostics Respiratory pathogens 21 assay for the diagnosis of pediatric respiratory viral infections.

C. Concato, Livia Piccioni, S. Ranno, F. Antonelli, A. Buonomini, L. Coltella, G. Pizzichemi, S. Chiavelli, E. Riva,

Acute respiratory tract infections frequently occur in children and represent one of the leading causes of morbidity and mortality worldwide. Quick and accurate pathogen detection can lead to a more appropriate use of antimicrobial treatment as well as timely implementation of isolation precautions. In the last decade, several commercial assays ... Read more >>

Arch. Virol. (Archives of virology)
[0, :1-6]

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Evaluation of pre- and post-fusion Human metapneumovirus F proteins as subunit vaccine candidates in mice.

Martin Pilaev, Yao Shen, Julie Carbonneau, Marie-Christine Venable, Chantal Rhéaume, Sophie Lavigne, Christian Couture, Alba Guarné, Marie-Ève Hamelin, Guy Boivin,

Human metapneumovirus (hMPV) is an important respiratory pathogen especially in young children and elderly subjects. Our objective was to assess the immunogenicity and protection conferred by predominant pre- and post-fusion (F) hMPV-F constructs in Balb/C mice. Immunizations without adjuvant were not immunogenic whereas alum-adjuvanted hMPV-F proteins, regardless of their conformations, ... Read more >>

Vaccine (Vaccine)
[2020, 38(9):2122-2127]

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Role for maternal asthma in severe human metapneumovirus lung disease susceptibility in children.

Romina Libster, Ignacio Esteban, Alejandra Bianchi, Luciano Alva Grimaldi, Karina Dueñas, Andrea Sancillo, Andrea Rodriguez, Fernando Ferrero, Katherine Stein, Patricio L Acosta, Fausto M Ferolla, Eduardo Bergel, Mauricio T Caballero, Fernando P Polack, ,

BACKGROUND:Severity of human metapneumovirus (hMPV) lower respiratory illness (LRTI) is considered similar to that observed for respiratory syncytial virus (RSV). However, differences in severity between both pathogens have been noted, suggesting degree of illness may vary in different populations. Moreover, a potential association between hMPV and asthma also suggests that ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2020, :]

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Molecular Diagnosis of Pneumonia Using Multiplex Real-Time PCR Assay RespiFinder® SMART 22 FAST in a Group of Moroccan Infants.

Kenza Hattoufi, Houssain Tligui, Majdouline Obtel, Sobha El Ftouh, Aicha Kharbach, Amina Barkat,

Background:In Morocco, pediatric pneumonia remains a serious public health problem, as it constitutes the first cause of mortality due to infectious diseases. The etiological diagnosis of acute respiratory tract infections is difficult. Therefore, it is necessary to use Multiplex real-time polymerase chain reaction assay tests in a routine setting for ... Read more >>

Adv Virol (Advances in virology)
[2020, 2020:6212643]

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Multicenter evaluation of the QIAstat Respiratory Panel-A new rapid highly multiplexed PCR based assay for diagnosis of acute respiratory tract infections.

Marijo Parčina, Uffe Vest Schneider, Benoit Visseaux, Robert Jozić, Irene Hannet, Jan Gorm Lisby,

Acute respiratory tract infections (ARTI), including the common cold, pharyngitis, sinusitis, otitis media, bronchiolitis and pneumonia are the most common diagnoses among patients seeking medical care in western countries, and account for most antibiotic prescriptions. While a confirmed and fast ARTI diagnosis is key for antibiotic prescribing, empiric antimicrobial treatment ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0230183]

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Comparative Seasonal Respiratory Virus Epidemic Timing in Utah.

Zayne Y Callahan, Trevor K Smith, Celeste Ingersoll, Rebecca Gardner, E Kent Korgenski, Chantel D Sloan,

Previous studies have found evidence of viral interference between seasonal respiratory viruses. Using laboratory-confirmed data from a Utah-based healthcare provider, Intermountain Health Care, we analyzed the time-specific patterns of respiratory syncytial virus (RSV), influenza A, influenza B, human metapneumovirus, rhinovirus, and enterovirus circulation from 2004 to 2018, using descriptive methods ... Read more >>

Viruses (Viruses)
[2020, 12(3):]

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