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Full Text Journal Articles about
High Altitude Pulmonary Edema

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Effect of mindfulness meditation protocol in subjects with various psychometric characteristics at high altitude.

Disha Bhanushali, Rahul Tyagi, Nitin Limaye Rishi Nityapragya, Akshay Anand,

INTRODUCTION:Incidence of high altitude-related sickness is increasing due to more number of people visiting the areas of high altitude which may result in life-threatening conditions including acute mountain sickness (AMS), high altitude pulmonary edema (HAPE), high altitude cerebral edema (HACE), and High-altitude pulmonary hypertension (HAPH). We hypothesized that an advanced ... Read more >>

Brain Behav (Brain and behavior)
[2020, :e01604]

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Early Hours in the Development of High Altitude Pulmonary Edema- Time Course and Mechanisms.

Erik Swenson,

Clinically evident high altitude pulmonary edema (HAPE) is one of severe cyanosis, dyspnea and edema. This usually occurs within 1-2 days of ascent often with additional stresses of exercise and sleep-related hypoventilation. The earliest events in HAPE occur rapidly and progress through clinically silent and then minimally recognized problems. The ... Read more >>

J. Appl. Physiol. (Journal of applied physiology (Bethesda, Md. : 1985))
[2020, :]

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Acetazolamide, Nifedipine and Phosphodiesterase Inhibitors: Rationale for Their Utilization as Adjunctive Countermeasures in the Treatment of Coronavirus Disease 2019 (COVID-19).

Isaac Solaimanzadeh,

Effective treatments for Coronavirus Disease 2019 (COVID-19) outbreak are urgently needed. While anti-viral approaches and vaccines are being considered immediate countermeasures are unavailable. The aim of this article is to outline a perspective on the pathophysiology of COVID-19 in the context of the currently available clinical data published in the literature. This article ... Read more >>

Cureus (Cureus)
[2020, 12(3):]

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Uncommon causes of noncardiogenic pulmonary edema.

Lynn Coletta Simko, Alicia L Culleiton,

Although acute respiratory distress syndrome is the most common cause of noncardiogenic pulmonary edema, NPs also should be familiar with several other less common causes, including transfusion-related acute lung injury, neurogenic pulmonary edema, preeclampsia/eclampsia, opioid overdose, high-altitude pulmonary edema, and pulmonary embolism. This article addresses the pathophysiology, clinical presentation, diagnostics, ... Read more >>

Nurse Pract (The Nurse practitioner)
[2020, 45(4):26-32]

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EDN1 gene potentially involved in the development of acute mountain sickness.

Jie Yu, Chuan Liu, Chen Zhang, ShiZhu Bian, Jie Yang, JiHang Zhang, XuBin Gao, YouZhu Qiu, Lan Huang,

Previous investigations have indicated that environmental and genetic factors collectively contribute to the development of acute mountain sickness (AMS), but whether the EDN1 gene is involved in AMS remains to be elucidated. A total of 356 healthy male soldiers who had not traveled to high altitudes in the previous 12 ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5414]

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Acetazolamide, Nifedipine and Phosphodiesterase Inhibitors: Rationale for Their Utilization as Adjunctive Countermeasures in the Treatment of Coronavirus Disease 2019 (COVID-19).

Isaac Solaimanzadeh,

Effective treatments for Coronavirus Disease 2019 (COVID-19) outbreak are urgently needed. While anti-viral approaches and vaccines are being considered immediate countermeasures are unavailable. The aim of this article is to outline a perspective on the pathophysiology of COVID-19 in the context of the currently available clinical data published in the literature. This article ... Read more >>

Cureus (Cureus)
[2020, 12(3):e7343]

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Downregulation of lung miR-203a-3p expression by high-altitude hypoxia enhances VEGF/Notch signaling.

Wei Cai, Sanli Liu, Ziquan Liu, Shike Hou, Qi Lv, Huanhuan Cui, Xue Wang, Yuxin Zhang, Haojun Fan, Hui Ding,

Hypoxia-related microRNAs (miRNAs) are involved in the pathogenesis of various diseases. Because potential variations in miRNA expression mediated by hypoxic lung injury at high altitude remain incompletely characterized, we used a rat model to investigate the biochemical and miRNA changes induced by high-altitude hypoxia. After 24, 48, or 72 h ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(5):4247-4267]

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Rapid Ascent to 4559 m Is Associated with Increased Plasma Components of the Vascular Endothelial Glycocalyx and May Be Associated with Acute Mountain Sickness.

Kai Erik Swenson, Marc Moritz Berger, Mahdi Sareban, Franziska Macholz, Peter Schmidt, Lisa Maria Schiefer, Heimo Mairbäurl, Erik Richard Swenson,

Swenson, Kai Erik, Marc Moritz Berger, Mahdi Sareban, Franziska Macholz, Peter Schmidt, Lisa Maria Schiefer, Heimo Mairbäurl, and Erik Richard Swenson. Rapid ascent to 4559 m is associated with increased plasma components of the vascular endothelial glycocalyx and may be associated with acute mountain sickness. High Alt Med Biol 00:000-000, 2020. ... Read more >>

High Alt. Med. Biol. (High altitude medicine & biology)
[2020, :]

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Transient Cerebral Ischemia at High Altitude and Hyper-Responsiveness to Hypoxia.

Jean-Paul Richalet, Philippe Larmignat, Patricia Poignard,

A 36-year-old woman with no medical history participated in a trekking in Ladakh up to 5300 m of altitude. She was well acclimatized and presented no previous sign of acute mountain sickness, high altitude pulmonary edema or high altitude cerebral edema. After an intense effort to catch up with her group, ... Read more >>

High Alt. Med. Biol. (High altitude medicine & biology)
[2020, 21(1):105-108]

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Genetic Predisposition to High-Altitude Pulmonary Edema.

Christina A Eichstaedt, Heimo Mairbäurl, Jie Song, Nicola Benjamin, Christine Fischer, Christoph Dehnert, Kai Schommer, Marc M Berger, Peter Bärtsch, Ekkehard Grünig, Katrin Hinderhofer,

Background: Exaggerated pulmonary arterial hypertension (PAH) is a hallmark of high-altitude pulmonary edema (HAPE). The objective of this study was therefore to investigate genetic predisposition to HAPE by analyzing PAH candidate genes in a HAPE-susceptible (HAPE-S) family and in unrelated HAPE-S mountaineers. Materials and Methods: Eight family members and 64 ... Read more >>

High Alt. Med. Biol. (High altitude medicine & biology)
[2020, 21(1):28-36]

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Adaptation to Hypoxia: A Chimera?

Michele Samaja, Giuseppina Milano,

"The Chimera was, according to Greek mythology, a monstrous fire-breathing hybrid creature of Lycia in Asia Minor, composed of the parts of more than one animal [...]. ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(4):]

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Structural and functional alterations of nitric oxide synthase 3 due to missense variants associate with high-altitude pulmonary edema through dynamic study.

Hema Kanipakam, Kavita Sharma, Tashi Thinlas, Ghulam Mohammad, M A Qadar Pasha,

The human endothelial nitric oxide synthase (NOS3) is 28 Kbp at 7q36.1 and encodes protein comprising of 1280 amino acids. Being a major source of nitric oxide, the enzyme is crucial to the vascular homeostasis and thereby to be an important pharmaceutical target. We hence have been investigating this molecule ... Read more >>

J. Biomol. Struct. Dyn. (Journal of biomolecular structure & dynamics)
[2020, :1-16]

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High-Altitude Decompression Sickness Treated with Hyperbaric Therapy and Extracorporeal Oxygenation.

Jacek Siewiera, Przemysław Szałański, Dariusz Tomaszewski, Jacek Kot,

BACKGROUND: High-altitude decompression sickness (HADCS) is a rare condition that has been associated with aircraft accidents. To the best of our knowledge, the present paper is the first case report of a patient treated for severe HADCS using recompression therapy and veno-venous extracorporeal oxygenation (VV-ECMO) with a complete recovery.CASE REPORT: ... Read more >>

Aerosp Med Hum Perform (Aerospace medicine and human performance)
[2020, 91(2):106-109]

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Distinct role of the CYP4F2 polymorphisms in determining the risk of HAPE among Chinese Han population

Lining Si, Yanli Zhao, Haiyuan Wang, Guifen Gan, Rong Wang, Qifu Long, Derui Zhu, Guoping Shen,

<title>Abstract</title> <p> <bold>Background: </bold><italic>CYP4F2</italic> is potentially associated with High altitude pulmonary edema (HAPE) risk by regulating inflammatory mediator leukotriene B4 and arachidonic acid. However, the role of <italic>CYP4F2</italic> in HAPE susceptibility remains unknown. For the first time, we conducted a case-control study to assess the potential association of ... Read more >>

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Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population.

Yang Shen, Jihang Zhang, Jie Yang, Chuan Liu, Shizhu Bian, Chen Zhang, Jie Yu, Xubin Gao, Lan Huang,

Background:High-altitude headache (HAH) is the most common complication after high-altitude exposure. Hypoxia-inducible factor- (HIF-) related genes have been confirmed to contribute to high-altitude acclimatization. We aim to investigate a possible association between HIF-related genes and HAH in the Chinese Han population. Methods:In total, 580 healthy Chinese Han volunteers were recruited ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:1593068]

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Angiotensin-converting enzyme gene insertion/deletion polymorphism and high-altitude pulmonary edema: An updated meta-analysis.

Yan Zheng, Jin Huang,

OBJECTIVE:The purpose of the study was to investigate the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and high-altitude pulmonary edema. METHODS:A systematic search for relevant literature was performed in MEDLINE, CNKI, and EMBASE. The pooled odds ratios and their corresponding 95% confidence intervals were calculated in STATA 12.0 software. RESULTS:Seven ... Read more >>

J Renin Angiotensin Aldosterone Syst (Journal of the renin-angiotensin-aldosterone system : JRAAS)
[2020, 21(1):1470320319900039]

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[A case from the alpine medicine].

S Stuppner, A Ruiu, E Stirpe, L Bonazza,

Radiologe (Der Radiologe)
[2020, 60(3):269-272]

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Susceptibility to high-altitude pulmonary edema is associated with increased pulmonary arterial stiffness during exercise.

A Mulchrone, H Moulton, M W Eldridge, N C Chesler,

High-altitude pulmonary edema (HAPE), a reversible form of capillary leak, is a common consequence of rapid ascension to high altitude and a major cause of death related to high-altitude exposure. Individuals with a prior history of HAPE are more susceptible to future episodes, but the underlying risk factors remain uncertain. ... Read more >>

J. Appl. Physiol. (Journal of applied physiology (Bethesda, Md. : 1985))
[2020, 128(3):514-522]

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Sleeping with Elevated Upper Body Does Not Attenuate Acute Mountain Sickness: Pragmatic Randomized Clinical Trial.

Ulrich Limper, Vera Fiala, Jens Tank, Eva-Maria Elmenhorst, Gereon Schaelte, Ya-Yu Monica Hew, Peter Gauger, Peter Martus, Jens Jordan,

PURPOSE:Acute mountain sickness commonly occurs following ascent to high altitude and is aggravated following sleep. Cephalad fluid shifts have been implicated. We hypothesized that sleeping with the upper body elevated by 30º reduces the risk of acute mountain sickness. METHODS:In a pragmatic, randomized, observer-blinded field study at 4554 meters altitude, ... Read more >>

Am. J. Med. (The American journal of medicine)
[2020, :]

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A Dramatic Presentation of Pulmonary Edema Due to Renal Failure.

Natalie Farha, Cyrus Munguti,

Kans J Med (Kansas Journal of Medicine)
[2020, 13:56-57]

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Iron and Sphingolipids as Common Players of (Mal)Adaptation to Hypoxia in Pulmonary Diseases.

Sara Ottolenghi, Aida Zulueta, Anna Caretti,

Hypoxia, or lack of oxygen, can occur in both physiological (high altitude) and pathological conditions (respiratory diseases). In this narrative review, we introduce high altitude pulmonary edema (HAPE), acute respiratory distress syndrome (ARDS), Chronic Obstructive Pulmonary Disease (COPD), and Cystic Fibrosis (CF) as examples of maladaptation to hypoxia, and highlight ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(1):]

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Primer for Mainstreaming Mind-Body Techniques for Extreme Climates-Insights and Future Directions.

Akshay Anand, Gurkeerat Kaur, Sridhar Bammidi, Deepali Mathur, Priya Battu, Kanupriya Sharma, Rahul Tyagi, Viraaj Pannu, Disha Bhanushali, Nitin Limaye,

Background: The deprivation of oxygen reaching the tissues (also termed as hypoxia) affects the normal functioning of the body. This results in development of many diseases like ischemia, glaucoma, MCI (Mild Cognitive Impairment), pulmonary and cerebral edema, stress and depression. There are no effective drugs that can treat such diseases. ... Read more >>

Medicines (Basel) (Medicines (Basel, Switzerland))
[2020, 7(3):]

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Serious Altitude Illness at the South Pole.

John S Rose, Jennifer Law, Richard Scheuring, Matthew H Ramage, James J McKeith,

BACKGROUND: Gradual ascent is impractical for personnel deploying to the South Pole due to logistical challenges. Prevention of altitude illness relies on prophylactic medications such as acetazolamide and behavioral modifications including hydration and avoidance of overexertion. We present three recent cases of altitude illness that occurred in previously healthy individuals ... Read more >>

Aerosp Med Hum Perform (Aerospace medicine and human performance)
[2020, 91(1):46-50]

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Long Non-coding RNA LINC-PINT and LINC00599 Polymorphisms are Associated With High-altitude Pulmonary Edema in Chinese.

Xue He, Jianwen Zheng, Yongjun He, Yuhe Wang, Li Wang, Mei Bai, Tianbo Jin, Dongya Yuan,

BACKGROUND:High-altitude pulmonary edema (HAPE) is a kind of non-cardiogenic edema with high incidence and life-threatening. This study was designed to explore the association of LINC-PINT and LINC00599 polymorphisms with HAPE susceptibility. METHODS:This study included 244 HAPE patients and 243 age-, sex-matched healthy controls from the Chinese population. The genotypes of ... Read more >>

Arch. Bronconeumol. (Archivos de bronconeumologia)
[2019, :]

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[High altitude illness and related diseases - a review].

Tomas Gudbjartsson, Engilbert Sigurdsson, Magnus Gottfredsson, Olafur Mar Bjornsson, Gunnar Gudmundsson,

Upon reaching a height over 2500 m above seal level symptoms of altitude illness can develop over 1 - 5 days. The risk is mainly -determined by the altitude and rate of ascent and the symptoms vary. Most common are symptoms of acute mountain illness (AMS) but more dangerous high ... Read more >>

Laeknabladid (Laeknabladid)
[2019, 105(11):499-507]

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