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Hemolytic Disease of Newborn

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A qualitative examination of barriers against effective medical education and practices related to breastfeeding promotion and support in Lebanon.

Sara Moukarzel, Christoforos Mamas, Antoine Farhat, Antoine Abi Abboud, Alan J Daly,

Background: Insufficient breastfeeding promotion and support by physicians contribute to suboptimal breastfeeding rates globally. Understanding setting-specific barriers against breastfeeding promotion and support from the perspective of medical students and addressing those that can be modified through undergraduate medical education may help improve learning outcomes, medical practice, and ultimately health outcomes ... Read more >>

Med Educ Online (Medical education online)
[2020, 25(1):1723950]

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Management strategies of neonatal jaundice during the coronavirus disease 2019 outbreak.

Xiao-Lu Ma, Zheng Chen, Jia-Jun Zhu, Xiao-Xia Shen, Ming-Yuan Wu, Li-Ping Shi, Li-Zhong Du, Jun-Fen Fu, Qiang Shu,

The outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV) has become a most challenging health emergency. Owing to rigorous quarantine and control measures taken in China, routine neonatal health surveillance and follow-up have become challenging. Without follow-up surveillance, some rapid and progressive newborn diseases, such as bilirubin encephalopathy, may be ... Read more >>

World J Pediatr (World Journal of Pediatrics)
[0, :1-4]

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Effect of skin-to-skin contact at birth on early neonatal hospitalization.

Sergio Agudelo, Diana Díaz, María José Maldonado, Eduardo Acuña, Daniel Mainero, Oman Pérez, Laura Pérez, Carlos Molina,

BACKGROUND:Skin-to-skin contact (SCC) at birth has a positive impact on breastfeeding indicators and physiological stabilization at birth. On the other hand, globally and in Colombia, morbidity and mortality have increased in intermediate- and low-risk infants. The aim of the study was to assess the effect of immediate skin-to-skin contact, compared ... Read more >>

Early Hum. Dev. (Early human development)
[2020, 144:105020]

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Prevalence of and mothers' knowledge, attitude and practice towards glucose-6-phosphate dehydrogenase deficiency among neonates with jaundice: a cross-sectional study.

Zeinab A Kasemy, Wael A Bahbah, Sally M El Hefnawy, Safa H Alkalash,

BACKGROUND:Neonatal jaundice (NNJ) is a frequent complication of glucose-6-phosphate dehydrogenase (G6PD) deficiency. OBJECTIVES:To estimate the prevalence of G6PD deficiency among neonates with jaundice and to assess mothers' perception towards G6PD and NNJ. METHODS:A cross-sectional study was carried out on 487 ethnic Egyptian neonates with indirect hyperbilirubinaemia from June 2018 to ... Read more >>

BMJ Open (BMJ open)
[2020, 10(2):e034079]

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Clinical value of different anti-D immunoglobulin strategies for preventing Rh hemolytic disease of the fetus and newborn: A network meta-analysis.

Xiaohui Xie, Qiurong Fu, Ziwei Bao, Yi Zhang, Dan Zhou,

BACKGROUND:Several anti-D immunoglobulin strategies exist for preventing Rh hemolytic disease of the fetus and newborn. This study systematically assessed the clinical value of those therapeutic strategies. METHODS:The Web of Science, PubMed, EMBASE, China National Knowledge Infrastructure (CNKI) and Wanfang databases were searched for eligible studies that evaluated the value of ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0230073]

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An Overview of Tickborne Infections in Pregnancy and Outcomes in the Newborn: The Need for Prospective Studies.

John S Lambert,

Tick-borne infections are an ever-increasing issue internationally, many factors contribute to this including a changing climate. Pregnant women represent the single largest vulnerable group in populations due to a relative immune deficiency status. Infections in pregnant women have the added gravity of potential infection in the developing fetus which may ... Read more >>

Front Med (Lausanne) (Frontiers in Medicine)
[2020, 7:72]

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Suppression of compensatory erythropoiesis in hemolytic disease of the fetus and newborn due to intrauterine transfusions.

Isabelle M C Ree, Enrico Lopriore, Carolien Zwiers, Stefan Böhringer, Marleen W M Janssen, Dick Oepkes, Masja De Haas,

BACKGROUND:Infants with severe hemolytic disease of the fetus and newborn often require 1 or multiple intrauterine transfusions to treat fetal anemia. Intrauterine transfusions may have an inhibiting effect on fetal and neonatal erythropoiesis. OBJECTIVE:To quantify the effect of 1 or multiple intrauterine transfusions on the fetal erythropoiesis by assessing the ... Read more >>

Am. J. Obstet. Gynecol. (American journal of obstetrics and gynecology)
[2020, :]

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Minor blood group incompatibility due to blood groups other than Rh(D) leading to hemolytic disease of fetus and newborn: a need for routine antibody screening during pregnancy.

Anika Agrawal, Karamalla Saddam Hussain, Ajay Kumar,

Minor blood group incompatibility due to blood groups other than Rh(D), although an uncommon cause of neonatal hyperbilirubinemia, has the potential to cause severe hyperbilirubinemia and its sequelae in infants, if left undiagnosed and untreated. Here, we describe clinical presentation, diagnosis and treatment of three cases of minor blood group ... Read more >>

Intractable Rare Dis Res (Intractable & rare diseases research)
[2020, 9(1):43-47]

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Resolving Blocked Antigen Phenomenon in Hemolytic Disease of the Fetus and Newborn Due to Anti-K.

Mitchell Moosavi, Yao Ma, Janet Baez, Rebecca Jeffreys, Dawn C Ward, Alyssa Ziman, Andrea M McGonigle,

High-titer antibodies are a cause of false-negative reactions in red blood cell antigen phenotyping, an event referred to as blocked antigen phenomenon (BAP). In hemolytic disease of the fetus and newborn, BAP complicates laboratory workups as fetal phenotype is helpful in confirming the responsible antibody. Acid elution techniques, techniques using ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2020, :]

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Congenital Cytomegalovirus Infection Presenting with Hyperbilirubinemia and Splenomegaly in a Term Infant with Trisomy 21.

Kate Wilson, Lindsay Ellsworth, Megan H Pesch,

Congenital cytomegalovirus infection (cCMV) is very common, yet the presentation can be varied, making the diagnosis challenging. However, early diagnosis for treatment with medication in symptomatic cases within the first month of life is critical. Hyperbilirubinemia and splenomegaly are less common manifestations at birth and may be overlooked in the ... Read more >>

Case Rep Pediatr (Case reports in pediatrics)
[2020, 2020:2534629]

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Two novel mutations in ADAMTS13 in a Chinese boy with congenital thrombocytopenic purpura: a case report.

Ling Hou, Yue Du,

BACKGROUND:Mutations in the ADAMTS13 gene family have been reported to cause congenital thrombotic thrombocytopenic purpura (cTTP), a rare disease characterized by thrombocytopenia and hemolytic anemia. Nearly 150 causative mutations in ADAMTS13 have been identified; however, only a few of them were detected in Chinese patients. CASE PRESENTATION:A 5-year-old Chinese boy ... Read more >>

BMC Med. Genet. (BMC medical genetics)
[2020, 21(1):57]

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Etiology and therapeutic management of neonatal jaundice in Iran: a systematic review and meta-analysis.

Yadollah Zahed Pasha, Shaghayegh Alizadeh-Tabari, Ermia Zahed Pasha, Mohammad Zamani,

BACKGROUND:Jaundice is a life-threatening disorder in the neonates. In the present study, we aimed to assess systematically available evidence on causes and management of jaundice in Iranian newborn patients. METHODS:We searched the databases of PubMed, Web of Sciences, Scopus and Google Scholar for English articles published since inception until May ... Read more >>

World J Pediatr (World Journal of Pediatrics)
[2020, :]

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Management strategies of neonatal jaundice during the coronavirus disease 2019 outbreak.

Xiao-Lu Ma, Zheng Chen, Jia-Jun Zhu, Xiao-Xia Shen, Ming-Yuan Wu, Li-Ping Shi, Li-Zhong Du, Jun-Fen Fu, Qiang Shu,

The outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV) has become a most challenging health emergency. Owing to rigorous quarantine and control measures taken in China, routine neonatal health surveillance and follow-up have become challenging. Without follow-up surveillance, some rapid and progressive newborn diseases, such as bilirubin encephalopathy, may be ... Read more >>

World J Pediatr (World Journal of Pediatrics)
[2020, :]

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Artificial intelligence in pediatrics.

Ya-Wen Li, Fang Liu, Tian-Nan Zhang, Fang Xu, Yu-Chen Gao, Tian Wu,

Chin. Med. J. (Chinese medical journal)
[2020, 133(3):358-360]

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Rhesus Isoimmunization: Late-onset Hemolytic Disease of the Newborn Without Jaundice.

Maryam Haider, Snober Memon, Fizza Tariq, Sara Fatima, Ammara Hameed,

Rhesus (Rh) isoimmunization commonly presents with anemia and jaundice of varying intensity in the early postnatal period and is usually treated with phototherapy and exchange transfusion. Rarely, babies with mild or no symptoms at birth may present later with severe hemolytic anemia. This report describes a newborn infant with no ... Read more >>

Cureus (Cureus)
[2020, 12(1):e6559]

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Evaluation of the Diagnostic Accuracy of the CareStart™ Glucose-6-Phosphate Dehydrogenase Deficiency Rapid Diagnostic Test among Chinese Newborns.

Fengting Yu, Sufen Zhang, Binhuan Chen, Yuqiu Zhou, Chengjie Ma, Siyuan Yang, Yunxia Tang, Dan Huang, Xiaohui Xie, Qizhi Xiao, Linghang Wang,

Previous studies have shown that the CareStart™ G6PD Deficiency rapid diagnostic test has high diagnostic accuracy on G6PD deficiency in Africa and Thailand, but not in China. As there are regional differences of G6PD genotype distribution, we are attending to verify the effectiveness of the kit in Chinese population. The ... Read more >>

J. Trop. Pediatr. (Journal of tropical pediatrics)
[2020, :]

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Congenital nephrotic syndrome as a complication of whooping cough: a case report.

Ayah Kouli, Sana Sheikh Trab, Shahed Alshaghel, Mohamad Bassel Mouti, Hiba Hamdoun,

Bordetella organisms are responsible for whooping cough, which is an extremely contagious respiratory illness with substantial morbidity in infants. It is also considered one of the 10 predominant reasons for childhood decease globally, particularly before vaccination was available. Congenital nephrotic syndrome (CNS) presents within the first 3 months of life. It ... Read more >>

Oxf Med Case Reports (Oxford medical case reports)
[2020, 2020(2):omaa007]

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[Consensus on hyperbilirubinemia of the first trimester of life].

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Neonatal jaundice may be due to different causes, ranging from physiological conditions to severe diseases. In term neonates with persistent jaundice beyond 14 days of life, it should be determined whether hyperbilirubinemia is unconjugated or conjugated, in order to study the etiology and start early treatment. In the majority of ... Read more >>

Arch Argent Pediatr (Archivos argentinos de pediatria)
[2020, 118(1):S12-S49]

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Uncommon clinical presentation of cystic fibrosis in a patient homozygous for a rare CFTR mutation: a case report.

Joanna Jaworska, Aleksandra Marach-Mocarska, Dorota Sands,

BACKGROUND:Cystic fibrosis (CF) is the most common, life-threatening, autosomal-recessive disorder among Caucasians. To date, approximately 2000 mutations in the CFTR gene have been reported. Some of these mutations are very rare, and some represent individual sequence changes in the gene. The introduction of newborn screening (NBS) in high prevalence countries ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):90]

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Addressing the Challenges to Diagnose Neonatal Hemolytic Anemia's Aetiologies in Low Ressources Countries: A Case Report.

Lydie Ocini Ngolet, Josue Simo Louokdom, Nelly Guembo, Ocko Ngokaba Thibault,

Background. The diagnosis of neonatal hemolysis is an easy exercise. However, the diagnosis of its etiology can be very challenging especially in low ressources countries where laboratory capacities are limited. We report the case of hemolytic anemia episodes that started in the neonatal period, for which the trigger factor, infectious ... Read more >>

Case Rep Hematol (Case reports in hematology)
[2020, 2020:3247127]

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Preventive Effect of Bifidobacterium Supplementation on Neonatal Cholestasis in Preterm Neonates with Very Low Birth Weight.

Gaohong Wu, Xiaoqian Chen, Ningxun Cui, Yunxia He, Jiaying Fan, Dongya Yan, Xueping Zhu, Xiaoli Zhu,

Background:Cholestasis is a common but serious clinical condition in preterm neonates. The current management for preterm neonatal cholestasis has limitations. The aim of this study was to determine effects of Bifidobacterium supplementation on the prevention and alleviation of cholestasis in preterm infants with very low birth weight. Methods:Preterm neonates with ... Read more >>

Gastroenterol Res Pract (Gastroenterology Research and Practice)
[2020, 2020:4625315]

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[Predictive factors for poor prognosis of neonates with early-onset sepsis].

Jie Chen, Jia-Lin Yu,

OBJECTIVE:To study the predictive factors for poor prognosis of neonates with early-onset sepsis (EOS). METHODS:The clinical data of 371 neonates with EOS were collected. According to prognosis, they were divided into a good prognosis group with 264 neonates and a poor prognosis group with 107 neonates. The two groups were ... Read more >>

Zhongguo Dang Dai Er Ke Za Zhi (Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics)
[2020, 22(2):146-151]

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Efficacy of zinc sulfate on indirect hyperbilirubinemia in premature infants admitted to neonatal intensive care unit: a double-blind, randomized clinical trial.

Gholamreza Faal, Hoda Khatib Masjedi, Gholamreza Sharifzadeh, Zahra Kiani,

BACKGROUND:Hyperbilirubinemia is a common neonatal problem. Studies conducted on the effectiveness of zinc salts on serum indirect bilirubin levels in newborns have yielded different results, all calling for further research. This study aimed to determine the effect of oral zinc sulfate on indirect hyperbilirubinemia in preterm infants admitted to the ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):130]

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Identifying risk effectors involved in neonatal hypoglycemia occurrence.

Tian Zhao, Qiying Liu, Man Zhou, Wei Dai, Yin Xu, Li Kuang, Yaqiong Ming, Guiyu Sun,

Hypoglycemia is a common metabolic condition in neonatal period, but severe and persistent hypoglycemia can cause neurological damage and brain injury. The aim of the present study was to analyze the risk factors of neonatal hypoglycemia in clinic. A total of 135 neonatal hypoglycemia infants and 135 healthy infants were ... Read more >>

Biosci. Rep. (Bioscience reports)
[2020, 40(3):]

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Assessing quality of newborn care at district facilities in Malawi.

Kondwani Kawaza, Mai-Lei Woo Kinshella, Tamanda Hiwa, Jenala Njirammadzi, Mwai Banda, Marianne Vidler, Laura Newberry, Alinane Linda Nyondo-Mipando, Queen Dube, Elizabeth Molyneux, David M Goldfarb,

BACKGROUND:Malawi is celebrated as one of the few countries in sub-Saharan Africa to meet the Millennium Development Goal of reducing under-5 mortality by two-thirds between 1990 and 2015. However, within this age range neonatal mortality rates are the slowest to decline, even though rates of facility births are increasing. Examining ... Read more >>

BMC Health Serv Res (BMC health services research)
[2020, 20(1):227]

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