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Haemophilus Meningitis

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Coverage rates of the children vaccination programme in Greenland.

Nadja Albertsen, Anna Rask Lynge, Nils Skovgaard, Jesper Søndergaard Olesen, Michael Lynge Pedersen,

In order to estimate the current coverage rate among all children in Greenland, we conducted an observational cross-sectional study identifying all children in Greenland eligible for a vaccination between 1 March 2018 and 16 June 2019. we found an overall national coverage of 85.4%. The national coverage for the vaccinations ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1721983]

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Multicenter Hospital-Based Prospective Surveillance Study of Bacterial Agents Causing Meningitis and Seroprevalence of Different Serogroups of Neisseria meningitidis, Haemophilus influenzae Type b, and Streptococcus pneumoniae during 2015 to 2018 in Turkey.

Mehmet Ceyhan, Yasemin Ozsurekci, Sevgen Tanır Basaranoglu, Nezahat Gurler, Enes Sali, Melike Keser Emiroglu, Fatma Nur Oz, Nursen Belet, Murat Duman, Emel Ulusoy, Zafer Kurugol, Hasan Tezer, Aslinur Ozkaya Parlakay, Ener Cagri Dinleyici, Umit Celik, Solmaz Celebi, Ahmet Faik Oner, Mehmet Ali Solmaz, Adem Karbuz, Nevin Hatipoglu, Ilker Devrim, Ilknur Caglar, Sefika Elmas Bozdemir, Emine Kocabas, Ozlem Ozgur Gundeslioglu, Murat Sutcu, Ozge Metin Akcan, Necdet Kuyucu, Fesih Aktar, Soner Sertan Kara, Havva Ozlem Altay Akisoglu, Nilden Tuygun, Zeynep Diyar Tamburaci Uslu, Eda Karadag Oncel, Cihangul Bayhan, Ali Bulent Cengiz,

The etiology of bacterial meningitis in Turkey changed after the implementation of conjugated vaccines against Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) in the Turkish National Immunization Program (NIP). Administration of Hib vaccine and PCV-7 (7-valent pneumococcal conjugate vaccine) was implemented in NIP in 2006 and 2009, respectively. In ... Read more >>

mSphere (mSphere)
[2020, 5(2):]

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Two cases of type-a Haemophilus influenzae meningitis within the same week in the same hospital are phylogenetically unrelated but recently exchanged capsule genes.

Yves Terrat, Lauge Farnaes, John Bradley, Nicolas Tromas, B Jesse Shapiro,

Haemophilus influenzae causes common and sometimes severe adult and pediatric disease including chronic obstructive respiratory disease, otitis media and infections of the central nervous system. Serotype b strains, with a b-type capsule, have been the historical cause of invasive disease, and the introduction of a serotype b-specific vaccine has led ... Read more >>

Microb Genom (Microbial genomics)
[2020, :]

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Adult cochlear implant recipients and meningitis in New Zealand: are patients receiving the recommended immunisations?

Scott Mitchell, Lesina Nakhid-Schuster, Michel Neeff,

AIM:To investigate if adult cochlear implant (CI) recipients have received the recommended immunisations as compared to current guidelines and to report instances of meningitis within this population. METHODS:Telephone interview of CI recipient's general practitioner (GP) surgeries for details regarding immunisations received. Subsequent reporting of immunisation rates of adult patients, under ... Read more >>

N. Z. Med. J. (The New Zealand medical journal)
[2020, 133(1511):14-20]

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Haemophilus influenzae type b invasive infections in children hospitalized between 2000 and 2017 in a Pediatric Reference Hospital (PRH).

Marcos Delfino Sosa, Cristina Zabala, Lorena Pardo, Lucía Fernández, Cecilia Nieves, Mariana Más, Patricia Barrios, Gabriela Algorta, María Inés Mota, Adriana Varela, Claudia Gutiérrez, Stella Gutiérrez, Gustavo Giachetto, María Catalina Pírez,

Background:Uruguay incorporated the conjugate vaccine against Haemophilus influenzae b (Hib) in 1994. In 2008, the vaccine was changed from one with natural conjugated capsular polysaccharide to one with a synthetic polysaccharide component. We describe the frequency and characteristics of invasive Hib infections in children hospitalized in a Pediatric Reference Hospital ... Read more >>

Heliyon (Heliyon)
[2020, 6(3):e03483]

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Isolated Oculomotor Nerve Palsy: A Unique Presentation of Haemophilus influenzae Type A Meningitis.

Richard F Latuska, Jaime K Otillio,

In this case report, we describe a unique case of Haemophilus influenzae type A meningitis in a 7-month-old previously healthy girl that presented with an isolated cranial nerve (oculomotor) palsy without other signs and symptoms classically associated with this entity such as fever, meningismus, or a generally ill appearance. Oculomotor ... Read more >>

Pediatr Emerg Care (Pediatric emergency care)
[2020, 36(3):e172-e174]

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Predisposing Conditions and Etiology of Pediatric Recurrent Bacterial Meningitis in Beijing Children's Hospital, 2006-2018

GANG LIU, Tian-ming Chen, He-ying Chen, Bing Hu, Hui-li Hu, Xin Guo, Ling-yun Guo, Shao-ying Li,

<title>Abstract</title> <p> Objective To investigate the predisposing conditions, etiology and clinical characteristics of recurrent bacterial meningitis (RBM) in children. Methods Seventy patients of RBM treated in Beijing Children's Hospital from January 2006 through December 2018 were retrospectively analyzed. Results Predisposing conditions of RBM include: inner ear malformations 24(34.3%), ... Read more >>

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Epidemiologic study of Haemophilus influenzae causing invasive and non-invasive disease in Paraguay (1999-2017).

María Eugenia León, Aníbal Kawabata, Minako Nagai, Liliana Rojas, Gustavo Chamorro, Noemí Zárate, Gloria Gómez, Myrian Leguizamón, Juan Irala, Juana Ortellado, Rossana Franco, Nancy Segovia,

INTRODUCTION:Haemophilus influenzae is a cause of mild and severe invasive infections, especially among children under 5 years old. Serotype b (Hib) was very frequent before the introduction of the vaccine, which was introduced in Paraguay in 2004. METHODS:A total of 523 isolates of H. influenzae obtained from 1999 to 2017 ... Read more >>

Enferm. Infecc. Microbiol. Clin. (Enfermedades infecciosas y microbiologia clinica)
[2020, :]

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Ten years of experience with the pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (Synflorix) in children.

Nicolas Lecrenier, Alen Marijam, Jan Olbrecht, Lamine Soumahoro, Javier Nieto Guevara, Bruce Mungall,

Introduction: Pneumococcal diseases (including pneumonia, meningitis and sepsis) are among the leading vaccine-preventable causes of death in under-5-year-olds. Pneumococci are also one of the main bacterial pathogens associated with acute otitis media (AOM). Infant immunization programs with pneumococcal conjugate vaccines (PCVs) have led to stark reductions in pneumococcal disease rates.Areas ... Read more >>

Expert Rev Vaccines (Expert review of vaccines)
[2020, :1-19]

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Fatal, Fulminant and Invasive Non-Typeable Haemophilus influenzae Infection in a Preterm Infant: A Re-Emerging Cause of Neonatal Sepsis.

Sudipta Roy Chowdhury, Srabani Bharadwaj, Suresh Chandran,

Early-onset neonatal sepsis (EOS) is a major cause of neonatal death and long-term neurodevelopmental disabilities among survivors. The common pathogens causing EOS are group B streptococcus (GBS) and Escherichia coli. Haemophilus influenzae (H. influenzae) is a Gram-negative coccobacillus that can cause severe invasive disease and can be divided into either ... Read more >>

Trop Med Infect Dis (Tropical medicine and infectious disease)
[2020, 5(1):]

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Hereditary Deficiency of the Second Component of Complement: Early Diagnosis and 21-Year Follow-Up of a Family.

Rosa Maria Dellepiane, Lucia Augusta Baselli, Marco Cazzaniga, Vassilios Lougaris, Paolo Macor, Mara Giordano, Roberta Gualtierotti, Massimo Cugno,

Complement deficiencies are rare and often underdiagnosed primary immunodeficiencies that may be associated with invasive bacterial diseases. Serious infections with encapsulated organisms (mainly Streptococcus pneumoniae, but also Neisseria meningitides and Haemophilus influenzae type B) are frequent in patients with a deficiency of the second component of complement (C2), but no ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2020, 56(3):]

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Binding of pDNA with cDNA using hybridization strategy towards monitoring of Haemophilus influenza genome in human plasma samples.

Arezoo Saadati, Soodabeh Hassanpour, Mohammad Hasanzadeh, Nasrin Shadjou,

Haemophilus Influenza leads to respiratory infections such as sinusitis, acute otitis media, pneumonia and bronchitis. In addition, it causes invasive infections such as cellulite, septic arthritis, and meningitis. Therefore, quick and sensitive detection of H. influenza is of great importance in medical microbiology. In this study, a novel DNA-based bioassay ... Read more >>

Int. J. Biol. Macromol. (International journal of biological macromolecules)
[2020, 150:218-227]

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Molecular epidemiology and evolution of Haemophilus influenzae.

Shuxian Wen, Donghua Feng, Dingqiang Chen, Ling Yang, Zhenbo Xu,

Haemophilus influenzae remains a common cause of illness in children worldwide. H. influenzae type b is the leading cause of bacterial meningitis in children before introduction of vaccination and is a common cause of pneumonia, epiglottis and septic arthritis. Since the implementation of the Hib conjugate vaccine, the non-typeable H. ... Read more >>

Infect. Genet. Evol. (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases)
[2020, 80:104205]

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Metagenomic Next-Generation Sequencing for Diagnosis of Infectious Encephalitis and Meningitis: A Large, Prospective Case Series of 213 Patients.

Xiao-Wei Xing, Jia-Tang Zhang, Yu-Bao Ma, Mian-Wang He, Guo-En Yao, Wei Wang, Xiao-Kun Qi, Xiao-Yan Chen, Lei Wu, Xiao-Lin Wang, Yong-Hua Huang, Juan Du, Hong-Fen Wang, Rong-Fei Wang, Fei Yang, Sheng-Yuan Yu,

Purpose: We assessed the performance of metagenomic next-generation sequencing (mNGS) in the diagnosis of infectious encephalitis and meningitis. Methods: This was a prospective multicenter study. Cerebrospinal fluid samples from patients with viral encephalitis and/or meningitis, tuberculous meningitis, bacterial meningitis, fungal meningitis, and non-central nervous system (CNS) infections were subjected to ... Read more >>

Front Cell Infect Microbiol (Frontiers in Cellular and Infection Microbiology)
[2020, 10:88]

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Delays in diagnosis and treatment of vaccine preventable community acquired bacterial meningitis (CABM): a retrospective analysis at three tertiary care centers

Carla Kim, Sarah Torres, Mitashee Das, Jyoti Ankam, Nicole Luche, Michael Harmon, Emily Schorr, Brittany Glassberg, Stephen Morse, Don Weiss, Jacqueline Gofshteyn, Anusha Yeshokumar, Kiran Thakur,

<title>Abstract</title> <p> Background Outcomes in community-acquired bacterial meningitis (CABM) are significantly impacted by delays in diagnosis and treatment. This retrospective case series aims to describe the sociodemographic, epidemiological, and clinical variables including time to diagnosis and treatment of vaccine preventable CABM in three tertiary care settings in New ... Read more >>

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Multiple Linear Regression Model of Meningococcal Disease in Ukraine: 1992-2015.

Hennadii Mokhort,

Estimating the rates of invasive meningococcal disease (IMD) from epidemiologic data remains critical for making public health decisions. In Ukraine, such estimations have not been performed. We used epidemiological data to develop a national database. These data were used to estimate the population susceptible to IMD and identify the prevalence ... Read more >>

Comput Math Methods Med (Computational and mathematical methods in medicine)
[2020, 2020:5105120]

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Validation of a New Rapid Detection Test for Detection of Neisseria meningitidis A/C/W/X/Y Antigens in Cerebrospinal Fluid.

Cyrille H Haddar, Aude Terrade, Paul Verhoeven, Berthe-Marie Njanpop-Lafourcade, Mireille Dosso, Fati Sidikou, Ali Elhaj Mahamane, Jean-Pierre Lombart, Aziza Razki, Eva Hong, Alain Agnememel, Evelyne Begaud, Yves Germani, Bruno Pozzetto, Muhamed-Kheir Taha,

Meningococcal meningitis remains a life-threatening disease worldwide, with high prevalence in the sub-Saharan meningitis belt. A rapid diagnosis is crucial for implementing adapted antimicrobial treatment. We describe the performances of a new immunochromatographic test (MeningoSpeed, BioSpeedia, France) for detecting and grouping Neisseria meningitidis Cerebrospinal fluids (CSFs) were collected from 5 ... Read more >>

J. Clin. Microbiol. (Journal of clinical microbiology)
[2020, 58(3):]

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Licensure of a Diphtheria and Tetanus Toxoids and Acellular Pertussis, Inactivated Poliovirus, Haemophilus influenzae Type b Conjugate, and Hepatitis B Vaccine, and Guidance for Use in Infants.

Sara E Oliver, Kelly L Moore,

On December 21, 2018 the Food and Drug Administration (FDA) licensed a hexavalent combined diphtheria and tetanus toxoids and acellular pertussis (DTaP) adsorbed, inactivated poliovirus (IPV), Haemophilus influenzae type b (Hib) conjugate (meningococcal protein conjugate) and hepatitis B (HepB) (recombinant) vaccine, DTaP-IPV-Hib-HepB (Vaxelis; MCM Vaccine Company),* for use as a ... Read more >>

MMWR Morb. Mortal. Wkly. Rep. (MMWR. Morbidity and mortality weekly report)
[2020, 69(5):136-139]

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Clinical and Molecular Epidemiology of Invasive Haemophilus influenzae Serotype a Infections in Utah Children.

Hillary Crandall, Jennifer Christiansen, Alyssa A Varghese, Adam Russon, E Kent Korgenski, Erika K Bengtson, Mandy Dickey, Jarrett Killpack, Elizabeth D Knackstedt, Judy A Daly, Krow Ampofo, Andrew T Pavia, Anne J Blaschke,

BACKGROUND:Following widespread use of the Haemophilus influenzae serotype b (Hib) vaccine, H. influenzae serotype a (Hia) has emerged as an important pathogen in children in some regions. We describe the clinical features and molecular epidemiology of invasive Hia disease in children in Utah over an 11-year period. METHODS:We identified cases ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2019, :]

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Molecular Detection and Serotyping of Streptococcus pneumoniae in Children with Suspected Meningitis in Northeast Iran.

Sepideh Abdoli, Saghar Safamanesh, Mahsa Khosrojerdi, Amir Azimian,

Background:To date, more than 90 Streptococcus pneumoniae (S. pneumoniae) capsular serotypes are known. The prevalence of these serotypes varies according to the geographical area and the regional vaccination program. Due to the lack of regular vaccination programs for S. pneumoniae in developing countries, serotyping of the prevalent isolates is useful ... Read more >>

Iran J Med Sci (Iranian journal of medical sciences)
[2020, 45(2):125-133]

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A case of bacterial meningitis with burst waves of local onset on ictal Electroencephalography.

Hisako Yamamoto, Yusaku Miyamoto, Hitoshi Yamamoto,

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2019, 61(12):1263-1264]

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A rare case of purulent meningitis caused by Capnocytophaga canimorsus in the Czech Republic - case report and review of the literature.

Petr Prasil, Lenka Ryskova, Stanislav Plisek, Pavel Bostik,

BACKGROUND:Invasive infections caused by Capnocytophaga canimorsus are rare. Immunocompromised patients, who report being bitten by or having a close contact with an animal, represent a high-risk group for this infection. There are only few dozens of infections by this bacteria manifesting as purulent meningitis reported worldwide. The reported case is ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2020, 20(1):100]

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Meningitis trends in Niger 2008-2015: a secondary data analysis.

I Djibo, P K Yanogo, J Kaboré, B Sawadogo, I Alkassoum, S Antara, N Meda,

INTRODUCTION:Niger, located in the meningitis belt, faces recurrent epidemics of magnitudes that vary with the year. The objective of this study was to describe the trends in meningitis and identify the profile of the microbes implicated in meningitis epidemics in Niger. METHODS:We conducted a descriptive study (a secondary analysis) of ... Read more >>

Med Sante Trop (Medecine et sante tropicales)
[2019, 29(4):435-439]

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Effect of cAMP Receptor Protein Gene on Growth Characteristics and Stress Resistance of Haemophilus parasuis Serovar 5.

Changsheng Jiang, Yufang Cheng, Hua Cao, Bingzhou Zhang, Jing Li, Ling Zhu, Zhonghua Li, Wei Zeng, Chang Li, Qigai He,

Haemophilus parasuis (HPS), a member of the family Pasteurellaceae, is a common bacteria in the upper respiratory tract of pigs but under certain circumstances can cause serious systemic disease (Glasser's disease) characterized by severe infection of the upper respiratory tract, fibrinous polyserositis, polyarthritis, and meningitis. cAMP receptor protein (CRP) is ... Read more >>

Front Cell Infect Microbiol (Frontiers in Cellular and Infection Microbiology)
[2020, 10:19]

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Case report of congenital asplenia presenting with Haemophilus influenzae type a (Hia) sepsis: an emerging pediatric infection in Minnesota.

Tiffany Albrecht, Kristina Poss, Satja Issaranggoon Na Ayuthaya, Lori Triden, Katherine L Schleiss, Mark R Schleiss,

BACKGROUND:In the pre-vaccine era, invasive disease with Haemophilus influenzae, type b (Hib) commonly presented with osteoarticular involvement. Haemophilus influenzae, type a (Hia) sepsis is a rare but emerging problem in recent years. Here, we report a case of sepsis with concomitant osteoarthritis due to Hia that was the presenting infectious ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2019, 19(1):947]

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