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The resting membrane potential of hSC-CM in a syncytium is more hyperpolarised than that of isolated cells.

Dieter V Van de Sande, Ivan Kopljar, Alaerts Maaike, Ard Teisman, David J Gallacher, Loeys Bart, Dirk J Snyders, Luc Leybaert, Hua Rong Lu, Alain J Labro,

Human-induced pluripotent stem cell (hiPSC) and stem cell (hSC) derived cardiomyocytes (CM) are gaining popularity as in vitro model for cardiology and pharmacology studies. A remaining flaw of these cells, as shown by single-cell electrophysiological characterization, is a more depolarized resting membrane potential (RMP) compared to native CM. Most reports ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2021, 15(1):239-252]

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Symmetric and asymmetric activation of hematopoietic stem cells.

Dirk Loeffler, Timm Schroeder,

<h4>Purpose of review</h4>Hematopoietic stem cells (HSCs) are in an inactive quiescent state for most of their life. To replenish the blood system in homeostasis and after injury, they activate and divide. HSC daughter cells must then decide whether to return to quiescence and metabolic inactivity or to activate further to ... Read more >>

Curr Opin Hematol (Current opinion in hematology)
[2021, 28(4):262-268]

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Granulocyte colony-stimulating factor acts on lymphoid-biased, short-term hematopoietic stem cells.

Yulin Chen, K Lenhard Rudolph,

Haematologica (Haematologica)
[2021, 106(6):1516-1518]

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Granulocyte colony-stimulating factor directly acts on mouse lymphoid-biased but not myeloid-biased hematopoietic stem cells.

Miner Xie, Shanshan Zhang, Fang Dong, Qingyun Zhang, Jinhong Wang, Chenchen Wang, Caiying Zhu, Sen Zhang, Bingqing Luo, Peng Wu, Hideo Ema,

Granulocyte colony-stimulating factor (G-CSF) is widely used in clinical settings to mobilize hematopoietic stem cells (HSCs) into the circulation for HSC harvesting and transplantation. However, whether G-CSF directly stimulates HSCs to change their cell cycle state and fate is controversial. HSCs are a heterogeneous population consisting of different types of ... Read more >>

Haematologica (Haematologica)
[2021, 106(6):1647-1658]

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Cellular components of the hematopoietic niche and their regulation of hematopoietic stem cell function.

Joydeep Ghosh, Roy El Koussa, Safa F Mohamad, Jianyun Liu, Melissa A Kacena, Edward F Srour,

<h4>Purpose of review</h4>Development and functions of hematopoietic stem cells (HSC) are regulated by multiple cellular components of the hematopoietic niche. Here we review the recent advances in studying the role of three such components -- osteoblasts, osteomacs, and megakaryocytes and how they interact with each other in the hematopoietic niche ... Read more >>

Curr Opin Hematol (Current opinion in hematology)
[2021, 28(4):243-250]

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C/EBP homologous protein deficiency enhances hematopoietic stem cell function via reducing ATF3/ROS-induced cell apoptosis.

Zhencan Shi, Daojun Diao, Yanan Zhao, Ying Luo, Yafei Li, Dingdong Liu, Kai Zhang, Yugang Qiu, Li Yu, Zhangfa Song, Zhenyu Ju,

Hematopoietic stem cells (HSCs) reside in a quiescent niche to reserve their capacity of self-renewal. Upon hematopoietic injuries, HSCs enter the cell cycle and encounter protein homeostasis problems caused by accumulation of misfolded proteins. However, the mechanism by which protein homeostasis influences HSC function and maintenance remains poorly understood. Here, ... Read more >>

Aging Cell (Aging cell)
[2021, :e13382]

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Differentiated Cells Derived from Hematopoietic Stem Cells and Their Applications in Translational Medicine.

Sophia S Fernandes, Lalita S Limaye, Vaijayanti P Kale,

Hematopoietic stem cells (HSCs) and their development are one of the most widely studied model systems in mammals. In adults, HSCs are predominantly found in the bone marrow, from where they maintain homeostasis. Besides bone marrow and mobilized peripheral blood, cord blood is also being used as an alternate allogenic ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2021, :]

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Human placental mesenchymal stem cells ameliorate liver fibrosis in mice by upregulation of Caveolin1 in hepatic stellate cells.

Yunqi Yao, Zhemin Xia, Fuyi Cheng, Qingyuan Jang, Jiao He, Cheng Pan, Lin Zhang, Yixin Ye, Yuan Wang, Shuang Chen, Dongsheng Su, Xiaolan Su, Lin Cheng, Gang Shi, Lei Dai, Hongxin Deng,

<h4>Background</h4>Liver fibrosis (LF) is a common pathological process characterized by the activation of hepatic stellate cells (HSCs) and accumulation of extracellular matrix. Severe LF causes cirrhosis and even liver failure, a major cause of morbidity and mortality worldwide. Transplantation of human placental mesenchymal stem cells (hPMSCs) has been considered as ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2021, 12(1):294]

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The NF-κB pathway regulates heterochromatin at intronic young LINE-1 elements and hematopoietic stem cell gene expression during irradiation stress

Yanis Pelinski, Donia Hidaoui, François Hermetet, Anne Stolz, M’boyba Khadija Diop, Amir Chioukh, Françoise Porteu, Emilie Elvira-Matelot,

<h4>SUMMARY</h4> Understanding how ionizing radiations (IR) alter hematopoietic stem cell (HSC) function on the long-term is crucial. We recently showed a link between derepression of L1Md, the mouse young subfamilies of LINE-1/L1 retroelements, and IR-induced HSC injury. L1 contribute to gene regulatory networks. However, the mechanisms involved in IR-induced L1Md ... Read more >>

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Hematopoietic Stem Cells: Nature and Niche Nurture.

Geoffrey Brown,

Like all cells, hematopoietic stem cells (HSCs) and their offspring, the hematopoietic progenitor cells (HPCs), are highly sociable. Their capacity to interact with bone marrow niche cells and respond to environmental cytokines orchestrates the generation of the different types of blood and immune cells. The starting point for engineering hematopoiesis ... Read more >>

Bioengineering (Basel) (Bioengineering (Basel, Switzerland))
[2021, 8(5):]

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Small molecule-mediated modulation of ubiquitination and neddylation improves HSC function ex vivo.

Esra Albayrak, Merve Uslu, Sezer Akgol, Emre Can Tuysuz, Fatih Kocabas,

Hematopoietic stem cells (HSCs) are particularly characterized by their quiescence and self-renewal. Cell cycle regulators tightly control quiescence and self-renewal capacity. Studies suggest that modulation of ubiquitination and neddylation could contribute to HSC function via cyclin-dependent kinase inhibitors (CDKIs). S-phase kinase-associated protein 2 (SKP2) is responsible for ubiquitin-mediated proteolysis of ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2021, :]

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Hepatic stellate cell-derived exosomes modulate macrophage inflammatory response.

Jennifer H Benbow, Emilio Marrero, Rachel M McGee, Elizabeth Brandon-Warner, Neha Attal, Nicole A Feilen, Catherine R Culberson, Iain H McKillop, Laura W Schrum,

<h4>Background</h4>Hepatic stellate cell (HSC) differentiation/activation is central to liver fibrosis and is innately linked to the immune response to liver injury. Exosomes (EXOs) are important means of communication between cell populations. This study sought to characterize EXO release from HSCs and the effect of HSC-EXOs on macrophage cytokine release/function.<h4>Methods</h4>Liver from ... Read more >>

Exp Cell Res (Experimental cell research)
[2021, 405(1):112663]

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JAK-STAT in Early Hematopoiesis and Leukemia.

Eirini Sofia Fasouli, Eleni Katsantoni,

Hematopoietic stem cells (HSCs) produce all the terminally differentiated blood cells and are controlled by extracellular signals from the microenvironment, the bone marrow (BM) niche, as well as intrinsic cell signals. Intrinsic signals include the tightly controlled action of signaling pathways, as the Janus kinase-signal transducer and activator of transcription ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:669363]

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Extracellular Vesicles and Hematopoietic Stem Cell Aging.

Laura R Goldberg,

Extracellular vesicles (EVs), important mediators of intercellular communication, play a critical role in modulating hematopoiesis within the bone marrow microenvironment. Although few studies have explicitly examined the connections between EVs and hematopoietic stem cell (HSC) aging, there is a growing body of evidence that implicates EVs in numerous age-related biologic ... Read more >>

Arterioscler Thromb Vasc Biol (Arteriosclerosis, thrombosis, and vascular biology)
[2021, :ATVBAHA120314643]

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Exogenous Plant gma-miR-159a, Identified by miRNA Library Functional Screening, Ameliorated Hepatic Stellate Cell Activation and Inflammation via Inhibiting GSK-3β-Mediated Pathways.

Wen-Ying Yu, Wei Cai, Hua-Zhong Ying, Wen-You Zhang, Huan-Huan Zhang, Chen-Huan Yu,

<h4>Purpose</h4>Plant-derived exogenous microRNAs (miRNAs) regulate human physiological functions by blocking the translation of target mRNAs. Although several computational approaches have been developed to elucidate the interactions of cross-species miRNAs and their targets in mammals, the number of verified plant miRNAs is still limited, and the biological roles of most exogenous ... Read more >>

J Inflamm Res (Journal of inflammation research)
[2021, 14:2157-2172]

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Redox Control in Acute Lymphoblastic Leukemia: From Physiology to Pathology and Therapeutic Opportunities.

Yongfeng Chen, Jing Li, Zhiqiang Zhao,

Acute lymphoblastic leukemia (ALL) is a hematological malignancy originating from B- or T-lymphoid progenitor cells. Recent studies have shown that redox dysregulation caused by overproduction of reactive oxygen species (ROS) has an important role in the development and progression of leukemia. The application of pro-oxidant therapy, which targets redox dysregulation, ... Read more >>

Cells (Cells)
[2021, 10(5):]

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MMP8 increases tongue carcinoma cell-cell adhesion and diminishes migration via cleavage of anti-adhesive FXYD5.

K Juurikka, A Dufour, K Pehkonen, B Mainoli, P Campioni Rodrigues, N Solis, T Klein, P Nyberg, C M Overall, T Salo, P Åström,

Matrix metalloproteinases (MMPs) modify bioactive factors via selective processing or degradation resulting in tumour-promoting or tumour-suppressive effects, such as those by MMP8 in various cancers. We mapped the substrates of MMP8 to elucidate its previously shown tumour-protective role in oral tongue squamous cell carcinoma (OTSCC). MMP8 overexpressing (+) HSC-3 cells, ... Read more >>

Oncogenesis (Oncogenesis)
[2021, 10(5):44]

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Integrated Single-cell Bioinformatics Analysis Reveals Intrinsic and Extrinsic Biological Characteristics of Hematopoietic Stem Cell Aging

Xiangjun Zeng, Xia Li, Mi Shao, Yulin Xu, Wei Shan, Cong Wei, Xiaoqing Li, Limengmeng Wang, Yongxian Hu, Yanmin Zhao, Pengxu Qian, He Huang,

Hematopoietic stem cell (HSC) aging, which is accompanied by loss of self-renewal capacity, myeloid-biased differentiation and increased risks of hematopoietic malignancies, is an important focus in stem cell research. However, the mechanisms underlying HSC aging have not been fully elucidated. In the present study, we integrated 3 independent single-cell transcriptome ... Read more >>

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Involvement of TLR4 signaling regulated-COX2/PGE2 axis in liver fibrosis induced by Schistosoma japonicum infection.

Lan Chen, Xiaofang Ji, Manni Wang, Xiaoyan Liao, Cuiying Liang, Juanjuan Tang, Zhencheng Wen, Ferrandon Dominique, Zi Li,

<h4>Background</h4>Hepatic stellate cell (HSC) activation plays a pivotal role in hepatic inflammation and liver fibrosis. TLR4 pathway activation has been reported to be involved in mice liver fibrosis induced by hepatitis virus infection, alcohol abuse, biliary ligation, carbon tetrachloride 4 treatment, and Schistosoma japonicum (Sj) infection. The effect and mechanisms ... Read more >>

Parasit Vectors (Parasites & vectors)
[2021, 14(1):279]

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The transformative potential of HSC gene therapy as a genetic medicine.

Pervinder Sagoo, H Bobby Gaspar,

Hematopoietic stem cells (HSCs) are precursor cells that give rise to blood, immune and tissue-resident progeny in humans. Their position at the starting point of hematopoiesis offers a unique therapeutic opportunity to treat certain hematologic diseases by implementing corrective changes that are subsequently directed through to multiple cell lineages. Attempts ... Read more >>

Gene Ther (Gene therapy)
[2021, :]

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Dihydroartemisinin alleviates hepatic fibrosis through inducing ferroptosis in hepatic stellate cells.

Zili Zhang, Xian Wang, Zilong Wang, Zhiyue Zhang, Yashi Cao, Zonghui Wei, Jiangjuan Shao, Anping Chen, Feng Zhang, Shizhong Zheng,

Targeting the elimination of activated hepatic stellate cells (HSCs) and blocking excessive deposition of extracellular matrix are recognized as an effective strategy for the treatment of hepatic fibrosis. As a newly discovered programmed cell death mode, the regulatory mechanism of ferroptosis in the clearance of activated HSCs has not been ... Read more >>

Biofactors (BioFactors (Oxford, England))
[2021, :]

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Megakaryocyte progenitor cell function is enhanced upon aging despite the functional decline of aged hematopoietic stem cells.

Donna M Poscablo, Atesh K Worthington, Stephanie Smith-Berdan, E Camilla Forsberg,

Age-related morbidity is associated with a decline in hematopoietic stem cell (HSC) function, but the mechanisms of HSC aging remain unclear. We performed heterochronic HSC transplants followed by quantitative analysis of cell reconstitution. Although young HSCs outperformed old HSCs in young recipients, young HSCs unexpectedly failed to outcompete the old ... Read more >>

Stem Cell Reports (Stem cell reports)
[2021, 16(6):1598-1613]

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Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury.

Kuo Du, Seh Hoon Oh, Rajesh Kumar Dutta, Tianai Sun, Wen-Hsuan Yang, Jen-Tsan Ashley Chi, Anna Mae Diehl,

<h4>Background & aims</h4>The outcome of liver injury is dictated by factors that control accumulation of myofibroblastic (activated) hepatic stellate cells (MF-HSCs) but therapies that specifically block this process have not been discovered. We evaluated the hypothesis that MF-HSCs and liver fibrosis could be safely reduced by inhibiting the cysteine/glutamate antiporter ... Read more >>

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2021, :]

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Single-cell transcriptomic analysis reveals a hepatic stellate cell-activation roadmap and myofibroblast origin during liver fibrosis.

Wu Yang, Hao He, Tongtong Wang, Nan Su, Feng Zhang, Kai Jiang, Jing Zhu, Chonghe Zhang, Kongyan Niu, Luyue Wang, Xiaodong Yuan, Nan Liu, Lingjie Li, Wu Wei, Junhao Hu,

Hepatic stellate cells (HSCs) and portal fibroblasts (PFs) are the major sources of collagen-producing myofibroblasts during liver fibrosis, depending on different etiologies. However, the mechanisms by which their dynamic gene expression directs the transition from the quiescent to the activated state-as well as their contributions to fibrotic myofibroblasts-remain unclear. Here, ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2021, :]

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The emergent role of digital technologies in the context of humanitarian supply chains: a systematic literature review.

Josip Marić, Carlos Galera-Zarco, Marco Opazo-Basáez,

The role of digital technologies (DTs) in humanitarian supply chains (HSC) has become an increasingly researched topic in the operations literature. While numerous publications have dealt with this convergence, most studies have focused on examining the implementation of individual DTs within the HSC context, leaving relevant literature, to date, dispersed ... Read more >>

Ann Oper Res (Annals of operations research)
[2021, :1-42]

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