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Graft Versus Host Disease

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The emerging world of subcellular biological medicine: extracellular vesicles as novel biomarkers, targets, and therapeutics.

Leon G Coleman,

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1020-1022]

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Role of folinic acid in methotrexate-based prophylaxis of graft-versus-host disease following hematopoietic stem cell transplantation.

Naif I AlJohani,

Methotrexate (MTX) is one of the main therapeutic agents currently used for the prophylaxis of graft-versus-host disease (GvHD) following hematopoietic stem cell transplantation. However, it is associated with significant toxicity and considerable side effects in many patients, which lead to either early withdrawal or dose reductions that may expose patients ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):620-627]

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Mesenchymal stem cells (MSC) delays the occurrence of graft-versus-host disease(GVHD) in the inhibition of hematopoietic stem cells in major histocompatibility complex semi-consistent mice by regulating the expression of IFN-γ/IL-6.

Ying Wang,

In recent years, because of its low immunogenicity and immunosuppression, mesenchymal stem cells (MSCs) have become a potential cell therapy for Graft-versus-host disease (GVHD). However, many experiments now focus on the interference of MSCs on T-cell proliferation in vitro and the prevention of GVHD in vivo. However, whether MSCs can ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):4500-4507]

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Impact of pre-transplantation minimal residual disease (MRD) on the outcome of Allogeneic hematopoietic stem cell transplantation for acute leukemia.

Xing Shen, Jing Pan, Chenchen Qi, Yuan Feng, Hanxin Wu, Sixuan Qian, Hua Lu, Lijuan Chen, Jianyong Li, Kourong Miao, Hairong Qiu, Han Zhu,

<h4>Objective</h4>To investigate the impact of minimal residual disease (MRD) before allogeneic hematopoietic stem cell transplantation (allo-HSCT) on the outcome of acute leukemia.<h4>Methods</h4>Data from 114 patients who were diagnosed with acute leukemia (AL) and underwent allo-HSCT between Jan 2013 and Dec 2019 were collected and analyzed. The patients were attributed into ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):295-300]

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Risk Factors for Graft-Versus-Host Disease and Survival in Pediatric Hematopoietic Stem Cell Transplant Recipients: A Single-Center Experience.

Tuğba Bedir Demirdağ, Gözde Kurşun Ağlamiş, Serap Kirkiz Kayal, Asiye Uğraş Dikmen, Zühre Kaya, İdil Yenicesu, Ülker Koçak,

Graft-versus-host disease is still one of the most important complications after hematopoietic stem cell transplantation. The risk factors remain unclear, with effects of graft-versus-host disease on survival varying among different centers. We aimed to determine risk factors that may affect development of graft-versus-host disease and the corresponding patient survival rates ... Read more >>

Exp Clin Transplant (Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation)
[2021, :]

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Impact of pre-transplant use of antibiotics on the graft-versus-host disease in adult patients with hematological malignancies.

Myung-Won Lee, Sang-Hoon Yeon, Bu-Yeon Heo, Jaeyul Kwon, Hyewon Ryu, Hyo-Jin Lee, Hwan-Jung Yun, Deog-Yeon Jo, Ik-Chan Song,

<h4>Objectives</h4>Changes in fecal microbiota affect the incidence and extent of graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). Most patients with hematological malignancies receive antibiotics for the treatment of febrile neutropenia prior to allogeneic HSCT, and pre-transplant use of antibiotics may influence the fecal microbiota and GVHD.<h4>Methods</h4>We retrospectively ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):96-102]

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A comparative study of porcine antihuman lymphocyte globulin versus antithymocyte globulin-fresenius in an allogeneic hematopoietic cell transplantation conditioning regimen for severe aplastic anemia.

Yanming Zhang, Limin Liu, Yejun Si, Miao Miao, Huiying Qiu, Xiaowen Tang, Yue Han, Chengcheng Fu, Zhengming Jin, Suning Chen, Aining Sun, Depei Wu,

<h4>Objectives</h4>To compare the outcomes of antihuman T lymphocyte globulin (ATG-F) and porcine antihuman lymphocyte globulin (p-ALG) as part of a conditioning regimen in hematopoietic stem cell transplantation (HSCT) for severe aplastic anemia (SAA).<h4>Methods</h4>we performed a retrospective analysis, evaluating the outcome of patients with SAA who received ATG-F based conditioning (<i>n</i> = 26) ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):741-750]

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New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD).

Hannah Choe, James L M Ferrara,

<h4>Introduction</h4>Acute Graft-versus-Host Disease (GVHD) is the major toxicity of allogeneic hematopoietic cell transplantation (HCT). Systemic steroids are the standard primary treatment but only half of the patients will respond completely and the survival of steroid-refractory patients is poor. The gastrointestinal (GI) tract is a key target organ that usually determines ... Read more >>

Expert Opin Ther Targets (Expert opinion on therapeutic targets)
[2021, :1-11]

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Allogeneic hematopoietic cell transplantation using fludarabine plus myeloablative busulfan and melphalan confers promising survival in high-risk hematopoietic neoplasms: a single-center retrospective analysis.

Taro Edahiro, Takakazu Kawase, Hisao Nagoshi, Keita Fujino, Kayo Toishigawa, Takahiko Miyama, Tatsuji Mino, Tetsumi Yoshida, Takehiko Morioka, Yuji Hirata, Mitsunori Noma, Teruhisa Fujii, Masatoshi Nishizawa, Noriyasu Fukushima, Tatsuo Ichinohe,

<h4>Objectives</h4>Optimal selection of pretransplant conditioning is crucially vital for improving survival and quality-of-life of patients who receive allogeneic hematopoietic cell transplantation (allo-HCT), particularly in those with high-risk diseases. In this study, we evaluated the efficacy and safety of recently-developed reduced-toxicity myeloablative regimen that combines fludarabine, intravenous busulfan, and melphalan (FBM).<h4>Methods</h4>We ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):186-198]

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Association of cytotoxic T-lymphocyte antigen-4 (CTLA-4) single nucleotide polymorphism in donors with clinical outcome after allogeneic hematopoietic stem cell transplantation: a meta-analysis.

Zhuo Wang, Yunwei Zhang, Yazhe Du, Fei Song, Sujun Gao,

<h4>Objective</h4>Cytotoxic T-lymphocyte antigen 4 (CTLA-4) polymorphisms at positions of +49 and CT60 in donors have been reported to influence clinical outcome following allogeneic hematopoietic stem cell transplantation (allo-HSCT), such as overall survival (OS), disease free survival (DFS), relapse and the risk of graft versus host disease (GVHD). However, the results ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2021, 26(1):144-152]

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Graft-Versus-Host Disease Associated Angiomatosis with Striking Lipomatous Metaplasia.

M Llamas Velasco, E Muñoz-Aceituno, J Sánchez-Pérez, C Camarero-Mulas, J Fraga, M Aragüés,

Sclerodermatous graft-versus-host disease (GVHD) is one of the many clinicopathological variants of chronic GVHD. One of the rarest forms of this variant is GVHD-associated angiomatosis (GVHD-AA). We describe the case of a 62-year-old male with sclerodermatous GVHD who presented, in consecutive years, two different lesions that showed characteristics of GVHD-AA. ... Read more >>

J Cutan Pathol (Journal of cutaneous pathology)
[2021, :]

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Dynamic forecasting of severe acute graft-versus-host disease after transplantation

XUEOU LIU, YIGENG CAO, YE GUO, XIAOWEN GONG, YAHUI FENG, YAO WANG, MINGYANG WANG, MENGXUAN CUI, WENWEN GUO, LUYANG ZHANG, NINGNING ZHAO, XIAOQIANG SONG, XUETONG ZHENG, XIA CHEN, QIUJIN SHEN, SONG ZHANG, ZHEN SONG, LINFENG LI, SIZHOU FENG, MINGZHE HAN, XIAOFAN ZHU, ERLIE JIANG, JUNREN CHEN,

To anticipate critical events, clinicians intuitively rely on multidimensional time-series data. It is, however, difficult to model such decision process using machine learning (ML), since real-world medical records often have irregular missing and data sparsity in both feature and longitudinal dimensions. Here we propose a nonparametric approach that updates risk ... Read more >>

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Corneal perforation in ocular graft-versus-host disease

Cathy Y. Zhang, Asim V. Farooq, George J. Harocopos, Eric L. Sollenberger, Joshua H. Hou, Charles S. Bouchard, Christine Shieh, Uyen L. Tran, Anthony J. Lubniewski, Andrew J.W. Huang, Grace L. Paley,

<h4>Purpose</h4> Corneal perforation is a rare, vision-threatening complication of ocular graft-versus-host disease (GVHD) and is not well understood. Our objective was to examine the clinical disease course and histopathologic correlation in patients who progressed to this outcome. <h4>Methods</h4> This study is a retrospective case series from four academic centers in ... Read more >>

Am J Ophthalmol Case Rep (American journal of ophthalmology case reports)
[2021, 24:]

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T-Cell Metabolism in Graft Versus Host Disease.

Franziska Karl, Michael Hudecek, Friederike Berberich-Siebelt, Andreas Mackensen, Dimitrios Mougiakakos,

Allogeneic-hematopoietic stem cell transplantation (allo-HSCT) represents the only curative treatment option for numerous hematological malignancies. Elimination of malignant cells depends on the T-cells' Graft-versus-Tumor (GvT) effect. However, Graft-versus-Host-Disease (GvHD), often co-occurring with GvT, remains an obstacle for therapeutic efficacy. Hence, approaches, which selectively alleviate GvHD without compromising GvT activity, are ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:760008]

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Ruxolitinib As a Salvage Therapy for Acute and Chronic Graft-versus-Host Disease in Children and Young Adults: a single institution experience

Melissa Mavers, Edna Klinger, David Shyr, Ami Shah, Alice Bertaina, Sandeep Soni,

<h4>ABSTRACT</h4> <h4>Background</h4> Ruxolitinib, a Janus kinase (JAK)-1/JAK-2 inhibitor that reduces T-cell activation and proliferation leading to a potent anti-inflammatory effect, was recently approved to treat steroid-refractory acute graft-versus-host disease (aGvHD) and is under study for chronic GvHD (cGvHD). However, there are few reports on its use in pediatric and young ... Read more >>

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Diverting Enterostomy Improves Overall Survival of Patients With Severe Steroid-refractory Gastrointestinal Acute Graft-Versus-Host Disease.

Justine Khodr, Philippe Zerbib, Moshe Rogosnitzky, Leonardo Magro, Stéphanie Truant, Ibrahim Yakoub-Agha, Alain Duhamel, David Seguy,

<h4>Objective</h4>The aim of this study was to evaluate the benefit of diverting enterostomy (DE) in patients with severe steroid-refractory (SR) gastrointestinal acute graft-versus-host-disease (GI-aGVHD) following allogeneic hematopoietic stem-cell transplantation (ASCT).<h4>Summary and background data</h4>Severe GI-aGVHD refractory to the first-line steroid therapy is a rare but dramatic life-threatening complication. Second lines of ... Read more >>

Ann Surg (Annals of surgery)
[2021, 274(5):773-779]

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Letermovir Prophylaxis and Cytomegalovirus Reactivation in Adult Hematopoietic Cell Transplant Recipients with and without Acute Graft Versus Host Disease.

Delaney Wolfe, Qiuhong Zhao, Emma Siegel, Marcin Puto, Danielle Murphy, Julianna Roddy, Yvonne Efebera, Justin Tossey,

Cytomegalovirus (CMV) is the most clinically significant infection after allogeneic hematopoietic-cell transplantation (allo-HCT) and is associated with increased mortality. The risk for CMV reactivation increases with graft versus host disease (GVHD). GVHD contributes to significant morbidity and mortality and is treated with immunosuppressive therapies that can further increase CMV infection ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(21):]

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Graft-versus-host disease: a disorder of tissue regeneration and repair.

Ronjon Chakraverty, Takanori Teshima,

Regenerative failure at barrier surfaces and maladaptive repair leading to fibrosis are hallmarks of graft-versus-host disease (GVHD). Although immunosuppressive treatment can control inflammation, impaired tissue homeostasis leads to prolonged organ damage and impaired quality of life. In this Blood Spotlight, we review recent research that addresses the critical failures in ... Read more >>

Blood (Blood)
[2021, 138(18):1657-1665]

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Treatment of oral chronic graft-versus-host disease: a retrospective cohort study.

Gabriela de Assis Ramos, Taísa Domingues Boehmer Leite, Camila Brandão Lobo, Paulo Sérgio da Silva Santos, Maria Claudia Rodrigues Moreira, Héliton Spindola Antunes,

<h4>Objective</h4>The aim of this study was to evaluate patients with complete response of oral chronic graft-versus-host disease to immunosuppressive treatment.<h4>Methods</h4>A total of 29 patients submitted to allogeneic hematopoietic stem cell transplantation, with oral chronic graft-versus-host disease, were enrolled in this retrospective study, from September 2012 to February 2018. Patients were ... Read more >>

Einstein (Sao Paulo) (Einstein (Sao Paulo, Brazil))
[2021, 19:eAO6177]

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Letermovir Prophylaxis and Cytomegalovirus Reactivation in Adult Hematopoietic Cell Transplant Recipients with and without Acute Graft Versus Host Disease

Delaney Wolfe, Qiuhong Zhao, Emma Siegel, Marcin Puto, Danielle Murphy, Julianna Roddy, Yvonne Efebera, Justin Tossey,

<h4>Simple Summary</h4> Cytomegalovirus (CMV) infection and graft versus host disease (GVHD) both contribute to increased morbidity and mortality following allogeneic hematopoietic cell transplantation (allo-HCT). Since the development of GVHD can increase a patient’s risk of developing CMV infection post-allo-HCT, the aim of our retrospective study was to assess the effectiveness ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(21):]

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The oral histopathological and immunological characteristics of a xenogeneic mouse chronic graft-versus-host disease model.

Qiaozhi Jiang, Xiangzhi Yong, Zhenmin Liu, Yuxi Zhou, Guocheng Mei, Qianming Chen, Tiantian Wu, Renchuan Tao,

Oral lesions are important clinical manifestations of chronic graft-verse-host disease (cGVHD). However, the oral characteristics of cGVHD mouse model are not yet clear. This study aims to demonstrate oral histopathological and immunological characteristics of a xenogeneic cGVHD mouse model. 2.5 × 106 , 5.0 × 106 , 7.5 × 106 , and 10.0 × 106  human peripheral blood ... Read more >>

J Oral Pathol Med (Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology)
[2021, :]

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Beyond antivirals: virus-specific T-cell immunotherapy for BK virus haemorrhagic cystitis and JC virus progressive multifocal leukoencephalopathy.

Adam S Nelson, Niveditha Yalamarthi, Michelle K Yong, Emily Blyth,

<h4>Purpose of review</h4>The clinical manifestations of the polyomaviruses BK and JC in immunocompromised patients include BK virus (BKV) induced haemorrhagic cystitis and nephropathy, and JC virus (JCV) associated progressive multifocal leukoencephalopathy (PML) and are typically a consequence of impaired adaptive immunity in the host. To date, little clinical success has ... Read more >>

Curr Opin Infect Dis (Current opinion in infectious diseases)
[2021, 34(6):627-634]

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Liver Transplant Associated Systemic Graft-Versus-Host Disease Following Complete Donor Hematopoietic Chimerism.

Alexis J Gumm, Alvin Y Chan, David A Margolis, Miranda Gries, Stacee Lerret,

Prog Transplant (Progress in transplantation (Aliso Viejo, Calif.))
[2021, :15269248211046013]

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Improved Therapeutic Approaches are Needed to Manage Graft-versus-Host Disease.

Deborah S Hooker, Kristin Grabe-Heyne, Christof Henne, Peter Bader, Mondher Toumi, Stephen J Furniss,

Allogeneic haematopoietic stem cell transplantation (alloHSCT) offers a potentially curative therapy for patients suffering from diseases of the haematopoietic system but requires a high level of expertise and is both resource intensive and expensive. A frequent and life-threatening complication is graft-versus-host disease (GvHD). Acute GvHD (aGvHD) generally causes skin, gastrointestinal ... Read more >>

Clin Drug Investig (Clinical drug investigation)
[2021, 41(11):929-939]

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Recommendations on service delivery to help reduce suffering and anxiety in patients and caregivers post-hematopoietic cell transplantation: a case report.

Jaleel Mohammed, Hadeel R Bakhsh, Cliodhna Craig, Shahrukh K Hashmi,

<h4>Background</h4>The aim of this study is to highlight the importance of having a central case managing team and to make some strong recommendations that can have a positive impact on the lives of hematopoietic stem cell transplantation survivors.<h4>Case presentation</h4>A 2-year-old white child who was diagnosed with acute myeloid leukemia and ... Read more >>

J Med Case Rep (Journal of medical case reports)
[2021, 15(1):549]

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