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Geriatric Sleep Disorder

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Phenoconversion from rapid eye movement sleep behaviour disorder to multiple system atrophy is predicted by abnormal dopamine transporter imaging combined with normal 123 I-metaiodobenzylguanidine myocardial scintigraphy: a case report.

Ryota Kobayashi, Hiroshi Hayashi, Shinobu Kawakatsu, Daichi Morioka, Chifumi Iseki, Kenichi Ishizawa, Koichi Otani,

Psychogeriatrics (Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society)
[2020, :]

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Let's CHAT (community health approaches to) dementia in Aboriginal and Torres Strait Islander communities: protocol for a stepped wedge cluster randomised controlled trial.

Kate Bradley, Robyn Smith, Jo-Anne Hughson, David Atkinson, Dawn Bessarab, Leon Flicker, Kylie Radford, Kate Smith, Edward Strivens, Sandra Thompson, Irene Blackberry, Dina LoGiudice,

BACKGROUND:Documented rates of dementia and cognitive impairment not dementia (CIND) in older Aboriginal and Torres Strait Islander Peoples is 3-5 times higher than the rest of the population, and current evidence suggests this condition is under-diagnosed and under-managed in a clinical primary care setting. This study aims to implement and ... Read more >>

BMC Health Serv Res (BMC Health Services Research)
[2020, 20(1):208]

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The Association Between Biomarkers and Neuropsychiatric Symptoms Across the Alzheimer's Disease Spectrum.

Leonie C P Banning, Inez H G B Ramakers, Sebastian Köhler, Esther E Bron, Frans R J Verhey, Peter Paul de Deyn, Jurgen A H R Claassen, Huiberdina L Koek, Huub A M Middelkoop, Wiesje M van der Flier, Aad van der Lugt, Pauline Aalten, , ,

OBJECTIVE:To investigate the relationship between Alzheimer's disease biomarkers and neuropsychiatric symptoms. METHODS:Data from two large cohort studies, the Dutch Parelsnoer Institute - Neurodegenerative Diseases and the Alzheimer's Disease Neuroimaging Initiative was used, including subjects with subjective cognitive decline (N = 650), mild cognitive impairment (N = 887), and Alzheimer's disease dementia (N = 626). Cerebrospinal fluid ... Read more >>

Am J Geriatr Psychiatry (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry)
[2020, :]

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Orexin/hypocretinin in multiple sclerosis and experimental autoimmune encephalomyelitis.

Jean Pierre Pallais, Catherine M Kotz, Milos Stanojlovic,

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1039-1040]

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Examination of the Correlation Between Physical and Psychological Measures in Community-Dwelling Older Adults.

William H Staples, Adam Kays, Rachel Richman,

Introduction:The purpose of this study was to determine if correlations exist between strength and mobility and psychological measures of anxiety and depression in community-dwelling older adults. Methods:One hundred and eleven participants randomly completed trials of grip strength (GS), the Timed Up and Go (TUG), the 10-meter walk test (10MWT), the ... Read more >>

Clin Interv Aging (Clinical Interventions in Aging)
[2020, 15:293-300]

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Sleep quality mediates the relationship between frailty and cognitive dysfunction in non-demented middle aged to older adults.

Sonya Kaur, Nikhil Banerjee, Michelle Miranda, Mitchell Slugh, Ni Sun Suslow, Katalina F McInerney, Xiaoyan Sun, Alberto Ramos, Tatjana Rundek, Ralph L Sacco, Bonnie E Levin,

Int Psychogeriatr (International psychogeriatrics)
[2020, :1]

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A two-step surgery and a multidisciplinary approach in a centenarian patient with an acute presentation of right colon cancer.

Chiara Giannotti, Andrea Massobrio, Daniela Cannata, Alessio Nencioni, Fiammetta Monacelli, Alessandra Aprile, Domenico Soriero, Stefano Scabini, Davide Pertile,

BACKGROUND:As surgery remains the cornerstone of colorectal cancer (CRC) treatment, the number of older patients presented for colorectal resection is rapidly increasing. Nevertheless, the choice to operate an oldest-old patient still remain challenging and requires a careful assessment of risk to benefit ratio in order to guarantee appropriate surgical strategies ... Read more >>

BMC Surg (BMC surgery)
[2020, 20(1):52]

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Supporting and maintaining the frail patient on long-term renal replacement therapy.

Louise Ryan, Edwina Brown,

The number of frail patients reaching end-stage kidney disease is increasing. They have a high level of comorbidity and symptom burden which need to be considered when making management plans. For those who choose renal replacement therapy, it is important to establish goals and ceilings of care and to provide ... Read more >>

Clin Med (Lond) (Clinical medicine (London, England))
[2020, 20(2):139-141]

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Multimorbidity patterns in chronic older patients, potentially inappropriate prescribing and adverse drug reactions: protocol of the multicentre prospective cohort study MoPIM.

Marisa Baré, Susana Herranz, Rosa Jordana, Maria Queralt Gorgas, Sara Ortonobes, Daniel Sevilla, Elisabet De Jaime, Olatz Ibarra, Candelaria Martín, ,

INTRODUCTION:Multimorbidity is a major challenge for current healthcare systems and professionals. From the different approaches that have been proposed to analyse this issue, the hypothesis of the existence of association patterns of different chronic conditions is gaining visibility. In addition, multimorbidity can be associated to polypharmacy, which can lead to ... Read more >>

BMJ Open (BMJ open)
[2020, 10(1):e033322]

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Assessment of sleep and sleep disorders in geriatric patients.

Helmut Frohnhofen, Roland Popp, Sven Stieglitz, Nikolaus Netzer, Heidi Danker-Hopfe,

Sufficient and refreshing sleep is important for good health, physical and cognitive functioning as well as quality of life. An assessment of sleep quality and sleep disorders is therefore mandatory in geriatric patients. Despite a variety of clinical assessment tools for screening and diagnosing sleep disorders, only some of them have ... Read more >>

Z Gerontol Geriatr (Zeitschrift fur Gerontologie und Geriatrie)
[2020, 53(2):100-104]

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Applicability of the 48/6 Model of Care as a Health Screening Tool, and its Association with Mobility in Community-Dwelling Older Adults.

Kyeong Eun Uhm, Mooyeon Oh-Park, Yoon Sook Kim, Jae Min Park, Jaekyung Choi, Yeonsil Moon, Seol Heui Han, Jeong Hae Hwang, Kun Sei Lee, Jongmin Lee,

BACKGROUND:The 48/6 Model of Care is an integrative care initiative for improving the health outcomes of hospitalized older patients; however, its applicability in community-dwelling older adults as a health screening tool has not been investigated. The present study aimed to examine the applicability of this model, prevalence of dysfunction in ... Read more >>

J. Korean Med. Sci. (Journal of Korean medical science)
[2020, 35(7):e43]

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Motor, cognitive and mobility deficits in 1000 geriatric patients: protocol of a quantitative observational study before and after routine clinical geriatric treatment - the ComOn-study.

Johanna Geritz, Sara Maetzold, Maren Steffen, Andrea Pilotto, Marta F Corrà, Mariana Moscovich, Maria C Rizzetti, Barbara Borroni, Alessandro Padovani, Annekathrin Alpes, Corinna Bang, Igor Barcellos, Ralf Baron, Thorsten Bartsch, Jos S Becktepe, Daniela Berg, Lu M Bergeest, Philipp Bergmann, Raquel Bouça-Machado, Michael Drey, Morad Elshehabi, Susan Farahmandi, Joaquim J Ferreira, Andre Franke, Anja Friederich, Corinna Geisler, Philipp Hüllemann, Janne Gierthmühlen, Oliver Granert, Sebastian Heinzel, Maren K Heller, Markus A Hobert, Marc Hofmann, Björn Jemlich, Laura Kerkmann, Stephanie Knüpfer, Katharina Krause, Maximilian Kress, Sonja Krupp, Jennifer Kudelka, Gregor Kuhlenbäumer, Roland Kurth, Frank Leypoldt, Corina Maetzler, Luis F Maia, Andreas Moewius, Patricia Neumann, Katharina Niemann, Christian T Ortlieb, Steffen Paschen, Minh H Pham, Thomas Puehler, Franziska Radloff, Christian Riedel, Marten Rogalski, Simone Sablowsky, Elena M Schanz, Linda Schebesta, Andreas Schicketmüller, Simone Studt, Martina Thieves, Lars Tönges, Sebastian Ullrich, Peter P Urban, Nuno Vila-Chã, Anna Wiegard, Elke Warmerdam, Tobias Warnecke, Michael Weiss, Julius Welzel, Clint Hansen, Walter Maetzler,

BACKGROUND:Motor and cognitive deficits and consequently mobility problems are common in geriatric patients. The currently available methods for diagnosis and for the evaluation of treatment in this vulnerable cohort are limited. The aims of the ComOn (COgnitive and Motor interactions in the Older populatioN) study are (i) to define quantitative ... Read more >>

BMC Geriatr (BMC geriatrics)
[2020, 20(1):45]

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Cognitive behavioural therapy for the treatment of late life depression: study protocol of a multicentre, randomized, observer-blinded, controlled trial (CBTlate).

Forugh S Dafsari, Bettina Bewernick, Matthias Biewer, Hildegard Christ, Katharina Domschke, Lutz Froelich, Martin Hellmich, Melanie Luppa, Oliver Peters, Alfredo Ramirez, Steffi Riedel-Heller, Elisabeth Schramm, Magnus-Sebastian Vry, Michael Wagner, Martin Hautzinger, Frank Jessen,

BACKGROUND:Late-life depression (LLD) is one of the most prevalent mental disorders in old age. It is associated with various adverse outcomes and frequent use of health care services thereby remaining a serious public health concern. Compared with depression in early adulthood, most treatment options of LLD are less effective. Psychotherapy ... Read more >>

BMC Psychiatry (BMC psychiatry)
[2019, 19(1):423]

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Risk factors of insomnia in the elderly with special reference to depression and hypertension.

Tomoyuki Kawada,

Psychogeriatrics (Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society)
[2019, :]

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Anxiety symptoms are quantitatively and qualitatively different in dementia with Lewy bodies than in Alzheimer's disease in the years preceding clinical diagnosis.

Kurt Segers, Florence Benoit, Jean-Marie Meyts, Murielle Surquin,

AIM:Dementia with Lewy bodies (DLB) is a common but underdiagnosed type of cognitive impairment and dementia. The current diagnostic criteria for research purposes have a high specificity but lack sensitivity. Moreover, patients who live alone are not always aware that they have core clinical features such as cognitive fluctuations, visual ... Read more >>

Psychogeriatrics (Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society)
[2019, :]

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Sleep Disturbances in the Elderly Patient with Inflammatory Bowel Disease.

Taha Qazi, Francis A Farraye,

PURPOSE OF REVIEW:Studies have suggested that sleep and inflammatory bowel disease (IBD) appear to have an important bi-directional relationship, where active disease promotes sleep disruption and poor sleep promotes ongoing and worsening inflammation. In the geriatric population, poor sleep has been linked to increasing morbidity and mortality. The etiologies of ... Read more >>

Curr Treat Options Gastroenterol (Current treatment options in gastroenterology)
[2019, 17(4):470-491]

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Associations of Widowhood and β-Amyloid With Cognitive Decline in Cognitively Unimpaired Older Adults.

Kelsey D Biddle, Heidi I L Jacobs, Federico d'Oleire Uquillas, Benjamin S Zide, Dylan R Kirn, Michael R Properzi, Dorene M Rentz, Keith A Johnson, Reisa A Sperling, Nancy J Donovan,

Importance:To reduce the rising incidence of clinical impairment due to Alzheimer disease, it is essential to define older adults at highest risk. Widowhood may be an unrecognized factor contributing to accelerated clinical progression along the Alzheimer disease pathway among cognitively unimpaired older adults. Objective:To determine whether widowhood status and level ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(2):e200121]

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The role of perceived stress and cognitive function on the relationship between neuroticism and depression among the elderly: a structural equation model approach.

Mukda Banjongrewadee, Nahathai Wongpakaran, Tinakon Wongpakaran, Tanyong Pipanmekaporn, Yodying Punjasawadwong, Sirirat Mueankwan,

BACKGROUND:Depression comprises common psychological problems, and has been strongly related to neuroticism and perceived stress. While neuroticism has been shown to have a direct effect on depression, it also has an indirect effect via perceived stress. Among the elderly, cognitive function produces influences that should not be overlooked when investigating ... Read more >>

BMC Psychiatry (BMC psychiatry)
[2020, 20(1):25]

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Heart failure disease management: a systematic review of effectiveness in heart failure with preserved ejection fraction.

Fotini Kalogirou, Faye Forsyth, Martha Kyriakou, Rhys Mantle, Christi Deaton,

AIMS:Heart failure with preserved ejection fraction (HFpEF) poses a substantial challenge for clinicians, but there is little guidance for effective management. The aim of this systematic review was to determine if there was evidence that disease management programmes (DMPs) improved outcomes for patients with HFpEF. METHODS AND RESULTS:A systematic review ... Read more >>

ESC Heart Fail (ESC heart failure)
[2020, 7(1):194-212]

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Benzodiazepine and antipsychotic medication use in older adults.

Michael W Neft, Sarah Oerther, Shannon Halloway, Sandra K Hanneman, Ann M Mitchell,

Nurs Open (Nursing open)
[2020, 7(1):4-6]

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The Longitudinal Impact of Excessive Daytime Somnolence on Motor and Nonmotor Symptoms of Parkinson's Disease in a Southeast Asian Cohort.

Lai Gwen Chan, Kimberly Sim Soon Siang, Ting Ting Yong, Russell Chander, Louis Tan, Nagaendran Kandiah,

OBJECTIVE:Sleep-wake disturbances, such as excessive daytime somnolence (EDS), are nonmotor symptoms of Parkinson's disease (PD) and significantly affect the quality of life. This study aimed to examine the relationship between EDS and motor and nonmotor symptoms of PD. METHODS:Eighty-two patients with idiopathic mild PD were followed up twice a year ... Read more >>

J Geriatr Psychiatry Neurol (Journal of geriatric psychiatry and neurology)
[2019, :891988719892326]

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Epidemiology of at-risk alcohol use and associated comorbidities of interest among community-dwelling older adults: a protocol for a systematic review.

Maria Latanioti, Jean-Pierre Schuster, Joelle Rosselet Amoussou, Marie-Pierre F Strippoli, Armin von Gunten, Karsten Ebbing, Henk Verloo,

INTRODUCTION:There is little epidemiological evidence and knowledge about at-risk alcohol use among community-dwelling older adults and their chronic and acute alcohol-related comorbidities of interest. This systematic review will summarise and examine relevant studies about the epidemiology of at-risk alcohol use and associated comorbidities of interest in this population. METHODS:We will ... Read more >>

BMJ Open (BMJ open)
[2020, 10(1):e035481]

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Hemichorea Associated With Non-ketotic Hyperglycemia: A Case Report and Literature Review.

Wei Zheng, Lin Chen, Jian-Hao Chen, Xiang Lin, Yi Tang, Xiao-Juan Lin, Jing Wu, Zhao-Min Lin, Jing-Yuan Lin,

Objective: To explore the clinical manifestation, diagnosis, therapy, and mechanism of hemichorea associated with non-ketotic hyperglycemia (HC-NH) so as to enhance awareness and avoid misdiagnosis or missed diagnosis of the disease. Methods: A case of HC-NH was reported and reviewed in terms of the clinical features, diagnosis and treatment. Results: ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:96]

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Evaluation of clarity of the STOPP/START criteria for clinical applicability in prescribing for older people: a quality appraisal study.

Bastiaan Theodoor Gerard Marie Sallevelt, Corlina Johanna Alida Huibers, Wilma Knol, Eugene van Puijenbroek, Toine Egberts, Ingeborg Wilting,

OBJECTIVES:Appropriate prescribing in older people continues to be challenging. Studies still report a high prevalence of inappropriate prescribing in older people. To reduce the problem of underprescribing and overprescribing in this population, explicit drug optimisation tools like Screening Tool of Older Persons' potentially inappropriate Prescriptions/Screening Tool to Alert to Right ... Read more >>

BMJ Open (BMJ open)
[2020, 10(2):e033721]

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Advances in pain management for older patients with cancer.

Georges El Hachem, Francisco Oliveira Rocha, Thierry Pepersack, Youssef Jounblat, Annie Drowart, Lissandra Dal Lago,

The population of older patients is growing with a rising prevalence of cancer diagnoses and cancer-related pain syndromes. Older patients are also vulnerable to misleading pain evaluations and under treatment with opioids. Barriers to the effective and safe management of analgesics include pain assessments and the complex management of the ... Read more >>

Ecancermedicalscience (Ecancermedicalscience)
[2019, 13:980]

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