Warning: simplexml_load_file(): SSL operation failed with code 1. OpenSSL Error messages: error:14095126:SSL routines:ssl3_read_n:unexpected eof while reading in /home/manuscriptpro/public_html/pdf/index.php on line 429

Warning: simplexml_load_file(): SSL: Success in /home/manuscriptpro/public_html/pdf/index.php on line 429



Full Text Journal Articles about
Genetics of Asthma

Advertisement

Find full text journal articles






The ADRB3 rs4994 polymorphism increases risk of childhood and adolescent overweight/obesity for East Asia's population: an evidence-based meta-analysis.

Chenyao Xie, Wenxi Hua, Yuening Zhao, Jingwen Rui, Jiarong Feng, Yanjie Chen, Yu Liu, Jingjing Liu, Xiaoqin Yang, Xiaojing Xu,

Whether the Adrenoceptor Beta 3 (ADRB3) gene rs4994 polymorphism could affect the individual risk of childhood and adolescent overweight/obesity remains controversial. This meta-analysis was performed to estimate the prevalence of this polymorphism in overweight/obesity, and test the potential association by summarizing existing evidence. Comprehensive literature search in PubMed, Web of ... Read more >>

Adipocyte (Adipocyte)
[2020, 9(1):77-86]

Cited: 0 times

View full text PDF listing >>



Understanding the Molecular Mechanisms of Asthma through Transcriptomics.

Heung Woo Park, Scott T Weiss,

The transcriptome represents the complete set of RNA transcripts that are produced by the genome under a specific circumstance or in a specific cell. High-throughput methods, including microarray and bulk RNA sequencing, as well as recent advances in biostatistics based on machine learning approaches provides a quick and effective way ... Read more >>

Allergy Asthma Immunol Res (Allergy, asthma & immunology research)
[2020, 12(3):399-411]

Cited: 0 times

View full text PDF listing >>



Advertisement

The Pediatric Asthma Risk Score (PARS) Predicts Allergic and Non-Allergic Asthma.

Eric Schauberger, Jocelyn M Biagini Myers, Hua He, Lisa J Martin, S Hasan Arshad, Ramesh Kurukulaaratchy, Gurjit K Khurana Hershey,

Ann. Allergy Asthma Immunol. (Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Household airborne endotoxin associated with asthma and allergy in elementary school-age children: a case-control study in Kaohsiung, Taiwan.

Yu-Chuan Yen, Chun-Yuh Yang, Tsu-Nai Wang, Pei-Chun Yen, Chi-Kung Ho, Kristina D Mena, Tzu-Chi Lee, Kang-Shin Chen, Yuan-Chung Lin, Pei-Shih Chen,

To evaluate the association between the presence of asthma and allergy, and airborne endotoxin in homes of school-age children in Kaohsiung City, Taiwan, with a case-control study design by matching the age and class exposure. Data collection of home visits included an interviewer-administered questionnaire and air sampling of participants' homes ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Childhood asthma in the new omics era: challenges and perspectives.

Korneliusz Golebski, Michael Kabesch, Erik Melén, Uroš Potočnik, Cornelis M van Drunen, Susanne Reinarts, Anke H Maitland-van der Zee, Susanne J H Vijverberg, ,

PURPOSE OF REVIEW:Childhood asthma is a heterogeneous inflammatory disease comprising different phenotypes and endotypes and, particularly in its severe forms, has a large impact on the quality-of-life of patients and caregivers. The application of advanced omics technologies provides useful insights into underlying asthma endotypes and may provide potential clinical biomarkers ... Read more >>

Curr Opin Allergy Clin Immunol (Current opinion in allergy and clinical immunology)
[2020, 20(2):155-161]

Cited: 0 times

View full text PDF listing >>



A Fresh Take on the "TCA" Cycle: TETs, Citrate, and Asthma.

Steven Huang,

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Genome-wide interaction study reveals age-dependent determinants of responsiveness to inhaled corticosteroids in individuals with asthma.

Amber Dahlin, Joanne E Sordillo, Michael McGeachie, Rachel S Kelly, Kelan G Tantisira, Sharon M Lutz, Jessica Lasky-Su, Ann Chen Wu,

While genome-wide association studies have identified genes involved in differential treatment responses to inhaled corticosteroids (ICS) in asthma, few studies have evaluated the potential effects of age in this context. A significant proportion of asthmatics experience exacerbations (hospitalizations and emergency department visits) during ICS treatment. We evaluated the interaction of ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0229241]

Cited: 0 times

View full text PDF listing >>



Genetic susceptibility to severe childhood asthma and rhinovirus-C maintained by balancing selection in humans for 150 000 years.

Mary B O'Neill, Guillaume Laval, João C Teixeira, Ann C Palmenberg, Caitlin S Pepperell,

Selective pressures imposed by pathogens have varied among human populations throughout their evolution, leading to marked inter-population differences at some genes mediating susceptibility to infectious and immune-related diseases. Here, we investigated the evolutionary history of a common polymorphism resulting in a Y529 versus C529 change in the cadherin related family ... Read more >>

Hum. Mol. Genet. (Human molecular genetics)
[2020, 29(5):736-744]

Cited: 0 times

View full text PDF listing >>



Asthma - An Untoward Consequence of Endurance Sports?

Ynuk Bossé, Andréanne Côté,

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Validation of the breathmobile case identification survey for asthma screening in children with sickle cell disease.

Ashwin P Patel, Soornela Krupani, James M Stark, Ricardo A Mosquera, Dorothy Kim Waller, Traci Gonzales, Deborah L Brown, Trinh T Nguyen, Cindy K Jon, Aravind Yadav,

Background: Asthma is a chronic airway disorder with variable/recurring symptoms, airflow obstruction, bronchial hyperresponsiveness, and an inflammation. The expert panel report of the National Heart Lung and Blood Institute recommends asthma screening in sickle cell disease (SCD); however, specific approach is not mentioned. We hypothesize that the breathmobile case identification ... Read more >>

J Asthma (The Journal of asthma : official journal of the Association for the Care of Asthma)
[2020, :1-9]

Cited: 0 times

View full text PDF listing >>



Optogenetic Control of Airway Cholinergic Neurons In Vivo.

Alexandra B Pincus, Sweta Adhikary, Katherine M Lebold, Allison D Fryer, David B Jacoby,

Dysregulation of airway nerves leads to airway hyperreactivity, a hallmark of asthma. Although changes to nerve density and phenotype have been described in asthma, the relevance of these changes to nerve function has not been investigated due to anatomical limitations where afferent and efferent nerves run in the same nerve ... Read more >>

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2020, 62(4):423-429]

Cited: 0 times

View full text PDF listing >>



Smooth Muscle Differentiation Is Essential for Airway Size, Tracheal Cartilage Segmentation, but Dispensable for Epithelial Branching.

Randee E Young, Mary-Kayt Jones, Elizabeth A Hines, Rongbo Li, Yongfeng Luo, Wei Shi, Jamie M Verheyden, Xin Sun,

Airway smooth muscle is best known for its role as an airway constrictor in diseases such as asthma. However, its function in lung development is debated. A prevalent model, supported by in vitro data, posits that airway smooth muscle promotes lung branching through peristalsis and pushing intraluminal fluid to branching tips. ... Read more >>

Dev. Cell (Developmental cell)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Investigation of the Possible Role of Tie2 Pathway and TEK Gene in Asthma and Allergic Conjunctivitis.

Zsófia Gál, András Gézsi, Viktor Molnár, Adrienne Nagy, András Kiss, Monika Sultész, Zsuzsanna Csoma, Lilla Tamási, Gabriella Gálffy, Bálint L Bálint, Szilárd Póliska, Csaba Szalai,

Tie2, coded by the TEK gene, is a tyrosine kinase receptor and plays a central role in vascular stability. It was suggested that variations in the TEK gene might influence the susceptibility to asthma and allergic conjunctivitis. The aim of this study was to further investigate these suggestions, involving different ... Read more >>

Front Genet (Frontiers in Genetics)
[2020, 11:128]

Cited: 0 times

View full text PDF listing >>



Sex Differences in the Impact of Dietary Fiber on Pulmonary Responses to Ozone.

Hiroki Tashiro, David I Kasahara, Ross S Osgood, Traci Brown, Aline Cardoso, Youngji Cho, Stephanie A Shore,

Ozone causes airway hyperresponsiveness, a defining feature of asthma. We have reported that the gut microbiome contributes to sex differences in ozone-induced airway hyperresponsiveness. Altering dietary fiber affects the gut microbiome. The purpose of this study was to determine the effects of dietary fiber on pulmonary responses to ozone and ... Read more >>

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2020, 62(4):503-512]

Cited: 0 times

View full text PDF listing >>



Blocking Notch3 Signaling Abolishes MUC5AC Production in Airway Epithelial Cells from Individuals with Asthma.

Andrew T Reid, Kristy S Nichol, Punnam Chander Veerati, Fatemeh Moheimani, Anthony Kicic, Stephen M Stick, Nathan W Bartlett, Chris L Grainge, Peter A B Wark, Philip M Hansbro, Darryl A Knight,

In asthma, goblet cell numbers are increased within the airway epithelium, perpetuating the production of mucus that is more difficult to clear and results in airway mucus plugging. Notch1, Notch2, or Notch3, or a combination of these has been shown to influence the differentiation of airway epithelial cells. How the ... Read more >>

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2020, 62(4):513-523]

Cited: 0 times

View full text PDF listing >>



Joint variable selection and network modeling for detecting eQTLs.

Xuan Cao, Lili Ding, Tesfaye B Mersha,

In this study, we conduct a comparison of three most recent statistical methods for joint variable selection and covariance estimation with application of detecting expression quantitative trait loci (eQTL) and gene network estimation, and introduce a new hierarchical Bayesian method to be included in the comparison. Unlike the traditional univariate ... Read more >>

Stat Appl Genet Mol Biol (Statistical applications in genetics and molecular biology)
[2020, 19(1):]

Cited: 0 times

View full text PDF listing >>



IL-5 Exposure In Utero Increases Lung Nerve Density and Airway Reactivity in Adult Offspring.

Katie M Lebold, Matthew G Drake, Lauren B Hales-Beck, Allison D Fryer, David B Jacoby,

Asthma is characterized by airway hyperreactivity and inflammation. In the lungs, parasympathetic and sensory nerves control airway tone and induce bronchoconstriction. Dysregulation of these nerves results in airway hyperreactivity. Humans with eosinophilic asthma have significantly increased sensory nerve density in airway epithelium, suggesting that type 2 cytokines and inflammatory cells ... Read more >>

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2020, 62(4):493-502]

Cited: 0 times

View full text PDF listing >>



Conceptualization of Heterogeneity of Chronic Diseases and Atherosclerosis as a Pathway to Precision Medicine: Endophenotype, Endotype, and Residual Cardiovascular Risk.

Vadim V Genkel, Igor I Shaposhnik,

The article discusses modern approaches to the conceptualization of pathogenetic heterogeneity in various branches of medical science. The concepts of endophenotype, endotype, and residual cardiovascular risk and the scope of their application in internal medicine and cardiology are considered. Based on the latest results of studies of the genetic architecture ... Read more >>

Int J Chronic Dis (International journal of chronic diseases)
[2020, 2020:5950813]

Cited: 0 times

View full text PDF listing >>



Integrative study of the upper and lower airway microbiome and transcriptome in asthma.

Yoojin Chun, Anh Do, Galina Grishina, Alexander Grishin, Gang Fang, Samantha Rose, Chantal Spencer, Alfin Vicencio, Eric Schadt, Supinda Bunyavanich,

Relatively little is known about interactions between the airway microbiome and airway host transcriptome in asthma. Since asthma affects and is affected by the entire airway, studying the upper (e.g., nasal) and lower (e.g., bronchial) airways together represents a powerful approach to understanding asthma. Here, we performed a systematic, integrative ... Read more >>

JCI Insight (JCI insight)
[2020, 5(5):]

Cited: 0 times

View full text PDF listing >>



Admixture mapping of asthma in southwestern Europeans with North African ancestry influences.

Beatriz Guillen-Guio, Tamara Hernández-Beeftink, Itahisa Marcelino-Rodriguez, Héctor Rodríguez-Pérez, Jose M Lorenzo-Salazar, Marta Espinilla-Peña, Almudena Corrales, Maria Pino-Yanes, Ariel Callero, Eva Perez-Rodriguez, Jesús Villar, Rafaela González-Montelongo, Carlos Flores,

The prevalence of asthma symptoms in Canary Islanders, a southwestern European population from Spain, is almost three times higher than the country average. Because the genetic risks identified so far explain less than 5% of asthma heritability, here we aimed to discover new asthma loci by completing the first admixture ... Read more >>

Am. J. Physiol. Lung Cell Mol. Physiol. (American journal of physiology. Lung cellular and molecular physiology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Preface.

Bianca Schaub,

Semin Immunopathol (Seminars in immunopathology)
[2020, 42(1):1-3]

Cited: 0 times

View full text PDF listing >>



Loeys-Dietz Syndrome Presented with Giant Bullae and Asthma.

Ryobu Mori, Hisako Matsumoto, Shigeo Muro, Hiroko Morisaki, Ryozo Otsuki,

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Disease Burden and Long-Term Risk of Persistent Very Poorly Controlled Asthma: TENOR II.

Tmirah Haselkorn, Stanley J Szefler, Bradley E Chipps, Eugene R Bleecker, Michelle S Harkins, Brandee Paknis, Farid Kianifard, Benjamin Ortiz, Robert S Zeiger,

BACKGROUND:Severe/difficult-to-treat disease occurs in 5% to 10% of patients with asthma, but accounts for more than 50% of related economic costs. Understanding factors associated with persistent very poorly controlled (VPC) asthma may improve outcomes. OBJECTIVE:To characterize persistent VPC asthma after more than 10 years of standard of care. METHODS:The Epidemiology ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Join or Leave the Club: Jagged1 and Notch2 Dictate the Fate of Airway Epithelial Cells.

Virinchi Ns Kuchibhotla, Irene H Heijink,

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Design of a home-based intervention for Houston-area African-American adults with asthma: Methods and lessons learned from a pragmatic randomized trial.

Rebecca Jensen Bruhl, William Brett Perkison, Nicola A Hanania, Lorna H McNeill, Abiodun O Oluyomi, Ellen Baskin Fiesinger, Charles G Minard, Abida Solomon, Winifred J Hamilton, , Brian Butler, James Caldwell, Eunice Crosby, Cellie Davis, Hope Galvan, Rachel Harris, Frene' Lacour-Chestnut, Carol Martin, Shereda Pannell, Kathy Phipps, Gwendolyn Richardson, Adriene Solomon, William White, Jamie Boles, Adriana Rangel, Ritupreet Virk, Melissa Brock, Danielle Guffey, Uma Ramamurthy, David Persse, Salvador Maffei, Wenyaw Chan, Brenda Reyes,

A growing body of evidence demonstrates that home-based, multicomponent interventions can effectively reduce exposures to asthma triggers and decrease asthma symptoms. However, few of these studies have targeted adults. To address this and other research gaps, we designed and implemented a pragmatic randomized clinical trial, the Houston Home-based Integrated Intervention ... Read more >>

Contemp Clin Trials (Contemporary clinical trials)
[2020, 91:105977]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1.6258 s