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Generalized Epilepsies on EEG

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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

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Electro-clinical and neurodevelopmental outcome in six children with early diagnosis of tuberous sclerosis complex and role of the genetic background.

M N Savini, A Mingarelli, A Peron, F La Briola, F Cervi, R M Alfano, M P Canevini, A Vignoli,

BACKGROUND:Seizures in individuals affected by tuberous sclerosis complex (TSC) commonly develop in the first year of life, are often preceded by a progressive deterioration of the electroencephalogram (EEG), and likely influence developmental outcome. Although early diagnosis of TSC has offered a tremendous opportunity to monitor affected patients before seizure onset, ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):36]

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Electrographic seizures and ictal-interictal continuum (IIC) patterns in critically ill patients.

Sahar F Zafar, Thanujaa Subramaniam, Gamaleldin Osman, Aline Herlopian, Aaron F Struck,

Critical care long-term continuous electroencephalogram (cEEG) monitoring has expanded dramatically in the last several decades spurned by technological advances in EEG digitalization and several key clinical findings: 1-Seizures are relatively common in the critically ill-large recent observational studies suggest that around 20% of critically ill patients placed on cEEG have ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 106:107037]

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Electroencephalography in Neonatal Epilepsies.

Akihisa Okumura,

Neonatal epilepsies, neonatal seizures caused by remote symptomatic etiologies, are infrequent compared with those caused by acute symptomatic etiologies. The etiologies of neonatal epilepsies are classified into structural, genetic, and metabolic. EEG and amplitude-integrated EEG (aEEG) are essential for the diagnosis and monitoring of neonatal epilepsies. EEG/aEEG findings may differ ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, :]

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Efficacy, Tolerability, and Safety of Concentrated Intranasal Midazolam Spray as Emergency Medication in Epilepsy Patients During Video-EEG Monitoring.

Anemone von Blomberg, Lara Kay, Susanne Knake, Sven Fuest, Johann Philipp Zöllner, Philipp S Reif, Eva Herrmann, Ümniye Balaban, Susanne Schubert-Bast, Felix Rosenow, Adam Strzelczyk,

BACKGROUND:An efficient, well tolerated, and safe emergency treatment with a rapid onset of action is needed to prevent seizure clusters and to terminate prolonged seizures and status epilepticus. OBJECTIVES:This study aimed to examine the efficacy, tolerability, and safety of intranasal midazolam (in-MDZ) spray in clinical practice. METHODS:In this retrospective, multicenter ... Read more >>

CNS Drugs (CNS drugs)
[2020, :]

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Electroencephalogram studies of hypoxic ischemia in fetal and neonatal animal models.

Hamid Abbasi, Charles P Unsworth,

Alongside clinical achievements, experiments conducted on animal models (including primate or non-primate) have been effective in the understanding of various pathophysiological aspects of perinatal hypoxic/ischemic encephalopathy (HIE). Due to the reasonably fair degree of flexibility with experiments, most of the research around HIE in the literature has been largely concerned ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(5):828-837]

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Changes in Interictal Pretreatment and Posttreatment EEG in Childhood Absence Epilepsy.

Pawel Glaba, Miroslaw Latka, Małgorzata J Krause, Marta Kuryło, Wojciech Jernajczyk, Wojciech Walas, Bruce J West,

Spike and wave discharges (SWDs) are a characteristic manifestation of childhood absence epilepsy (CAE). It has long been believed that they unpredictably emerge from otherwise almost normal interictal EEG. Herein, we demonstrate that pretreatment closed-eyes theta and beta EEG wavelet powers of CAE patients (20 girls and 10 boys, mean ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:196]

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Electric source imaging for presurgical epilepsy evaluation: current status and future prospects.

Pierre Mégevand, Margitta Seeck,

Introduction: Electric source imaging (ESI) refers to the estimation of the cerebral sources of electric signals recorded at the head surface using electroencephalography (EEG). Thanks to the availability of EEG systems with high numbers of electrodes and to progress in software to analyze the signals they collect, ESI can be ... Read more >>

Expert Rev Med Devices (Expert review of medical devices)
[2020, :1-8]

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Visual seizure annotation and automated seizure detection using behind-the-ear electroencephalographic channels.

Kaat Vandecasteele, Thomas De Cooman, Jonathan Dan, Evy Cleeren, Sabine Van Huffel, Borbála Hunyadi, Wim Van Paesschen,

OBJECTIVE:Seizure diaries kept by patients are unreliable. Automated electroencephalography (EEG)-based seizure detection systems are a useful support tool to objectively detect and register seizures during long-term video-EEG recording. However, this standard full scalp-EEG recording setup is of limited use outside the hospital, and a discreet, wearable device is needed for ... Read more >>

Epilepsia (Epilepsia)
[2020, :]

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Analyzing clinical and genetic characteristics of a cohort with multiple congenital anomalies-hypotonia-seizures syndrome (MCAHS).

Xianru Jiao, Jiao Xue, Pan Gong, Xinhua Bao, Ye Wu, Yuehua Zhang, Yuwu Jiang, Zhixian Yang,

OBJECTIVE:To summarize and extend the phenotypic characterization of Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome, and to discuss genotype-phenotype correlations. METHODS:Collecting clinical information of 17 patients with pathogenic variants in PIGN, PIGA, and PIGT. Genetic studies were performed on all patients. RESULTS:There were 7 patients with 15 PIGN mutations (one patient carrying 3 ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2020, 15(1):78]

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The clinical value of long - term electroencephalogram (EEG) in seizure - free populations: implications from a cross-sectional study.

Tang Xinghua, Li Lin, Fan Qinyi, Wei Yarong, Pu Zheng, Liu Zhenguo,

BACKGROUD:This study aimed to explore the clinical value of long - term electroencephalogram (LTM EEG) in seizure-free individuals taking antiepileptic drugs (AEDs) for more than 2 years. We try to look for clinical factors associated with epileptiform activity on LTM EEG in seizure free patients. We hope that the detection of ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):88]

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Improvement of epilepsy with lacosamide in a patient with ring chromosome 20 syndrome.

Takahiro Tayama, Tatsuo Mori, Aya Goji, Yoshihiro Toda, Shoji Kagami,

BACKGROUND:Ring chromosome 20 syndrome is a rare chromosomal disorder characterized by refractory seizure, mental retardation, and behavioral problems. Although there are reports of the effective treatment of patients with antiepileptic drugs (AEDs), no study has reported the effects of lacosamide(LCM) in children with this syndrome. We report a 7-year-old boy ... Read more >>

Brain Dev. (Brain & development)
[2020, :]

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Efficacy and economic evaluation of delivery of care with tele-continuous EEG in critically ill patients: a multicentre, randomised controlled trial (Tele-cRCT) study protocol.

Chusak Limotai, Atiporn Ingsathit, Kunlawat Thadanipon, Oraluck Pattanaprateep, Anuchate Pattanateepapon, Kammant Phanthumchinda, Nijasri C Suwanwela, Iyavut Thaipisuttikul, Kanokwan Boonyapisit, Ammarin Thakkinstian,

INTRODUCTION:Some critically ill patients are confirmed by continuous electroencephalography (cEEG) monitoring that non-convulsive seizure (NCS) and/or non-convulsive status epilepticus (NCSE) are causes of their depressed level of consciousness. Shortage of epilepsy specialists, especially in developing countries, is a major limiting factor in implementing cEEG in general practice. Delivery of care ... Read more >>

BMJ Open (BMJ open)
[2020, 10(3):e033195]

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EEG Monitoring of the Epileptic Newborn.

Francesco Pisani, Carlotta Spagnoli, Carlo Fusco,

PURPOSE OF REVIEW:Although differentiating neonatal-onset epilepsies from acute symptomatic neonatal seizures has been increasingly recognized as crucial, existing guidelines, and recommendations on EEG monitoring are mainly based on acute symptomatic seizures, especially secondary to hypoxic-ischemic encephalopathy. We aimed to narratively review current knowledge on neonatal-onset epilepsies of genetic, metabolic, and ... Read more >>

Curr Neurol Neurosci Rep (Current neurology and neuroscience reports)
[2020, 20(4):6]

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Nonconvulsive status epilepticus in the elderly.

S Dupont, K Kinugawa,

There is a higher incidence of status epilepticus in the older adult population that commonly presents as nonconvulsive status epilepticus (NCSE). NCSE most often corresponds to prolonged focal seizures with impaired consciousness with three main clinical presentations: i) an unexplained acute confusional state, ii) subtle eye, motor or behavioral signs ... Read more >>

Rev. Neurol. (Paris) (Revue neurologique)
[2020, :]

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Epileptic seizure recognition using EEG wavelet decomposition based on nonlinear and statistical features with support vector machine classification.

Dib Nabil, Radhwane Benali, Fethi Bereksi Reguig,

Epileptic seizure (ES) is a neurological brain dysfunction. ES can be detected using the electroencephalogram (EEG) signal. However, visual inspection of ES using long-time EEG recordings is a difficult, time-consuming and a costly procedure. Thus, automatic epilepsy recognition is of primary importance. In this paper, a new method is proposed ... Read more >>

Biomed Tech (Berl) (Biomedizinische Technik. Biomedical engineering)
[2020, 65(2):133-148]

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Comparison of pseudocontinuous arterial spin labeling perfusion MR images and time-of-flight MR angiography in the detection of periictal hyperperfusion.

Noritoshi Shirozu, Takato Morioka, So Tokunaga, Takafumi Shimogawa, Daisuke Inoue, Shoji Arihiro, Ayumi Sakata, Nobutaka Mukae, Sei Haga, Koji Iihara,

Background:Magnetic resonance imaging (MRI), including perfusion MRI with three-dimensional pseudocontinuous arterial spin labeling (ASL) and diffusion-weighted imaging (DWI), are applied in the periictal (including ictal and postictal) detection of circulatory and metabolic consequences associated with epilepsy. Our previous report revealed that periictal hyperperfusion can firstly be detected on ASL, and ... Read more >>

eNeurologicalSci (eNeurologicalSci)
[2020, 19:100233]

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Cingulate gyrus epilepsy: semiology, invasive EEG, and surgical approaches.

Chien-Chen Chou, Cheng-Chia Lee, Chun-Fu Lin, Yi-Hsiu Chen, Syu-Jyun Peng, Fu-Jung Hsiao, Hsiang-Yu Yu, Chien Chen, Hsin-Hung Chen, Yang-Hsin Shih,

OBJECTIVE:The semiology of cingulate gyrus epilepsy is varied and may involve the paracentral area, the adjacent limbic system, and/or the orbitofrontal gyrus. Invasive electroencephalography (iEEG) recording is usually required for patients with deeply located epileptogenic foci. This paper reports on the authors' experiences in the diagnosis and surgical treatment of ... Read more >>

Neurosurg Focus (Neurosurgical focus)
[2020, 48(4):E8]

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Characterization of Pediatric Seizures in the Commonwealth of the Northern Mariana Islands.

Ahana Yogesh, Michael Taylor, And Mary P Chang,

Saipan is a United States (US) territory Western Pacific island where little recent data exists regarding epidemiology, clinical presentation, and standard of care for pediatric seizures. This paper characterizes these features in Saipan's pediatric population with comparisons to mainland US. This is a retrospective chart review of all pediatric patients ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2020, 7(4):]

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Clinical and Genetic Profile of Autism Spectrum Disorder-Epilepsy (ASD-E) Phenotype: Two Sides of the Same Coin!

Sudhakar Karunakaran, Ramshekhar N Menon, Sruthi S Nair, S Santhakumar, Muralidharan Nair, Soumya Sundaram,

The clinical phenotype of autism spectrum disorder and epilepsy (ASD-E) is a common neurological presentation in various genetic disorders, irrespective of the underlying pathophysiological mechanisms. Here we describe the demographic and clinical profiles, coexistent neurological conditions, type of seizures, epilepsy syndrome, and EEG findings in 11 patients with ASD-E phenotype ... Read more >>

Clin EEG Neurosci (Clinical EEG and neuroscience)
[2020, :1550059420909673]

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Use of Combined Electroencephalography and Tilt Table Testing to Determine Etiology of Loss of Consciousness.

Neeraj Singh, Timothy Lynch, Anthony Ritaccio,

Tilt table testing is a common noninvasive diagnostic test performed to reproduce and evaluate syncope in a vulnerable patient and subsequently guide therapy. Electroencephalography (EEG) is typically useful for identifying interictal and ictal abnormalities within the context of epilepsy or suspected epilepsy. We report a series of patients who underwent ... Read more >>

Neurodiagn J (The Neurodiagnostic journal)
[2020, 60(1):36-40]

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Detection of Postictal Generalized Electroencephalogram Suppression: Random Forest Approach.

Xiaojin Li, Shiqiang Tao, Shirin Jamal-Omidi, Yan Huang, Samden D Lhatoo, Guo-Qiang Zhang, Licong Cui,

BACKGROUND:Sudden unexpected death in epilepsy (SUDEP) is second only to stroke in neurological events resulting in years of potential life lost. Postictal generalized electroencephalogram (EEG) suppression (PGES) is a period of suppressed brain activity often occurring after generalized tonic-clonic seizure, a most significant risk factor for SUDEP. Therefore, PGES has ... Read more >>

JMIR Med Inform (JMIR medical informatics)
[2020, 8(2):e17061]

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Novel CDKL5 mutations were found in patients in China: retrospective investigation in cases of CDKL5-related disorders.

Yumei Yan, Dake He, Jing Wu, Ruolin Hou, Kun Sun, Ling Li,

OBJECTIVE:CDKL5-related disorders (CDD) is an epileptic encephalopathy resulted of gene mutations of CDKL5. This study aimed to explore the development process of CDD and to expand its mutation spectrum. METHODS:Clinic datawas collected about three infantile epileptic encephalopathy cases diagnosed at Xinhua Hospital Affiliated to Shanghai Jiaotong University, School of Medicine. ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):27]

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Status Epilepticus Manifested as Continuous Epileptic Spasms.

Jianxiang Liao, Tieshuan Huang, Myriam Srour, Yuhan Xiao, Yan Chen, Sufang Lin, Li Chen, Yan Hu, Lina Men, Jialun Wen, Bing Li, Feiqiu Wen, Lan Xiong,

Objective: The etiology and outcome of status epilepticus with continuous epileptic spasms have not been fully understood; and only rare cases have been reported in the literature. Here, we described 11 children, who manifested continuous epileptic spasms with various etiologies and different outcomes. Methods: This is a case series study ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:65]

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Spatiotemporal patterns of high-frequency activity (80-170 Hz) in long-term intracranial EEG

Zhuying Chen, David Grayden, Anthony Burkitt, Udaya Seneviratne, Wendyl D’Souza, Chris French, Philippa Karoly, Katrina Dell, Mark Cook, Matias Maturana,

Abstract Objective To assess the variability in the rates and locations of high-frequency activity (HFA) and epileptiform spikes after electrode implantation, and to examine the long-term patterns of HFA using ambulatory intracranial EEG (iEEG) recordings. Methods Continuous iEEG recordings obtained over an average of 1.4 years from 15 patients with ... Read more >>

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