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Fungemia and Other Fungal Infections Associated with Use of Saccharomyces boulardii Probiotic Supplements.

Juha Rannikko, Ville Holmberg, Matti Karppelin, Pertti Arvola, Reetta Huttunen, Eero Mattila, Niina Kerttula, Teija Puhto, Ülle Tamm, Irma Koivula, Risto Vuento, Jaana Syrjänen, Ulla Hohenthal,

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(8):]

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Trichosporon asahii superinfections in critically ill COVID-19 patients overexposed to antimicrobials and corticosteroids.

João Nobrega de Almeida, Lis Moreno, Elaine Cristina Francisco, Gabriela Noronha Marques, Ana Verena Mendes, Maria Goreth Barberino, Arnaldo Lopes Colombo,

<h4>Objectives</h4>To investigate the occurrence of Trichosporon asahii fungemia among critically ill COVID-19 patients.<h4>Methods</h4>From 1 July to 30 September 2020, cases of T asahii fungemia (TAF) in a Brazilian COVID-19 referral centre were investigated. The epidemiology and clinical courses were detailed, along with a mycological investigation that included molecular species identification, ... Read more >>

Mycoses (Mycoses)
[2021, 64(8):817-822]

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A successful daptomycin and micafungin dosing strategy in veno-venous ECMO and continuous renal replacement.

M Gabriela Cabanilla, Nicholas Villalobos,

<h4>What is known and objective</h4>Studies have demonstrated that ECMO leads to pharmacokinetic changes, with alterations in volume of distribution, clearance and drug sequestration by the circuit. We describe a successful dosing approach for daptomycin and micafungin for the treatment of VRE faecium bacteremia and C. glabrata fungemia in a patient receiving ... Read more >>

J Clin Pharm Ther (Journal of clinical pharmacy and therapeutics)
[2021, :]

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Isolation of Candida auris in large hospitals in the Autonomous Community of Valencia; population-based study (2013-2017).

Laura Ruiz-Azcona, Miguel Santibañez, Francisco Javier Roig, Hermelinda Vanaclocha, Maria Paz Ventero, Vicente Boix, Joaquín Portilla-Sogorb, José Sánchez-Paya, Esperanza Merino, Juan Carlos Rodriguez,

<h4>Background</h4>Candida auris is an emerging multidrug-resistant and highly virulent yeast that spreads easily among patients.<h4>Aims</h4>To describe the characteristics of candidemia caused by C. auris in the southeast of Spain (Autonomous Community of Valencia - ACV) through a 5-year population-based study.<h4>Methods</h4>An analysis of all the episodes of candidemia diagnosed in the ... Read more >>

Rev Iberoam Micol (Revista iberoamericana de micologia)
[2021, :]

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Development and validation of a risk score for predicting positivity of blood cultures and mortality in patients with bacteremia and fungemia.

Felipe Francisco Tuon, João Paulo Telles, Juliette Cieslinski, Marilia Burdini Borghi, Raquel Zanella Bertoldo, Victoria Stadler Tasca Ribeiro,

<h4>Introduction</h4>Bacteremia is a major cause of morbidity and mortality in hospitalized patients. Predictors of mortality are critical for the management and survival of hospitalized patients. The objective of this study was to determine the factors related to blood culture positivity and the risk factors for mortality in patients whose blood ... Read more >>

Braz J Microbiol (Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology])
[2021, :]

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Risk factors and biofilm formation analyses of hospital-acquired infection of Candida pelliculosa in a neonatal intensive care unit.

Zhijie Zhang, Yu Cao, Yanjian Li, Xufang Chen, Chen Ding, Yong Liu,

<h4>Background</h4>Candida pelliculosa is an ecological fungal species that can cause infections in immunocompromised individuals. Numerous studies globally have shown that C. pelliculosa infects neonates. An outbreak recently occurred in our neonatal intensive care unit; therefore, we aimed to evaluate the risk factors in this hospital-acquired fungal infection.<h4>Methods</h4>We performed a case-control ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2021, 21(1):620]

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Disseminated Candida lusitaniae: Nosocomial Acquisition Secondary to an Indwelling Urinary Catheter.

Ali Raja, Julia Park,

<i>Candida lusitaniae</i> is a rare opportunistic pathogen, and its most common risk factors include immunocompromised patients often with an underlying malignancy. It commonly displays resistance to amphotericin B, and historically, echinocandins have been considered first-line treatment. We present a 77-year-old male with a history of diabetes mellitus. He was treated ... Read more >>

Case Rep Infect Dis (Case reports in infectious diseases)
[2021, 2021:6632730]

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Two different clones of Candida pelliculosa bloodstream infection in a tertiary neonatal intensive care unit.

Yulan Yang, Weiyuan Wu, Lu Ding, Lin Yang, Jinzhen Su, Benqing Wu,

<h4>Introduction</h4>Fungemia in preterm infants results in high mortality and morbidity. The genotypes, drug susceptibilities of Candida pelliculosa strains, and clinical features of two outbreaks of neonatal candidemia caused by C. pelliculosa were analyzed, in order to provide evidence for the outbreaks and characteristics of C. pelliculosa neonatal candidemia.<h4>Methodology</h4>The strains were ... Read more >>

J Infect Dev Ctries (Journal of infection in developing countries)
[2021, 15(6):870-876]

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A Report of Candida blankii Fungemia and Possible Endocarditis in an Immunocompetent Individual and the Review of Literature.

Vidya S Kollu, Pramod K Kalagara, Shehla Islam, Asmita Gupte,

<i>Candida blankii</i> is an emerging pathogenic fungus, first identified in 1968 as a new species. In the past five years, it has been identified in cystic fibrosis patient's airways and as fungemia in immunocompromised patients (post lung transplant and preterm neonates). It has been postulated to be a possible opportunistic pathogen based ... Read more >>

Cureus (Cureus)
[2021, 13(5):e14945]

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No Impact of Fluconazole to Echinocandins Replacement as First-Line Therapy on the Epidemiology of Yeast Fungemia (Hospital-Driven Active Surveillance, 2004-2017, Paris, France).

Stéphane Bretagne, Marie Desnos-Ollivier, Karine Sitbon, Olivier Lortholary, Didier Che, Françoise Dromer, ,

Replacement of fluconazole by echinocandins as the first-line therapy for yeast-related fungemia could have an impact on both the mortality rate and the epidemiology of yeast species responsible for candidemia. We analyzed the individual clinical and microbiological data collected through the active surveillance program on yeast fungemia (YEASTS program, 2004-2016, ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:641965]

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Disseminated nontuberculous mycobacteriosis and fungemia after second delivery in a patient with MonoMAC syndrome/GATA2 mutation: a case report.

Mizuki Haraguchi, Norihiro Harada, Junko Watanabe, Hitomi Yoshikawa, Yukina Shirai, Moegi Komura, Mika Koyama, Jun Ito, Yutaka Tsukune, Yoshiya Horimoto, Takuo Hayashi, Tetsutaro Nagaoka, Toshimasa Uekusa, Kazuhisa Takahashi,

<h4>Background</h4>Heterozygous mutations in the transcription factor GATA2 result in a wide spectrum of clinical phenotypes, including monocytopenia and Mycobacterium avium complex (MAC) infection (MonoMAC) syndrome. Patients with MonoMAC syndrome typically are infected by disseminated nontuberculous mycobacteria, fungi, and human papillomavirus, exhibit pulmonary alveolar proteinosis during late adolescence or early adulthood, ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2021, 21(1):502]

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Axillary Digital Thermometers uplifted a multidrug-susceptible Candida auris outbreak among COVID-19 patients in Brazil.

João Nobrega de Almeida, Igor B Brandão, Elaine C Francisco, Silvio Luis R de Almeida, Patrícia de Oliveira Dias, Felicidade M Pereira, Fábio Santos Ferreira, Thaisse Souza de Andrade, Magda M de Miranda Costa, Regiane T de Souza Jordão, Jacques F Meis, Arnaldo L Colombo, ,

<h4>Objectives</h4>To describe the first outbreak of Candida auris in Brazil, including epidemiological, clinical and microbiological data.<h4>Methods</h4>After the first Candida auris-colonised patient was diagnosed in a COVID-19 ICU at a hospital in Salvador, Brazil, a multidisciplinary team conducted a local C. auris prevalence investigation. Screening cultures for C. auris were collected ... Read more >>

Mycoses (Mycoses)
[2021, :]

Cited: 1 time

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False-positive HIV serology, Candida lusitaniae pneumonia, and a novel mutation in the CYBB gene.

Aaqib Zaffar Banday, Lokesh Nataraj, Ankur Kumar Jindal, Harsimran Kaur, Anjani Gummadi, Madhubala Sharma, Vignesh Pandiarajan, Amit Rawat,

<h4>Background</h4>Chronic granulomatous disease (CGD) presents with a myriad of clinical manifestations pertaining to both immunodeficiency and hyperinflammation. Although Candida infection is a signature organism for patients with CGD, C. lusitaniae pneumonia in CGD has rarely been reported. C. lusitaniae is a ubiquitous ascomycete predominantly infecting immunocompromised hosts and has the ... Read more >>

Immunobiology (Immunobiology)
[2021, 226(4):152110]

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A Case of Multiple Organ Disseminated Cryptococcosis.

Rebecca Masel, Karl Herman, Kwame Dapaah-Afriyie,

Cryptococcus neoformans is an encapsulated yeast found worldwide.1 Patients with immunosuppression, including individuals with HIV/AIDS, transplant recipients and/or individuals with other T-cell mediated immunosuppression are more susceptible to becoming infected with Cryptococcus neoformans than immunocompetent individuals.2 This is a case report of a 66-year-old woman who presented to the emergency ... Read more >>

R I Med J (2013) (Rhode Island medical journal (2013))
[2021, 104(5):44-46]

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The proportion, species distribution and dynamic trends of bloodstream infection cases in a tertiary hospital in China, 2010-2019.

Jiewei Cui, Meng Li, Jiemin Cui, Juan Wang, Xiaofei Qiang, Zhixin Liang,

<h4>Background</h4>Recent epidemiological studies on bloodstream infection (BSI) that include the proportion, species distribution and dynamic changes are scarce in China. This study was performed to understand these epidemiological data of BSI over the past 10 years in China.<h4>Methods</h4>Using a prospective nosocomial infection surveillance system, this study was retrospectively performed in one ... Read more >>

Infection (Infection)
[2021, :]

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Diffuse Recalcitrant Osteomyelitis and Joint Septicemia Because of Bowel Perforation Secondary to Gunshot Injury: A Case Report.

David E Ruckle, Rebecca Rajfer, Joseph P Johnson,

<h4>Case</h4>A previously healthy 22-year-old man was brought into the emergency department after sustaining a low-velocity, civilian gunshot wound to the abdomen that perforated the bowel. Over the next 300 days, he would be admitted and discharged multiple times, requiring a total of 48 debridements, 23 different antimicrobials in 81 unique ... Read more >>

JBJS Case Connect (JBJS case connector)
[2021, 11(2):]

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Epidemiological characteristics and drug resistance of fungemia: a 10-year data analysis in general hospitals

Yunxi LIU, Yanling Bai, Zhigang Zheng, Ting Liu, Zhongqiang Yan, Mingmei Du, Hongwu Yao, Jijiang Suo,

<h4>Background: </h4> with the increasing use of immunosuppressive agents, broad-spectrum antibiotics and biological agents, the incidence rate of fungemia has been increasing, and the drug resistance has been widely concerned. However, the epidemic trend and drug resistance analysis of fungal bloodstream infection are lack of large sample data. This study ... Read more >>

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COVID-19 and Candida duobushaemulonii superinfection: A case report.

Bassem Awada, Walid Alam, Maria Chalfoun, George Araj, Abdul Rahman Bizri,

<h4>Introduction</h4>Critically ill COVID-19 patients are at high risk for nosocomial bacterial and fungal infections due to several predisposing factors such as intensive care unit stay, mechanical ventilation, and broad-spectrum antibiotics. Data regarding multidrug resistant (MDR) Candida species in COVID-19 patients is scarce, and nonexistent regarding Candida duobushaemulonii superinfections.<h4>Case description</h4>A 34-year-old ... Read more >>

J Mycol Med (Journal de mycologie medicale)
[2021, 31(3):101168]

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Oligonucleotide-capped nanoporous anodic alumina biosensor as diagnostic tool for rapid and accurate detection of Candida auris in clinical samples.

Luis Pla, Sara Santiago-Felipe, María Ángeles Tormo-Mas, Alba Ruiz-Gaitán, Javier Pemán, Eulogio Valentín, Félix Sancenón, Elena Aznar, Ramón Martínez-Máñez,

<i>Candida auris</i> has arisen as an important multidrug-resistant fungus because of several nosocomial outbreaks and elevated rates of mortality. Accurate and rapid diagnosis of <i>C. auris</i> is highly desired; nevertheless, current methods often present severe limitations and produce misidentification. Herein a sensitive, selective, and time-competitive biosensor based on oligonucleotide-gated nanomaterials ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):407-415]

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Low sensitivity of conventional fungal agars in fungemia by Rhodotorula mucilaginosa: description of two cases.

Carmen Alicia Garcia-Gutiérrez, María Soledad Cuétara-García, María Dolores Moragues, Jorge Ligero, Sara María Quevedo, María José Buitrago,

<h4>Background</h4>Although most bloodstream yeast infections are caused by Candida spp., infections by rare or less common species have increased in recent years. Diagnosis of infections caused by these species is difficult due to the lack of specific symptoms and adequate diagnostic tools.<h4>Cases presentation</h4>We describe two cases of fungemia by Rhodotorula ... Read more >>

Ann Clin Microbiol Antimicrob (Annals of clinical microbiology and antimicrobials)
[2021, 20(1):21]

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Invasive Candidiasis Associated with Adenovirus Pneumonia.

Guwani Liyanage, Madhusha Gonapaladeniya, Thushari Dissanayake,

Invasive <i>Candida</i> infections in immunocompetent children lead to high morbidity and mortality despite available treatment. <i>Candida albicans</i> and <i>Candida parapsilosis</i> are the most common pathogens; however, there are newly emerging pathogenic non-<i>albicans</i> species. Adenovirus accounts for at least 5-10% of respiratory infections in children, and specific serotypes are associated with ... Read more >>

Case Rep Pediatr (Case reports in pediatrics)
[2021, 2021:9905474]

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Candida auris Fungemia and a local spread taken under control with infection control measures: First report from Turkey.

Ahmet Furkan Kurt, Mert Ahmet Kuskucu, IIker Inanc Balkan, Ayse Baris, Zeynep Yazgan, Ayşe Serife Oz, Ayse Istanbullu Tosun, Bilgul Mete, Fehmi Tabak, Gokhan Aygun,

Candidaauris, draws attention as a new emerging antifungal resistant pathogen, leading to healthcare-associated infections and outbreaks. This is the first report of C. auris fungemia in a 81-year-old patient, confirmed by sequential analysis, from Turkey. Although the source of the isolate could not be identified, its spread in the hospital has ... Read more >>

Indian J Med Microbiol (Indian journal of medical microbiology)
[2021, 39(2):228-230]

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Monitoring the Epidemiology and Antifungal Resistance of Yeasts Causing Fungemia in a Tertiary Care Hospital in Madrid, Spain: Any Relevant Changes in the Last 13 Years?

Judith Díaz-García, Aina Mesquida, Carlos Sánchez-Carrillo, Elena Reigadas, Patricia Muñoz, Pilar Escribano, Jesús Guinea,

We conducted an updated analysis on yeast isolates causing fungemia in patients admitted to a tertiary hospital in Madrid, Spain, over a 13-year period. We studied 896 isolates associated with 872 episodes of fungemia in 857 hospitalized patients between January 2007 and December 2019. Antifungal susceptibility was assessed by EUCAST ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2021, 65(4):]

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Fungal Infections in Liver Transplant Recipients.

Michael Scolarici, Margaret Jorgenson, Christopher Saddler, Jeannina Smith,

Invasive fungal infections (IFIs) are one of the most feared complications associated with liver transplantation, with high rates of morbidity and mortality. We discuss the most common invasive fungal infections in the setting of liver transplant, including <i>Candida</i>, <i>Aspergillus</i>, and <i>Cryptococcal</i> infections, and some less frequent but devastating mold infections. ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2021, 7(7):]

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Candidemia among Iranian Patients with Severe COVID-19 Admitted to ICUs.

Amir Arastehfar, Tahmineh Shaban, Hossein Zarrinfar, Maryam Roudbary, Mona Ghazanfari, Mohammad-Taghi Hedayati, Alireza Sedaghat, Macit Ilkit, Mohammad Javad Najafzadeh, David S Perlin,

As a novel risk factor, COVID-19 has led to an increase in the incidence of candidemia and an elevated mortality rate. Despite being of clinical importance, there is a lack of data regarding COVID-19-associated candidemia (CAC) among Iranian patients. Therefore, in this retrospective study, we assessed CAC epidemiology in the ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2021, 7(4):]

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