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Zika virus infects human osteoclasts and blocks differentiation and bone resorption.

Noreen Mumtaz, Marijke Koedam, Johannes P T M van Leeuwen, Marion P G Koopmans, Bram C J van der Eerden, Barry Rockx,

Bone-related complications are commonly reported following arbovirus infection. These arboviruses are known to disturb bone-remodeling and induce inflammatory bone loss via increased activity of bone resorbing osteoclasts (OCs). We previously showed that Zika virus (ZIKV) could disturb the function of bone forming osteoblasts, but the susceptibility of OCs to ZIKV ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2022, 11(1):1621-1634]

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Broad-spectrum anti-flavivirus activity and chemistry of compounds containing sulfur and oxygen chalcogens.

Maria Sole Burali, Violetta Cecchetti, Giuseppe Manfroni,

Sulfur and oxygen containing-compounds are a relevant class of derivatives that is constantly growing due to their wide range of pharmacological activity, including the antiviral one. As a proof of this, there are several FDA approved antiviral compounds having sulfur and oxygen in their structures. Among RNA viruses, the flavivirus ... Read more >>

Curr Med Chem (Current medicinal chemistry)
[2022, :]

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