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Satisfaction of young ENT surgeons with their work. A Finnish national study.

Elina Penttilä, Samuli Hannula, Jura Numminen, Heikki Irjala, Tuomas Selander, Piitu Parmanne, Antti Mäkitie,

The objective was to investigate work satisfaction among recently graduated otorhinolaryngologist - head and neck surgeons - (ENT surgeons). An electronic questionnaire was sent to all ENT surgeons graduated in Finland during a ten-year period. Answers about work satisfaction were analyzed in detail with regards to age, gender, university of ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1925445]

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Influence of early-life body mass index and systolic blood pressure on left ventricle in adulthood - the Cardiovascular Risk in Young Finns Study.

Jarkko S Heiskanen, Jussi A Hernesniemi, Saku Ruohonen, Nina Hutri-Kähönen, Mika Kähönen, Eero Jokinen, Päivi Tossavainen, Merja Kallio, Tomi Laitinen, Terho Lehtimäki, Jorma Viikari, Markus Juonala, Jaakko Nevalainen, Olli T Raitakari,

<h4>Background</h4>Increased left ventricular mass (LVM) predicts cardiovascular events and mortality. The objective of this study was to determine whether early-life exposures to body mass index (BMI) and systolic blood pressure (SPB) affects the left ventricular structure in adulthood.<h4>Methods</h4>We used longitudinal data from a 31-year follow-up to examine the associations between ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):160-168]

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Bacterial quality and safety of raw beef: A comparison between Finland and Nigeria

Etinosa Osemwowa, Iyekhoetin Matthew Omoruyi, Paula Kurittu, Annamari Heikinheimo, Maria Fredriksson-Ahomaa,

Beef can easily be contaminated with bacteria during the meat production chain. In this work, we studied the contamination levels of mesophilic aerobic bacteria (MAB) and thermotolerant coliform bacteria (TCB) on raw beef surfaces from small shops in Helsinki, Finland and meat markets in Benin City, Nigeria. We also investigated ... Read more >>

Food Microbiol (Food microbiology.)
[2021, 100:Not Available]

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Factors predicting 31-year survival among a population cohort in Northern Finland.

Yrjö Perkkiö, Juha Auvinen, Markku Timonen, Jari Jokelainen, Nihkolas Valkeapää, Markku Koiranen, Juha Saltevo, Sirkka Keinänen-Kiukaanniemi,

We evaluated the survival of a subarctic population and the significance of traditional risk factors for mortality, causes of death and their seasonal variation from the period of 1984-2014. By the end of 2014 (follow-up), 644 (34.4% from 1,869) participants had died (42.1% of cardiovascular causes, 22.4% of neoplastic diseases). ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1909334]

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Neural-level associations of non-verbal pragmatic comprehension in young Finnish autistic adults.

Aija Kotila, Jussi Tohka, Jukka-Pekka Kauppi, Ilaria Gabbatore, Leena Mäkinen, Tuula M Hurtig, Hanna E Ebeling, Vesa Korhonen, Vesa J Kiviniemi, Soile Loukusa,

This video-based study examines the pragmatic non-verbal comprehension skills and corresponding neural-level findings in young Finnish autistic adults, and controls. Items from the Assessment Battery of Communication (ABaCo) were chosen to evaluate the comprehension of non-verbal communication. Inter-subject correlation (ISC) analysis of the functional magnetic resonance imaging data was used ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1909333]

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Risk factors for major adverse cardiovascular events after the first acute coronary syndrome.

Marjo Okkonen, Aki S Havulinna, Olavi Ukkola, Heikki Huikuri, Arto Pietilä, Heli Koukkunen, Seppo Lehto, Juha Mustonen, Matti Ketonen, Juhani Airaksinen, Y Antero Kesäniemi, Veikko Salomaa,

<h4>Aims</h4>To evaluate risk factors for major adverse cardiac event (MACE) after the first acute coronary syndrome (ACS) and to examine the prevalence of risk factors in post-ACS patients.<h4>Methods</h4>We used Finnish population-based myocardial infarction register, FINAMI, data from years 1993-2011 to identify survivors of first ACS (<i>n</i> = 12686), who were then followed ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):817-823]

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Fatty liver index predicts incident risk of prediabetes, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).

Daniel J Cuthbertson, Juha Koskinen, Emily Brown, Costan G Magnussen, Nina Hutri-Kähönen, Matthew Sabin, Päivi Tossavainen, Eero Jokinen, Tomi Laitinen, Jorma Viikari, Olli T Raitakari, Markus Juonala,

<h4>Aims</h4>To investigate the association between overweight/obesity and fatty liver index (FLI) on the odds of incident prediabetes/type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) in 2020 participants after 10 years follow up.<h4>Methods</h4>At baseline (in 2001) 2020 participants, males and females, aged 24-39 years, were stratified according to body mass index (BMI), ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1256-1264]

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Development of cancer support services for patients and their close ones from the Cancer Society of Finland's perspective.

Heli Tiirola, Veli-Matti Poutanen, Riitta Vornanen, Liisa Pylkkänen,

<b>Purpose</b>: This study examined what support cancer patients and their close ones need and how this support should be organized when developing cancer care pathways. The study focused on the opinions of professionals of the Cancer Society of Finland (CSF), who play a central role in presenting the third sector's ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2021, 16(1):1915737]

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School professionals committed to student well-being.

Anna Onnela, Tuula Hurtig, Hanna Ebeling,

The northern provinces of Finland are mostly not densely populated, with long distances to healthcare services. This creates a challenge for how to reach all children and adolescents with mental health services. In order to assess the effectiveness of school-based mental health promotion interventions, it is essential to understand the ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1873589]

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Childhood exposure to parental smoking and life-course overweight and central obesity.

Johanna M Jaakkola, Suvi P Rovio, Katja Pahkala, Jorma Viikari, Tapani Rönnemaa, Antti Jula, Harri Niinikoski, Juha Mykkänen, Markus Juonala, Nina Hutri-Kähönen, Mika Kähönen, Terho Lehtimäki, Olli T Raitakari,

<h4>Objective</h4>To evaluate the association between childhood parental smoking exposure and the risk of overweight/obesity from childhood to adulthood.<h4>Methods</h4>This study leverages the data from two longitudinal population based cohort studies, the Cardiovascular Risk in Young Finns Study between years 1980-2011/2012 (YFS; <i>N</i> = 2,303; baseline age 3-18 years) and the Special Turku Coronary Risk ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):208-216]

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Inadequate oral anticoagulation with warfarin in women with cerebrovascular event and history of atrial fibrillation: the FibStroke study.

Aissa Bah, Ilpo Nuotio, Antti Palomäki, Pirjo Mustonen, Tuomas Kiviniemi, Antti Ylitalo, Päivi Hartikainen, K E Juhani Airaksinen, Juha E K Hartikainen,

<h4>Background</h4>Women with atrial fibrillation (AF) may be treated less actively with oral anticoagulation (OAC) than men.<h4>Patients and methods</h4>We assessed sex differences in the implementation of stroke risk stratification with CHADS<sub>2</sub> and CHA<sub>2</sub>DS<sub>2</sub>-VASc scores and reasons not to use OAC in 1747 AF patients suffering their first cerebrovascular event after the AF ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):287-294]

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Blood alcohol levels in Finnish victims of non-ischaemic sudden cardiac death.

Janna P Kauppila, Lasse Pakanen, Katja Porvari, Juha Vähätalo, Lauri Holmström, Juha S Perkiömäki, Heikki V Huikuri, M Juhani Junttila,

<h4>Introduction</h4>Non-ischaemic heart disease (NIHD) is the underlying pathology in∼20% of all sudden cardiac deaths (SCDs). Heavy drinking is known to be associated with SCD due to ischaemic heart disease, but studies on association of recent alcohol consumption and SCD in patients with NIHD are scarce. We evaluated the blood alcohol ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):413-419]

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IL-6 and other biomarkers as predictors of severity in COVID-19.

N Broman, K Rantasärkkä, T Feuth, M Valtonen, M Waris, U Hohenthal, E Rintala, A Karlsson, H Marttila, V Peltola, T Vuorinen, J Oksi,

<h4>Objective</h4>Cytokine release syndrome is suggested to be the most important mechanism triggering acute respiratory distress syndrome and end organ damage in COVID-19. The severity of disease may be measured by different biomarkers.<h4>Methods</h4>We studied markers of inflammation and coagulation as recorded in 29 patients on admission to the hospital in order ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):410-412]

Cited: 5 times

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COVID-19: anxiety among hospital staff and associated factors.

Elina Mattila, Jaana Peltokoski, Marko H Neva, Marja Kaunonen, Mika Helminen, Anna-Kaisa Parkkila,

<h4>Background</h4>During the COVID-19 pandemic, hospital staff have experienced a variety of mental health challenges. European research on anxiety and stress among hospital workers during the pandemic is limited. This study aimed to describe the anxiety levels of Finnish hospital workers during the COVID-19 pandemic.<h4>Methods</h4>The multidimensional, cross-sectional survey was distributed to ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):237-246]

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MercuNorth - monitoring mercury in pregnant women from the Arctic as a baseline to assess the effectiveness of the Minamata Convention.

Bryan Adlard, Mélanie Lemire, Eva C Bonefeld-Jørgensen, Manhai Long, Kristín Ólafsdóttir, Jon O Odland, Arja Rautio, Päivi Myllynen, Torkjel M Sandanger, Alexey A Dudarev, Ingvar A Bergdahl, Maria Wennberg, James Berner, Pierre Ayotte,

Exposure to mercury (Hg) is a global concern, particularly among Arctic populations that rely on the consumption of marine mammals and fish which are the main route of Hg exposure for Arctic populations.The MercuNorth project was created to establish baseline Hg levels across several Arctic regions during the period preceding ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1881345]

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Differences between recorded diagnoses of patients of an emergency department and office-hours primary care doctors: a register-based study in a Finnish town.

Mika Lehto, Katri Mustonen, Marko Raina, Timo Kauppila,

To determine the extent to which it is possible to provide continuity of primary care for those who visit Emergency Departments (EDs) we studied how recorded diagnoses in primary care differ, depending on whether the patient is met in an ED or a primary care office-hours practice. In the present, ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1935593]

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Higher carotid-radial pulse wave velocity is associated with non-melancholic depressive symptoms in men - findings from Helsinki Birth Cohort Study.

Mia D Eriksson, Johan G Eriksson, Hannu Kautiainen, Minna K Salonen, Tuija M Mikkola, Eero Kajantie, Niko Wasenius, Mikaela von Bonsdorff, Päivi Korhonen, Merja K Laine,

<h4>Background</h4>Depression and cardiovascular disease (CVD) are major causes of global disease burden that are interrelated through mostly unknown mechanisms. We studied the relationship of melancholic and non-melancholic depressive symptoms with arterial stiffness, an important underlying mechanism of CVD.<h4>Methods</h4>The Helsinki Birth Cohort Study recruited 683 previously extensively phenotyped subjects for this ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):531-540]

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Support among healthcare workers for the new mandatory seasonal influenza vaccination policy and its effects on vaccination coverage.

Aleksi Hämäläinen, Riitta-Liisa Patovirta, Ella Mauranen, Sari Hämäläinen, Irma Koivula,

<h4>Introduction</h4>Finland was the first European country to introduce a nation-wide mandatory seasonal influenza vaccination policy for healthcare workers (HCWs) by mandating that administrators of health care institutions only employ vaccinated HCWs. In this study, we examine the effects of the new policy and the view of HCWs on the new ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):384-390]

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The "second wave" of the COVID-19 pandemic in the Arctic: regional and temporal dynamics.

Andrey N Petrov, Mark Welford, Nikolay Golosov, John DeGroote, Michele Devlin, Tatiana Degai, Alexander Savelyev,

This article focuses on the "second wave" of the COVID-19 pandemic in the Arctic and examines spatiotemporal patterns between July 2020 and January 2021. We analyse available COVID-19 data at the regional (subnational) level to elucidate patterns and typology of Arctic regions with respect to the COVID-19 pandemic. This article ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1925446]

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Risk profile, antithrombotic treatment and clinical outcomes of patients in Nordic countries with atrial fibrillation - results from the GARFIELD-AF registry.

Marita Knudsen Pope, Dan Atar, Arne Svilaas, Torstein Hole, Jørn Dalsgaard Nielsen, Ulrik Hintze, Milita Crisby, Pekka Raatikainen, K E Juhani Airaksinen, Saverio Virdone, Karen Pieper, Gloria Kayani, Jean-Yves Le Heuzey, Jan Steffel, Janina Stepinska, Jean-Pierre Bassand, A John Camm, ,

<h4>Aims</h4>The objective was to evaluate the clinical characteristics, management and two-year outcomes of patients with newly diagnosed non-valvular atrial fibrillation at risk for stroke in Nordic countries.<h4>Methods</h4>We examined the baseline characteristics, antithrombotic treatment, and two-year clinical outcomes of patients from four Nordic countries.<h4>Results</h4>A total of 52,080 patients were enrolled in ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):485-494]

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Inhibition of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with sulphonamides.

Linda J Urbański, Andrea Angeli, Vesa P Hytönen, Anna Di Fiore, Giuseppina De Simone, Seppo Parkkila, Claudiu T Supuran,

Sulphonamides and their isosteres are classical inhibitors of the carbonic anhydrase (CAs, EC 4.2.1.1) metalloenzymes. The protozoan pathogen <i>Trichomonas vaginalis</i> encodes two such enzymes belonging to the β-class, TvaCA1 and TvaCA2. Here we report the first sulphonamide inhibition study of TvaCA1, with a series of simple aromatic/heterocyclic primary sulphonamides as ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):329-334]

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One-hour post-load glucose improves the prediction of cardiovascular events in the OPERA study.

Anni Saunajoki, Juha Auvinen, Aini Bloigu, Olavi Ukkola, Sirkka Keinänen-Kiukaanniemi, Markku Timonen,

<h4>Background</h4>To estimate the ability of fasting, 1-h, and 2-h post-load glucose to predict cardiovascular outcomes.<h4>Methods</h4>We examined a population-based study consisting of 977 middle-aged subjects who underwent an oral glucose tolerance test with glucose values measured at 0, 60, and 120 min. Participants were followed up to 24 years, and cardiovascular outcomes were ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):478-484]

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Outlining the role of experiential expertise in professional work in health care service co-production.

Hannele Palukka, Arja Haapakorpi, Petra Auvinen, Jaana Parviainen,

Patient and public involvement is widely thought to be important in the improvement of health care delivery and in health equity.<b>Purpose:</b> The article examines the role of experiential knowledge in service co-production in order to develop opiate substitution treatment services (OST) for high-risk opioid users.<b>Method:</b> Drawing on social representations theory ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2021, 16(1):1954744]

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An anion and small molecule inhibition study of the β-carbonic anhydrase from Staphylococcus aureus.

Linda J Urbanski, Daniela Vullo, Seppo Parkkila, Claudiu T Supuran,

Pathogenic bacteria resistant to most antibiotics, including the methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) represent a serious medical problem. The search for new antiinfectives, possessing a diverse mechanism of action compared to the clinically used antibiotics, has become an attractive research field. <i>S. aureus</i> DNA encodes a β-class carbonic anhydrase, SauBCA. It ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):1088-1092]

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Activation of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with amines and amino acids.

Andrea Angeli, Linda J Urbański, Vesa P Hytönen, Seppo Parkkila, Claudiu T Supuran,

We report the first activation study of the β-class carbonic anhydrase (CA, EC 4.2.1.1) encoded in the genome of the protozoan pathogen <i>Trichomonas vaginalis</i>, TvaCA1. Among 24 amino acid and amine activators investigated, derivatives incorporating a second carboxylic moiety, such as L-Asp, L- and D-Glu, were devoid of activating effects ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):758-763]

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