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The potential involvement of cholinergic system in finasteride induced cognitive dysfunction.

Ashutosh Ahire, Kala P Nair, B S Shankaranarayana Rao, B N Srikumar,

<b>Objective:</b>Neurosteroids are known to exert diverse functions in the brain. 5α-reductase (5α-R), a rate-limiting enzyme involved in the biosynthesis of neurosteroids is inhibited by finasteride. Clinical studies suggest that administration of finasteride causes the emergence of affective symptoms and cognitive dysfunction. Modeling this in rats would provide an opportunity to ... Read more >>

Psychoneuroendocrinology (Psychoneuroendocrinology)
[2020, 124:105066]

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Methylated CpG dinucleotides in the 5-α reductase 2 gene may explain finasteride resistance in benign prostatic enlargement patients.

Zhe-Min Lin, Dong-Dong Fan, Song Jin, Zhan-Liang Liu, Yi-Nong Niu,

The inhibition of 5-α reductase type 2 (SRD5A2) by finasteride is commonly used for the management of urinary obstruction resulting from benign prostatic enlargement (BPE). Certain BPE patients showing no SRD5A2 protein expression are resistant to finasteride therapy. Our previous work showed that methylated cytosine-phosphate-guanine (CpG) islands in the SRD5A2 ... Read more >>

Asian J Androl (Asian journal of andrology)
[2020, :]

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Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride.

David-Dan Nguyen, Maya Marchese, Eugene B Cone, Marco Paciotti, Shehzad Basaria, Naeem Bhojani, Quoc-Dien Trinh,

Importance:There is ongoing controversy about the adverse events of finasteride, a drug used in the management of alopecia and benign prostatic hyperplasia (BPH). In 2012, reports started emerging on men who had used finasteride and either attempted or completed suicide. Objective:To investigate the association of suicidality (ideation, attempt, and completed ... Read more >>

JAMA Dermatol (JAMA dermatology)
[2020, :]

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Development of Stable and Simple Finasteride 333-μg,mL Suspensions that Minimize Occupational Exposure.

Nathan Ma, William Perks, Shirley Law, John Iazzetta, Scott Walker,

Finasteride is not commercially available in a liquid format, which stimulated the development of a stable and simple finasteride suspension formulation. The objectives of this work were to develop and test a finasteride suspension for 1) simplicity to compound, 2) pharmaceutical acceptability, 3) stability, and 4) potential for occupational exposure. ... Read more >>

Int J Pharm Compd (International journal of pharmaceutical compounding)
[2020, 24(6):519-527]

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In vivo and in silico evaluation of the ameliorative effect of hesperidin on finasteride-induced testicular oxidative stress in Wistar rats.

Ebenezer Tunde Olayinka, Kayode Ezekiel Adewole,

Finasteride used for treating benign prostatic hyperplasia is associated with undesirable side effects via oxidative stress related mechanisms. This study employed in vivo and in silico methods to investigate the protective role of hesperidin against testicular toxicity induced by finasteride and the possible molecular mechanisms involved. Male Wistar rats were randomized ... Read more >>

Toxicol Mech Methods (Toxicology mechanisms and methods)
[2020, :1-9]

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Correction to: Toxicity of the pharmaceuticals finasteride and melengestrol acetate to benthic invertebrates.

Ève A M Gilroy, Adrienne J Bartlett, Patricia L Gillis, Nicholas A Bendo, Joseph Salerno, Amanda M Hedges, Lisa R Brown, Emily A M Holman, Naomi L Stock, Shane R de Solla,

A Correction to this paper has been published: https://doi.org/10.1007/s11356-020-11617-y. ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2020, :]

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Biochemical and histomorphological changes in testosterone propionate-induced benign prostatic hyperplasia in male Wistar rats treated with ketogenic diet.

Omowumi Titilola Kayode, Adetomiwa Victor Owolabi, Azeez Abideen Abolanle Kayode,

PURPOSE:Benign prostatic hyperplasia (BPH) is a urological disease characterized by proliferation of the stromal and epithelial cells of the prostate of older men. Ketogenic diet (KD) is a high fat, moderate protein and low carbohydrate diet which acts on metabolic systems through hormonal modulation and simulation amongst other mechanisms. This ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 132:110863]

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Resveratrol Ameliorates the Seminiferous Tubules Damages Induced by Finasteride in Adult Male Rats.

Amany Mohamed Shalaby, Mohamed Ali Alabiad, Dina Fouad El Shaer,

Finasteride is commonly used in the management of alopecia and nodular prostatic hyperplasia. It was reported to have a harmful effect on spermatogenesis with subsequent infertility. Thus, this research was to determine the ameliorative effect of resveratrol against testicular damage caused by finasteride. Forty adult male rats were randomly divided ... Read more >>

Microsc Microanal (Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada)
[2020, :1-11]

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Ongoing Concerns Regarding Finasteride for the Treatment of Male-Pattern Androgenetic Alopecia.

Roger S Ho,

JAMA Dermatol (JAMA dermatology)
[2020, :]

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Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic Hyperplasia.

Yu Tong, Ren-Yuan Zhou,

The lower urinary tract symptoms (LUTSs) and acute urinary retention (AUR) caused by benign prostatic hyperplasia (BPH) can seriously affect the quality of life of elderly men. Studies suggest that both androgens and inflammation greatly influence the occurrence and development of BPH in most patients. These two factors combined can ... Read more >>

Mediators Inflamm (Mediators of inflammation)
[2020, 2020:7958316]

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Origanum vulgare L. leaves extract alleviates testis and sperm damages induced by finasteride: Biochemical, Immunohistological and apoptosis genes based evidences.

Xiaoning Chen, Hui Feng, Attalla F El-Kott, Eman M Abd-Ella,

The aim of the current study was to investigate antioxidant, anti-inflammatory and anti-apoptotic effects of Origanum vulgare on finasteride-induced oxidative injury in mouse testis and sperm parameters. Thirty BALB/c mice were divided into 5 groups: negative control, received 0.5 ml/day distilled water; positive control, received 25 mg/kg finasteride orally; and three groups ... Read more >>

Andrologia (Andrologia)
[2020, 52(11):e13823]

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Reproductive and endocrinological effects of Benign Prostatic Hyperplasia and finasteride therapy in dogs.

Daniel S R Angrimani, Maíra M Brito, Bruno R Rui, Marcílio Nichi, Camila I Vannucchi,

Benign prostatic hyperplasia (BPH) is one of the most important reproductive disorders in aging dogs. Therapeutic measures include orchiectomy and pharmacological treatment, leading to reduction of prostate volume and clinical signs. One of the most common drugs used in BPH treatment is finasteride, but data regarding its possible side effects ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):14834]

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The 5α-reductase inhibitor finasteride reduces opioid self-administration

Gabriel Bosse, Roberto Cadeddu, Gabriele Floris, Ryan Farero, Eva Vigato, Suhjung Lee, Tejia Zhang, Nilesh Gaikwad, Kristen Keefe, Paul E.M. Philips, Marco Bortolato, Randall Peterson,

Abstract Opioid use disorder (OUD) has become a leading cause of death in the US, yet current therapeutic strategies remain highly inadequate. To identify novel potential treatments for OUD, we screened a targeted selection of over 100 drugs, using a recently developed opioid self-administration assay in zebrafish. This paradigm showed ... Read more >>

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A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review.

Sumel Ashique, Navjot Kaur Sandhu, Sk Niyamul Haque, Kartick Koley,

Androgens have an intense consequence on the human scalp and body hair. Scalp hair sprouts fundamentally in awol of androgens whereas the body hair hike is vulnerable to the activity of androgens. Androgenetic alopecia (AGA) invoked as males emulate Alopecia due to the cause of the dynamic reduction of scalp ... Read more >>

Nat Prod Bioprospect (Natural products and bioprospecting)
[2020, 10(6):345-365]

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Synthesis and Study of Some 17a-aza-D-homo Steroids as 5α-Reductase Inhibitors.

Priyanka Rana, Neelima Dhingra, Poonam Arora, Richa Dhingra, Monika Chauhan, Ankit Gupta,

BACKGROUND AND OBJECTIVE:Tremendous advances have been made in the development of new pharmacotherapuetic agents and less invasive techniques to help men with lower urinary tract symptoms. The use of 5α-reductase inhibitor (5-ARI) is restricted to the patients with large prostate volumes, whose symptoms are refractory to antiandrogens or α- adrenergic ... Read more >>

Curr Drug Discov Technol (Current drug discovery technologies)
[2020, :]

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Alterations of gut microbiota composition in post-finasteride patients: a pilot study.

F Borgo, A D Macandog, S Diviccaro, E Falvo, S Giatti, G Cavaletti, R C Melcangi,

PURPOSE:Post-finasteride syndrome (PFS) has been reported in a subset of patients treated with finasteride (an inhibitor of the enzyme 5alpha-reductase) for androgenetic alopecia. These patients showed, despite the suspension of the treatment, a variety of persistent symptoms, like sexual dysfunction and cognitive and psychological disorders, including depression. A growing body ... Read more >>

J Endocrinol Invest (Journal of endocrinological investigation)
[2020, :]

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Association between 5α-reductase inhibitors therapy and incidence, cancer-specific mortality, and progression of prostate cancer: evidence from a meta-analysis.

Lian-Min Luo, Re-Dian Yang, Jia-Min Wang, Shan-Kun Zhao, Yang-Zhou Liu, Zhi-Guo Zhu, Qian Xiang, Zhi-Gang Zhao,

5α-reductase inhibitors (5-ARI) are widely employed for the treatment of benign prostatic hyperplasia. It has been noted that 5-ARI exhibit the potential to attenuate the risk of prostate cancer, but consistent agreement has not been achieved. Moreover, the effect of 5-ARI on cancer-specific mortality and progression of prostate cancer remains ... Read more >>

Asian J Androl (Asian journal of andrology)
[2020, 22(5):532-538]

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Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment.

Ratchathorn Panchaprateep, Suparuj Lueangarun,

INTRODUCTION:Oral minoxidil is an antihypertensive vasodilator known to stimulate hair growth. The use of low-dose oral minoxidil for the treatment of male androgenetic alopecia (AGA) is receiving increasing attention. The aim of this study was to evaluate the efficacy and safety of oral minoxidil for the treatment of male AGA. ... Read more >>

Dermatol Ther (Heidelb) (Dermatology and therapy)
[2020, 10(6):1345-1357]

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TSPO ligand etifoxine attenuates LPS-induced cognitive dysfunction in mice.

Hui Zhang, Li Ma, Wen-Zhi Guo, Lin-Bo Jiao, Hong-Yu Zhao, Ya-Qun Ma, Xue-Mei Hao,

The translocator protein (TSPO), once known as peripheral-type benzodiazepine receptor, was reported to be related with several physiological functions. Etifoxine is a clinically available anxiolytic drug, and has recently shown neuroprotective effects as a TSPO ligand. The aim of the present study was to investigate the influence of etifoxine on ... Read more >>

Brain Res Bull (Brain research bulletin)
[2020, 165:178-184]

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Anti-androgens may protect against severe COVID-19 outcomes: results from a prospective cohort study of 77 hospitalized men.

A Goren, C G Wambier, S Herrera, J McCoy, S Vaño-Galván, F Gioia, B Comeche, R Ron, S Serrano-Villar, P M Ramos, F A Cadegiani, M Kovacevic, A Tosti, J Shapiro, R Sinclair,

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2020, :]

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Quisqualis indica extract ameliorates low urinary tract symptoms in testosterone propionate-induced benign prostatic hyperplasia rats.

Dae-Geon Kim, Hyo-Jeong Kwon, Jong-Hwan Lim, Joo-Heon Kim, Kyu Pil Lee,

Benign prostate hyperplasia (BPH) is a common disease in old-age males, accounting for approximately 77% of morbidity within the age range of 40 to 70 years. It has been shown that morbidity increases with social graying. Quisqualis indica linn (QI) has been used to treat inflammation, stomach pain, and digestion problems. ... Read more >>

Lab Anim Res (Laboratory animal research)
[2020, 36:26]

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Evaluation of the effect of autologous platelet-rich plasma on androgenic alopecia.

Mahmoud Makki, Abdel-Khalek Hassan Younes, Islam Salah,

In spite of several modalities for androgenic alopecia therapy used such as topical minoxidil solution or oral finasteride; it still has a great challenge. This study evaluated the effect of platelet-rich plasma in androgenic alopecia treatment regarding improvement percentage as well as the rate of adverse. Fifty patients complaining of ... Read more >>

J Cosmet Laser Ther (Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology)
[2020, :1-5]

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Statewide Price Variation for Generic Benign Prostatic Hyperplasia Medications.

Anup A Shah, Praveen Kumar, Ayodele G Ogunmola, Omar Ayyash, Jonathan G Yabes, Lindsay M Sabik, Anobel Y Odisho, Jathin Bandari, Liam C Macleod, Benjamin J Davies, Bruce L Jacobs,

OBJECTIVE:To examine the geographic and pharmacy-type variation in costs for generic benign prostatic hyperplasia (BPH) medications in order to improve drug price transparency and reduce health disparities. Medical therapy for BPH can be expensive, having significant implications for uninsured and underinsured patients. METHODS:We generated a 20% random sample of all ... Read more >>

Urology (Urology)
[2020, :]

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5α-reductase inhibitors impact prognosis of urothelial carcinoma.

Chien-Sheng Wang, Ching-Chia Li, Yung-Shun Juan, Wen-Jeng Wu, Hsiang-Ying Lee,

BACKGROUND:5α-reductase inhibitors (5-ARIs) inhibit the pathway of converting the testosterone to dihydrotestosterone and are widely used in benign prostatic hyperplasia patients. Since androgen receptor activation may play a role in urothelial tumorigenesis, we conducted this retrospective cohort study to determine whether 5α-reductase inhibitors (5-ARIs) administration is associated with bladder cancer ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):872]

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Preoperative predictors of enucleation time during en bloc 'no-touch' holmium laser enucleation of the prostate.

Chun-Hsuan Lin, Wen-Jeng Wu, Ching-Chia Li, Sheng-Chen Wen,

BACKGROUND:To evaluate preoperative predictors of enucleation time during en bloc 'no-touch' holmium laser enucleation of the prostate (HoLEP) METHODS: We enrolled 135 patients with symptomatic benign prostatic hyperplasia (BPH) treated with en bloc 'no-touch' HoLEP from July 2017 to March 2019 by a single surgeon. Preoperative, perioperative, and postoperative clinical ... Read more >>

BMC Urol (BMC urology)
[2020, 20(1):185]

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